All Stories

  1. Low level DUX4 expression disrupts myogenesis through deregulation of myogenic gene expression

    Article • Scientific Reports, November 2018, Springer Science + Business Media

    Michael Kyba

  2. Evolutionarily conserved Tbx5 – Wnt2/2b pathway orchestrates cardiopulmonary development

    Article • Proceedings of the National Academy of Sciences, October 2018, Proceedings of the National Academy of Sciences

    Michael Kyba

  3. Comment on structural basis of DUX4/IGH-driven transactivation

    Article • Leukemia, July 2018, Springer Science + Business Media

    Michael Kyba

  4. A moderate estradiol level enhances neutrophil number and activity in muscle after traumatic injury but strength recovery is accelerated

    Article • The Journal of Physiology, July 2018, Wiley

    Dr Gordon L Warren, Michael Kyba

  5. DNMT3A and TET1 cooperate to regulate promoter epigenetic landscapes in mouse embryonic stem cells

    Article • July 2018, Springer Science + Business Media

    Michael Kyba

  6. Skeletal Muscle Stem Cells from PSC-Derived Teratomas Have Functional Regenerative Capacity

    Article • Cell Stem Cell, July 2018, Elsevier

    Michael Kyba

  7. Author Correction: Muscle pathology from stochastic low level DUX4 expression in an FSHD mouse model

    Article • Nature Communications, February 2018, Nature

    Michael Kyba

  8. ULK1 phosphorylates Ser30 of BECN1 in association with ATG14 to stimulate autophagy induction

    Article • Autophagy, January 2018, Taylor & Francis

    Michael Kyba

  9. Mouse models of two missense mutations in actin-binding domain 1 of dystrophin associated with Duchenne or Becker muscular dystrophy

    Article • Human Molecular Genetics, November 2017, Oxford University Press (OUP)

    Michael Kyba

  10. Notch activation is required for downregulation of HoxA3-dependent endothelial cell phenotype during blood formation

    Article • PLoS ONE, October 2017, PLOS

    Michael Kyba

  11. The DUX4 homeodomains mediate inhibition of myogenesis and are functionally exchangeable with the Pax7 homeodomain

    Article • Journal of Cell Science, September 2017, The Company of Biologists

    Michael Kyba

  12. Muscle pathology from stochastic low level DUX4 expression in an FSHD mouse model

    Article • Nature Communications, September 2017, Nature

    Michael Kyba

  13. p53-independent DUX4 pathology in cell and animal models of facioscapulohumeral muscular dystrophy

    Article • Disease Models & Mechanisms, July 2017, The Company of Biologists

    Michael Kyba

  14. Expansion and Purification Are Critical for the Therapeutic Application of Pluripotent Stem Cell-Derived Myogenic Progenitors

    Article • Stem Cell Reports, July 2017, Elsevier

    Michael Kyba

  15. A PPARγ transcriptional cascade directs adipose progenitor cell-niche interaction and niche expansion

    Article • Nature Communications, June 2017, Nature

    Michael Kyba

  16. Pax7 remodels the chromatin landscape in skeletal muscle stem cells

    Article • PLoS ONE, April 2017, PLOS

    Michael Kyba

  17. Cellular Aging Contributes to Failure of Cold-Induced Beige Adipocyte Formation in Old Mice and Humans

    Article • Cell Metabolism, February 2017, Elsevier

    Michael Kyba

  18. Modulating the malignancy of Hox proteins

    Article • Blood, January 2017, American Society of Hematology

    Michael Kyba

  19. miR-125bpromotesMLL-AF9–driven murine acute myeloid leukemia involving aVEGFA-mediated non–cell-intrinsic mechanism

    Article • Blood, January 2017, American Society of Hematology

    Michael Kyba

  20. Cellular Aging Contributes to Failure of Cold-Induced Beige Adipocyte Formation in Old Mice and Humans

    Article • Cell Metabolism, January 2017, Elsevier

    Michael Kyba

  21. Transcriptional Inhibitors Identified in a 160,000-Compound Small-Molecule DUX4 Viability Screen

    Article • SLAS DISCOVERY, July 2016, SAGE Publications

    Michael Kyba

  22. MLL-AF9 Expression in Hematopoietic Stem Cells Drives a Highly Invasive AML Expressing EMT-Related Genes Linked to Poor Outcome

    Article • Cancer Cell, July 2016, Elsevier

    Michael Kyba

  23. Heterogeneity of Mesp1+ mesoderm revealed by single-cell RNA-seq

    Article • Biochemical and Biophysical Research Communications, June 2016, Elsevier

    Michael Kyba

  24. High Frequency Hearing Loss and Hyperactivity in DUX4 Transgenic Mice

    Article • PLoS ONE, March 2016, PLOS

    Michael Kyba

  25. DUX4 recruits p300/CBP through its C-terminus and induces global H3K27 acetylation changes

    Article • Nucleic Acids Research, March 2016, Oxford University Press (OUP)

    Michael Kyba

  26. Lineage Reprogramming of Fibroblasts into Proliferative Induced Cardiac Progenitor Cells by Defined Factors

    Article • Cell Stem Cell, March 2016, Elsevier

    Michael Kyba

  27. Germ Cell Nuclear Factor (GCNF) Represses Oct4 Expression and Globally Modulates Gene Expression in Human Embryonic Stem (hES) Cells

    Article • Journal of Biological Chemistry, January 2016, American Society for Biochemistry & Molecular Biology (ASBMB)

    Michael Kyba

  28. GSK3β inhibition activates the CDX/HOX pathway and promotes hemogenic endothelial progenitor differentiation from human pluripotent stem cells

    Article • Experimental Hematology, January 2016, Elsevier

    Michael Kyba

  29. Development of Bipotent Cardiac/Skeletal Myogenic Progenitors from MESP1+ Mesoderm

    Article • Stem Cell Reports, January 2016, Elsevier

    Michael Kyba

  30. Flow Cytometry and Transplantation-Based Quantitative Assays for Satellite Cell Self-Renewal and Differentiation

    Article • January 2016, Springer Science + Business Media

    Michael Kyba

  31. Freeze Injury of the Tibialis Anterior Muscle

    Article • January 2016, Springer Science + Business Media

    Michael Kyba

  32. DNA-binding sequence specificity of DUX4

    Article • Skeletal Muscle, December 2015, Springer Science + Business Media

    Michael Kyba

  33. Inducible Gata1 suppression expands megakaryocyte-erythroid progenitors from embryonic stem cells

    Article • Journal of Clinical Investigation, May 2015, American Society for Clinical Investigation

    Michael Kyba

  34. Drosophila Cyclin G and epigenetic maintenance of gene expression during development

    Article • Epigenetics & Chromatin, May 2015, Springer Science + Business Media

    Michael Kyba

  35. Derivation and High Engraftment of Patient-Specific Cardiomyocyte Sheet Using Induced Pluripotent Stem Cells Generated From Adult Cardiac Fibroblast

    Article • Circulation Heart Failure, November 2014, Wolters Kluwer Health

    Michael Kyba

  36. Acquisition of a Quantitative, Stoichiometrically Conserved Ratiometric Marker of Maturation Status in Stem Cell-Derived Cardiac Myocytes

    Article • Stem Cell Reports, October 2014, Elsevier

    Michael Kyba

  37. OVOL2 is a critical regulator of ER71/ETV2 in generating FLK1+, hematopoietic, and endothelial cells from embryonic stem cells

    Article • Blood, September 2014, American Society of Hematology

    Michael Kyba

  38. Dominant Lethal Pathologies in Male Mice Engineered to Contain an X-Linked DUX4 Transgene

    Article • Cell Reports, September 2014, Elsevier

    Michael Kyba

  39. Direct induction of haematoendothelial programs in human pluripotent stem cells by transcriptional regulators

    Article • Nature Communications, July 2014, Nature

    Michael Kyba

  40. TBX3 Directs Cell-Fate Decision toward Mesendoderm

    Article • Stem Cell Reports, May 2014, Elsevier

    Michael Kyba

  41. Cooperative interaction of Etv2 and Gata2 regulates the development of endothelial and hematopoietic lineages

    Article • Developmental Biology, May 2014, Elsevier

    Michael Kyba

  42. Reconstruction of phrenic neuron identity in embryonic stem cell-derived motor neurons

    Article • Development, February 2014, The Company of Biologists

    Michael Kyba

  43. High-throughput screening identifies inhibitors of DUX4-induced myoblast toxicity

    Article • Skeletal Muscle, January 2014, Springer Science + Business Media

    Michael Kyba

  44. Molecular Functions of the LIM-Homeobox Transcription Factor Lhx2 in Hematopoietic Progenitor Cells Derived from Mouse Embryonic Stem Cells

    Article • Stem Cells, December 2013, Oxford University Press (OUP)

    Michael Kyba

  45. Rapid Genetic Modification of Mouse Embryonic Stem Cells by Inducible Cassette Exchange Recombination

    Article • October 2013, Springer Science + Business Media

    Michael Kyba

  46. NLRP7 affects trophoblast lineage differentiation, binds to overexpressed YY1 and alters CpG methylation

    Article • Human Molecular Genetics, September 2013, Oxford University Press (OUP)

    Michael Kyba

  47. DNA methylation of Runx1 regulatory regions correlates with transition from primitive to definitive hematopoietic potential in vitro and in vivo

    Article • Blood, September 2013, American Society of Hematology

    Michael Kyba

  48. TBX3 Directs Cell-Fate Decision toward Mesendoderm

    Article • Stem Cell Reports, September 2013, Elsevier

    Michael Kyba

  49. Expression of the Human FSHD-Linked DUX4 Gene Induces Neurogenesis During Differentiation of Murine Embryonic Stem Cells

    Article • Stem Cells and Development, September 2013, Mary Ann Liebert Inc

    Michael Kyba

  50. Expression levels of endoglin distinctively identify hematopoietic and endothelial progeny at different stages of yolk sac hematopoiesis

    Article • Stem Cells, September 2013, Wiley

    Michael Kyba

  51. Nkx2-5 Mediates Differential Cardiac Differentiation Through Interaction with Hoxa10

    Article • Stem Cells and Development, August 2013, Mary Ann Liebert Inc

    Michael Kyba

  52. A New Immuno-, Dystrophin-Deficient Model, theNSG-mdx4CvMouse, Provides Evidence for Functional Improvement Following Allogeneic Satellite Cell Transplantation

    Article • Stem Cells, August 2013, Wiley

    Michael Kyba

  53. Mesp1 Patterns Mesoderm into Cardiac, Hematopoietic, or Skeletal Myogenic Progenitors in a Context-Dependent Manner

    Article • Cell Stem Cell, May 2013, Elsevier

    Michael Kyba

  54. An ex vivo gene therapy approach to treat muscular dystrophy using inducible pluripotent stem cells

    Article • Nature Communications, March 2013, Nature

    Michael Kyba

  55. Hemogenic endothelium in a dish

    Article • Blood, January 2013, American Society of Hematology

    Michael Kyba

  56. A focal domain of extreme demethylation within D4Z4 in FSHD2

    Article • Neurology, January 2013, Wolters Kluwer Health

    Michael Kyba

  57. BCL6 controls neurogenesis through Sirt1-dependent epigenetic repression of selective Notch targets

    Article • Nature Neuroscience, November 2012, Nature

    Michael Kyba

  58. The Plasminogen Activation System Modulates Differently Adipogenesis and Myogenesis of Embryonic Stem Cells

    Article • PLoS ONE, November 2012, PLOS

    Dr Bernard Binetruy, Michael Kyba

  59. Generation of functional thyroid from embryonic stem cells

    Article • Nature, October 2012, Nature

    Michael Kyba

  60. Etv2 Is Expressed in the Yolk Sac Hematopoietic and Endothelial Progenitors and Regulates Lmo2 Gene Expression

    Article • Stem Cells, July 2012, Wiley

    Michael Kyba

  61. The H19 lincRNA is a developmental reservoir of miR-675 that suppresses growth and Igf1r

    Article • Nature, June 2012, Nature

    Michael Kyba

  62. Human ES- and iPS-Derived Myogenic Progenitors Restore DYSTROPHIN and Improve Contractility upon Transplantation in Dystrophic Mice

    Article • Cell Stem Cell, May 2012, Elsevier

    Michael Kyba

  63. A critical role for endoglin in the emergence of blood during embryonic development

    Article • Blood, April 2012, American Society of Hematology

    Michael Kyba

  64. Eomesodermin induces Mesp1 expression and cardiac differentiation from embryonic stem cells in the absence of Activin

    Article • EMBO Reports, March 2012, EMBO

    Michael Kyba

  65. p53 Regulates Cell Cycle and MicroRNAs to Promote Differentiation of Human Embryonic Stem Cells

    Article • PLoS Biology, February 2012, PLOS

    Michael Kyba

  66. Satellite cell heterogeneity revealed by G-Tool, an open algorithm to quantify myogenesis through colony-forming assays

    Article • Skeletal Muscle, January 2012, Springer Science + Business Media

    Michael Kyba

  67. Zinc Finger Protein ZFP57 Requires Its Co-factor to Recruit DNA Methyltransferases and Maintains DNA Methylation Imprint in Embryonic Stem Cells via Its Transcriptional Repression Domain

    Article • Journal of Biological Chemistry, December 2011, American Society for Biochemistry & Molecular Biology (ASBMB)

    Michael Kyba

  68. Embryonic stem cell–based mapping of developmental transcriptional programs

    Article • Nature Methods, November 2011, Nature

    Michael Kyba

  69. ER71 directs mesodermal fate decisions during embryogenesis

    Article • Development, October 2011, The Company of Biologists

    Michael Kyba

  70. Inducible Cassette Exchange: A Rapid and Efficient System Enabling Conditional Gene Expression in Embryonic Stem and Primary Cells

    Article • Stem Cells, September 2011, Wiley

    Michael Kyba

  71. Characterization of an In Vitro Differentiation Assay for Pancreatic-Like Cell Development from Murine Embryonic Stem Cells: Detailed Gene Expression Analysis

    Article • Assay and Drug Development Technologies, August 2011, Mary Ann Liebert Inc

    Michael Kyba

  72. The Wnt3a/β-catenin target gene Mesogenin1 controls the segmentation clock by activating a Notch signalling program

    Article • Nature Communications, July 2011, Nature

    Michael Kyba

  73. Modulation of TGF-  signaling by endoglin in murine hemangioblast development and primitive hematopoiesis

    Article • Blood, May 2011, American Society of Hematology

    Michael Kyba

  74. Decreased Proliferation Kinetics of Mouse Myoblasts Overexpressing FRG1

    Article • PLoS ONE, May 2011, PLOS

    Michael Kyba

  75. Snail and the microRNA-200 Family Act in Opposition to Regulate Epithelial-to-Mesenchymal Transition and Germ Layer Fate Restriction in Differentiating ESCs

    Article • Stem Cells, April 2011, Wiley

    Michael Kyba

  76. Assessment of the Myogenic Stem Cell Compartment Following Transplantation ofPax3/Pax7-Induced Embryonic Stem Cell-Derived Progenitors

    Article • Stem Cells, April 2011, Wiley

    Michael Kyba

  77. Nkx2-5 Represses Gata1 Gene Expression and Modulates the Cellular Fate of Cardiac Progenitors During Embryogenesis

    Article • Circulation, April 2011, Wolters Kluwer Health

    Michael Kyba

  78. Functional Myogenic Engraftment from Mouse iPS Cells

    Article • Stem Cell Reviews and Reports, April 2011, Springer Science + Business Media

    Michael Kyba

  79. Genome-wide analysis of target genes regulated by HoxB4 in hematopoietic stem and progenitor cells developing from embryonic stem cells

    Article • Blood, February 2011, American Society of Hematology

    Michael Kyba

  80. Gene therapy by allele selection in a mouse model of beta-thalassemia

    Article • Journal of Clinical Investigation, February 2011, American Society for Clinical Investigation

    Michael Kyba

  81. Transcripts that associate with the RNA binding protein, DEAD-END (DND1), in embryonic stem (ES) cells

    Article • BMC Molecular Biology, January 2011, Springer Science + Business Media

    Michael Kyba

  82. An Inducible Expression System of the Calcium-Activated Potassium Channel 4 to Study the Differential Impact on Embryonic Stem Cells

    Article • Stem Cells International, January 2011, Hindawi Publishing Corporation

    Michael Kyba

  83. HoxA3 is an apical regulator of haemogenic endothelium

    Article • Nature, December 2010, Nature

    Michael Kyba, Ondine Cleaver

  84. Hematopoietic differentiation of induced pluripotent stem cells from patients with mucopolysaccharidosis type I (Hurler syndrome)

    Article • Blood, October 2010, American Society of Hematology

    Michael Kyba

  85. Facioscapulohumeral Dystrophy: Incomplete Suppression of a Retrotransposed Gene

    Article • PLoS Genetics, October 2010, PLOS

    Michael Kyba

  86. Proteomic Analysis of Sox2-Associated Proteins During Early Stages of Mouse Embryonic Stem Cell Differentiation Identifies Sox21 as a Novel Regulator of Stem Cell Fate

    Article • Stem Cells, October 2010, Wiley

    Michael Kyba

  87. The Retinoid Signaling Pathway Inhibits Hematopoiesis and Uncouples from the Hox Genes During Hematopoietic Development

    Article • Stem Cells, August 2010, Wiley

    Michael Kyba

  88. Engraftment of embryonic stem cell-derived myogenic progenitors in a dominant model of muscular dystrophy

    Article • Experimental Neurology, November 2009, Elsevier

    Michael Kyba

  89. Biphasic Myopathic Phenotype of Mouse DUX, an ORF within Conserved FSHD-Related Repeats

    Article • PLoS ONE, September 2009, PLOS

    Michael Kyba

  90. Engraftment of mesenchymal stem cells into dystrophin-deficient mice is not accompanied by functional recovery

    Article • Experimental Cell Research, September 2009, Elsevier

    Michael Kyba

  91. A JAK2 Interdomain Linker Relays Epo Receptor Engagement Signals to Kinase Activation

    Article • Journal of Biological Chemistry, July 2009, American Society for Biochemistry & Molecular Biology (ASBMB)

    Michael Kyba

  92. A Conserved Role for Hox Paralog Group 4 in Regulation of Hematopoietic Progenitors

    Article • Stem Cells and Development, June 2009, Mary Ann Liebert Inc

    Michael Kyba

  93. Nkx2–5 transactivates the Ets-related protein 71 gene and specifies an endothelial/endocardial fate in the developing embryo

    Article • Proceedings of the National Academy of Sciences, January 2009, Proceedings of the National Academy of Sciences

    Michael Kyba

  94. Mesodermal patterning activity of SCL

    Article • Experimental Hematology, December 2008, Elsevier

    Michael Kyba

  95. DUX4c, an FSHD candidate gene, interferes with myogenic regulators and abolishes myoblast differentiation

    Article • Experimental Neurology, November 2008, Elsevier

    Michael Kyba

  96. White Fat Progenitor Cells Reside in the Adipose Vasculature

    Article • Science, October 2008, American Association for the Advancement of Science

    Michael Kyba

  97. An isogenetic myoblast expression screen identifies DUX4-mediated FSHD-associated molecular pathologies

    Article • The EMBO Journal, October 2008, Wiley

    Michael Kyba

  98. Prospective Isolation of Skeletal Muscle Stem Cells with a Pax7 Reporter

    Article • Stem Cells, September 2008, Wiley

    Michael Kyba, Ondine Cleaver

  99. Mesp1 Coordinately Regulates Cardiovascular Fate Restriction and Epithelial-Mesenchymal Transition in Differentiating ESCs

    Article • Cell Stem Cell, July 2008, Elsevier

    Michael Kyba

  100. Mesp1 Acts as a Master Regulator of Multipotent Cardiovascular Progenitor Specification

    Article • Cell Stem Cell, July 2008, Elsevier

    Michael Kyba

  101. Caspase Activity Mediates the Differentiation of Embryonic Stem Cells

    Article • Cell Stem Cell, June 2008, Elsevier

    Michael Kyba

  102. ER71 Acts Downstream of BMP, Notch, and Wnt Signaling in Blood and Vessel Progenitor Specification

    Article • Cell Stem Cell, May 2008, Elsevier

    Michael Kyba

  103. An ES cell-derived immune system

    Article • Blood, March 2008, American Society of Hematology

    Michael Kyba

  104. Functional skeletal muscle regeneration from differentiating embryonic stem cells

    Article • Nature Reports Stem Cells, January 2008, Nature

    Michael Kyba

  105. GATA2 functions at multiple steps in hemangioblast development and differentiation

    Article • Development, January 2007, The Company of Biologists

    Michael Kyba

  106. Canonical Wnt signaling is required for development of embryonic stem cell-derived mesoderm

    Article • Development, October 2006, The Company of Biologists

    Michael Kyba

  107. Acceleration of mesoderm development and expansion of hematopoietic progenitors in differentiating ES cells by the mouse Mix-like homeodomain transcription factor

    Article • Blood, April 2006, American Society of Hematology

    Michael Kyba

  108. Genesis of Hematopoietic Stem Cells In Vitro and In Vivo: New Insights into Developmental Maturation

    Article • International Journal of Hematology, May 2005, Springer Science + Business Media

    Michael Kyba

  109. Nuclear transplantation, embryonic stem cells and the potential for cell therapy

    Article • The Hematology Journal, January 2004, Nature

    Michael Kyba

  110. Hematopoiesis from embryonic stem cells: lessons from and for ontogeny

    Article • Experimental Hematology, November 2003, Elsevier

    Michael Kyba

  111. Enhanced hematopoietic differentiation of embryonic stem cells conditionally expressing Stat5

    Article • Proceedings of the National Academy of Sciences, September 2003, Proceedings of the National Academy of Sciences

    Michael Kyba

  112. Development of Hematopoietic Repopulating Cells from Embryonic Stem Cells

    Article • January 2003, Elsevier

    Michael Kyba

  113. HoxB4 Confers Definitive Lymphoid-Myeloid Engraftment Potential on Embryonic Stem Cell and Yolk Sac Hematopoietic Progenitors

    Article • Cell, April 2002, Elsevier

    Michael Kyba

  114. Efficiency of embryoid body formation and hematopoietic development from embryonic stem cells in different culture systems

    Article • Biotechnology and Bioengineering, April 2002, Wiley

    Michael Kyba

  115. Correction of a Genetic Defect by Nuclear Transplantation and Combined Cell and Gene Therapy

    Article • Cell, April 2002, Elsevier

    Michael Kyba

  116. Tantalus, a Novel ASX-Interacting Protein with Tissue-Specific Functions

    Article • Developmental Biology, June 2001, Elsevier

    Michael Kyba

  117. A novel member of murine Polycomb-group proteins, Sex comb on midleg homolog protein, is highly conserved, and interacts with RAE28/mph1 in vitro

    Article • Differentiation, December 1999, Elsevier

    Michael Kyba

  118. The Drosophila Polycomb Group Protein Psc Contacts ph and Pc through Specific Conserved Domains

    Article • Molecular and Cellular Biology, May 1998, ASM Journals

    Michael Kyba

  119. RAE28, BMI1, and M33 Are Members of Heterogeneous Multimeric Mammalian Polycomb Group Complexes

    Article • Biochemical and Biophysical Research Communications, April 1998, Elsevier

    Michael Kyba

  120. The SAM domain of polyhomeotic, RAE28, and Scm mediates specific interactions through conserved residues

    Article • Developmental Genetics, January 1998, Wiley

    Michael Kyba

  121. A domain shared by the Polycomb group proteins Scm and ph mediates heterotypic and homotypic interactions.

    Article • Molecular and Cellular Biology, November 1997, ASM Journals

    Michael Kyba

  122. The polyhomeotic locus of Drosophila melanogaster is transcriptionally and post-transcriptionally regulated during embryogenesis

    Article • Mechanisms of Development, August 1997, Elsevier

    Michael Kyba