Journal of Clinical Hepatology
This article studies the clinical features and short-term prognosis of decompensated liver cirrhosis complicated with diastolic heart dysfunction, aiming to identify key factors affecting patient prognosis. The study retrospectively analyzed the clinical data of 263 liver cirrhosis patients, finding that age, NT-proBNP level, and mild to moderate ascites are independent predictive factors for diastolic heart dysfunction. Advanced age and decreasing NT-proBNP levels suggest an increased risk of impaired heart function, while mild to moderate ascites are associated with a lower risk, possibly reflecting an early intervention window. The innovation lies in combining multi-parameter evaluation to construct a predictive model for the Chinese population and emphasizing the value of the E/A ratio in echocardiography in diagnosis. In addition, the study followed up on re-admission rates and mortality rates within 90 days, finding that the mortality rate in the heart dysfunction group was higher (12/84 vs 18/142), but the difference in re-admission rates was not significant, suggesting that heart function status has an important impact on short-term survival. The study also points out that electrocardiographic abnormalities and jaundice are common admission manifestations, providing a basis for early clinical identification. Overall, the study optimizes the predictive indicator system of CCM, proposing that attention should be focused on high-risk populations and symptomatic treatments such as diuretics should be given to improve prognosis.
This study focuses on the clinical features and short-term prognosis of decompensated liver cirrhosis complicated with diastolic heart dysfunction (i.e., cirrhotic cardiomyopathy, CCM), which has important clinical significance. Firstly, the study clarifies that the incidence of heart dysfunction in this population reaches 37.2%, significantly higher than that in compensated patients, indicating that disease progression is closely related to heart function damage. Secondly, through multivariate analysis, it is found that age, NT-proBNP level, and mild to moderate ascites are independent predictive factors for CCM, providing practical indicators for early identification of high-risk patients. In addition, although the re-admission rate in patients with diastolic dysfunction is slightly higher, there is no significant difference in 90-day mortality, suggesting that a comprehensive assessment of prognosis is needed in complex pathological conditions. The study also emphasizes the importance of routine electrocardiogram and echocardiography screening and suggests that attention should be paid to the dynamic changes of NT-proBNP to guide treatment. Overall, the study improves the cognitive understanding of the clinical phenotype of CCM, optimizes the risk stratification model, and has realistic guiding value for improving patient management strategies and prognosis.
Objective: To retrospectively study the characteristics and short-term outcomes of patients with decompensated liver cirrhosis accomp…
