Journal of Clinical Hepatology
This study dynamically observed the changes in depression, anxiety, and fatigue of 118 chronic hepatitis B (CHB) patients who had been receiving nucleoside (acid) drug (NA) treatment for a long time before and after 104 weeks. The results showed that the overall improvement of the three psychological symptoms was significant (P<0.05), confirming that antiviral treatment has a positive impact on mental health. However, subgroup analysis found that it was more difficult for those with liver cirrhosis and family history of liver cancer to relieve fatigue; the anxiety relief rate was lower for women, those with a family history of liver cancer, and those with low education levels; women and family history of liver cancer were the main risk factors for persistent depression. Multivariate Logistic regression further quantified the effect values of various risk factors (such as the OR for liver cancer family history on depression relief was 0.091, P=0.003). The study emphasizes that the improvement of psychology is not homogeneous and it is necessary to identify high-risk populations for stratified intervention.
This study fills the evidence-based gap in the long-term management of CHB for "treating both body and mind" and systematically reveals the heterogeneous law of psychological state evolution and its controllable risk factors under the background of NA treatment. It breaks through the traditional limitation of only focusing on virological response and promotes the clinical shift from "simple antiviral" to "biopsychosocial integrated management model". Especially, it provides early identification indicators and precise intervention targets for high psychological load groups such as women and those with a family history of liver cancer, helping to formulate individualized psychological support pathways. At the same time, the study points out the limitations such as single-center sample and limited follow-up nodes, calling for multicenter longitudinal studies to optimize the full-cycle mental health management strategy. Its conclusions have important practical value for improving patient compliance, quality of life, and long-term prognosis.
Objective: To investigate the change in psychological state, especially depression, anxiety, and fatigue, among chronic hepatitis B...
