Journal of Clinical Hepatology
This article studies the impact of triglyceride glucose index (TyG) and C-reactive protein (CRP) on the occurrence of non-alcoholic fatty liver disease (NAFLD) and aims to explore whether there is a synergistic pathogenic effect between them, providing a basis for identifying high-risk populations. The study is based on long-term follow-up data of 31,935 employees of the Kailuan Group, grouped by the median levels of TyG and CRP at baseline, and analyzes the risk of NAFLD occurrence using the Kaplan-Meier method and the multivariate Cox regression model. The results show that with the increase of TyG and CRP levels, the cumulative incidence of NAFLD significantly rises, with the highest risk in the group with TyG≥8.42 and CRP≥0.60 mg/L (HR=1.54), indicating a synergistic effect. The innovation lies in the first systematic evaluation of the combined predictive value of TyG and CRP for NAFLD, revealing the important mechanism of the interaction between metabolic abnormalities and chronic inflammation in the occurrence of NAFLD. In addition, the large sample size and long follow-up time of the study enhance the reliability of the results. This finding is helpful for the early screening and intervention of high-risk populations in clinical practice, and has important public health significance.
The main significance of this study lies in revealing the synergistic effect of tyrosine glucose index (TyG) and C-reactive protein (CRP) in the occurrence of non-alcoholic fatty liver disease (NAFLD), providing an important basis for the primary prevention of NAFLD. With the prevalence of unhealthy lifestyles, NAFLD has become the most common chronic liver disease worldwide and is closely related to metabolic diseases and malignant tumors. However, there is currently no effective therapeutic drug, so identifying high-risk populations and strengthening early prevention and control is particularly crucial. This study found that with the higher levels of TyG and CRP, the cumulative incidence of NAFLD shows a significant upward trend. In particular, the group with TyG≥8.42 and CRP≥0.60 mg/L has the highest risk of NAFLD (HR=1.54), indicating that insulin resistance and inflammatory response promote the occurrence of NAFLD together. This result supports the theory of "inflammation-insulin resistance" interaction in the pathogenesis of NAFLD and shows that the joint detection of TyG and CRP can more effectively identify high-risk individuals, with good clinical application value and public health significance.
Objective: To investigate whether there is a synergistic pathogenic effect between triglyceride glucose index (TyG) and C-reactive pr…
