What is it about?
Complement activation plays an important role in the pathogenesis of anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV). Neutrophil activation via binding of C5a to C5aR results in neutrophil influx and boosts ROS generation leading to severe vessel necrosis. We aimed to examine anti-C5aR antibody concentrations in comparison to anti-C3aR antibodies and their associations with other complement components and markers of disease activity and survival.
Featured Image
Photo by Hush Naidoo Jade Photography on Unsplash
Why is it important?
Our findings identified low concentrations of anti-C5aR antibodies as a risk factor for AAV relapse and extended evidence that the C5aR axis represents a valid target for therapeutic modulation in both MPO-AAV and PR3-AAV. First, this is important to evaluate the best individual therapy for AAV patients. Further, new therapeutical strategies targeting C5aR might be adjusted with the individual levels of anti-C5aR antibodies.
Perspectives
Future therapeutical options regarding C5aR as a checkpoint in ANCA-associated vasculitis.
Sebastian Klapa
University of Luebeck
Read the Original
This page is a summary of: Low concentrations of C5a complement receptor antibodies are linked to disease activity and relapse in
ANCA
‐associated vasculitis, Arthritis & Rheumatology, November 2022, Wiley, DOI: 10.1002/art.42410.
You can read the full text:
Resources
Contributors
The following have contributed to this page
