All Stories

  1. Cellular and Humoral Responses following Minimally Invasive Surgery: Role of Reactive Oxygen Species

    Article • Current Metabolomics, March 2015, Bentham Science Publishers

    Dr Helen Anne Leaver

  2. Arachidonic Acid in Human Endothelial Cell Stress Signalling

    Article • Microvascular Research, March 2015, Elsevier

    Dr Helen Anne Leaver, MD Aaron A Cohen-Gadol

  3. Blood Immunoglobulins, Complement and TNF Receptor Following Minimally Invasive Surgery in Patients Undergoing Pulmonary Lobectomy

    Article • Current Metabolomics, January 2015, Bentham Science Publishers

    Dr Helen Anne Leaver

  4. Oxidative Stress and Brain Endothelial Cells

    Article • January 2014, Springer Science + Business Media

    Dr Helen Anne Leaver

  5. Lipid Signalling in Cell Death

    Article • British Journal of Pharmacology, May 2012, Wiley

    Dr Helen Anne Leaver

  6. To Die or Not To Die? Current Questions in Cell Death Signalling

    Article • Molecular Neurobiology, May 2010, Springer Science + Business Media

    Dr Helen Anne Leaver

  7. Glioma Cell Death: Cell–Cell Interactions and Signalling Networks

    Article • Molecular Neurobiology, May 2010, Springer Science + Business Media

    Dr Helen Anne Leaver

  8. Brain Endothelial Cell Death: Modes, Signaling Pathways, and Relevance to Neural Development, Homeostasis, and Disease

    Article • Molecular Neurobiology, April 2010, Springer Science + Business Media

    Dr Helen Anne Leaver

  9. Prostaglandin E2 activates cAMP response element-binding protein in glioma cells via a signaling pathway involving PKA-dependent inhibition of ERK

    Article • Prostaglandins & Other Lipid Mediators, February 2010, Elsevier

    Dr Helen Anne Leaver

  10. 38. Mitochondrial and Calpain-dependent Signalling Pathways Mediate Cell Death in Human Platelets

    Article • Mitochondrion, February 2009, Elsevier

    Dr Helen Anne Leaver

  11. Immunologic and Stress Responses Following Video-Assisted Thoracic Surgery and Open Pulmonary Lobectomy in Early Stage Lung Cancer

    Article • Thoracic Surgery Clinics, May 2007, Elsevier

    Dr Helen Anne Leaver

  12. c-jun amino-terminal kinase and mitogen activated protein kinase 1/2 mediate hepatocyte growth factor-induced migration of brain endothelial cells

    Article • Experimental Cell Research, January 2007, Elsevier

    Dr Helen Anne Leaver

  13. Microsomal prostaglandin E synthase-1 regulates human glioma cell growth via prostaglandin E2-dependent activation of type II protein kinase A

    Article • Molecular Cancer Therapeutics, July 2006, American Association for Cancer Research (AACR)

    Dr Helen Anne Leaver

  14. Calcium-sensitive mitochondrial membrane potential in human platelets and intrinsic signals of cell death

    Article • Platelets, January 2006, Taylor & Francis

    Dr Helen Anne Leaver

  15. Intracellular oxidation by human glioma cell populations: effect of arachidonic acid

    Article • Prostaglandins Leukotrienes and Essential Fatty Acids, May 2004, Elsevier

    Dr Helen Anne Leaver

  16. Highly unsaturated fatty acid induced tumour regression in glioma pharmacodynamics and bioavailability of gamma linolenic acid in an implantation glioma model: effects on tumour biomass, apoptosis and neuronal tissue histology

    Article • Prostaglandins Leukotrienes and Essential Fatty Acids, November 2002, Elsevier

    Dr Helen Anne Leaver

  17. Specificity of arachidonic acid-induced inhibition of growth and activation of c-jun kinases and p38 mitogen-activated protein kinase in hematopoietic cells

    Article • Prostaglandins Leukotrienes and Essential Fatty Acids, January 2002, Elsevier

    Dr Helen Anne Leaver

  18. Antitumour actions of highly unsaturated fatty acids: cell signalling and apoptosis

    Article • Prostaglandins Leukotrienes and Essential Fatty Acids, January 2002, Elsevier

    Dr Helen Anne Leaver

  19. Antitumour and pro-apoptotic actions of highly unsaturated fatty acids in glioma

    Article • Prostaglandins Leukotrienes and Essential Fatty Acids, January 2002, Elsevier

    Dr Helen Anne Leaver

  20. Specificity of arachidonic acid-induced growth inhibition in Chronic Myeloid Leukemia

    Article • Biochemical Society Transactions, October 2001, Portland Press Ltd.

    Dr Helen Anne Leaver

  21. Acute phase responses following minimal access and conventional thoracic surgery

    Article • European Journal of Cardio-Thoracic Surgery, September 2001, Oxford University Press (OUP)

    Dr Helen Anne Leaver

  22. The development of necrosis and apoptosis in glioma: experimental findings using spheroid culture systems*

    Article • Neuropathology and Applied Neurobiology, August 2001, Wiley

    Dr Helen Anne Leaver

  23. Lymphocyte responses following open and minimally invasive thoracic surgery

    Article • European Journal of Clinical Investigation, March 2000, Wiley

    Dr Helen Anne Leaver

  24. Glioma growth and development using spheroid culture

    Article • Journal of Neurosurgery, December 1999, Journal of Neurosurgery Publishing Group (JNSPG)

    Dr Helen Anne Leaver

  25. Dynamics of reactive oxygen intermediate production in human glioma: n -6 essential fatty acid effects

    Article • European Journal of Clinical Investigation, March 1999, Wiley

    Dr Helen Anne Leaver

  26. Arachidonic acid induces mobilization of calcium stores and c-jun gene expression: evidence that intracellular calcium release is associated with c-jun activation

    Article • Prostaglandins Leukotrienes and Essential Fatty Acids, March 1999, Elsevier

    Dr Helen Anne Leaver

  27. Effect of blood transfusion on survival after esophagogastrectomy for carcinoma11This article has been selected for the open discussion forum on the STS Web site: http://www.sts.org/annals

    Article • The Annals of Thoracic Surgery, August 1998, Elsevier

    Dr Helen Anne Leaver

  28. Prions: Properties, Occurrence, Modes of Transmission and Relevance for Blood Transfusion and Blood Derivatives

    Article • Vox Sanguinis, June 1998, Wiley

    Dr Helen Anne Leaver

  29. Kinetics of Reactive Oxygen Intermediate Formation and Apoptosis in Human Glioma and Glioma C6 Cell Line: Effects of Radiation and n-6 Essential Fatty Acids

    Article • Biochemical Society Transactions, May 1998, Portland Press Ltd.

    Dr Helen Anne Leaver

  30. Apoptosis in human primary brain tumours: actions of arachidonic acid

    Article • Prostaglandins Leukotrienes and Essential Fatty Acids, March 1998, Elsevier

    Dr Helen Anne Leaver

  31. Apoptosis in human primary brain tumours

    Article • British Journal of Neurosurgery, January 1998, Taylor & Francis

    Dr Helen Anne Leaver

  32. Network Analysis of Arachidonic Acid Pathophysiology in Human Phagocytes and Primary Brain Tumors

    Article • Annals of the New York Academy of Sciences, December 1997, Wiley

    Dr Helen Anne Leaver

  33. Arachidonic Acid Activation of Monocyte and Neutrophil Reactive Oxygen in Lung Cancer Patients Undergoing Pulmonary Resection

    Article • Biologicals, December 1996, Elsevier

    Dr Helen Anne Leaver

  34. Apoptosis and the Dynamics of Infection and Disease

    Article • Biologicals, December 1996, Elsevier

    Dr Helen Anne Leaver

  35. Peroxides in human leucocytes in acute septic shock: a preliminary study of acute phase changes and mortality

    Article • European Journal of Clinical Investigation, October 1995, Wiley

    Dr Helen Anne Leaver

  36. Arachidonic acid in the reticuloendothelial network

    Article • Biochemical Society Transactions, May 1995, Portland Press Ltd.

    Dr Helen Anne Leaver

  37. Macrophage prostaglandin E2 and oxidative responses to endotoxin during immunosuppression associated with anaesthesia and transfusion

    Article • Prostaglandins Leukotrienes and Essential Fatty Acids, December 1993, Elsevier

    Dr Helen Anne Leaver

  38. New pathways of phagocyte activation: an overview

    Article • FEMS Microbiology Letters, December 1992, Oxford University Press (OUP)

    Dr Helen Anne Leaver

  39. New pathways of phagocyte activation: an overview

    Article • FEMS Microbiology Letters, December 1992, Oxford University Press (OUP)

    Dr Helen Anne Leaver

  40. Pathways controlling the superoxide response during phagocyte differentiation: involvement of arachidonic acid and Ca 2+ in the response to bacterial endotoxin

    Article • FEMS Microbiology Letters, December 1992, Oxford University Press (OUP)

    Dr Helen Anne Leaver

  41. Pathways controlling the superoxide response during phagocyte differentiation: involvement of arachidonic acid and Ca2+ in the response to bacterial endotoxin

    Article • FEMS Microbiology Letters, December 1992, Oxford University Press (OUP)

    Dr Helen Anne Leaver

  42. Developmental changes in the fatty acids of rat uterus and the influence of dietary essential fatty acids

    Article • Prostaglandins Leukotrienes and Essential Fatty Acids, June 1992, Elsevier

    Dr Helen Anne Leaver

  43. The influence of dietary essential fatty acids on uterine C20 and C22 fatty acid composition

    Article • Prostaglandins Leukotrienes and Essential Fatty Acids, June 1992, Elsevier

    Dr Helen Anne Leaver

  44. Kinetics of calcium mobilisation and Inositol Phosphate metabolism in endotoxin-stimulated HL-60 cells

    Article • Biochemical Society Transactions, April 1991, Portland Press Ltd.

    Dr Helen Anne Leaver

  45. Phosphoinositide and superoxide responses to endotoxin during HL-60 cell differentiation

    Article • Biochemical Society Transactions, April 1991, Portland Press Ltd.

    Dr Helen Anne Leaver

  46. The biosynthesis of the 3-series prostaglandins in rat uterus after alpha-linolenic acid feeding: Mass spectroscopy of prostaglandins E and F produced by rat uteri in tissue culture

    Article • Prostaglandins Leukotrienes and Essential Fatty Acids, April 1991, Elsevier

    Dr Helen Anne Leaver

  47. The effect of endotoxin lipopolysaccharide from different bacterial species on the generation of intracellular inositol triphosphate and superoxide in a human phagocytic cell line

    Article • FEMS Microbiology Letters, December 1990, Oxford University Press (OUP)

    Dr Helen Anne Leaver

  48. Prostaglandin E 2 production by rat peritoneal macrophages: role of cellular and humoral factors in vivo in transfusion-associated immunosuppression

    Article • FEMS Microbiology Letters, December 1990, Oxford University Press (OUP)

    Dr Helen Anne Leaver

  49. The effect of endotoxin lipopolysaccharide from different bacterial species on the generation of intracellular inositol triphosphate and superoxide in a human phagocytic cell line

    Article • FEMS Immunology & Medical Microbiology, December 1990, Wiley

    Dr Helen Anne Leaver

  50. Prostaglandin E2 production by rat peritoneal macrophages: role of cellular and humoral factors in vivo in transfusion-associated immunosuppression

    Article • FEMS Microbiology Letters, December 1990, Oxford University Press (OUP)

    Dr Helen Anne Leaver

  51. Prostaglandin E2 production by rat peritoneal macrophages: role of cellular and humoral factors in vivo in transfusion-associated immunosuppression

    Article • FEMS Immunology & Medical Microbiology, December 1990, Wiley

    Dr Helen Anne Leaver

  52. Bacteria-phagocyte interactions

    Article • FEMS Immunology & Medical Microbiology, December 1990, Wiley

    Dr Helen Anne Leaver

  53. Bacteria-phagocyte interactions

    Article • FEMS Microbiology Letters, December 1990, Oxford University Press (OUP)

    Dr Helen Anne Leaver

  54. Bacteria-phagocyte interactions

    Article • FEMS Microbiology Letters, December 1990, Oxford University Press (OUP)

    Dr Helen Anne Leaver

  55. Endotoxin releases platelet-activating factor from human monocytes in vitro

    Article • Immunopharmacology, September 1990, Elsevier

    Dr Helen Anne Leaver

  56. Endotoxin-stimulated generation of inositol trisphosphate in human promyelocyte leukaemic (HL-60) cells

    Article • Biochemical Society Transactions, June 1990, Portland Press Ltd.

    Dr Helen Anne Leaver

  57. Endotoxin stimulated release of platelet activating factor by human monocytes

    Article • FEMS Microbiology Letters, May 1990, Oxford University Press (OUP)

    Dr Helen Anne Leaver

  58. The second phagocyte discussion meeting dedicated to the memory of David Flenley 1933–1989

    Article • FEMS Microbiology Letters, May 1990, Oxford University Press (OUP)

    Dr Helen Anne Leaver

  59. Cellular response to bacterial endotoxin in mononuclear phagocytes detected by superoxide production

    Article • FEMS Microbiology Letters, May 1990, Oxford University Press (OUP)

    Dr Helen Anne Leaver

  60. The endotoxin receptor on mononuclear phagocytes

    Article • FEMS Microbiology Letters, May 1990, Oxford University Press (OUP)

    Dr Helen Anne Leaver

  61. Cellular response to bacterial endotoxin in mononuclear phagocytes detected by superoxide production

    Article • FEMS Immunology & Medical Microbiology, May 1990, Wiley

    Dr Helen Anne Leaver

  62. Cellular response to bacterial endotoxin in mononuclear phagocytes detected by superoxide production

    Article • FEMS Microbiology Letters, May 1990, Oxford University Press (OUP)

    Dr Helen Anne Leaver

  63. Endotoxin stimulated release of platelet activating factor by human monocytes

    Article • FEMS Immunology & Medical Microbiology, May 1990, Wiley

    Dr Helen Anne Leaver

  64. The second phagocyte discussion meeting dedicated to the memory of David Flenley 1933–1989

    Article • FEMS Immunology & Medical Microbiology, May 1990, Wiley

    Dr Helen Anne Leaver

  65. Endotoxin stimulated release of platelet activating factor by human monocytes

    Article • FEMS Microbiology Letters, May 1990, Oxford University Press (OUP)

    Dr Helen Anne Leaver

  66. The endotoxin receptor on mononuclear phagocytes

    Article • FEMS Immunology & Medical Microbiology, May 1990, Wiley

    Dr Helen Anne Leaver

  67. The endotoxin receptor on mononuclear phagocytes

    Article • FEMS Microbiology Letters, May 1990, Oxford University Press (OUP)

    Dr Helen Anne Leaver

  68. The second phagocyte discussion meeting dedicated to the memory of David Flenley 1933–1989

    Article • FEMS Microbiology Letters, May 1990, Oxford University Press (OUP)

    Dr Helen Anne Leaver

  69. The effect of chlamydial infection on the initiation of premature labour: Serial measurements of intrauterine Prostaglandin E2 in amniotic fluid, allantoic fluid and utero-ovarian vein, using catheterised sheep experimentally infected with an ovine abo...

    Article • Prostaglandins Leukotrienes and Essential Fatty Acids, September 1989, Elsevier

    Dr Helen Anne Leaver

  70. Endotoxin binding, and changes in monocyte sub-populations subsequent to binding, detected by flow cytometry

    Article • FEMS Microbiology Letters, April 1989, Oxford University Press (OUP)

    Dr Helen Anne Leaver

  71. Phagocyte responses to endotoxin: intracellular signals and oxidative activity

    Article • FEMS Microbiology Letters, April 1989, Oxford University Press (OUP)

    Dr Helen Anne Leaver

  72. Interaction of human monocytes and endothelial cells potentiates the oxidative response to phorbol myristoyl acetate (PMA) and endotoxin in vitro

    Article • FEMS Microbiology Letters, April 1989, Oxford University Press (OUP)

    Dr Helen Anne Leaver

  73. Therapeutic applications of phagocytes

    Article • FEMS Microbiology Letters, April 1989, Oxford University Press (OUP)

    Dr Helen Anne Leaver

  74. Phagocyte responses to endotoxin: intracellular signals and oxidative activity

    Article • FEMS Microbiology Letters, April 1989, Oxford University Press (OUP)

    Dr Helen Anne Leaver

  75. Interaction of human monocytes and endothelial cells potentiates the oxidative response to phorbol myristoyl acetate (PMA) and endotoxin in vitro

    Article • FEMS Microbiology Letters, April 1989, Oxford University Press (OUP)

    Dr Helen Anne Leaver

  76. Therapeutic applications of phagocytes

    Article • FEMS Microbiology Letters, April 1989, Oxford University Press (OUP)

    Dr Helen Anne Leaver

  77. Endotoxin binding, and changes in monocyte sub-populations subsequent to binding, detected by flow cytometry

    Article • FEMS Microbiology Letters, April 1989, Oxford University Press (OUP)

    Dr Helen Anne Leaver

  78. Changes in Progesterone, Oestradiol 17 , and Intrauterine Prostaglandin E2 during Late Gestation in Sheep Experimentally Infected with an Ovine Abortion Strain of Chlamydia psittaci

    Article • Microbiology, March 1989, Society for General Microbiology

    Dr Helen Anne Leaver

  79. Prostaglandin E2 in induction of labour: a pharmacokinetic study of dose and treatment protocols

    Article • Prostaglandins Leukotrienes and Essential Fatty Acids, January 1988, Elsevier

    Dr Helen Anne Leaver

  80. Amniotic fluid prostaglandins F2α and E2 , measured at artificial rupture of the membranes”, predict the subsequent progress of labour

    Article • Prostaglandins Leukotrienes and Medicine, August 1987, Elsevier

    Dr Helen Anne Leaver

  81. Altered steroid hormone and prostaglandin metabolism during chlamydial infection in sheep

    Article • Biochemical Society Transactions, June 1987, Portland Press Ltd.

    Dr Helen Anne Leaver

  82. Phorbol myristoyl acetate- and endotoxin-stimulated generation of intracellular superoxide in human monocytes during endotoxaemia

    Article • Biochemical Society Transactions, June 1987, Portland Press Ltd.

    Dr Helen Anne Leaver

  83. Selective binding of endotoxin by human monocytes demonstrated using flo cytometry: requirement of serum

    Article • Biochemical Society Transactions, June 1987, Portland Press Ltd.

    Dr Helen Anne Leaver

  84. The effect of dietary ω3 and ω6 polyunsaturated fatty acids on gestation, parturition and prostaglandin E2 in intrauterine tissues and the kidney

    Article • Progress in Lipid Research, January 1986, Elsevier

    Dr Helen Anne Leaver

  85. The effect of oxytocin, estrogen, calcium ionophore A23187 and hydrocortisone on prostaglandin F2α and 6-oxo-prostaglandin F1α production by cultured human endometrial and myometrial explants

    Article • Prostaglandins Leukotrienes and Medicine, February 1984, Elsevier

    Dr Helen Anne Leaver

  86. The release of arachidonic acid and prostaglandins at human parturition: evidence for a precursor–product relationship between membrane diacylglycerol, monoacylglycerol, prostaglandin E 2 and amniotic-fluid prostaglandin F 2α

    Article • Biochemical Society Transactions, December 1983, Portland Press Ltd.

    Dr Helen Anne Leaver

  87. Inhibitors of eukaryotic protein synthesis that do not cause short-term inhibition of steroidogenesis in rat corpus luteum

    Article • Biochemical Society Transactions, December 1983, Portland Press Ltd.

    Dr Helen Anne Leaver

  88. Arachidonic acid uptake into and release from guinea-pig endometrium in vitro on days 7 and 15 of the oestrous cycle

    Article • Prostaglandins Leukotrienes and Medicine, April 1983, Elsevier

    Dr Helen Anne Leaver

  89. Control of endometrial prostaglandin output during the estrous cycle of the guinea-pig : influence of estradiol 17-β, progesterone, oxytocin and calcium ionophore A23187

    Article • Prostaglandins Leukotrienes and Medicine, December 1982, Elsevier

    Dr Helen Anne Leaver

  90. Prostacyclin and thromboxane A

    Article • BMJ, February 1982, BMJ

    Dr Helen Anne Leaver

  91. Evidence for two particulate cholesterol ester hydrolase enzymes in rat corpus luteum

    Article • Journal of Steroid Biochemistry, December 1981, Elsevier

    Dr Helen Anne Leaver

  92. Prostacyclin and thromboxane A2 in thrombotic thrombocytopenic purpura.

    Article • BMJ, November 1981, BMJ

    Dr Helen Anne Leaver

  93. CONTROL OF STEROIDOGENESIS IN RAT CORPUS LUTEUM: THE RATE OF ACCESS OF CHOLESTEROL TO THE ACTIVE SITE OF THE CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME

    Article • October 1981, Bioscientifica

    Dr Helen Anne Leaver

  94. Action of gonadotrophic hormones on cholesterol side-chain cleavage and cholesterol ester hydrolase in the ovary of the immature rat

    Article • September 1981

    Dr Helen Anne Leaver

  95. HORMONE SENSITIVITY OF PROSTAGLANDIN F 2 α(PGF 2 α) PRODUCTION BY GUINEA-PIG ENDOMETRIUM IN VITRO DURING THE DESIROUS CYCLE

    Article • Biochemical Society Transactions, April 1981, Portland Press Ltd.

    Dr Helen Anne Leaver

  96. Distribution of arachidonic acid and other fatty acids in the lipids of guinea-pig uterus and plasma in relation to uterine prostaglandin synthesis

    Article • March 1981

    Dr Helen Anne Leaver

  97. The cholesterol-side-chain-cleavage enzyme complex in corpus luteum: kinetics of interaction of a lipid substrate with a membrane-bound enzyme

    Article • Biochemical Society Transactions, February 1980, Portland Press Ltd.

    Dr Helen Anne Leaver

  98. Uptake and Metabolism of Cholesterol by Rat Corpus-Luteum Mitochondria

    Article • Biochemical Society Transactions, August 1977, Portland Press Ltd.

    Dr Helen Anne Leaver