What is it about?

The results from the “Comparative analytical performance of multiple plasma Aβ42and Aβ40 assays and their ability to predict positron emission tomography amyloid positivity” represent the collaborative work supported by the Foundation for the National Institutes of Health (FNIH) and 11 partner organizations from across the public and private sectors. The study conducted a unique large-scale comparative assessment of blood tests that measure the levels of amyloid beta in blood with all data made available to any interested parties. The study employed samples from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) and confirmed that blood tests can predict patients’ amyloid positivity, which is important for Alzheimer’s diagnosis. Project data and methodology report are publicly available on the ADNI Laboratory of Neuroimaging (LONI) website. To learn more about the Plasma Aβ Project, visit https://fnih.org/our-programs/biomarkers-consortium/programs/plasma-abeta

Featured Image

Why is it important?

The blood-based Aβ tests will serve as a powerful, cost-effective, and readily available tool to identify individuals to participate in clinical trials and will accelerate the development of effective treatments for Alzheimer’s disease.


This study differs from other round robins, not only in terms of design but, more importantly, in providing for and making widely available a data repository for others to make their conclusions. A core driver behind any Biomarkers Consortium project is generating a foundational dataset that industry and other scientists could interrogate and not simply depend on a single analytic approach leading to a specific set of results and interpretation. -Posted on behalf of the project team

Erin Rosenbaugh
Foundation for the National Institutes of Health

Read the Original

This page is a summary of: Comparative analytical performance of multiple plasma amyloid‐beta assays and their relationship to amyloid PET, Alzheimer s & Dementia, December 2021, Wiley, DOI: 10.1002/alz.055504.
You can read the full text:




The following have contributed to this page