Journal of Clinical Hepatology
This article investigates the relationship between the GHSR gene rs2922126 polymorphism and the genetic susceptibility to non-alcoholic fatty liver disease (NAFLD) in the Chinese Han population. The study included 220 NAFLD patients and 167 healthy controls, detecting genotypes through mass spectrometry and analyzing their association with clinical biochemical indicators. The results showed that the proportion of individuals carrying the AA genotype was significantly higher in the NAFLD group, and the AA genotype in the recessive model was associated with an increased risk of NAFLD (OR=2.156, P=0.008), suggesting that the rs2922126 locus may affect disease susceptibility. In addition, this locus is also associated with lipid metabolism and may participate in the occurrence of NAFLD by regulating cholesterol homeostasis. The innovation lies in the first verification of the association between GHSR rs2922126 and NAFLD in the Han population in Qingdao, China, expanding the genetic evidence of this gene in metabolic diseases and providing potential molecular markers for early risk prediction of NAFLD. The study also controlled for confounding factors such as age and BMI, enhancing the reliability of the results.
This study explores the relationship between the GHSR gene rs2922126 polymorphism and the susceptibility to non-alcoholic fatty liver disease (NAFLD) in the Chinese Han population, which has important clinical and genetic significance. The pathogenesis of NAFLD is complex, involving the interaction of metabolic disorders and genetic factors. The "multiple hits" hypothesis suggests that insulin resistance, lipotoxicity, and inflammatory reactions collectively promote disease progression, and genes related to energy metabolism may play a key role. As an important receptor that regulates appetite and energy balance, GHSR gene variants may affect an individual's genetic susceptibility to NAFLD. By comparing the genotype distribution between NAFLD patients and healthy controls, the study found that the AA genotype in the recessive model significantly increased the risk of NAFLD, with an adjusted OR value of 2.156 (P=0.008), suggesting that this locus may be a potential genetic marker for NAFLD. In addition, the study also analyzed the relationship between different genotypes and the risk of liver fibrosis and biochemical indicators, providing a reference for the non-invasive evaluation of disease progression. The research achievements help to reveal the molecular mechanism of NAFLD, provide a theoretical basis for screening high-risk populations and personalized prevention and treatment strategies, and have translational medical value.
Objective: To investigate growth hormone secretagogue receptor (GHSR) rs2922126 gene polymorphisms and their association with genetic…
