What is it about?
Single Crystal Diamond Needles (SCDNs) enriched with point defects of a certain type form a specific group of diamond materials which preserve all the unique physical properties of a bulk diamond but can be applied for accurate bio-sensing on the sub-micron scale. In the present study, we show the application of SCDNs both for bioimaging based on the NV color center photoluminescence (PL) and accurate temperature sensing in the physiologically significant range (from 25C to 55C), based on the PL temperature dependence of SiV color centers. Zero phonon line (ZPL) position for NV and SiV color centers are spectrally separated, allowing cell imaging and all-optical thermometry independently in different spectral regions.
Photo by Michael Dziedzic on Unsplash
Why is it important?
Single crystal diamond needles (SCDNs) enriched with NV and SiV color centers are perfect candidates to breakthrough many obstacles arising in techniques traditionally applied for living cells visualization and simultaneous temperature control. Controlling the thermodynamics of intracellular processes is crucial for early detection of the dramatic changes which may switch the cell from its normal functioning to a pathological state. However, it is hardly to be studied due to complexity of applying existing, often invasive thermometric approaches. Approach based on SCDNs enriched with several types of color centers is non-invasive, highly effective and accurate, as it proposes very fast, all-optical remote monitoring of the cellular thermal dynamics and simultaneous cell imaging.
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This page is a summary of: All‐Optical Thermometry with NV and SiV Color Centers in Biocompatible Diamond Microneedles, Advanced Optical Materials, May 2022, Wiley, DOI: 10.1002/adom.202200631.
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