All Stories

  1. Rejuvenating the Activity of Usual Antibiotics on Resistant Gram-Negative Bacteria: Recent Issues and Perspectives

    Article • International Journal of Molecular Sciences, January 2023, MDPI AG

    Dr Jean-Marie PAGES

  2. A framework for dissecting affinities of multidrug efflux transporter AcrB to fluoroquinolones

    Article • Communications Biology, October 2022, Springer Science + Business Media

    Dr Jean-Marie PAGES

  3. Cephalosporin translocation across enterobacterial OmpF and OmpC channels, a filter across the outer membrane

    Article • Communications Biology, October 2022, Springer Science + Business Media

    Dr Jean-Marie PAGES

  4. Clinical Status of Efflux Resistance Mechanisms in Gram-Negative Bacteria

    Article • Antibiotics, September 2021, MDPI AG

    Dr Jean-Marie PAGES

  5. Quinazoline Derivatives Designed as Efflux Pump Inhibitors: Molecular Modeling and Spectroscopic Studies

    Article • Molecules, April 2021, MDPI AG

    Dr Jean-Marie PAGES

  6. Molecular Insights into an Antibiotic Enhancer Action of New Morpholine-Containing 5-Arylideneimidazolones in the Fight against MDR Bacteria

    Article • International Journal of Molecular Sciences, February 2021, MDPI AG

    Dr Jean-Marie PAGES

  7. Chemical Highlights Supporting the Role of Lipid A in Efficient Biological Adaptation of Gram-Negative Bacteria to External Stresses

    Article • Journal of Medicinal Chemistry, February 2021, American Chemical Society (ACS)

    Dr Jean-Marie PAGES

  8. Acacia senegal Extract Rejuvenates the Activity of Phenicols on Selected Enterobacteriaceae Multi Drug Resistant Strains

    Article • Antibiotics, June 2020, MDPI AG

    Dr Jean-Marie PAGES

  9. An Intertwined Network of Regulation Controls Membrane Permeability Including Drug Influx and Efflux in Enterobacteriaceae

    Article • Microorganisms, June 2020, MDPI AG

    Dr Jean-Marie PAGES

  10. Complex Response of the CpxAR Two-Component System to β-Lactams on Antibiotic Resistance and Envelope Homeostasis in Enterobacteriaceae

    Article • Antimicrobial Agents and Chemotherapy, March 2020, ASM Journals

    Dr Jean-Marie PAGES

  11. Synthesis and Biological Evaluation of Four New Ricinoleic Acid-Derived 1-O-alkylglycerols

    Article • Marine Drugs, February 2020, MDPI AG

    Dr Jean-Marie PAGES

  12. A simple phenotypic test for detecting the contribution of outer membrane permeability to carbapenem resistance

    Article • Journal of Medical Microbiology, January 2020, Society for General Microbiology

    Dr Jean-Marie PAGES

  13. Enterobacter spp.: Update on Taxonomy, Clinical Aspects, and Emerging Antimicrobial Resistance

    Article • Clinical Microbiology Reviews, July 2019, ASM Journals

    Dr Jean-Marie PAGES

  14. Fluoroquinolone-derived fluorescent probes for studies of bacterial penetration and efflux

    Article • MedChemComm, January 2019, Royal Society of Chemistry

    Dr Jean-Marie PAGES

  15. Getting Drugs into Gram-Negative Bacteria: Rational Rules for Permeation through General Porins

    Article • ACS Infectious Diseases, July 2018, American Chemical Society (ACS)

    Dr Jean-Marie PAGES

  16. Spectrofluorimetric quantification of antibiotic drug concentration in bacterial cells for the characterization of translocation across bacterial membranes

    Article • Nature Protocols, May 2018, Springer Science + Business Media

    Matthieu Refregiers, Dr Jean-Marie PAGES

  17. Fluoroquinolone structure and translocation flux across bacterial membrane

    Article • Scientific Reports, August 2017, Nature

    Matthieu Refregiers, Dr Jean-Marie PAGES

  18. In-vivo loss of carbapenem resistance by extensively drug-resistant Klebsiella pneumoniae during treatment via porin expression modification

    Article • Scientific Reports, July 2017, Springer Science + Business Media

    Dr Jean-Marie PAGES

  19. Providencia stuartii form biofilms and floating communities of cells that display high resistance to environmental insults

    Article • PLoS ONE, March 2017, PLOS

    Dr Jean-Marie PAGES

  20. Transports des antibiotiques et perméabilité membranaire : nouvelles perspectives afin de combattre la résistance bactérienne

    Article • Biologie Aujourd hui, January 2017, EDP Sciences

    Dr Jean-Marie PAGES

  21. Polyamino-Isoprenic Derivatives Block Intrinsic Resistance of P. aeruginosa to Doxycycline and Chloramphenicol In Vitro

    Article • PLoS ONE, May 2016, PLOS

    Dr Jean-Marie PAGES

  22. Modulation of Membrane Influx and Efflux in Escherichia coli Sequence Type 131 Has an Impact on Bacterial Motility, Biofilm Formation, and Virulence in a Caenorhabditis elegans Model

    Article • Antimicrobial Agents and Chemotherapy, February 2016, ASM Journals

    Dr Jean-Marie PAGES

  23. Cloning, Expression, Purification, Regulation, and Subcellular Localization of a Mini-protein from Campylobacter jejuni

    Article • Current Microbiology, January 2016, Springer Science + Business Media

    Dr Jean-Marie PAGES

  24. Antimicrobial Drug Efflux Pumps in Enterobacter and Klebsiella

    Article • January 2016, Springer Science + Business Media

    Dr Jean-Marie PAGES

  25. Role of the Outer Membrane and Porins in Susceptibility of β-Lactamase-Producing Enterobacteriaceae to Ceftazidime-Avibactam

    Article • Antimicrobial Agents and Chemotherapy, December 2015, ASM Journals

    Dr Jean-Marie PAGES, Wright Nichols

  26. Microspectrometric insights on the uptake of antibiotics at the single bacterial cell level

    Article • Scientific Reports, December 2015, Nature

    Matthieu Refregiers, Dr Jean-Marie PAGES

  27. Role of the culture medium in porin expression and piperacillin-tazobactam susceptibility in Escherichia coli

    Article • Journal of Medical Microbiology, November 2015, Society for General Microbiology

    Dr Jean-Marie PAGES

  28. Enterobacter gergoviae membrane modifications are involved in the adaptive response to preservatives used in cosmetic industry

    Article • Journal of Applied Microbiology, November 2014, Wiley

    Dr Jean-Marie PAGES

  29. Natural extracts stimulate membrane-associated mechanisms of resistance in Gram-negative bacteria

    Article • Letters in Applied Microbiology, February 2014, Oxford University Press (OUP)

    Dr Jean-Marie PAGES

  30. Antibiotic Transport through Porins

    Article • Biophysical Journal, January 2014, Elsevier

    Dr Jean-Marie PAGES, Harsha Bajaj

  31. Role of Antibiotic Side Chains in Uptake Through OmpPst1 Channel from Providencia Stuartii

    Article • Biophysical Journal, January 2014, Elsevier

    Dr Jean-Marie PAGES, Harsha Bajaj

  32. Bacterial Membrane, a Key for Controlling Drug Influx and Efflux

    Article • October 2013, Wiley

    Dr Jean-Marie PAGES

  33. Polyamino geranic derivatives as new chemosensitizers to combat antibiotic resistant Gram-negative bacteria

    Article • Bioorganic & Medicinal Chemistry, March 2013, Elsevier

    Dr Jean-Marie PAGES

  34. Microbicides - The Double-Edged Sword: Environmental Toxicity and Emerging Resistance

    Article • December 2012, Wiley

    Dr Jean-Marie PAGES

  35. Antibiotic Transport in Resistant Bacteria: Synchrotron UV Fluorescence Microscopy to Determine Antibiotic Accumulation with Single Cell Resolution

    Article • PLoS ONE, June 2012, PLOS

    Matthieu Refregiers, Dr Jean-Marie PAGES

  36. Broad-specificity efflux pumps and their role in multidrug resistance of Gram-negative bacteria

    Article • FEMS Microbiology Reviews, March 2012, Oxford University Press (OUP)

    Dr Jean-Marie PAGES

  37. Les mécanismes d’efflux et la résistance chez Pseudomonas aeruginosa

    Article • Revue Francophone des Laboratoires, September 2011, Elsevier

    Dr Jean-Marie PAGES

  38. Strategies for bypassing the membrane barrier in multidrug resistant Gram-negative bacteria

    Article • FEBS Letters, May 2011, Wiley

    Dr Jean-Marie PAGES

  39. BM0701: Antibiotic Transport and Efflux: New Strategies to Combat Bacterial Resistance (ATENS)

    Article • Letters in Drug Design & Discovery, February 2011, Bentham Science Publishers

    Professor Séamus Fanning, Dr Jean-Marie PAGES

  40. Time Stability Studies of Quinazoline Derivative Designed to Fight Drug Resistance Acquired by Bacteria

    Article • Letters in Drug Design & Discovery, February 2011, Bentham Science Publishers

    Dr Jean-Marie PAGES

  41. How β-Lactam Antibiotics Enter Bacteria: A Dialogue with the Porins

    Article • PLoS ONE, May 2009, PLOS

    Dr Jean-Marie PAGES

  42. Efflux Pump, the Masked Side of ß-Lactam Resistance in Klebsiella pneumoniae Clinical Isolates

    Article • PLoS ONE, March 2009, PLOS

    Dr Jean-Marie PAGES

  43. Efflux Mechanism, an Attractive Target to Combat Multidrug Resistant Plasmodium falciparum and Pseudomonas aeruginosa

    Article • Current Medicinal Chemistry, January 2009, Bentham Science Publishers

    Dr Jean-Marie PAGES

  44. The porin and the permeating antibiotic: a selective diffusion barrier in Gram-negative bacteria

    Article • Nature Reviews Microbiology, November 2008, Springer Science + Business Media

    Dr Jean-Marie PAGES

  45. Membrane Permeability and Regulation of Drug “Influx and Efflux” in Enterobacterial Pathogens

    Article • Current Drug Targets, September 2008, Bentham Science Publishers

    Dr Jean-Marie PAGES

  46. The omp50 gene is transcriptionally controlled by a temperature-dependent mechanism conserved among thermophilic Campylobacter species

    Article • Research in Microbiology, May 2008, Elsevier

    Dr Jean-Marie PAGES

  47. Efflux pump inhibitors in bacteria

    Article • Expert Opinion on Therapeutic Patents, August 2007, Informa Healthcare

    Dr Jean-Marie PAGES

  48. Antibiotic Stress, Genetic Response and Altered Permeability of E. coli

    Article • PLoS ONE, April 2007, PLOS

    Professor Miguel Viveiros, Dr Jean-Marie PAGES

  49. Chromosomal His-tagging: An alternative approach to membrane protein purification

    Article • PROTEOMICS, February 2007, Wiley

    Dr Jean-Marie PAGES

  50. Quinoline Derivatives as Promising Inhibitors of Antibiotic Efflux Pump in Multidrug Resistant Enterobacter Aerogenes Isolates

    Article • Current Drug Targets, July 2006, Bentham Science Publishers

    Dr Jean-Marie PAGES

  51. Inhibitors of efflux pumps in Gram-negative bacteria

    Article • Trends in Molecular Medicine, August 2005, Elsevier

    Dr Jean-Marie PAGES

  52. Chloramphenicol and expression of multidrug efflux pump in Enterobacter aerogenes

    Article • Biochemical and Biophysical Research Communications, March 2005, Elsevier

    Dr Jean-Marie PAGES

  53. Enterobacter aerogenesOmpX, a cation-selective channelmar- and osmo-regulated

    Article • FEBS Letters, June 2004, Wiley

    Dr Jean-Marie PAGES

  54. Functional refolding of the Campylobacter jejuni MOMP (major outer membrane protein) porin by GroEL from the same species

    Article • Biochemical Journal, March 2004, Portland Press Ltd.

    Dr Jean-Marie PAGES

  55. Alkylaminoquinolines inhibit the bacterial antibiotic efflux pump in multidrug-resistant clinical isolates

    Article • Biochemical Journal, December 2003, Portland Press Ltd.

    Dr Jean-Marie PAGES

  56. Overexpression and purification of the three components of the Enterobacter aerogenes AcrA–AcrB–TolC multidrug efflux pump

    Article • Journal of Chromatography B, March 2003, Elsevier

    Dr Elizabeth Pradel, Dr Jean-Marie PAGES

  57. Inhibitors of antibiotic efflux pump in resistant Enterobacter aerogenes strains

    Article • Biochemical and Biophysical Research Communications, May 2002, Elsevier

    Dr Jean-Marie PAGES

  58. Purification, characterization and sequence analysis of Omp50,a new porin isolated from Campylobacter jejuni

    Article • Biochemical Journal, December 2000, Portland Press Ltd.

    Dr Jean-Marie PAGES

  59. Purification, characterization and sequence analysis of Omp50,a new porin isolated from Campylobacter jejuni

    Article • Biochemical Journal, December 2000, Portland Press Ltd.

    Dr Jean-Marie PAGES

  60. Membrane Permeability Modifications Are Involved in Antibiotic Resistance in Klebsiella pneumoniae

    Article • Biochemical and Biophysical Research Communications, August 2000, Elsevier

    Dr Jean-Marie PAGES

  61. Comparative aspects of the diffusion of norfloxacin, cefepime and spermine through the F porin channel of Enterobacter cloacae

    Article • Biochemical Journal, May 2000, Portland Press Ltd.

    Dr Jean-Marie PAGES

  62. Comparative aspects of the diffusion of norfloxacin, cefepime and spermine through the F porin channel of Enterobacter cloacae

    Article • Biochemical Journal, May 2000, Portland Press Ltd.

    Dr Jean-Marie PAGES

  63. MOMP (major outer membrane protein) of Campylobacter jejuni ; a versatile pore-forming protein

    Article • FEBS Letters, March 2000, Wiley

    Dr Jean-Marie PAGES

  64. In Vivo Modification of Porin Activity Conferring Antibiotic Resistance to Enterobacter aerogenes

    Article • Biochemical and Biophysical Research Communications, December 1999, Elsevier

    Dr Jean-Marie PAGES

  65. Crucial domains are conserved in Enterobacteriaceae porins

    Article • FEMS Microbiology Letters, February 1996, Oxford University Press (OUP)

    Dr Jean-Marie PAGES

  66. Export and secretion of overproduced OmpA-β-lactamase in Escherichia coli

    Article • FEBS Letters, November 1987, Wiley

    Dr Jean-Marie PAGES