Journal of Clinical Hepatology
This article systematically analyzes the expression characteristics of HBsAg and HBcAg in the liver tissues of 257 children and adult patients with chronic hepatitis B (CHB) and discusses their correlation with serological markers. The study finds that there are significant differences in the expression patterns, areas, and intensities of antigens among different age groups and HBeAg states, especially in children under 5 years old. The innovation lies in the first-time revelation of the multi-level correlation between liver viral antigen expression in children with CHB and serum indicators (such as qHBsAg, HBV DNA, ALT, etc.) based on immunohistochemical quantitative methods, and the construction of age-specific correlation data models. The study further shows that the expression of HBsAg in children under 5 years old is significantly negatively correlated with anti-HBs, while the expression of HBcAg is highly positively correlated with viral replication indicators, suggesting that serological markers can indirectly reflect the pathological state of the liver. This achievement provides an important basis for reducing the frequency of liver biopsy in children, achieving non-invasive immune staging, and making individualized treatment decisions, and has strong clinical transformation value.
This study systematically analyzes the expression characteristics of HBsAg and HBcAg in the liver tissues of children with chronic hepatitis B (CHB) and discusses their correlation with serological markers, revealing the unique viral antigen expression patterns of children, especially those under 5 years old. The study finds that the expression areas and intensities of HBsAg and HBcAg in the liver are significantly correlated with serological indicators such as qHBsAg, HBeAg, and HBV DNA, suggesting that serological detection can indirectly reflect the state of viral antigens in the liver. In particular, the expression of HBcAg is highly consistent with viral replication indicators, confirming its value as a reliable histological indicator for evaluating the activity of HBV replication. Compared with invasive liver biopsy, serological markers are easier to dynamically monitor, and the research results provide a theoretical basis for establishing non-invasive evaluation models and reducing the frequency of liver biopsy in children. In addition, this study helps to accurately judge the immune staging and liver inflammation status of children with CHB, providing evidence-based support for the selection of individualized treatment timing. Therefore, this study not only deepens the understanding of the pathogenesis of CHB in children but also has important clinical guiding significance.
Objective: To investigate the expression features of HBsAg and HBcAg in liver tissue and their correlation with HBV serum markers in ch…
