What is it about?
Mesenchymal stem cell (MSCs) is a heterogeneous population. We have mapped the spatial and temporal heterogeneity of Wharton's Jelly-derived MSCs (WJ-MSCs) for the first time, and revealed a subpopulation, termed S100A9+CD29+CD142+ WJ-MSCs, possessing the better ability to facilitate the repair of skin wound compared with other subpopulation, which validated in various in vitro and in vivo experiments.
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Why is it important?
We identified the four heterogeneous WJ-MSC subsets at the single-cell level, among which a S100A9+CD29+CD142+ subpopulation exhibited promising wound repair properties in vitro and in vivo. Importantly, by integrating omics data, we found that S100A9+CD29+CD142+ subpopulation were more enriched in fetal segment of umbilical cord. Overall, we comprehensively mapped the heterogeneity of WJ-MSCs and presented the idea that S100A9+CD29+CD142+ subpopulation isolated from the fetal end may be a preferred source of wound repair.
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This page is a summary of: Single‐Cell and Spatial Transcriptomics Decodes Wharton's Jelly‐Derived Mesenchymal Stem Cells Heterogeneity and a Subpopulation with Wound Repair Signatures, Advanced Science, December 2022, Wiley, DOI: 10.1002/advs.202204786.
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