What is it about?

Complement activation plays an important role in the pathogenesis of anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV). Neutrophil activation via binding of C5a to C5aR results in neutrophil influx and boosts ROS generation leading to severe vessel necrosis. We aimed to examine anti-C5aR antibody concentrations in comparison to anti-C3aR antibodies and their associations with other complement components and markers of disease activity and survival.

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Why is it important?

Our findings identified low concentrations of anti-C5aR antibodies as a risk factor for AAV relapse and extended evidence that the C5aR axis represents a valid target for therapeutic modulation in both MPO-AAV and PR3-AAV. First, this is important to evaluate the best individual therapy for AAV patients. Further, new therapeutical strategies targeting C5aR might be adjusted with the individual levels of anti-C5aR antibodies.


Future therapeutical options regarding C5aR as a checkpoint in ANCA-associated vasculitis.

Sebastian Klapa
University of Luebeck

Read the Original

This page is a summary of: Low concentrations of C5a complement receptor antibodies are linked to disease activity and relapse in ANCA ‐associated vasculitis, Arthritis & Rheumatology, November 2022, Wiley,
DOI: 10.1002/art.42410.
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