What is it about?
We found a unique cell population in the inflamed lung of rheumatoid arthritis-model mice. We named the cells as CD11b+Gr-1dim cells from the cell surface makers. CD11b+Gr-1dim cells were phenotypically and morphologically dendritic cell-like and differentiated from monocytic-myeloid derived suppressor cells. The cells inhibited the proliferation of T cells in vtro and suppressed the progression of interstitial lung disease in this model mice. All together, CD11b+Gr-1dim cells were thought to be suppressive dendritic cell-like cells.
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Why is it important?
The unique cells we found in in the inflamed lung of rheumatoid arthritis-model mice had suppressive function on T cells and actually suppressed lung inflammation. If we can find the counterparts of CD11b+Gr1dim cells in human rheumatoid arthritis associated interstitial lung disease (RA-ILD), it could be a potential target for new therapy in refractory RA-ILD.
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This page is a summary of: CD11b+Gr-1dim
Tolerogenic Dendritic Cell-Like Cells Are Expanded in Interstitial Lung Disease in SKG Mice, Arthritis & Rheumatology, November 2017, Wiley,
DOI: 10.1002/art.40231.
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