Predictors of preoperative and early postoperative seizures in patients with intra-axial primary and metastatic brain tumors: A retrospective observational single center study

  • Predictors of Seizures
  • Marco Skardelly, Elina Brendle, Susan Noell, Felix Behling, Thomas V. Wuttke, Jens Schittenhelm, Sotirios Bisdas, Christoph Meisner, Sabine Rona, Marcos Soares Tatagiba, Ghazaleh Tabatabai
  • Annals of Neurology, October 2015, Wiley
  • DOI: 10.1002/ana.24522

Criteria for the occurrence of brain tumor associated seizures

What is it about?

Antiepileptic treatment of brain tumor patients mainly depends on the individual physician`s choice rather than on well-defined predictive factors. The study investigated and quantified the risk factors (predictors) that are associated with the occurrence of seizures in patients with primary and metastatic brain tumors.

Why is it important?

Antiepileptic drugs (AEDs) are not recommended as a primary seizure prophylaxis in brain tumor patients, nevertheless many physicians routinely use AEDs to overcome the potential risks related to seizures. Based on the identified risk factors we developed prognostic scores to enable the calculation of the individual seizure risk of a patient to identify high-risk patients, who might benefit from antiepileptic seizure prophylaxis.


Dr Marco Skardelly
University Hospital of Tuebingen

The quantification of the predictors of distinct events enable the calculation of individual risks (chances) for the occurrence of these events. We identified and quantified the predictors of preoperative and early-postoperative seizures and formulated models to estimate patients individual seizure risks. These models will help physicians to guide their decisions regarding primary seizure prophylaxis in daily practice based on patients individual risk to develop seizures but not on general recommendations.

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The following have contributed to this page: Dr Marco Skardelly