All Stories

  1. Images in Vascular Medicine: Usefulness of carotid ultrasonography for diagnosis and management of polymyalgia rheumatica-associated large-vessel vasculitis

    Article • Vascular Medicine, March 2021, SAGE Publications

    Shinichi Okuda

  2. Enhancing calmodulin binding to cardiac ryanodine receptor completely inhibits pressure-overload induced hypertrophic signaling

    Article • Communications Biology, November 2020, Springer Science + Business Media

    Shinichi Okuda

  3. Dantrolene prevents hepatic steatosis by reducing cytoplasmic Ca2+ level and ER stress

    Article • Biochemistry and Biophysics Reports, September 2020, Elsevier

    Shinichi Okuda

  4. Stabilizing cardiac ryanodine receptor prevents the development of cardiac dysfunction and lethal arrhythmia in Ca2+/calmodulin-dependent protein kinase IIδc transgenic mice

    Article • Biochemical and Biophysical Research Communications, April 2020, Elsevier

    Shinichi Okuda

  5. G790del mutation in DSC2 alone is insufficient to develop the pathogenesis of ARVC in a mouse model

    Article • Biochemistry and Biophysics Reports, March 2020, Elsevier

    Shinichi Okuda

  6. Dantrolene prevents ventricular tachycardia by stabilizing the ryanodine receptor in pressure- overload induced failing hearts

    Article • Biochemical and Biophysical Research Communications, January 2020, Elsevier

    Shinichi Okuda

  7. Detection of Active Inflammation Status Around Ventricular Aneurysms in Patients With Cardiac Sarcoidosis

    Article • Circulation Journal, November 2019, Japanese Circulation Society

    Shinichi Okuda

  8. Ryanodine receptor–bound calmodulin is essential to protect against catecholaminergic polymorphic ventricular tachycardia

    Article • JCI Insight, June 2019, American Society for Clinical Investigation

    Shinichi Okuda

  9. Addition of a β1-Blocker to Milrinone Treatment Improves Cardiac Function in Patients with Acute Heart Failure and Rapid Atrial Fibrillation

    Article • Cardiology, January 2019, Karger Publishers

    Shinichi Okuda

  10. Nuclear translocation of calmodulin in pathological cardiac hypertrophy originates from ryanodine receptor bound calmodulin

    Article • Journal of Molecular and Cellular Cardiology, December 2018, Elsevier

    Shinichi Okuda

  11. Inter-Technique Consistency and Prognostic Value of Intra-Procedural Angiographic and Echocardiographic Assessment of Aortic Regurgitation After Transcatheter Aortic Valve Implantation

    Article • Circulation Journal, August 2018, Japanese Circulation Society

    Shinichi Okuda

  12. Localized Doxorubicin-Induced Cardiomyopathy Complicated With Shower Emboli Originating From Apical Intramural Thrombi

    Article • Circulation Journal, August 2018, Japanese Circulation Society

    Shinichi Okuda

  13. Mutation-linked, excessively tight interaction between the calmodulin binding domain and the C-terminal domain of the cardiac ryanodine receptor as a novel cause of catecholaminergic polymorphic ventricular tachycardia

    Article • Heart Rhythm, June 2018, Elsevier

    Shinichi Okuda

  14. CaMKII-mediated phosphorylation of RyR2 plays a crucial role in aberrant Ca 2+ release as an arrhythmogenic substrate in cardiac troponin T-related familial hypertrophic cardiomyopathy

    Article • Biochemical and Biophysical Research Communications, January 2018, Elsevier

    Shinichi Okuda

  15. Urinary 8-Hydroxy-2′-Deoxyguanosine as a Myocardial Oxidative Stress Marker Is Associated With Ventricular Tachycardia in Patients With Active Cardiac SarcoidosisCLINICAL PERSPECTIVE

    Article • Circulation Cardiovascular Imaging, December 2017, Wolters Kluwer Health

    Shinichi Okuda

  16. Ischemic or Nonischemic Functional Mitral Regurgitation and Outcomes in Patients With Acute Decompensated Heart Failure With Preserved or Reduced Ejection Fraction

    Article • The American Journal of Cardiology, September 2017, Elsevier

    Shinichi Okuda

  17. Correction of impaired calmodulin binding to RyR2 as a novel therapy for lethal arrhythmia in the pressure-overloaded heart failure

    Article • Heart Rhythm, January 2017, Elsevier

    Shinichi Okuda

  18. Successful treatment with intravenous cyclophosphamide for anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis associated with myelodysplastic syndrome

    Article • Scandinavian Journal of Rheumatology, December 2016, Taylor & Francis

    Shinichi Okuda

  19. Recombinant Atrial Natriuretic Peptide Prevents Aberrant Ca2+ Leakage through the Ryanodine Receptor by Suppressing Mitochondrial Reactive Oxygen Species Production Induced by Isoproterenol in Failing Cardiomyocytes

    Article • PLoS ONE, September 2016, PLOS

    Shinichi Okuda

  20. An oxidative stress biomarker, urinary 8-hydroxy-2′-deoxyguanosine, predicts cardiovascular-related death after steroid therapy for patients with active cardiac sarcoidosis

    Article • International Journal of Cardiology, June 2016, Elsevier

    Shinichi Okuda

  21. Bow hunter's syndrome

    Article • European Heart Journal - Cardiovascular Imaging, May 2016, European Society of Cardiology

    Shinichi Okuda

  22. Transcatheter and percutaneous procedures for huge pelvic arteriovenous malformations causing high-output heart failure

    Article • Journal of Cardiology Cases, November 2015, Elsevier

    Shinichi Okuda

  23. Dantrolene Suppresses Arrhythmogenesis by Inhibition of Aberrant Ca2+ Release Mediated by CaMKII and Ca2+ Buffering in Troponin T-related Hypertrophic Cardiomyopathy

    Article • Journal of Cardiac Failure, October 2015, Elsevier

    Shinichi Okuda

  24. Urinary 8-hydroxy-2′-deoxyguanosine as a novel biomarker of inflammatory activity in patients with cardiac sarcoidosis

    Article • International Journal of Cardiology, July 2015, Elsevier

    Shinichi Okuda

  25. A Low-Dose β1-Blocker in Combination with Milrinone Improves Intracellular Ca2+ Handling in Failing Cardiomyocytes by Inhibition of Milrinone-Induced Diastolic Ca2+ Leakage from the Sarcoplasmic Reticulum

    Article • PLoS ONE, January 2015, PLOS

    Shinichi Okuda

  26. Enhanced binding of calmodulin to RyR2 corrects arrhythmogenic channel disorder in CPVT-associated myocytes

    Article • Biochemical and Biophysical Research Communications, May 2014, Elsevier

    Shinichi Okuda

  27. Does a Ripple of Ca2+ Leak Develop Into a Rogue Wave That Can Trigger Pathological Hypertrophy?∗

    Article • Journal of the American College of Cardiology, April 2014, Elsevier

    Shinichi Okuda

  28. Kinetics of left ventricular rotation during exercise and its relation to exercise tolerance in atrial fibrillation: assessment by two-dimensional speckle tracking echocardiography

    Article • Journal of Echocardiography, February 2014, Springer Science + Business Media

    Shinichi Okuda

  29. A Low-Dose β1-Blocker Effectively and Safely Slows the Heart Rate in Patients with Acute Decompensated Heart Failure and Rapid Atrial Fibrillation

    Article • Cardiology, November 2013, Karger Publishers

    Shinichi Okuda

  30. Assessment of the aortic valve annular geometry by real-time three-dimensional transthoracic echocardiography: comparison with two-dimensional transthoracic echocardiography and multidetector computed tomography

    Article • Journal of Echocardiography, November 2013, Springer Science + Business Media

    Shinichi Okuda

  31. New Data on Catecholaminergic Polymorphic Ventricular Tachycardia in Japan

    Article • Circulation Journal, January 2013, Japanese Circulation Society

    Shinichi Okuda

  32. Enhanced binding of calmodulin to the ryanodine receptor corrects contractile dysfunction in failing hearts

    Article • Cardiovascular Research, August 2012, European Society of Cardiology

    Shinichi Okuda

  33. Simultaneous Doppler Tracing of Transmitral Inflow and Mitral Annular Velocity as an Estimate of Elevated Left Ventricular Filling Pressure in Patients With Atrial Fibrillation

    Article • Circulation Journal, January 2012, Japanese Circulation Society

    Shinichi Okuda

  34. Low-Dose β-Blocker in Combination With Milrinone Safely Improves Cardiac Function and Eliminates Pulsus Alternans in Patients With Acute Decompensated Heart Failure

    Article • Circulation Journal, January 2012, Japanese Circulation Society

    Shinichi Okuda

  35. Urinary 8-Hydroxy-2'-Deoxyguanosine as a Novel Biomarker for Predicting Cardiac Events and Evaluating the Effectiveness of Carvedilol Treatment in Patients With Chronic Systolic Heart Failure

    Article • Circulation Journal, January 2012, Japanese Circulation Society

    Shinichi Okuda

  36. Mutation-Linked Defective Interdomain Interactions Within Ryanodine Receptor Cause Aberrant Ca 2+ Release Leading to Catecholaminergic Polymorphic Ventricular Tachycardia

    Article • Circulation, August 2011, Wolters Kluwer Health

    Shinichi Okuda

  37. A case of mitochondrial disease with severe left ventricular hypertrophy

    Article • Journal of Medical Ultrasonics, May 2011, Springer Science + Business Media

    Shinichi Okuda

  38. Urinary 8-hydroxy-2′-deoxyguanosine reflects symptomatic status and severity of systolic dysfunction in patients with chronic heart failure

    Article • European Journal of Heart Failure, January 2011, Wiley

    Shinichi Okuda

  39. Heterogeneity of apex-to-base dispersion in diastolic lengthening is related to impaired global left ventricular relaxation in patients with hypertrophic cardiomyopathy

    Article • Journal of Echocardiography, August 2010, Springer Science + Business Media

    Shinichi Okuda

  40. Catecholaminergic Polymorphic Ventricular Tachycardia Is Caused by Mutation-Linked Defective Conformational Regulation of the Ryanodine Receptor

    Article • Circulation Research, April 2010, Wolters Kluwer Health

    Shinichi Okuda

  41. Dissociation of calmodulin from cardiac ryanodine receptor causes aberrant Ca2+ release in heart failure

    Article • Cardiovascular Research, April 2010, European Society of Cardiology

    Shinichi Okuda

  42. Defective calmodulin binding to the cardiac ryanodine receptor plays a key role in CPVT-associated channel dysfunction

    Article • Biochemical and Biophysical Research Communications, April 2010, Elsevier

    Shinichi Okuda

  43. Dantrolene, a Therapeutic Agent for Malignant Hyperthermia, Inhibits Catecholaminergic Polymorphic Ventricular Tachycardia in a RyR2R2474S/+ Knock-In Mouse Model

    Article • Circulation Journal, January 2010, Japanese Circulation Society

    Shinichi Okuda

  44. Impact of intraoperative transesophageal echocardiography in cardiac and thoracic aortic surgery: Experience in 1011 cases

    Article • Journal of Cardiology, October 2009, Elsevier

    Shinichi Okuda

  45. Dantrolene, a Therapeutic Agent for Malignant Hyperthermia, Markedly Improves the Function of Failing Cardiomyocytes by Stabilizing Interdomain Interactions Within the Ryanodine Receptor

    Article • Journal of the American College of Cardiology, May 2009, Elsevier

    Shinichi Okuda

  46. Defective domain-domain interactions within the ryanodine receptor as a critical cause of diastolic Ca2+ leak in failing hearts

    Article • Cardiovascular Research, October 2008, European Society of Cardiology

    Shinichi Okuda

  47. AT1 Receptor Antagonist Restores Cardiac Ryanodine Receptor Function, Rendering Isoproterenol-Induced Failing Heart Less Susceptible to Ca2+-Leak Induced by Oxidative Stress

    Article • Circulation Journal, January 2006, Japanese Circulation Society

    Shinichi Okuda

  48. Correction of Defective Interdomain Interaction Within Ryanodine Receptor by Antioxidant Is a New Therapeutic Strategy Against Heart Failure

    Article • Circulation, December 2005, Wolters Kluwer Health

    Shinichi Okuda

  49. Defective Regulation of Interdomain Interactions Within the Ryanodine Receptor Plays a Key Role in the Pathogenesis of Heart Failure

    Article • Circulation, June 2005, Wolters Kluwer Health

    Shinichi Okuda

  50. Significance of predischarge BNP on one-year outcome in decompensated heart failure—comparative study with echo-Doppler indexes

    Article • Journal of Cardiac Failure, February 2005, Elsevier

    Shinichi Okuda

  51. Can Transthoracic Doppler Echocardiography Predict the Discrepancy Between Left Ventricular End-Diastolic Pressure and Mean Pulmonary Capillary Wedge Pressure in Patients With Heart Failure?

    Article • Circulation Journal, January 2005, Japanese Circulation Society

    Shinichi Okuda

  52. Valsartan Restores Sarcoplasmic Reticulum Function With No Appreciable Effect on Resting Cardiac Function in Pacing-Induced Heart Failure

    Article • Circulation, February 2004, Wolters Kluwer Health

    Shinichi Okuda

  53. Application of a Miniaturized Biplane Transesophageal Echocardiographic Probe in Adults

    Article • Journal of Echocardiography, January 2004, Japanese Society of Echocardiography

    Shinichi Okuda

  54. Is the Ratio of Transmitral Peak E-Wave Velocity to Color Flow Propagation Velocity Useful for Evaluating the Severity of Heart Failure in Atrial Fibrillation?

    Article • Circulation Journal, January 2004, Japanese Circulation Society

    Shinichi Okuda

  55. A new cardioprotective agent, JTV519, improves defective channel gating of ryanodine receptor in heart failure

    Article • AJP Heart and Circulatory Physiology, March 2003, American Physiological Society

    Shinichi Okuda

  56. FKBP12.6-Mediated Stabilization of Calcium-Release Channel (Ryanodine Receptor) as a Novel Therapeutic Strategy Against Heart Failure

    Article • Circulation, January 2003, Wolters Kluwer Health

    Shinichi Okuda

  57. O-4 Valsartan restores normal FKBP12.6-RYK interaction by a strong inhibition of PKA-mediated hyperphosphorylation of RYR in heart failure

    Article • Journal of Molecular and Cellular Cardiology, October 2002, Elsevier

    Shinichi Okuda

  58. Propranolol Prevents the Development of Heart Failure by Restoring FKBP12.6-Mediated Stabilization of Ryanodine Receptor

    Article • Circulation, March 2002, Wolters Kluwer Health

    Shinichi Okuda