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  1. Cover Picture: Proteomic Atomics Reveals a Distinctive Uracil‐5‐Methyltransferase (Mol. Inf. 5/2020)

    Article • Molecular Informatics, May 2020, Wiley

    Professor Klaus Heese

  2. Improvement of Saccharification and Delignification Efficiency of Trichoderma reesei Rut-C30 by Genetic Bioengineering

    Article • Microorganisms, January 2020, MDPI AG

    Professor Klaus Heese

  3. Proteomic Atomics Reveals a Distinctive Uracil‐5‐Methyltransferase

    Article • Molecular Informatics, January 2020, Wiley

    Professor Klaus Heese, Manisha Thaker, Dr. Rajasekaran Ekambaram

  4. Accurate high throughput alignment via line sweep-based seed processing

    Article • Nature Communications, April 2019, Springer Science + Business Media

    Professor Klaus Heese

  5. CRISPR-mediated upregulation of DR5 and downregulation of cFLIP synergistically sensitize HeLa cells to TRAIL-mediated apoptosis

    Article • Biochemical and Biophysical Research Communications, March 2019, Elsevier

    Professor Klaus Heese

  6. A Novel Divergent Gene Transcription Paradigm—the Decisive, Brain-Specific, Neural |-Srgap2–Fam72a-| Master Gene Paradigm

    Article • Molecular Neurobiology, January 2019, Springer Science + Business Media

    Professor Klaus Heese

  7. A cancer tissue-specific FAM72 expression profile defines a novel glioblastoma multiform (GBM) gene-mutation signature

    Article • Journal of Neuro-Oncology, November 2018, Springer Science + Business Media

    Professor Klaus Heese

  8. Establishing a Human Adrenocortical Carcinoma (ACC)-Specific Gene Mutation Signature

    Article • Cancer Genetics, November 2018, Elsevier

    Professor Klaus Heese

  9. Brain plasticity, cognitive functions and neural stem cells: a pivotal role for the brain-specific neural master gene |-SRGAP2–FAM72-|

    Article • Biological Chemistry, December 2017, De Gruyter

    Professor Klaus Heese

  10. Functional repertoire of interleukin-6 in the central nervous system – a review

    Article • Restorative Neurology and Neuroscience, November 2017, IOS Press

    Professor Klaus Heese

  11. A novel specialized single-linkage clustering algorithm for taxonomically ordered data

    Article • Journal of Theoretical Biology, August 2017, Elsevier

    Professor Klaus Heese

  12. Interleukin-6-Mediated Induced Pluripotent Stem Cell (iPSC)-Derived Neural Differentiation

    Article • Molecular Neurobiology, May 2017, Springer Science + Business Media

    Professor Klaus Heese

  13. Cognitive Functions: Human vs. Animal – 4:1 Advantage |-FAM72–SRGAP2-|

    Article • Journal of Molecular Neuroscience, March 2017, Springer Science + Business Media

    Professor Klaus Heese

  14. Livebearing or egg-laying mammals: 27 decisive nucleotides of FAM168

    Article • BioScience Trends, January 2017, International Research and Cooperation Association for Bio & Socio-Sciences Advancement (IRCA-BSSA)

    Professor Klaus Heese

  15. Neurotrophin Signaling and Stem Cells—Implications for Neurodegenerative Diseases and Stem Cell Therapy

    Article • Molecular Neurobiology, November 2016, Springer Science + Business Media

    Professor Klaus Heese

  16. Glutamate E15 and E171 are Hotspots in p60TRP-Related Cancer

    Article • Cancer Investigation, February 2016, Taylor & Francis

    Professor Klaus Heese

  17. All-or-(N)One – an epistemological characterization of the human tumorigenic neuronal paralogous FAM72 gene loci

    Article • Genomics, November 2015, Elsevier

    Professor Klaus Heese

  18. Characterization of a solvent, surfactant and temperature-tolerant laccase from Pleurotus sp. MAK-II and its dye decolorizing property

    Article • Biotechnology Letters, August 2015, Springer Science + Business Media

    Professor Klaus Heese

  19. Characterization of a Solvent-Tolerant Manganese Peroxidase (MnP) fromGanoderma Lucidumand Its Application in Fruit Juice Clarification

    Article • Journal of Food Biochemistry, August 2015, Wiley

    Professor Klaus Heese

  20. 3D Structure, Dimerization Modeling, and Lead Discovery by Ligand-protein Interaction Analysis of p60 Transcription Regulator Protein (p60TRP)

    Article • Molecular Informatics, July 2015, Wiley

    Professor Klaus Heese

  21. Characterization of a novel endoglucanase fromGanoderma lucidum

    Article • Journal of Basic Microbiology, April 2015, Wiley

    Professor Klaus Heese

  22. Ageing, dementia and society – an epistemological perspective

    Article • SpringerPlus, March 2015, Springer Science + Business Media

    Professor Klaus Heese

  23. The Ubiquitin-Proteasome System and Molecular Chaperone Deregulation in Alzheimer’s Disease

    Article • Molecular Neurobiology, January 2015, Springer Science + Business Media

    Professor Klaus Heese

  24. Proteomics in Traditional Chinese Medicine with an Emphasis on Alzheimer’s Disease

    Article • Evidence-based Complementary and Alternative Medicine, January 2015, Hindawi Publishing Corporation

    Professor Klaus Heese

  25. Mechanism Study of Traditional Medicine Using Proteomics Alone or Integrated with Other Systems Biology Technologies

    Article • Evidence-based Complementary and Alternative Medicine, January 2015, Hindawi Publishing Corporation

    Professor Klaus Heese

  26. Characterization of Lignocellulolytic Enzymes from White-Rot Fungi

    Article • Current Microbiology, December 2014, Springer Science + Business Media

    Professor Klaus Heese

  27. Lead discovery and in silico 3D structure modeling of tumorigenic FAM72A (p17)

    Article • Tumor Biology, September 2014, Springer Science + Business Media

    Professor Klaus Heese

  28. Oxygen distribution in proteins defines functional significance of the genome and proteome of the malaria parasite Plasmodium falciparum 3D7

    Article • FEMS Microbiology Letters, December 2013, Oxford University Press (OUP)

    Professor Klaus Heese

  29. Thymine distribution in genes provides novel insight into the functional significance of the proteome of the malaria parasite Plasmodium falciparum 3D7

    Article • Bioinformatics, October 2013, Oxford University Press (OUP)

    Professor Klaus Heese, Dr. Rajasekaran Ekambaram

  30. Quantitative clinical proteomic study of autopsied human infarcted brain specimens to elucidate the deregulated pathways in ischemic stroke pathology

    Article • Journal of Proteomics, October 2013, Elsevier

    Professor Klaus Heese

  31. Brain site-specific proteome changes in aging-related dementia

    Article • Experimental & Molecular Medicine, September 2013, Nature

    Professor Klaus Heese

  32. The protein p17 signaling pathways in cancer

    Article • Tumor Biology, July 2013, Springer Science + Business Media

    Professor Klaus Heese

  33. Establishing an in vivo p48ZnF bioluminescence mouse brain imaging model

    Article • Neuroscience Letters, May 2013, Elsevier

    Professor Klaus Heese

  34. G Proteins, p60TRP, and Neurodegenerative Diseases

    Article • Molecular Neurobiology, January 2013, Springer Science + Business Media

    Professor Klaus Heese

  35. Brain-Site-Specific Proteome Changes Induced by Neuronal P60TRP Expression

    Article • Neurosignals, January 2013, Karger Publishers

    Professor Klaus Heese

  36. Characterization of optimized production, purification and application of laccase from Ganoderma lucidum

    Article • Biochemical Engineering Journal, January 2013, Elsevier

    Professor Klaus Heese

  37. Secretome analysis of Ganoderma lucidum cultivated in sugarcane bagasse

    Article • Journal of Proteomics, December 2012, Elsevier

    Professor Klaus Heese

  38. Characterization of the novel protein P9TLDR (temporal lobe down-regulated) with a brain-site-specific gene expression modality in Alzheimer's disease brain

    Article • FEBS Letters, November 2012, Wiley

    Professor Klaus Heese

  39. MAGNITUDE OF THYMINE IN DIFFERENT FRAMES OF MESSENGER RNAs

    Article • International Journal of Bioinformatics Research, August 2012, Bioinfo Publications

    Professor Klaus Heese, Dr. Rajasekaran Ekambaram

  40. Characterizing the neurite outgrowth inhibitory effect of Mani

    Article • FEBS Letters, July 2012, Wiley

    Professor Klaus Heese

  41. Tianma Modulates Blood Vessel Tonicity

    Article • The Open Biochemistry Journal, June 2012, Bentham Science Publishers

    Professor Klaus Heese

  42. Tianma modulates proteins with various neuro-regenerative modalities in differentiated human neuronal SH-SY5Y cells

    Article • Neurochemistry International, June 2012, Elsevier

    Professor Klaus Heese

  43. New insights into the brain protein metabolism of Gastrodia elata-treated rats by quantitative proteomics

    Article • Journal of Proteomics, April 2012, Elsevier

    Professor Klaus Heese

  44. Neuronal p60TRP expression modulates cardiac capacity

    Article • Journal of Proteomics, February 2012, Elsevier

    Professor Klaus Heese

  45. Phenotyping of Tianma-Stimulated Differentiated Rat Neuronal B104 Cells by Quantitative Proteomics

    Article • Neurosignals, November 2011, Karger Publishers

    Professor Klaus Heese

  46. Quantitative Neuroproteomics of an In Vivo Rodent Model of Focal Cerebral Ischemia/Reperfusion Injury Reveals a Temporal Regulation of Novel Pathophysiological Molecular Markers

    Article • Journal of Proteome Research, November 2011, American Chemical Society (ACS)

    Professor Klaus Heese

  47. P60TRP interferes with the GPCR/secretase pathway to mediate neuronal survival and synaptogenesis

    Article • Journal of Cellular and Molecular Medicine, October 2011, Wiley

    Professor Klaus Heese

  48. The novel protein MANI modulates neurogenesis and neurite-cone growth

    Article • Journal of Cellular and Molecular Medicine, July 2011, Wiley

    Professor Klaus Heese

  49. Gastrodia elata modulates amyloid precursor protein cleavage and cognitive functions in mice

    Article • BioScience Trends, January 2011, International Research and Cooperation Association for Bio & Socio-Sciences Advancement (IRCA-BSSA)

    Professor Klaus Heese

  50. Characterizing the novel protein p33MONOX

    Article • Molecular and Cellular Biochemistry, December 2010, Springer Science + Business Media

    Professor Klaus Heese

  51. Neurotrophin-4 (Ntf4) Mediates Neurogenesis in Mouse Embryonic Neural Stem Cells Through the Inhibition of the Signal Transducer and Activator of Transcription-3 (Stat3) and the Modulation of the Activity of Protein Kinase B

    Article • Cellular and Molecular Neurobiology, April 2010, Springer Science + Business Media

    Professor Klaus Heese

  52. Cardiovascular Dementia - A Different Perspective

    Article • The Open Biochemistry Journal, March 2010, Bentham Science Publishers

    Professor Klaus Heese

  53. Phenotyping of an in Vitro Model of Ischemic Penumbra by iTRAQ-Based Shotgun Quantitative Proteomics

    Article • Journal of Proteome Research, January 2010, American Chemical Society (ACS)

    Dr Huoming Zhang, Professor Klaus Heese

  54. Ligand-Dependent Activation of the Chimeric Tumor Necrosis Factor Receptor-Amyloid Precursor Protein (APP) Reveals Increased APP Processing and Suppressed Neuronal Differentiation

    Article • Neurosignals, January 2010, Karger Publishers

    Professor Klaus Heese

  55. Identification and characterisation of the novel amyloid-beta peptide-induced protein p17

    Article • FEBS Letters, September 2009, Wiley

    Professor Klaus Heese

  56. Brain-Derived Neurotrophic Factor (BDNF) has Proliferative Effects on Neural Stem Cells through the Truncated TRK-B Receptor, MAP Kinase, AKT, and STAT-3 Signaling Pathways

    Article • Current Neurovascular Research, February 2009, Bentham Science Publishers

    Professor Klaus Heese

  57. Interleukin-6 and Neural Stem Cells: More Than Gliogenesis

    Article • Molecular Biology of the Cell, October 2008, American Society for Cell Biology (ASCB)

    Professor Klaus Heese

  58. Neurotrophins - More than Neurotrophic

    Article • Current Immunology Reviews, August 2007, Bentham Science Publishers

    Professor Klaus Heese

  59. Death effector domain DEDa, a self-cleaved product of caspase-8/Mch5, translocates to the nucleus by binding to ERK1/2 and upregulates procaspase-8 expression via a p53-dependent mechanism

    Article • The EMBO Journal, February 2007, Wiley

    Professor Klaus Heese

  60. ABC transporters, neural stem cells and neurogenesis – a different perspective

    Article • Cell Research, November 2006, Nature

    Professor Klaus Heese

  61. Brain site-specific gene expression analysis in Alzheimer's disease patients

    Article • European Journal of Clinical Investigation, November 2006, Wiley

    Professor Klaus Heese

  62. The Bad Guy Cooperates with Good Cop p53: Bad Is Transcriptionally Up-Regulated by p53 and Forms a Bad/p53 Complex at the Mitochondria To Induce Apoptosis

    Article • Molecular and Cellular Biology, September 2006, ASM Journals

    Professor Klaus Heese

  63. Livin promotes Smac/DIABLO degradation by ubiquitin–proteasome pathway

    Article • Cell Death and Differentiation, May 2006, Nature

    Professor Klaus Heese

  64. Alzheimers Disease - An Interactive Perspective

    Article • Current Alzheimer Research, April 2006, Bentham Science Publishers

    Professor Klaus Heese

  65. Cytokines and Neurotrophins Interact in Normal and Diseased States

    Article • Annals of the New York Academy of Sciences, January 2006, Wiley

    Professor Klaus Heese

  66. Nerve Growth Factor, Neural Stem Cells and Alzheimer’s Disease

    Article • Neurosignals, January 2006, Karger Publishers

    Professor Klaus Heese

  67. Nerve growth factor(NGF) induces mRNA expression of the new transcription factor protein p48ZnF

    Article • Experimental & Molecular Medicine, April 2004, Nature

    Professor Klaus Heese

  68. Identification of rTid-1, the rat homologue of the drosophila tumor suppressor l(2)tid gene

    Article • Molecular and Cellular Biochemistry, March 2004, Springer Science + Business Media

    Professor Klaus Heese

  69. The Splicing Regulatory Protein p18SRP Is Down-Regulated in Alzheimer's Disease Brain

    Article • Journal of Molecular Neuroscience, January 2004, Springer Science + Business Media

    Professor Klaus Heese

  70. The possible mechanisms of Aβ(1-40)- or Aβ(1-42)-induced cell death and their rescue factors

    Article • Folia Pharmacologica Japonica, January 2004, Japanese Pharmacological Society

    Professor Klaus Heese

  71. Characterizing the new transcription regulator protein p60TRP

    Article • Journal of Cellular Biochemistry, January 2004, Wiley

    Professor Klaus Heese

  72. Effects of high glucose on cytokine-induced nerve growth factor (NGF) expression in rat renal mesangial cells

    Article • Biochemical Pharmacology, January 2003, Elsevier

    Professor Klaus Heese

  73. Comparative gene identification-94—a pivotal regulator of apoptosis

    Article • Neuroscience, January 2003, Elsevier

    Professor Klaus Heese

  74. Inflammatory Signals Induce Neurotrophin Expression in Human Microglial Cells

    Article • Journal of Neurochemistry, November 2002, Wiley

    Professor Klaus Heese

  75. Characterizing the signaling pathway of rat p18 amyloid beta (A??) responsive protein (p18A??rP).

    Article • September 2002, Elsevier

    Professor Klaus Heese

  76. The 3′ untranslated region of the new rat synaptic vesicle protein 2B mRNA transcript inhibits translational efficiency

    Article • Molecular Brain Research, August 2002, Elsevier

    Professor Klaus Heese

  77. Characterizing CGI-94 (comparative gene identification-94) which is down-regulated in the hippocampus of early stage Alzheimer's disease brain

    Article • European Journal of Neuroscience, January 2002, Wiley

    Professor Klaus Heese

  78. Identification of a New Synaptic Vesicle Protein 2B mRNA Transcript Which Is Up-Regulated in Neurons by Amyloid β Peptide Fragment (1–42)

    Article • Biochemical and Biophysical Research Communications, December 2001, Elsevier

    Professor Klaus Heese

  79. Signals regulating neurotrophin expression in glial cells

    Article • January 2001, Elsevier

    Professor Klaus Heese

  80. Expression of interleukin-6 and its receptor in the sciatic nerve and cultured Schwann cells: relation to 18-kD fibroblast growth factor-2

    Article • Brain Research, December 2000, Elsevier

    Professor Klaus Heese

  81. Increased cerebrospinal fluid levels of neurotrophin 3 (NT-3) in elderly patients with major depression

    Article • Molecular Psychiatry, September 2000, Nature

    Professor Klaus Heese

  82. Induction of rat l-phosphoserine phosphatase by amyloid-β (1–42) is inhibited by interleukin-11

    Article • Neuroscience Letters, July 2000, Elsevier

    Professor Klaus Heese

  83. Region-Specific Neurotrophin Imbalances in Alzheimer Disease

    Article • Archives of Neurology, June 2000, American Medical Association (AMA)

    Professor Klaus Heese

  84. Increased CSF levels of nerve growth factor in patients with Alzheimer's disease

    Article • Neurology, May 2000, Wolters Kluwer Health

    Professor Klaus Heese

  85. GABAB receptor antagonists elevate both mRNA and protein levels of the neurotrophins nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) but not neurotrophin-3 (NT-3) in brain and spinal cord of rats

    Article • Neuropharmacology, March 2000, Elsevier

    Professor Klaus Heese

  86. Alterations in neurotrophins and neurotrophin receptors in Alzheimer’s disease

    Article • January 2000, Springer Science + Business Media

    Professor Klaus Heese

  87. Modulation of mRNA expression of the neurotrophins of the nerve-growth-factor family and their receptors in the septum and hippocampus of rats after transient postnatal thyroxine treatment. II. Effects on p75 and trk receptor expression

    Article • Experimental Brain Research, July 1999, Springer Science + Business Media

    Professor Klaus Heese

  88. Role of interleukin-6 and soluble IL-6 receptor in region-specific induction of astrocytic differentiation and neurotrophin expression

    Article • Glia, May 1999, Wiley

    Professor Klaus Heese

  89. NF-?B modulates lipopolysaccharide-induced microglial nerve growth factor expression

    Article • Glia, April 1998, Wiley

    Professor Klaus Heese

  90. Modulation of mRNA expression of the neurotrophins of the nerve growth factor family and their receptors in the septum and hippocampus of rats after transient postnatal thyroxine treatment

    Article • Experimental Brain Research, February 1998, Springer Science + Business Media

    Professor Klaus Heese

  91. Decreased trkA neurotrophin receptor expression in the parietal cortex of patients with Alzheimer's disease

    Article • Neuroscience Letters, January 1998, Elsevier

    Professor Klaus Heese

  92. Interleukin-6 (IL-6) and soluble forms of IL-6 receptors are not altered in cerebrospinal fluid of Alzheimer's disease patients

    Article • Neuroscience Letters, December 1997, Elsevier

    Professor Klaus Heese

  93. Nerve growth factor (NGF) expression in rat microglia is induced by adenosine A2a-receptors

    Article • Neuroscience Letters, August 1997, Elsevier

    Professor Klaus Heese