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What is it about?
This study analyzed 24-hour voided volume data in 450 nephrolithiasis patients from the ReSKU registry and found no significant association between voided volume and stone events. A negative correlation was noted between voided volume and stone events in calcium oxalate dihydrate stone formers, but not in others. These findings suggest that increasing voided volume may not be effective in preventing stone events in all patients and that further studies are needed to identify subgroups that may benefit from increased fluid intake.
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Why is it important?
This research is important because it challenges a widely accepted guideline recommendation for preventing kidney stones, which is to increase fluid intake to increase urinary volume. The study found that 24-hour voided volume was not associated with stone events in a large institutional cohort, and subset analysis reveals that some stone formers may benefit more from increased voided volume than others. This suggests that identifying such patients represents a novel precision medicine opportunity. Key Takeaways: 1. The study found that 24-hour voided volume was not associated with stone events in a large institutional cohort. 2. Subset analysis reveals that some stone formers may benefit more from increased voided volume than others. 3. Identifying such patients represents a novel precision medicine opportunity.
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This page is a summary of: Voided volume may not impact stone outcomes: Review of a large institutional nephrolithiasis cohort, BJUI Compass, April 2023, Wiley,
DOI: 10.1002/bco2.216.
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