All Stories

  1. Single‐cell RNA sequencing study of retinal immune regulators identified CD47 and CD59a expression in photoreceptors—Implications in subretinal immune regulation

    Article • Journal of Neuroscience Research, March 2020, Wiley

    Professor Heping Xu

  2. Circulating Leukocyte Alterations and the Development/Progression of Diabetic Retinopathy in Type 1 Diabetic Patients - A Pilot Study

    Article • Current Eye Research, January 2020, Taylor & Francis

    Professor Heping Xu

  3. Higher aqueous levels of matrix metalloproteinases indicated visual impairment in patients with retina vein occlusion after anti-VEGF therapy

    Article • British Journal of Ophthalmology, December 2019, BMJ

    Professor Heping Xu

  4. Uncoupled turnover disrupts mitochondrial quality control in diabetic retinopathy

    Article • JCI Insight, December 2019, American Society for Clinical Investigation

    Professor Heping Xu

  5. IL-33 deficiency causes persistent inflammation and severe neurodegeneration in retinal detachment

    Article • Journal of Neuroinflammation, December 2019, Springer Science + Business Media

    Professor Heping Xu

  6. Microplasma assisted synthesis of gold nanoparticle/graphene oxide nanocomposites and their potential application in SERS sensing

    Article • Nanotechnology, August 2019, Institute of Physics Publishing

    Professor Heping Xu

  7. STAT3 activation in circulating myeloid-derived cells contributes to retinal microvascular dysfunction in diabetes

    Article • Journal of Neuroinflammation, July 2019, Springer Science + Business Media

    Professor Heping Xu

  8. The vasoreparative potential of endothelial colony-forming cells in the ischemic retina is enhanced by cibinetide, a non-hematopoietic erythropoietin mimetic

    Article • Experimental Eye Research, May 2019, Elsevier

    Professor Heping Xu

  9. Attenuating Diabetic Vascular and Neuronal Defects by Targeting P2rx7

    Article • International Journal of Molecular Sciences, April 2019, MDPI AG

    Professor Heping Xu

  10. Sustained intraocular vascular endothelial growth factor neutralisation does not affect retinal and choroidal vasculature in Ins2Akita diabetic mice

    Article • Diabetes and Vascular Disease Research, April 2019, SAGE Publications

    Professor Heping Xu

  11. Immune regulation in the aging retina

    Article • Progress in Retinal and Eye Research, March 2019, Elsevier

    Professor Heping Xu

  12. Glucose transporter 1 critically controls microglial activation through facilitating glycolysis

    Article • Molecular Neurodegeneration, January 2019, Springer Science + Business Media

    Professor Heping Xu

  13. Loss of NRF-2 and PGC-1α genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration

    Article • Redox Biology, January 2019, Elsevier

    Dr Henri Olavi Leinonen, Professor Heping Xu

  14. Myofibroblasts in macular fibrosis secondary to neovascular age-related macular degeneration - the potential sources and molecular cues for their recruitment and activation

    Article • EBioMedicine, December 2018, Elsevier

    Professor Heping Xu

  15. Cholesterol homeostasis, macrophage malfunction and age-related macular degeneration

    Article • Annals of Translational Medicine, November 2018, AME Publishing Company

    Professor Heping Xu

  16. Modulation of three key innate immune pathways for the most common retinal degenerative diseases

    Article • EMBO Molecular Medicine, September 2018, EMBO

    Professor Heping Xu

  17. Polarized retinal pigment epithelium generates electrical signals that diminish with age and regulate retinal pathology

    Article • Journal of Cellular and Molecular Medicine, August 2018, Wiley

    Professor Heping Xu

  18. Antagonising Wnt/β-catenin signalling ameliorates lens-capsulotomy-induced retinal degeneration in a mouse model of diabetes

    Article • Diabetologia, July 2018, Springer Science + Business Media

    Professor Heping Xu

  19. Sustained high glucose exposure sensitizes macrophage responses to cytokine stimuli but reduces their phagocytic activity

    Article • BMC Immunology, July 2018, Springer Science + Business Media

    Professor Heping Xu

  20. The expression of C1 inhibitor (C1INH) in macrophages is upregulated by retinal pigment epithelial cells – implication in subretinal immune privilege in the aging eye

    Article • Aging, June 2018, Impact Journals, LLC

    Professor Heping Xu

  21. Cytokine Signaling Protein 3 Deficiency in Myeloid Cells Promotes Retinal Degeneration and Angiogenesis through Arginase-1 Up-Regulation in Experimental Autoimmune Uveoretinitis

    Article • American Journal Of Pathology, April 2018, Elsevier

    Professor Heping Xu

  22. Characterization of a Spontaneously Immortalized Murine Müller Glial Cell Line QMMuC-1

    Article • Investigative Ophthalmology & Visual Science, March 2018, Association for Research in Vision and Ophthalmology (ARVO)

    Professor Heping Xu

  23. Molecular Mechanisms Underlying Age-Related Ocular Diseases

    Article • Oxidative Medicine and Cellular Longevity, January 2018, Hindawi Publishing Corporation

    Professor Heping Xu

  24. A novel eyedrop for inflammatory eye disease

    Article • Current Molecular Medicine, October 2017, Bentham Science Publishers

    Professor Heping Xu, Johannes Korward

  25. Diabetic retinopathy and dysregulated innate immunity

    Article • Vision Research, October 2017, Elsevier

    Professor Heping Xu

  26. Topical Delivery of Anti-VEGF Drugs to the Ocular Posterior Segment Using Cell-Penetrating Peptides

    Article • Investigative Ophthalmology & Visual Science, May 2017, Association for Research in Vision and Ophthalmology (ARVO)

    Professor Heping Xu

  27. Comprehensive analysis of mouse retinal mononuclear phagocytes

    Article • Nature Protocols, May 2017, Springer Science + Business Media

    Professor Heping Xu

  28. Zinc Protects Oxidative Stress-Induced RPE Death by Reducing Mitochondrial Damage and Preventing Lysosome Rupture

    Article • Oxidative Medicine and Cellular Longevity, January 2017, Hindawi Publishing Corporation

    Professor Heping Xu

  29. Collectin-11 Is an Important Modulator of Retinal Pigment Epithelial Cell Phagocytosis and Cytokine Production

    Article • Journal of Innate Immunity, January 2017, Karger Publishers

    Professor Heping Xu

  30. Higher plasma levels of complement C3a, C4a and C5a increase the risk of subretinal fibrosis in neovascular age-related macular degeneration

    Article • Immunity & Ageing, February 2016, Springer Science + Business Media

    Professor Heping Xu

  31. RPE aging

    Article • Aging Cell, February 2016, Wiley

    Professor Heping Xu

  32. Sustained intraocular VEGF neutralization results in retinal neurodegeneration in the Ins2Akita diabetic mouse

    Article • Scientific Reports, December 2015, Springer Science + Business Media

    Professor Heping Xu

  33. Alterations in Circulating Immune Cells in Neovascular Age-Related Macular Degeneration

    Article • Scientific Reports, November 2015, Springer Science + Business Media

    Professor Heping Xu

  34. Targeting translocator protein (18 kDa) (TSPO) dampens pro-inflammatory microglia reactivity in the retina and protects from degeneration

    Article • Journal of Neuroinflammation, November 2015, Springer Science + Business Media

    Professor Heping Xu

  35. Wnt signaling in age-related macular degeneration: human macular tissue and mouse model

    Article • Journal of Translational Medicine, October 2015, Springer Science + Business Media

    Professor Heping Xu

  36. Parainflammation, chronic inflammation, and age-related macular degeneration

    Article • Journal of Leukocyte Biology, August 2015, Wiley

    Professor Heping Xu

  37. Experimental Autoimmune Uveoretinitis (EAU)-Related Tissue Damage and Angiogenesis Is Reduced in CCL2−/−CX3CR1gfp/gfpMice

    Article • Investigative Ophthalmology & Visual Science, November 2014, Association for Research in Vision and Ophthalmology (ARVO)

    Professor Heping Xu

  38. IL-33 attenuates the development of experimental autoimmune uveitis

    Article • European Journal of Immunology, October 2014, Wiley

    Professor Heping Xu

  39. Phytocannabinoids in Degenerative and Inflammatory Retinal Diseases: Glaucoma, Age-Related Macular Degeneration, Diabetic Retinopathy, and Uveoretinitis

    Article • August 2014, Oxford University Press (OUP)

    Professor Heping Xu

  40. Loss of Synaptic Connectivity, Particularly in Second Order Neurons Is a Key Feature of Diabetic Retinal Neuropathy in the Ins2Akita Mouse

    Article • PLoS ONE, May 2014, PLOS

    Professor Heping Xu

  41. Intravitreal Injection of Normal Saline Induces Retinal Degeneration in the C57BL/6J Mouse

    Article • Translational Vision Science & Technology, March 2014, Association for Research in Vision and Ophthalmology (ARVO)

    Professor Heping Xu

  42. RAGE Regulates Immune Cell Infiltration and Angiogenesis in Choroidal Neovascularization

    Article • PLoS ONE, February 2014, PLOS

    Professor Heping Xu

  43. Culture and Characterization of Microglia from the Adult Murine Retina

    Article • The Scientific World JOURNAL, January 2014, Hindawi Publishing Corporation

    Professor Heping Xu

  44. Extremely Complex Populations of Small RNAs in the Mouse Retina and RPE/Choroid

    Article • Investigative Ophthalmology & Visual Science, December 2013, Association for Research in Vision and Ophthalmology (ARVO)

    Professor Heping Xu

  45. Myeloid Cells Expressing VEGF and Arginase-1 Following Uptake of Damaged Retinal Pigment Epithelium Suggests Potential Mechanism That Drives the Onset of Choroidal Angiogenesis in Mice

    Article • PLoS ONE, August 2013, PLOS

    Professor Heping Xu

  46. Complement expression in retinal pigment epithelial cells is modulated by activated macrophages

    Article • Experimental Eye Research, July 2013, Elsevier

    Professor Heping Xu

  47. Vascular Endothelial Cell Growth–Activated XBP1 Splicing in Endothelial Cells Is Crucial for Angiogenesis

    Article • Circulation, April 2013, Wolters Kluwer Health

    Professor Heping Xu

  48. Age- and Light-Dependent Development of Localised Retinal Atrophy in CCL2−/−CX3CR1GFP/GFP Mice

    Article • PLoS ONE, April 2013, PLOS

    Professor Heping Xu

  49. The soluble isoform of CTLA-4 as a regulator of T-cell responses

    Article • European Journal of Immunology, March 2013, Wiley

    Professor Heping Xu

  50. Paraquat-Induced Retinal Degeneration Is Exaggerated in CX3CR1-Deficient Mice and Is Associated with Increased Retinal Inflammation

    Article • Investigative Ophthalmology & Visual Science, January 2013, Association for Research in Vision and Ophthalmology (ARVO)

    Professor Heping Xu

  51. CD11b + Bone Marrow–Derived Monocytes Are the Major Leukocyte Subset Responsible for Retinal Capillary Leukostasis in Experimental Diabetes in Mouse and Express High Levels of CCR5 in the Circulation

    Article • American Journal Of Pathology, August 2012, Elsevier

    Professor Heping Xu

  52. Expression of Complement Components and Regulators by Different Subtypes of Bone Marrow-Derived Macrophages

    Article • Inflammation, March 2012, Springer Science + Business Media

    Professor Heping Xu

  53. Para-inflammation-mediated retinal recruitment of bone marrow-derived myeloid cells following whole-body irradiation is CCL2 dependent

    Article • Glia, February 2012, Wiley

    Professor Heping Xu

  54. Inflammation in Age-Related Macular Degeneration – Implications for Therapy

    Article • February 2012, IntechOpen

    Professor Heping Xu

  55. Good news–bad news: the Yin and Yang of immune privilege in the eye

    Article • Frontiers in Immunology, January 2012, Frontiers

    Professor Heping Xu

  56. Persistent Inflammation Subverts Thrombospondin-1–Induced Regulation of Retinal Angiogenesis and Is Driven by CCR2 Ligation

    Article • American Journal Of Pathology, January 2012, Elsevier

    Professor Heping Xu

  57. Characterisation of a C1qtnf5 Ser163Arg Knock-In Mouse Model of Late-Onset Retinal Macular Degeneration

    Article • PLoS ONE, November 2011, PLOS

    Professor Heping Xu

  58. Proteomic profiling of human retinal pigment epithelium exposed to an advanced glycation-modified substrate

    Article • Graefe s Archive for Clinical and Experimental Ophthalmology, November 2011, Springer Science + Business Media

    Professor Heping Xu

  59. Modelling of pulsatile blood flow in arterial trees of retinal vasculature

    Article • Medical Engineering & Physics, September 2011, Elsevier

    Professor Heping Xu

  60. Dysregulation in Retinal Para-Inflammation and Age-Related Retinal Degeneration in CCL2 or CCR2 Deficient Mice

    Article • PLoS ONE, August 2011, PLOS

    Professor Heping Xu

  61. Development of an image-based model for capillary vasculature of retina

    Article • Computer Methods and Programs in Biomedicine, April 2011, Elsevier

    Professor Heping Xu

  62. Cataract Surgery Induces Retinal Pro-inflammatory Gene Expression and Protein Secretion

    Article • Investigative Ophthalmology & Visual Science, January 2011, Association for Research in Vision and Ophthalmology (ARVO)

    Professor Heping Xu

  63. An Image-Based Anatomical Network Model and Modelling of Circulation of Mouse Retinal Vasculature

    Article • January 2011, Springer Science + Business Media

    Professor Heping Xu

  64. Quantitative In Situ Analysis of Claudin Expression at the Blood–Retinal Barrier

    Article • January 2011, Springer Science + Business Media

    Professor Heping Xu

  65. Immune Activation in Retinal Aging: A Gene Expression Study

    Article • Investigative Ophthalmology & Visual Science, November 2010, Association for Research in Vision and Ophthalmology (ARVO)

    Professor Heping Xu

  66. Analysis of retinal circulation using an image-based network model of retinal vasculature

    Article • Microvascular Research, July 2010, Elsevier

    Professor Heping Xu

  67. Dendritic cell physiology and function in the eye

    Article • Immunological Reviews, March 2010, Wiley

    Professor Heping Xu

  68. Systemic and local anti-C5 therapy reduces the disease severity in experimental autoimmune uveoretinitis

    Article • Clinical & Experimental Immunology, March 2010, Wiley

    Professor Heping Xu

  69. Development of an Image-Based Network Model of Retinal Vasculature

    Article • Annals of Biomedical Engineering, February 2010, Springer Science + Business Media

    Professor Heping Xu

  70. Development of Experimental Autoimmune Uveitis: Efficient Recruitment of Monocytes Is Independent of CCR2

    Article • Investigative Ophthalmology & Visual Science, September 2009, Association for Research in Vision and Ophthalmology (ARVO)

    Professor Heping Xu

  71. The protective immune response of the retina against aging insults.

    Article • Progress in Retinal and Eye Research, September 2009, Elsevier

    Professor Heping Xu

  72. A clinical grading system for retinal inflammation in the chronic model of experimental autoimmune uveoretinitis using digital fundus images

    Article • Experimental Eye Research, October 2008, Elsevier

    Professor Heping Xu

  73. Critical but divergent roles for CD62L and CD44 in directing blood monocyte trafficking in vivo during inflammation

    Article • Blood, August 2008, American Society of Hematology

    Professor Heping Xu

  74. Characterization of a Spontaneous Mouse Retinal Pigment Epithelial Cell Line B6-RPE07

    Article • Investigative Ophthalmology & Visual Science, August 2008, Association for Research in Vision and Ophthalmology (ARVO)

    Professor Heping Xu

  75. Immune privilege or privileged immunity?

    Article • Mucosal Immunology, July 2008, Springer Science + Business Media

    Professor Heping Xu

  76. Retinal Microglia and Uveal Tract Dendritic Cells and Macrophages Are Not CX3CR1 Dependent in Their Recruitment and Distribution in the Young Mouse Eye

    Article • Investigative Ophthalmology & Visual Science, April 2008, Association for Research in Vision and Ophthalmology (ARVO)

    Professor Heping Xu

  77. Age-dependent accumulation of lipofuscin in perivascular and subretinal microglia in experimental mice

    Article • Aging Cell, February 2008, Wiley

    Professor Heping Xu

  78. Complement factor B in retinal pigment epithelial cell is up-regulated by inflammatory cytokine TNF-α and INF-γ

    Article • Molecular Immunology, September 2007, Elsevier

    Professor Heping Xu

  79. Anti-inflammatory property of the cannabinoid receptor-2-selective agonist JWH-133 in a rodent model of autoimmune uveoretinitis

    Article • Journal of Leukocyte Biology, May 2007, Wiley

    Professor Heping Xu

  80. LYVE-1–Positive Macrophages Are Present in Normal Murine Eyes

    Article • Investigative Ophthalmology & Visual Science, May 2007, Association for Research in Vision and Ophthalmology (ARVO)

    Professor Heping Xu

  81. Identification of Novel Dendritic Cell Populations in Normal Mouse Retina

    Article • Investigative Ophthalmology & Visual Science, April 2007, Association for Research in Vision and Ophthalmology (ARVO)

    Professor Heping Xu

  82. Synthesis of complement factor H by retinal pigment epithelial cells is down-regulated by oxidized photoreceptor outer segments

    Article • Experimental Eye Research, April 2007, Elsevier

    Professor Heping Xu

  83. Turnover of resident retinal microglia in the normal adult mouse

    Article • Glia, January 2007, Wiley

    Professor Heping Xu

  84. Involvement of CCR5 in the passage of Th1-type cells across the blood-retina barrier in experimental autoimmune uveitis

    Article • Journal of Leukocyte Biology, December 2005, Wiley

    Professor Heping Xu

  85. Differentiation to the CCR2+ Inflammatory Phenotype In Vivo Is a Constitutive, Time-Limited Property of Blood Monocytes and Is Independent of Local Inflammatory Mediators

    Article • The Journal of Immunology, November 2005, The American Association of Immunologists

    Professor Heping Xu

  86. Leukocyte Diapedesis In Vivo Induces Transient Loss of Tight Junction Protein at the Blood–Retina Barrier

    Article • Investigative Ophthalmology & Visual Science, July 2005, Association for Research in Vision and Ophthalmology (ARVO)

    Professor Heping Xu

  87. The Keratan Sulfate Disaccharide Gal(6S03) β1,4-GlcNAc(6S03) Modulates Interleukin 12 Production by Macrophages in Murine Thy-1 Type Autoimmune Disease

    Article • Journal of Biological Chemistry, March 2005, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Heping Xu

  88. The scanning laser ophthalmoscope—a review of its role in bioscience and medicine

    Article • Physics in Medicine and Biology, March 2004, Institute of Physics Publishing

    Professor Heping Xu

  89. Reduction in shear stress, activation of the endothelium, and leukocyte priming are all required for leukocyte passage across the blood-retina barrier

    Article • Journal of Leukocyte Biology, November 2003, Wiley

    Professor Heping Xu

  90. Requirements for passage of T lymphocytes across non-inflamed retinal microvessels

    Article • Journal of Neuroimmunology, September 2003, Elsevier

    Professor Heping Xu

  91. Effect of anti-macrophage inflammatory protein-1α on leukocyte trafficking and disease progression in experimental autoimmune uveoretinitis

    Article • European Journal of Immunology, February 2003, Wiley

    Professor Heping Xu

  92. Leukocyte Trafficking in Experimental Autoimmune Uveitis: Breakdown of Blood–Retinal Barrier and Upregulation of Cellular Adhesion Molecules

    Article • Investigative Ophthalmology & Visual Science, January 2003, Association for Research in Vision and Ophthalmology (ARVO)

    Professor Heping Xu

  93. Effect of Hyaluronan Oligosaccharides on the Expression of Heat Shock Protein 72

    Article • Journal of Biological Chemistry, May 2002, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Heping Xu

  94. Improved Leukocyte Tracking in Mouse Retinal and Choroidal Circulation

    Article • Experimental Eye Research, March 2002, Elsevier

    Professor Heping Xu

  95. IMAGING OCULAR IMMUNE RESPONSES BY INTRAVITAL MICROSCOPY

    Article • International Reviews of Immunology, January 2002, Taylor & Francis

    Professor Heping Xu

  96. IL-12 Enhances Lymphoaccumulation by Suppressing Cell Death of T Cells in MRL- lpr/lpr Mice

    Article • Journal of Autoimmunity, March 2001, Elsevier

    Professor Heping Xu

  97. Inflammation in Age-Related Macular Degeneration: What is the Evidence?

    Article • Springer Science + Business Media

    Professor Heping Xu