Journal of Clinical Hepatology
This article aims to explore the association between alpha-fetoprotein (AFP) and prealbumin (PAB) levels and the 90-day prognosis of patients with chronic-onset acute liver failure (HBV-ACLF) related to hepatitis B virus, and to analyze the differences in the impact of different AFP and PAB levels on prognosis. The study retrospectively included 371 patients with HBV-ACLF, divided into three groups according to AFP and PAB levels, and compared their baseline characteristics and 90-day survival rates. Kaplan-Meier survival analysis and multivariate regression models were used to evaluate the influencing factors of prognosis. The results showed that patients with higher AFP levels (log10 AFP≥2.04) had better prognosis, indicating stronger liver cell regeneration ability. At the same time, PAB, as an indicator of nutritional and synthetic function, is also closely related to short-term survival. The innovation lies in the joint evaluation of the predictive value of regeneration indicators (AFP) and synthetic function indicators (PAB), which makes up for the limitations of single indicators and provides a basis for clinical judgment of the condition and the formulation of individualized treatment plans (such as the timing of artificial liver intervention). The study also visually displays the differences between groups through stratified survival curves (Figure 1) and 90-day survival rate comparisons (Table 4), enhancing the readability of the results. This study provides a simple and practical biomarker combination strategy for the stratification of prognosis in HBV-ACLF.
The main significance of this study lies in exploring the impact of alpha-fetoprotein (AFP) and prealbumin (PAB) levels on the 90-day prognosis of patients with chronic-onset acute liver failure (HBV-ACLF) related to hepatitis B virus, providing reliable evidence for clinical early evaluation of the condition and the formulation of individualized treatment plans. HBV-ACLF has rapid progression and high mortality, and it is urgent to have effective biomarkers to predict prognosis. The study shows that AFP has a potential protective effect in liver cell regeneration, while PAB reflects liver synthetic function and nutritional status. The combined detection of both may more accurately reflect the dynamic changes and recovery potential of patient liver function. By comparing the survival rates of patients with different AFP and PAB levels, the study found that their levels were significantly associated with 90-day survival rates, indicating their important value in prognosis stratification. In addition, the study strictly follows ethical norms, ensuring the legality and scientificity of the data. All patients have signed informed consent, and the ethical committee has approved. The research results help optimize the risk stratification system for HBV-ACLF patients, improve the accuracy of clinical decision-making, and have important practical significance and promotional value.
Objective: To investigate the association of alpha-fetoprotein (AFP) and prealbumin (PAB) with the 90-day prognosis of patients with he…
