All Stories

  1. Brain Tissue-Derived Extracellular Vesicles in Alzheimer’s Disease Display Altered Key Protein Levels Including Cell Type-Specific Markers

    Article • Journal of Alzheimer s Disease, November 2022, IOS Press

    Dr. Kenneth W Witwer

  2. Extracellular vesicles or exosomes? On primacy, precision, and popularity influencing a choice of nomenclature

    Article • Journal of Extracellular Vesicles, August 2019, Taylor & Francis

    Dr. Kenneth W Witwer

  3. Acetylcholinesterase is not a generic marker of extracellular vesicles

    Article • Journal of Extracellular Vesicles, July 2019, Taylor & Francis

    Dr. Kenneth W Witwer, Lorena Martin Jaular, norman haughey

  4. Announcing the ISEV2019 special achievement award recipients: Takahiro Ochiya and Marca Wauben

    Article • Journal of Extracellular Vesicles, May 2019, Taylor & Francis

    Dr. Kenneth W Witwer

  5. Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

    Article • Journal of Extracellular Vesicles, November 2018, Taylor & Francis

    A. Paula Domínguez Rubio, Dr Muhammad Nawaz, Dr. Kenneth W Witwer, Dr. Ann M Wehman, Dr André Görgens, Daniel Bachurski, Anna C. Beardi, Dr Scott M Langevin, Dr Johnathon D Anderson, Maja Kosanovic

  6. miRNAs in platelet-poor blood plasma and purified RNA are highly stable: a confirmatory study

    Article • BMC Research Notes, May 2018, Springer Science + Business Media

    Dr. Kenneth W Witwer

  7. Towards mechanisms and standardization in extracellular vesicle and extracellular RNA studies: results of a worldwide survey

    Article • Journal of Extracellular Vesicles, April 2018, Taylor & Francis

    Dr Carolina Soekmadji, Dr. Edit I Buzás, Dr. Kenneth W Witwer

  8. miR-21-5p and miR-30a-5p are identical in human and bovine, have similar isomiR distribution, and cannot be used to identify xenomiR uptake from cow milk

    Article • March 2018, Cold Spring Harbor Laboratory Press

    Dr. Kenneth W Witwer

  9. TNFα and IL-1β modify the miRNA cargo of astrocyte shed extracellular vesicles to regulate neurotrophic signaling in neurons

    Article • Cell Death and Disease, March 2018, Springer Science + Business Media

    Dr. Kenneth W Witwer

  10. Alternative miRNAs? Human sequences misidentified as plant miRNAs in plant studies and in human plasma

    Article • F1000Research, February 2018, Faculty of 1000, Ltd.

    Dr. Kenneth W Witwer

  11. miRNA profiling of primate cervicovaginal lavage and extracellular vesicles reveals miR-186-5p as a potential retroviral restriction factor in macrophages

    Article • February 2018, Cold Spring Harbor Laboratory Press

    Dr. Kenneth W Witwer

  12. Proceedings of the 2017 ISEV symposium on “HIV, NeuroHIV, drug abuse, & EVs”

    Article • Journal of NeuroVirology, November 2017, Springer Science + Business Media

    Dr. Kenneth W Witwer

  13. An SIV/macaque model targeted to study HIV-associated neurocognitive disorders

    Article • Journal of NeuroVirology, October 2017, Springer Science + Business Media

    Dr. Kenneth W Witwer

  14. Concise Review: Developing Best-Practice Models for the Therapeutic Use of Extracellular Vesicles

    Article • Stem Cells Translational Medicine, July 2017, Wiley

    Dr. Kenneth W Witwer

  15. Diet-derived microRNAs: unicorn or silver bullet?

    Article • Genes & Nutrition, June 2017, Springer Science + Business Media

    Dr. Kenneth W Witwer

  16. Serum extracellular vesicle depletion processes affect release and infectivity of HIV-1 in culture

    Article • Scientific Reports, May 2017, Nature

    Dr. Kenneth W Witwer

  17. Modeling brain lentiviral infections during antiretroviral therapy in AIDS

    Article • Journal of NeuroVirology, May 2017, Springer Science + Business Media

    Dr. Kenneth W Witwer

  18. Age-Related Changes in Plasma Extracellular Vesicle Characteristics and Internalization by Leukocytes

    Article • Scientific Reports, May 2017, Springer Science + Business Media

    Dr. Kenneth W Witwer

  19. Astrocyte-shed extracellular vesicles regulate the peripheral leukocyte response to inflammatory brain lesions

    Article • Science Signaling, April 2017, American Association for the Advancement of Science

    Dr. Kenneth W Witwer, Prof Daniel C Anthony

  20. Alternative miRNAs: Human Sequences Misidentified As Plant miRNAs In Plant Studies And In Human Plasma

    Article • March 2017, Cold Spring Harbor Laboratory Press

    Dr. Kenneth W Witwer

  21. EV-TRACK: transparent reporting and centralizing knowledge in extracellular vesicle research

    Article • Nature Methods, February 2017, Nature

    Abhishek Garg, Dr. Kenneth W Witwer

  22. Mutant Cas9-transcriptional activator activates HIV-1 in U1 cells in the presence and absence of LTR-specific guide RNAs

    Article • Matters, January 2017, Sciencematters

    Dr. Kenneth W Witwer

  23. Ribonucleic artefacts: are some extracellular RNA discoveries driven by cell culture medium components?

    Article • Journal of Extracellular Vesicles, January 2017, Taylor & Francis

    Dr. Kenneth W Witwer

  24. Obstacles and opportunities in the functional analysis of extracellular vesicle RNA – an ISEV position paper

    Article • Journal of Extracellular Vesicles, January 2017, Taylor & Francis

    Dr Muhammad Nawaz, Dr. Kenneth W Witwer, Professor Raymond Schiffelers, Dr. Sabine Bartel

  25. Proceedings of the ISEV symposium on “HIV, NeuroAIDS, drug abuse & EVs”

    Article • Journal of Extracellular Vesicles, January 2017, Taylor & Francis

    Dr. Kenneth W Witwer

  26. Updating the MISEV minimal requirements for extracellular vesicle studies: building bridges to reproducibility

    Article • Journal of Extracellular Vesicles, January 2017, Taylor & Francis

    Dr. Edit I Buzás, Hang Yin, Yong Song Gho, Dr Carolina Soekmadji, Dr. Kenneth W Witwer

  27. Highlights of the São Paulo ISEV workshop on extracellular vesicles in cross-kingdom communication

    Article • Journal of Extracellular Vesicles, January 2017, Taylor & Francis

    Dr. Kenneth W Witwer

  28. Isolation and Characterization of Extracellular Vesicles in Stem Cell-Related Studies

    Article • January 2017, Springer Science + Business Media

    Dr. Kenneth W Witwer

  29. Serum extracellular vesicle depletion processes affect release and infectivity of HIV-1 in culture

    Article • December 2016, Cold Spring Harbor Laboratory Press

    Dr. Kenneth W Witwer

  30. Advancing the use of noncoding RNA in regulatory toxicology: Report of an ECETOC workshop

    Article • Regulatory Toxicology and Pharmacology, December 2016, Elsevier

    Dr. Kenneth W Witwer

  31. Opposing impacts on healthspan and longevity by limiting dietary selenium in telomere dysfunctional mice

    Article • Aging Cell, September 2016, Wiley

    Dr. Kenneth W Witwer

  32. Toward the promise of microRNAs – Enhancing reproducibility and rigor in microRNA research

    Article • RNA Biology, September 2016, Taylor & Francis

    Dr. Kenneth W Witwer

  33. Uptake of dietary milk miRNAs by adult humans: a validation study

    Article • F1000Research, April 2016, Faculty of 1000, Ltd.

    Dr. Kenneth W Witwer

  34. Synthetic miR-16-5p does not act as a reverse transcriptase co-factor to enhance detection of small RNA

    Article • April 2016, Cold Spring Harbor Laboratory Press

    Dr. Kenneth W Witwer

  35. Association of BRAF V600E Mutation and MicroRNA Expression with Central Lymph Node Metastases in Papillary Thyroid Cancer: A Prospective Study from Four Endocrine Surgery Centers

    Article • Thyroid, April 2016, Mary Ann Liebert Inc

    Dr. Kenneth W Witwer

  36. A benchmark for microRNA quantification algorithms using the OpenArray platform

    Article • BMC Bioinformatics, March 2016, Springer Science + Business Media

    Dr. Kenneth W Witwer

  37. SAMHD1 transcript upregulation during SIV infection of the central nervous system does not associate with reduced viral load

    Article • Scientific Reports, March 2016, Nature

    Dr. Kenneth W Witwer

  38. Extracellular Vesicles Exploit Viral Entry Routes for Cargo Delivery

    Article • Microbiology and Molecular Biology Reviews, March 2016, ASM Journals

    Dr. Kenneth W Witwer

  39. Hypothetical Plant-Mammal Small RNA CommunicationCommunication : Packaging and Stoichiometry

    Article • January 2016, Springer Science + Business Media

    Dr. Kenneth W Witwer

  40. Techniques used for the isolation and characterization of extracellular vesicles: results of a worldwide survey

    Article • Journal of Extracellular Vesicles, January 2016, Taylor & Francis

    Dr. Kenneth W Witwer

  41. MicroRNA Expression and Association with Clinicopathologic Features in Papillary Thyroid Cancer: A Systematic Review

    Article • Thyroid, December 2015, Mary Ann Liebert Inc

    Dr. Kenneth W Witwer

  42. Contamination or artifacts may explain reports of plant miRNAs in humans

    Article • The Journal of Nutritional Biochemistry, December 2015, Elsevier

    Dr. Kenneth W Witwer

  43. RNAi technologies in agricultural biotechnology: The Toxicology Forum 40th Annual Summer Meeting

    Article • Regulatory Toxicology and Pharmacology, November 2015, Elsevier

    Dr. Kenneth W Witwer

  44. miRNAs and SAMHD1 regulation in vitro and in a model of HIV CNS disease

    Article • Journal of Neuroinflammation, September 2015, Springer Science + Business Media

    Dr. Kenneth W Witwer

  45. Validated MicroRNA Target Databases: An Evaluation

    Article • Drug Development Research, August 2015, Wiley

    Dr. Kenneth W Witwer

  46. Potential role of cervicovaginal extracellular particles in diagnosis of endometriosis

    Article • BMC Veterinary Research, August 2015, Springer Science + Business Media

    Dr. Kenneth W Witwer

  47. Acute Hepatitis C Virus Infection Induces Consistent Changes in Circulating MicroRNAs That Are Associated with Nonlytic Hepatocyte Release

    Article • Journal of Virology, July 2015, ASM Journals

    Dr. Kenneth W Witwer, Dr Stuart C. Ray

  48. Paving the path to HIV neurotherapy: Predicting SIV CNS disease

    Article • European Journal of Pharmacology, July 2015, Elsevier

    Dr. Kenneth W Witwer

  49. Assessment of small RNA sorting into different extracellular fractions revealed by high-throughput sequencing of breast cell lines

    Article • Nucleic Acids Research, May 2015, Oxford University Press (OUP)

    Dr. Kenneth W Witwer

  50. Extracellular vesicle–depleted fetal bovine and human sera have reduced capacity to support cell growth

    Article • Journal of Extracellular Vesicles, March 2015, Co-Action Publishing

    Dr. Kenneth W Witwer

  51. Quinolinic acid/tryptophan ratios predict neurological disease in SIV-infected macaques and remain elevated in the brain under cART

    Article • Journal of NeuroVirology, March 2015, Springer Science + Business Media

    Dr. Kenneth W Witwer

  52. Minimal experimental requirements for definition of extracellular vesicles and their functions: a position statement from the International Society for Extracellular Vesicles

    Article • Journal of Extracellular Vesicles, December 2014, Co-Action Publishing

    Dr. Kenneth W Witwer

  53. Circulating MicroRNA Biomarker Studies: Pitfalls and Potential Solutions

    Article • Clinical Chemistry, November 2014, AACC

    Dr. Kenneth W Witwer

  54. EVpedia: a community web portal for extracellular vesicles research

    Article • Bioinformatics, November 2014, Oxford University Press (OUP)

    Professor Raymond Schiffelers, Dr Gabriella Pocsfalvi, Dr. Kenneth W Witwer

  55. Diet-Responsive Mammalian miRNAs Are Likely Endogenous

    Article • Journal of Nutrition, November 2014, Oxford University Press (OUP)

    Dr. Kenneth W Witwer

  56. SAMHD1 expression in blood cells of HIV-1 elite suppressors and viraemic progressors

    Article • Journal of Antimicrobial Chemotherapy, October 2014, Oxford University Press (OUP)

    Dr. Kenneth W Witwer

  57. Dietary flaxseed modulates the miRNA profile in irradiated and non-irradiated murine lungs

    Article • Cancer Biology & Therapy, April 2014, Taylor & Francis

    Dr. Kenneth W Witwer

  58. TRIM19-Positive and TRIM19-Negative Cells in and Around a Perivascular Cuff of CD68-Positive Macrophages

    Article • AIDS Research and Human Retroviruses, April 2014, Mary Ann Liebert Inc

    Dr. Kenneth W Witwer

  59. Elevated Brain Monoamine Oxidase Activity in SIV- and HIV-associated Neurological Disease

    Article • The Journal of Infectious Diseases, March 2014, Oxford University Press (OUP)

    Dr. Kenneth W Witwer

  60. Circulating Extracellular Micrornas In Hereditary Angioedema

    Article • Journal of Allergy and Clinical Immunology, February 2014, Elsevier

    Dr. Kenneth W Witwer

  61. HIV-1 Tat- and Vpr-responsive MicroRNAs of Neuronal Cells

    Article • Journal of Biological Chemistry, January 2014, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr. Kenneth W Witwer

  62. Transfer and functional consequences of dietary microRNAs in vertebrates: Concepts in search of corroboration

    Article • BioEssays, January 2014, Wiley

    Dr. Kenneth W Witwer

  63. OpenArray profiling reveals no differential modulation of miRNA by positive and negative CD4+ T cell immunoselection

    Article • Experimental Hematology, January 2014, Elsevier

    Dr. Kenneth W Witwer

  64. Real-time quantitative PCR and droplet digital PCR for plant miRNAs in mammalian blood provide little evidence for general uptake of dietary miRNAs

    Article • RNA Biology, July 2013, Taylor & Francis

    Dr. Kenneth W Witwer

  65. Standardization of sample collection, isolation and analysis methods in extracellular vesicle research

    Article • Journal of Extracellular Vesicles, May 2013, Co-Action Publishing

    Dr. Kenneth W Witwer

  66. Witwer, K.W.; et al. Correction: miRNA Profiles of Monocyte-Lineage Cells Are Consistent with Complicated Roles in HIV-1 Restriction. Viruses 2012, 4, 1844-1864.

    Article • Viruses, March 2013, MDPI AG

    Dr. Kenneth W Witwer

  67. Data Submission and Quality in Microarray-Based MicroRNA Profiling

    Article • Clinical Chemistry, January 2013, AACC

    Dr. Kenneth W Witwer

  68. Tristetraprolin expression and microRNA-mediated regulation during simian immunodeficiency virus infection of the central nervous system

    Article • Molecular Brain, January 2013, Springer Science + Business Media

    Dr. Kenneth W Witwer

  69. SIV replication is directly downregulated by four antiviral miRNAs

    Article • Retrovirology, January 2013, Springer Science + Business Media

    Dr. Kenneth W Witwer

  70. Comparison of Methods for miRNA Extraction from Plasma and Quantitative Recovery of RNA from Cerebrospinal Fluid

    Article • Frontiers in Genetics, January 2013, Frontiers

    Dr. Kenneth W Witwer

  71. miRNA Profiles of Monocyte-Lineage Cells Are Consistent with Complicated Roles in HIV-1 Restriction

    Article • Viruses, September 2012, MDPI AG

    Dr. Kenneth W Witwer

  72. XenomiRs and miRNA homeostasis in health and disease

    Article • RNA Biology, September 2012, Taylor & Francis

    Dr. Kenneth W Witwer

  73. Evidence for miRNA expression differences of HIV-1-positive, treatment-naive patients and elite suppressors: a re-analysis

    Article • Blood, June 2012, American Society of Hematology

    Dr. Kenneth W Witwer

  74. Relationships of PBMC microRNA expression, plasma viral load, and CD4+ T-cell count in HIV-1-infected elite suppressors and viremic patients

    Article • Retrovirology, January 2012, Springer Science + Business Media

    Dr. Kenneth W Witwer

  75. Influence of food intake on circulating extracellular vesicles and microrna profiles

    Article • Journal of Nutrition & Food Sciences, January 2012, OMICS Publishing Group

    Dr. Kenneth W Witwer

  76. Do Platform-Specific Factors Explain MicroRNA Profiling Disparities?

    Article • Clinical Chemistry, November 2011, AACC

    Dr. Kenneth W Witwer

  77. A plasma microRNA signature of acute lentiviral infection

    Article • AIDS, November 2011, Wolters Kluwer Health

    Dr. Kenneth W Witwer

  78. Induction of Innate Immune Responses by SIV In Vivo and In Vitro: Differential Expression and Function of RIG-I and MDA5

    Article • The Journal of Infectious Diseases, August 2011, Oxford University Press (OUP)

    Dr. Kenneth W Witwer

  79. MicroRNA Regulation of IFN-  Protein Expression: Rapid and Sensitive Modulation of the Innate Immune Response

    Article • The Journal of Immunology, February 2010, The American Association of Immunologists

    Dr. Kenneth W Witwer

  80. Coordinated Regulation of SIV Replication and Immune Responses in the CNS

    Article • PLoS ONE, December 2009, PLOS

    Dr. Kenneth W Witwer