All Stories

  1. Editorial overview: Tumour immunology: What's beyond today's success in tumor immunology
  2. Vaccines for established cancer: overcoming the challenges posed by immune evasion
  3. A beneficial tumor microenvironment in oropharyngeal squamous cell carcinoma is characterized by a high T cell and low IL-17+ cell frequency
  4. TAP-independent self-peptides enhance T cell recognition of immune-escaped tumors
  5. Toward harmonized phenotyping of human myeloid-derived suppressor cells by flow cytometry: results from an interim study
  6. Human papillomavirus 16-specific cell-mediated immunity in children born to mothers with incident cervical intraepithelial neoplasia (CIN) and to those constantly HPV negative
  7. The tumor area occupied by Tbet+ cells in deeply invading cervical cancer predicts clinical outcome
  8. Abstract 2494: Vaccine-induced TNF alpha producing T cells synergize with cisplatin in tumor eradication
  9. New approaches in vaccine-based immunotherapy for human papillomavirus-induced cancer
  10. Therapeutic cancer vaccines
  11. Synergy between chemotherapy and cancer vaccination
  12. Local and systemic XAGE-1b-specific immunity in patients with lung adenocarcinoma
  13. Cell mediated immunity against HPV16 E2, E6 and E7 peptides in women with incident CIN and in constantly HPV-negative women followed-up for 10-years
  14. Cooperative induction of apoptosis in NRAS mutant melanoma by inhibition of MEK and ROCK
  15. The interferon-related developmental regulator 1 is used by human papillomavirus to suppress NFκB activation
  16. Data analysis as a source of variability of the HLA-peptide multimer assay: from manual gating to automated recognition of cell clusters
  17. CD40-targeted dendritic cell delivery of PLGA-nanoparticle vaccines induce potent anti-tumor responses
  18. High-throughput epitope discovery reveals frequent recognition of neo-antigens by CD4+ T cells in human melanoma
  19. CD40-Mediated Amplification of Local Immunity by Epithelial Cells Is Impaired by HPV
  20. Dominant contribution of the proteasome and metalloproteinases to TAP-independent MHC-I peptide repertoire
  21. Cryopreservation of MHC multimers: Recommendations for quality assurance in detection of antigen specific T cells
  22. Abstract 2938: Synergistic effects of properly timed HPV16 synthetic long peptide vaccination during standard carboplatin-paclitaxel chemotherapy in animals and in patients with metastatic cervical carcinoma
  23. Expression of coinhibitory receptors on T cells in the microenvironment of usual vulvar intraepithelial neoplasia is related to proinflammatory effector T cells and an increased recurrence-free survival
  24. Intraepithelial macrophage infiltration is related to a high number of regulatory T cells and promotes a progressive course of HPV-induced vulvar neoplasia
  25. Flow Cytometry in Cancer Immunotherapy: Applications, Quality Assurance, and Future
  26. Harmonisation of short-term in vitro culture for the expansion of antigen-specific CD8+ T cells with detection by ELISPOT and HLA-multimer staining
  27. Inhibition of CSF-1R Supports T-Cell Mediated Melanoma Therapy
  28. Near-genomewide RNAi screening for regulators of BRAFV600E-induced senescence identifiesRASEF, a gene epigenetically silenced in melanoma
  29. Effect of Hypoxic Stress on Migration and Characteristics of Monocytes in Uveal Melanoma
  30. Immunoguiding, the Final Frontier in the Immunotherapy of Cancer
  31. Synergy of therapeutic vaccination against HPV16 oncogenic proteins and standard chemotherapeutics
  32. Detection and functional assessment of regulatory T cells in clinical samples
  33. Human papillomavirus 16 E2-, E6- and E7-specific T-cell responses in children and their mothers who developed incident cervical intraepithelial neoplasia during a 14-year follow-up of the Finnish Family HPV cohort
  34. Recent progress in peptide vaccination in cancer with a focus on non-small-cell lung cancer
  35. Hierarchical Modeling for Rare Event Detection and Cell Subset Alignment across Flow Cytometry Samples
  36. Human Papillomavirus (HPV) Upregulates the Cellular Deubiquitinase UCHL1 to Suppress the Keratinocyte's Innate Immune Response
  37. A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence
  38. Efficient ex vivo induction of T cells with potent anti-tumor activity by protein antigen encapsulated in nanoparticles
  39. Genome-wide promoter methylation analysis identifies epigenetic silencing ofMAPK13in primary cutaneous melanoma
  40. Abstract 1254: Tumor infiltrating M1 macrophages work side by side with T cells to prolong the survival in patients with cervical carcinoma.
  41. Abstract 4712: Chemotherapy-enhanced NFkB pathway activation in gynecological cancers increases the differentiation of monocytes to M2 macrophages instead of dendritic cells.
  42. Prospects of combinatorial synthetic peptide vaccine-based immunotherapy against cancer
  43. Comprehensive Immunomonitoring to Guide the Development of Immunotherapeutic Products for Cancer
  44. Alternative peptide repertoire of HLA-E reveals a binding motif that is strikingly similar to HLA-A2
  45. HPV16 synthetic long peptide (HPV16-SLP) vaccination therapy of patients with advanced or recurrent HPV16-induced gynecological carcinoma, a phase II trial
  46. Immunotherapy of Human Papilloma Virus Induced Disease
  47. Serum-free freezing media support high cell quality and excellent ELISPOT assay performance across a wide variety of different assay protocols
  48. Therapy of Human Papillomavirus-Related Disease
  49. The development of standard samples with a defined number of antigen-specific T cells to harmonize T cell assays: a proof-of-principle study
  50. Different Subsets of Tumor-Infiltrating Lymphocytes Correlate with Macrophage Influx and Monosomy 3 in Uveal Melanoma
  51. Interleukin-6/interleukin-6 Receptor Pathway as a New Therapy Target in Epithelial Ovarian Cancer
  52. Treatment failure in patients with HPV 16-induced vulvar intraepithelial neoplasia: understanding different clinical responses to immunotherapy
  53. A placebo-controlled randomized HPV16 synthetic long-peptide vaccination study in women with high-grade cervical squamous intraepithelial lesions
  54. Harmonization of the intracellular cytokine staining assay
  55. Identification of a novel antigen processing pathway
  56. Mechanism of superior cross-presentation of synthetic long peptides in comparison with protein for therapeutic cancer vaccination
  57. The simultaneous ex vivo detection of low-frequency antigen-specific CD4+ and CD8+ T-cell responses using overlapping peptide pools
  58. Potentiation of a p53-SLP vaccine by cyclophosphamide in ovarian cancer: A single-arm phase II study
  59. Mechanisms of Peptide Vaccination in Mouse Models
  60. Peptide transporter TAP mediates between competing antigen sources generating distinct surface MHC class I peptide repertoires
  61. T-cell immune monitoring assays to guide the development of new cancer vaccines
  62. T-cell immune monitoring assays to guide the development of new cancer vaccines
  63. Colorectal cancer vaccines in clinical trials
  64. Long-term clinical and immunological effects of p53-SLP® vaccine in patients with ovarian cancer
  65. Therapeutic vaccination against human papilloma virus induced malignancies
  66. Successful treatment of metastatic melanoma by adoptive transfer of blood-derived polyclonal tumor-specific CD4+ and CD8+ T cells in combination with low-dose interferon-alpha
  67. Human Papillomavirus Deregulates the Response of a Cellular Network Comprising of Chemotactic and Proinflammatory Genes
  68. Immunotherapy for persistent viral infections and associated disease
  69. Identification and manipulation of tumor associated macrophages in human cancers
  70. Tumor-infiltrating Cytotoxic T Lymphocytes as Independent Prognostic Factor in Epithelial Ovarian Cancer With Wilms Tumor Protein 1 Overexpression
  71. Generating HPV specific T helper cells for the treatment of HPV induced malignancies using TCR gene transfer
  72. Influenza matrix 1-specific human CD4+FOXP3+ and FOXP3− regulatory T cells can be detected long after viral clearance
  73. The detection of circulating human papillomavirus-specific T cells is associated with improved survival of patients with deeply infiltrating tumors
  74. The nonpolymorphic MHC Qa-1 b mediates CD8 + T cell surveillance of antigen-processing defects
  75. Anti-inflammatory M2 type macrophages characterize metastasized and tyrosine kinase inhibitor-treated gastrointestinal stromal tumors
  76. A prospective study on the natural course of low-grade squamous intraepithelial lesions and the presence of HPV16 E2-, E6- and E7-specific T-cell responses
  77. The nonpolymorphic MHC Qa-1 b mediates CD8 + T cell surveillance of antigen-processing defects
  78. 2-Azidoalkoxy-7-hydro-8-oxoadenine derivatives as TLR7 agonists inducing dendritic cell maturation
  79. Chirality of TLR-2 ligand Pam3CysSK4 in fully synthetic peptide conjugates critically influences the induction of specific CD8+ T-cells
  80. Human immunodeficiency virus and human papilloma virus - why HPV-induced lesions do not spontaneously resolve and why therapeutic vaccination can be successful
  81. T-regulatory cells in tumour-specific vaccination strategies
  82. Immune Response Against Frameshift-Induced Neopeptides in HNPCC Patients and Healthy HNPCC Mutation Carriers
  83. Prediction of the immunogenic potential of frameshift-mutated antigens in microsatellite instable cancer
  84. Immunotherapy of established (pre)malignant disease by synthetic long peptide vaccines
  85. Tumor-specific regulatory T cells in cancer patients
  86. Superior induction of anti-tumor CTL immunity by extended peptide vaccines involves prolonged, DC-focused antigen presentation
  87. Therapeutic vaccines in cancer: moving from immunomonitoring to immunoguiding
  88. Chapter 13 Therapeutic HPV vaccines
  89. Skin reactions to human papillomavirus (HPV) 16 specific antigens intradermally injected in healthy subjects and patients with cervical neoplasia
  90. Corrigendum to “Multiple CD4 and CD8 T-cell activation parameters predict vaccine efficacy in vivo mediated by individual DC-activating agonists” [Vaccine 2007;25(8):1379–89]
  91. Design and development of synthetic peptide vaccines: past, present and future
  92. Spontaneous tumor rejection by cbl-b –deficient CD8 + T cells
  93. Multiple CD4 and CD8 T-cell activation parameters predict vaccine efficacy in vivo mediated by individual DC-activating agonists
  94. Genetic variation of antigen processing machinery components and association with cervical carcinoma
  95. P53-specific T cell responses in patients with malignant and benign ovarian tumors: Implications for p53 based immunotherapy
  96. Circulating human papillomavirus type 16 specific T-cells are associated with HLA Class I expression on tumor cells, but not related to the amount of viral oncogene transcripts
  97. Human papilloma virus specific T cells infiltrating cervical cancer and draining lymph nodes show remarkably frequent use of HLA-DQ and –DP as a restriction element
  98. Chemical synthesis of the HPV16 E7 protein
  99. Improved peptide vaccine strategies, creating synthetic artificial infections to maximize immune efficacy
  100. Synthesis of 2-alkoxy-8-hydroxyadenylpeptides: Towards synthetic epitope-based vaccines
  101. p53: A Potential Target Antigen for Immunotherapy of Cancer
  102. Vaccination for Treatment and Prevention of Cancer in Animal Models
  103. Exploration of the Course of the p53 Specific Immune Response During Primary Treatment for Ovarian Cancer
  104. Detection of human papillomavirus type 18 E6 and E7-specific CD4+ T-helper 1 immunity in relation to health versus disease
  105. Distinct regulation and impact of type 1 T-cell immunity against HPV16 L1, E2 and E6 antigens during HPV16-induced cervical infection and neoplasia
  106. p53-Specific serum antibodies are not associated with a history of skin carcinoma in renal transplant recipients and immunocompetent individuals
  107. Immunology: Innate and Adaptive Immune Responses
  108. Chemically synthesized protein as tumour-specific vaccine: immunogenicity and efficacy of synthetic HPV16 E7 in the TC-1 mouse tumour model
  109. Rapid enrichment of human papillomavirus (HPV)‐specific polyclonal T cell populations for adoptive immunotherapy of cervical cancer
  110. Competition‐Based Cellular Peptide Binding Assay forHLAClass I
  111. Immunology: prophylactic vaccination
  112. Magnitude and polarization of P53-specific T-helper immunity in connection to leukocyte infiltration of colorectal tumors
  113. Safety of intravenous administration of a canarypox virus encoding the human wild-type p53 gene in colorectal cancer patients
  114. Competition-based cellular peptide binding assays for 13 prevalent HLA class I alleles using fluorescein-labeled synthetic peptides
  115. The status of HPV16-specific T-cell reactivity in health and disease as a guide to HPV vaccine development
  116. Effective therapeutic anticancer vaccines based on precision guiding of cytolytic T lymphocytes
  117. Natural T cell response against HPV16 and development of optimal peptide based vaccine
  118. Identification of three non‐VNTR MUC1‐derived HLA‐A*0201‐restricted T‐cell epitopes that induce protective anti‐tumor immunity in HLA‐A2/Kb‐transgenic mice
  119. Long lasting p53-specific T cell memory responses in the absence of anti-p53 antibodies in patients with resected primary colorectal cancer
  120. Design and evaluation of antigen-specific vaccination strategies against cancer
  121. Strategies for immunotherapy of cancer
  122. Molecular Mimicry of Human Cytochrome P450 by Hepatitis C Virus at the Level of Cytotoxic T Cell Recognition
  123. Cytotoxic T lymphocytes in HIV-1 infection: a killing paradox?
  124. Affinity, specificity and T-cell-receptor diversity of melanoma-specific CTL generatedin vitro against a single tyrosinase epitope
  125. Identification of Potential HLA-A *0201 Restricted CTL Epitopes Derived from the Epithelial Cell Adhesion Molecule (Ep-CAM) and the Carcinoembryonic Antigen (CEA)
  126. Do epitopes derived form autoantigens display low affinity for MHC class I?
  127. Analogues of CTL epitopes with improved MHC class-I binding capacity elicit anti-melanoma CTL recognizing the wild-type epitope
  128. Peptide-pulsed dendritic cells induce tumoricidal cytotoxic T lymphocytes from healthy donors against stably HLA-A*0201-binding peptides from the Melan-A/MART-1 self antigen
  129. Cytotoxic T lymphocytes raised against a subdominant epitope offered as a synthetic peptide eradicate human papillomavirus type 16-induced tumors
  130. The Use of Epstein-Barr Virus-Transformed B Lymphocyte Cell Lines in a Peptide-Reconstitution Assay
  131. Induction of a primary human cytotoxic T-lymphocyte response against a novel conserved epitope in a functional sequence of HIV-1 reverse transcriptase
  132. Induction of a primary human cytotoxic T-lymphocyte response against a novel conserved epitope in a functional sequence of HIV-1 reverse transcriptase
  133. p53, a potential target for tumor-directed T cells
  134. In vitro induction of human cytotoxic T lymphocyte responses against peptides of mutant and wild-type p53
  135. Characterization of Cytotoxic T Lymphocyte Epitopes of a Self-Protein, p53, and a Non-Self-Protein, Influenza Matrix
  136. Identification of peptide sequences that potentially trigger HLA-A2.1-restricted cytotoxic T lymphocytes
  137. Faculty of 1000 evaluation for Multipeptide immune response to cancer vaccine IMA901 after single-dose cyclophosphamide associates with longer patient survival.
  138. Faculty of 1000 evaluation for Synergistic inhibition of natural killer cells by the nonsignaling molecule CD94.
  139. Faculty of 1000 evaluation for Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity.
  140. Faculty of 1000 evaluation for Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma.