mRNA encapsulated in polymeric PBAE nanoparticles that in vivo targets antigen-presenting cells
What is it about?
This publication states for the first time the ability of oligopeptide-modified PBAE nanoparticles, encapsulating reporter mRNA to target antigen presenting cells (e.g. dendritic cells), if the terminal oligopeptides are carefully designed. It is the first proof-of-concept that these nanoparticles could be promising vaccines in a near future.
Why is it important?
The nanoparticles target antigen presenting cells by themselves. The synthesis of these nanotools is easy and cheap, becoming a promising nanomedicine available for large population groups.
The following have contributed to this page: Dr Cristina Fornaguera
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