mRNA Delivery System for Targeting Antigen-Presenting Cells In Vivo

Cristina Fornaguera, Marta Guerra-Rebollo, Miguel Ángel Lázaro, Cristina Castells-Sala, Oscar Meca-Cortés, Victor Ramos-Pérez, Anna Cascante, Núria Rubio, Jerónimo Blanco, Salvador Borrós
  • Advanced Healthcare Materials, June 2018, Wiley
  • DOI: 10.1002/adhm.201800335

mRNA encapsulated in polymeric PBAE nanoparticles that in vivo targets antigen-presenting cells

What is it about?

This publication states for the first time the ability of oligopeptide-modified PBAE nanoparticles, encapsulating reporter mRNA to target antigen presenting cells (e.g. dendritic cells), if the terminal oligopeptides are carefully designed. It is the first proof-of-concept that these nanoparticles could be promising vaccines in a near future.

Why is it important?

The nanoparticles target antigen presenting cells by themselves. The synthesis of these nanotools is easy and cheap, becoming a promising nanomedicine available for large population groups.

Perspectives

Dr Cristina Fornaguera (Author)
Sagetis-Biotech

I see this publication as the first step in the way to reach to mRNA vaccines for multiple purposes. It opens a new window of development.

Read Publication

http://dx.doi.org/10.1002/adhm.201800335

The following have contributed to this page: Dr Cristina Fornaguera

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