Teratogenic effects of vigabatrinin TO mouse fetuses

  • Yousef M. Abdulrazzaq, Salim M. A. Bastaki, R. Padmanabhan
  • Teratology, March 1997, Wiley
  • DOI: 10.1002/(sici)1096-9926(199703)55:3<165::aid-tera1>3.0.co;2-1

Birth defect effects of vigabatrin on mouse fetuses

What is it about?

Vigabatrin, which is an anti-epileptic agent when given to mice in the developmental phase of the fetus causes birth defects, several of which are lethal.

Why is it important?

It is important because pregnant women who have epilepsy have to continue taking anti-epileptic medications during pregnancy thereby exposing the fetuses to the deleterious effects of the drug. This paper details the these effects.

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http://dx.doi.org/10.1002/(sici)1096-9926(199703)55:3<165::aid-tera1>3.0.co;2-1

The following have contributed to this page: Pof Yousef Abdulrazzaq