Publication
Silversol® (a Colloidal Nanosilver Formulation) Inhibits Growth of Antibiotic-Resistant Staphylococcus aureus by Disrupting Its Physiology in Multiple Ways
Silver inhibits MRSA through pleiotropic mode of action
What is it about?
This project page showcases some aspects of our research in the field of AMR over past two decades.
Why is it important?
Antibiotic-resistance among pathogenic bacteria is one of the most serious global health threats. Identification of novel antibacterial leads as well as targets, and elucidation of potential novel anti-pathogenic mechanisms is necessary to combat this issue effectively. While the global AMR Expert Pool is shrinking, and major pharmaceutical companies have not sustained their interest in antimicrobial research, keeping meaningful AMR research live in academic laboratories is essential to develop human resources in this field.
Perspectives
While data generation is easy for the AMR Surveillance projects, real-life tackling of antibiotic-resistant infections relies heavily on discovery and development of new antimicrobials. Identification and validation of potentially novel targets in pathogens remains a bottleneck, and enriching the antimicrobial drug discovery pipeline with effective leads remains an even bigger challenge. A more detailed reflection of my personal perspective on this issue can be viewed here: https://journals.aboutscience.eu/index.php/dti/article/view/2545/2835
Dr
Vijay
Kothari
Institute of Science, Nirma University
