High-Affinity Multivalent DNA Binding by Using Low-Molecular-Weight Dendrons

Mauri A. Kostiainen, John G. Hardy, David K. Smith
  • Angewandte Chemie International Edition, April 2005, Wiley
  • DOI: 10.1002/anie.200500066

Cationic dendrimers for DNA binding

What is it about?

This manuscript is about molecules that can bind DNA which have potential to enable the delivery of therapeutic DNA across cell membranes (i.e. act as artificial viruses).

Why is it important?

The structures described used branched (tree-like) molecules displaying multiple copies of a biologically occuring polyamine (spermine) to bind DNA. The structures bound DNA very strongly because of this multivalent binding motif.

Perspectives

Dr John George Hardy (Author)
Lancaster University

This manuscript describes preliminary studies of branched (tree-like) molecules displaying multiple copies of a biologically occuring polyamine (spermine) to bind DNA. The structures bound DNA very strongly because of this multivalent binding motif. This was the first time I had the opportunity to work with Mauri Kostiainen, who is now a good friend.

Read Publication

http://dx.doi.org/10.1002/anie.200500066

The following have contributed to this page: Dr John George Hardy