All Stories

  1. 2-Deoxy-D-glucose Restore Glucocorticoid Sensitivity in Acute Lymphoblastic Leukemia via Modification of N-Linked Glycosylation in an Oxygen Tension-Independent Manner

    Article • Oxidative Medicine and Cellular Longevity, January 2017, Hindawi Publishing Corporation

    Dr Alexandre Arcaro

  2. The role of the PI3K/AKT/mTOR pathway in brain tumor metastasis

    Article • Journal of Cancer Metastasis and Treatment, March 2016, OAE Publishing

    Dr Alexandre Arcaro

  3. Targeted therapies for small cell lung cancer: Where do we stand?

    Article • Critical Reviews in Oncology/Hematology, August 2015, Elsevier

    Dr Alexandre Arcaro

  4. Fibroblast growth factor-2 induces translational regulation of Bcl-X L and Bcl-2 via a MEK-dependent pathway. CORRELATION WITH RESISTANCE TO ETOPOSIDE-INDUCED APOPTOSIS .

    Article • Journal of Biological Chemistry, June 2015, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Alexandre Arcaro

  5. The Phosphoinositide 3-Kinase p110α Isoform Regulates Leukemia Inhibitory Factor Receptor Expression via c-Myc and miR-125b to Promote Cell Proliferation in Medulloblastoma

    Article • PLoS ONE, April 2015, PLOS

    Dr Alexandre Arcaro

  6. Targeting PI3K in medulloblastoma

    Article • Current Molecular Medicine, January 2015, Bentham Science Publishers

    Dr Alexandre Arcaro

  7. Novel cross talk between MEK and S6K2 in FGF-2 induced proliferation of SCLC cells

    Article • Oncogene, December 2014, Nature

    Dr Alexandre Arcaro

  8. Abstract 4246: Probing the inhibitor selectivity site of class II PI3KC2β

    Article • Cancer Research, September 2014, American Association for Cancer Research (AACR)

    Dr Alexandre Arcaro

  9. Targeting PI3K/mTOR Signaling in Cancer

    Article • Frontiers in Oncology, April 2014, Frontiers

    Dr Alexandre Arcaro

  10. Targeting Class IA PI3K Isoforms Selectively Impairs Cell Growth, Survival, and Migration in Glioblastoma

    Article • PLoS ONE, April 2014, PLOS

    Dr Alexandre Arcaro

  11. Targeting PI3K/mTOR signaling in cancer

    Article • January 2014

    Dr Alexandre Arcaro

  12. NOTCH ligands JAG1 and JAG2 as critical pro-survival factors in childhood medulloblastoma

    Article • Acta Neuropathologica Communications, January 2014, Springer Science + Business Media

    Dr Alexandre Arcaro

  13. Class II Phosphoinositide 3-Kinases as Potential Novel Drug Targets

    Article • Current Signal Transduction Therapy, December 2013, Bentham Science Publishers

    Dr Alexandre Arcaro

  14. The Role of Phospholipase D in Modulating the MTOR Signaling Pathway in Polycystic Kidney Disease

    Article • PLoS ONE, August 2013, PLOS

    Dr Alexandre Arcaro, Professor Albert Ong

  15. Involvement of autophagy in the response of tumor cells to PtdIns3K inhibitors

    Article • Autophagy, April 2013, Taylor & Francis

    Dr Alexandre Arcaro

  16. Targeting the insulin-like growth factor-1 receptor in human cancer

    Article • Frontiers in Pharmacology, January 2013, Frontiers

    Dr Alexandre Arcaro

  17. Emerging Metabolic Targets in the Therapy of Hematological Malignancies

    Article • BioMed Research International, January 2013, Hindawi Publishing Corporation

    Dr Alexandre Arcaro

  18. Targeting the Phosphoinositide 3-Kinase p110-  Isoform Impairs Cell Proliferation, Survival, and Tumor Growth in Small Cell Lung Cancer

    Article • Clinical Cancer Research, November 2012, American Association for Cancer Research (AACR)

    Dr Alexandre Arcaro

  19. Novel Agents Targeting the IGF-1R/PI3K Pathway Impair Cell Proliferation and Survival in Subsets of Medulloblastoma and Neuroblastoma

    Article • PLoS ONE, October 2012, PLOS

    Dr Alexandre Arcaro

  20. RNA interference screening identifies a novel role for autocrine fibroblast growth factor signaling in neuroblastoma chemoresistance

    Article • Oncogene, October 2012, Nature

    Dr Alexandre Arcaro

  21. Phosphoinositide 3-Kinase C2β Regulates RhoA and the Actin Cytoskeleton through an Interaction with Dbl

    Article • PLoS ONE, September 2012, PLOS

    Dr Alexandre Arcaro

  22. Targeting phosphoinositide 3-kinase signalling in lung cancer

    Article • Critical Reviews in Oncology/Hematology, November 2011, Elsevier

    Dr Alexandre Arcaro

  23. MicroRNA-21 suppression impedes medulloblastoma cell migration

    Article • European Journal of Cancer, November 2011, Elsevier

    Dr Alexandre Arcaro

  24. The Phosphoinositide 3-Kinase Signaling Pathway as a Therapeutic Target in Grade IV Brain Tumors

    Article • Current Cancer Drug Targets, October 2011, Bentham Science Publishers

    Dr Alexandre Arcaro

  25. A Sensitized RNA Interference Screen Identifies a Novel Role for the PI3K p110  Isoform in Medulloblastoma Cell Proliferation and Chemoresistance

    Article • Molecular Cancer Research, June 2011, American Association for Cancer Research (AACR)

    Dr Alexandre Arcaro

  26. Phosphatidylinositol 3-Kinase Isoforms as Novel Drug Targets

    Article • Current Drug Targets, June 2011, Bentham Science Publishers

    Dr Alexandre Arcaro

  27. The catalytic class IA PI3K isoforms play divergent roles in breast cancer cell migration

    Article • Cellular Signalling, March 2011, Elsevier

    Dr Alexandre Arcaro

  28. Bone morphogenetic protein-7 is a MYC target with prosurvival functions in childhood medulloblastoma

    Article • Oncogene, February 2011, Nature

    Dr Alexandre Arcaro

  29. Quassinoids: From Traditional Drugs to New Cancer Therapeutics

    Article • Current Medicinal Chemistry, January 2011, Bentham Science Publishers

    Dr Alexandre Arcaro

  30. The Quassinoid Derivative NBT-272 Targets Both the AKT and ERK Signaling Pathways in Embryonal Tumors

    Article • Molecular Cancer Therapeutics, October 2010, American Association for Cancer Research (AACR)

    Dr Alexandre Arcaro

  31. Central Nervous System Atypical Teratoid/Rhabdoid Tumors: Role of Insulin-Like Growth Factor I Receptor

    Article • August 2010, Springer Science + Business Media

    Dr Alexandre Arcaro

  32. 359 Targeting class IA phosphoinositide 3-kinase isoforms in glioblastoma

    Article • European Journal of Cancer Supplements, June 2010, Elsevier

    Dr Alexandre Arcaro

  33. 361 Targeting phosphoinositide 3-kinase signalling in small cell lung cancer

    Article • European Journal of Cancer Supplements, June 2010, Elsevier

    Dr Alexandre Arcaro

  34. RNA interference screening identifies a novel role for PCTK1/CDK16 in medulloblastoma with c-Myc amplification

    Article • Oncotarget, May 2010, Impact Journals, LLC

    Dr Alexandre Arcaro

  35. Disabling c-Myc in Childhood Medulloblastoma and Atypical Teratoid/Rhabdoid Tumor Cells by the Potent G-Quadruplex Interactive Agent S2T1-6OTD

    Article • Molecular Cancer Therapeutics, January 2010, American Association for Cancer Research (AACR)

    Dr Alexandre Arcaro

  36. Pulse mTOR inhibitor treatment effectively controls cyst growth but leads to severe parenchymal and glomerular hypertrophy in rat polycystic kidney disease

    Article • AJP Renal Physiology, September 2009, American Physiological Society

    Dr Alexandre Arcaro

  37. Targeting Myc in Pediatric Malignancies of the Central and Peripheral Nervous System

    Article • Current Cancer Drug Targets, March 2009, Bentham Science Publishers

    Dr Alexandre Arcaro

  38. AKT/mTOR Pathway Activation and BCL-2 Family Proteins Modulate the Sensitivity of Human Small Cell Lung Cancer Cells to RAD001

    Article • Clinical Cancer Research, February 2009, American Association for Cancer Research (AACR)

    Dr Alexandre Arcaro

  39. RNA interference-mediated c-MYC inhibition prevents cell growth and decreases sensitivity to radio- and chemotherapy in childhood medulloblastoma cells

    Article • BMC Cancer, January 2009, Springer Science + Business Media

    Dr Alexandre Arcaro

  40. Immortalization of Human Alveolar Epithelial Cells to Investigate Nanoparticle Uptake

    Article • American Journal of Respiratory Cell and Molecular Biology, November 2008, American Thoracic Society

    Dr Alexandre Arcaro

  41. Targeting the PI3K p110  Isoform Inhibits Medulloblastoma Proliferation, Chemoresistance, and Migration

    Article • Clinical Cancer Research, November 2008, American Association for Cancer Research (AACR)

    Dr Alexandre Arcaro

  42. Targeting the Phosphoinositide 3-Kinase Isoform p110  Impairs Growth and Survival in Neuroblastoma Cells

    Article • Clinical Cancer Research, February 2008, American Association for Cancer Research (AACR)

    Dr Alexandre Arcaro

  43. Current Status of Clinical Trials for Small Cell Lung Cancer

    Article • Reviews on Recent Clinical Trials, January 2008, Bentham Science Publishers

    Dr Alexandre Arcaro

  44. Lipid Rafts and Caveolae in Signaling by Growth Factor Receptors

    Article • The Open Biochemistry Journal, November 2007, Bentham Science Publishers

    Dr Alexandre Arcaro

  45. Lipid Rafts and Caveolae in Signaling by Growth Factor Receptors

    Article • The Open Biochemistry Journal, September 2007, Bentham Science Publishers

    Dr Alexandre Arcaro

  46. Targeting receptor tyrosine kinase signaling in acute myeloid leukemia

    Article • Critical Reviews in Oncology/Hematology, September 2007, Elsevier

    Dr Alexandre Arcaro

  47. IGF signaling as a therapeutic target in pediatric solid tumors of the central and peripheral nervous system

    Article • Expert Review of Endocrinology & Metabolism, September 2007, Taylor & Francis

    Dr Alexandre Arcaro

  48. Novel role for insulin as an autocrine growth factor for malignant brain tumour cells

    Article • Biochemical Journal, August 2007, Portland Press Ltd.

    Dr Alexandre Arcaro

  49. The Phosphoinositide 3-Kinase Pathway in Human Cancer: Genetic Alterations and Therapeutic Implications

    Article • Current Genomics, August 2007, Bentham Science Publishers

    Dr Alexandre Arcaro

  50. Targeting mTOR signaling in lung cancer

    Article • Critical Reviews in Oncology/Hematology, August 2007, Elsevier

    Dr Alexandre Arcaro

  51. Mitotic activation of Akt signalling pathway in Han:SPRD rats with polycystic kidney disease

    Article • Nephrology, August 2007, Wiley

    Dr Alexandre Arcaro

  52. Antisense treatment of IGF-IR induces apoptosis and enhances chemosensitivity in central nervous system atypical teratoid/rhabdoid tumours cells

    Article • European Journal of Cancer, July 2007, Elsevier

    Dr Alexandre Arcaro

  53. Autocrine insulin-like growth factor-I signaling promotes growth and survival of human acute myeloid leukemia cells via the phosphoinositide 3-kinase/Akt pathway

    Article • Leukemia, June 2007, Nature

    Dr Alexandre Arcaro

  54. Targeting receptor tyrosine kinase signalling in small cell lung cancer (SCLC): What have we learned so far?

    Article • Cancer Treatment Reviews, June 2007, Elsevier

    Dr Alexandre Arcaro

  55. Critical role for lipid raft-associated Src kinases in activation of PI3K-Akt signalling

    Article • Cellular Signalling, May 2007, Elsevier

    Dr Alexandre Arcaro

  56. Recent Patents of Gene Sequences Relative to the Phosphatidylinositol 3-kinase / Akt Pathway and their Relevance to Drug Discovery

    Article • Recent Patents on DNA & Gene Sequences, February 2007, Bentham Science Publishers

    Dr Alexandre Arcaro

  57. Anti-proliferative activity of the quassinoid NBT-272 in childhood medulloblastoma cells

    Article • BMC Cancer, January 2007, Springer Science + Business Media

    Dr Alexandre Arcaro

  58. Lipid raft adhesion receptors and Syk regulate selectin-dependent rolling under flow conditions

    Article • Blood, November 2006, American Society of Hematology

    Dr Alexandre Arcaro

  59. Protein kinase B modulates the sensitivity of human neuroblastoma cells to insulin-like growth factor receptor inhibition

    Article • International Journal of Cancer, January 2006, Wiley

    Dr Alexandre Arcaro

  60. IGF-IR: Potential role in antitumor agents

    Article • Drug News & Perspectives, January 2006, Prous Science

    Dr Alexandre Arcaro

  61. Potent inhibition of small-cell lung cancer cell growth by simvastatin reveals selective functions of Ras isoforms in growth factor signalling

    Article • Oncogene, September 2005, Nature

    Dr Alexandre Arcaro

  62. 355 Inhibition of human small cell lung cancer growth by simvastatin reveals selective functions of Ras isoforms in growth factor signalling

    Article • European Journal of Cancer Supplements, September 2004, Elsevier

    Dr Alexandre Arcaro

  63. O-177 A novel epigenetic mechanism of chemo-resistance in SCLC induced by fibroblast growth factor-2 (FGF-2): dissociation of Smac/DIABLO from cytochrome c release

    Article • Lung Cancer, August 2003, Elsevier

    Dr Alexandre Arcaro

  64. Two distinct phosphoinositide 3-kinases mediate polypeptide growth factor-stimulated PKB activation

    Article • The EMBO Journal, October 2002, Wiley

    Dr Alexandre Arcaro

  65. Fibroblast Growth Factor-2 Induces Translational Regulation of Bcl-X L and Bcl-2 via a MEK-dependent Pathway

    Article • Journal of Biological Chemistry, January 2002, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Alexandre Arcaro

  66. CD8β Endows CD8 with Efficient Coreceptor Function by Coupling T Cell Receptor/CD3 to Raft-associated CD8/p56lckComplexes

    Article • The Journal of Experimental Medicine, November 2001, Rockefeller University Press

    Dr Alexandre Arcaro

  67. Novel cross talk between MEK and S6K2 in FGF-2 induced proliferation of SCLC cells

    Article • Oncogene, November 2001, Nature

    Dr Alexandre Arcaro

  68. Essential Role of CD8 Palmitoylation in CD8 Coreceptor Function

    Article • The Journal of Immunology, August 2000, The American Association of Immunologists

    Dr Alexandre Arcaro

  69. Class II Phosphoinositide 3-Kinases Are Downstream Targets of Activated Polypeptide Growth Factor Receptors

    Article • Molecular and Cellular Biology, June 2000, ASM Journals

    Dr Alexandre Arcaro

  70. Insulin Activates the   Isoform of Class II Phosphoinositide 3-Kinase

    Article • Journal of Biological Chemistry, May 1999, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Alexandre Arcaro

  71. Human Phosphoinositide 3-Kinase C2beta , the Role of Calcium and the C2 Domain in Enzyme Activity

    Article • Journal of Biological Chemistry, December 1998, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Alexandre Arcaro

  72. The Small GTP-binding Protein Rac Promotes the Dissociation of Gelsolin from Actin Filaments in Neutrophils

    Article • Journal of Biological Chemistry, January 1998, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Alexandre Arcaro

  73. Platelet-derived growth factor-induced phosphatidylinositol 3-kinase activation mediates actin rearrangements in fibroblasts

    Article • Biochemical Journal, March 1994, Portland Press Ltd.

    Dr Alexandre Arcaro

  74. Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses

    Article • Biochemical Journal, December 1993, Portland Press Ltd.

    Dr Alexandre Arcaro