Luban's Efficacy in Treating Renal Stones in Rats

What is it about?

The study aimed to investigate the effect of Luban, a resin extracted from Boswellia trees, on experimentally induced renal stones in rats. The rat model of urolithiasis was induced by trans-4-hydroxy-L-proline (HLP). Treatment groups were given Luban in doses of 50, 100, and 150 mg/kg/day for 14 days, while prevention groups were given Luban in similar doses for 28 days. The results showed that the lithogenic effects of HLP were significantly reversed by the Luban dose of 150 mg/kg/day. The histological changes of HLP on the kidney tissue, including calcium oxalate crystal formation, cystic dilatation, high degree of tubular necrosis, inflammatory changes, atrophy, and fibrosis, were also ameliorated by the Luban dose of 150 mg/kg/day. This study concluded that Luban has shown a significant improvement in the treatment and prevention of experimentally induced renal stones, particularly at a dose of 150 mg/kg/day.

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Why is it important?

This research is important as it investigates the potential therapeutic effects of Luban, a natural resin obtained from Boswellia trees, on experimentally induced renal stones in rats. The study contributes to the scientific community's growing interest in the anti-inflammatory and therapeutic potential of Luban. The findings could potentially have implications for the treatment and prevention of renal stones in humans. Key Takeaways: 1. Luban, a natural resin from Boswellia trees, shows promise in treating and preventing renal stones, particularly at a dose of 150 mg/kg/day. 2. The study used a rat model of urolithiasis induced by trans-4-hydroxy-L-proline (HLP) and monitored several plasma biochemical and histological parameters. 3. Luban significantly improved the treatment and prevention of renal stones compared to control groups, with the highest efficacy observed at the 150 mg/kg/day dose. 4. Further studies are needed in other animal models and humans to validate the findings and explore the full potential of Luban for renal stone treatment.