All Stories

  1. Promotion of lipid storage rather than of thermogenic competence by fetal versus newborn calf serum in primary cultures of brown adipocytes

    Article • Adipocyte, July 2018, Taylor & Francis

    Professor Jan Nedergaard

  2. Brown Adipose Tissue

    Article • January 2017, Elsevier

    Professor Jan Nedergaard

  3. Leptin Raises Defended Body Temperature without Activating Thermogenesis

    Article • Cell Reports, February 2016, Elsevier

    Professor Jan Nedergaard

  4. Leydig cell steroidogenesis unexpectedly escapes mitochondrial dysfunction in prematurely aging mice

    Article • The FASEB Journal, April 2015, Federation of American Societies For Experimental Biology (FASEB)

    Professor Jan Nedergaard

  5. The Browning of White Adipose Tissue: Some Burning Issues

    Article • Cell Metabolism, September 2014, Elsevier

    Professor Jan Nedergaard

  6. Assessing energy demand in living organisms: the influence of environmental temperature

    Article • Endocrine Abstracts, March 2014, Bioscientifica

    Professor Jan Nedergaard

  7. Brown Adipose Tissue as a Target

    Article • January 2014, Taylor & Francis

    Professor Jan Nedergaard

  8. UCP1 in Brite/Beige Adipose Tissue Mitochondria Is Functionally Thermogenic

    Article • Cell Reports, December 2013, Elsevier

    Professor Jan Nedergaard

  9. How brown is brown fat? It depends where you look

    Article • Nature Reports Stem Cells, May 2013, Nature

    Professor Jan Nedergaard

  10. Mild uncoupling to counteract ROS production: Physiologically relevant or not?

    Article • Biochimica et Biophysica Acta (BBA) - Bioenergetics, October 2012, Elsevier

    Professor Jan Nedergaard

  11. Cell biology: Neither brown nor white

    Article • Nature, August 2012, Nature

    Professor Jan Nedergaard

  12. Yes, even human brown fat is on fire!

    Article • Journal of Clinical Investigation, February 2012, American Society for Clinical Investigation

    Professor Jan Nedergaard

  13. Brown Adipose Tissue: A Seasonal Tissue in Mammals, Including Humans?

    Article • January 2012, Springer Science + Business Media

    Professor Jan Nedergaard

  14. Mitochondrial (‘mild’) uncoupling and ROS production: physiologically relevant or not?

    Article • Biochemical Society Transactions, October 2011, Portland Press Ltd.

    Professor Jan Nedergaard

  15. New Powers of Brown Fat: Fighting the Metabolic Syndrome

    Article • Cell Metabolism, March 2011, Elsevier

    Professor Jan Nedergaard

  16. Three years with adult human brown adipose tissue

    Article • Annals of the New York Academy of Sciences, November 2010, Wiley

    Professor Jan Nedergaard

  17. Increased fatigue resistance linked to Ca2+-stimulated mitochondrial biogenesis in muscle fibres of cold-acclimated mice

    Article • The Journal of Physiology, October 2010, Wiley

    Professor Jan Nedergaard

  18. Thyroid hormones: igniting brown fat via the brain

    Article • Nature Reports Stem Cells, September 2010, Nature

    Professor Jan Nedergaard

  19. UCP1 and mitochondrial uncoupling

    Article • Biochimica et Biophysica Acta (BBA) - Bioenergetics, July 2010, Elsevier

    Professor Jan Nedergaard

  20. The significance of thermogenesis for the ageing process

    Article • Biochimica et Biophysica Acta (BBA) - Bioenergetics, July 2010, Elsevier

    Professor Jan Nedergaard

  21. The Changed Metabolic World with Human Brown Adipose Tissue: Therapeutic Visions

    Article • Cell Metabolism, April 2010, Elsevier

    Professor Jan Nedergaard

  22. Metabolic and Angiogenic Consequences of the Presence or Absence of UCP1

    Article • January 2010, Springer Science + Business Media

    Professor Jan Nedergaard

  23. Thermogenesis challenges the adipostat hypothesis for body-weight control

    Article • Proceedings of The Nutrition Society, September 2009, Cambridge University Press

    Professor Jan Nedergaard

  24. UCP1 Ablation Induces Obesity and Abolishes Diet-Induced Thermogenesis in Mice Exempt from Thermal Stress by Living at Thermoneutrality

    Article • Cell Metabolism, February 2009, Elsevier

    Professor Jan Nedergaard

  25. Distinct expression of muscle-specific MicroRNAs (myomirs) in brown adipocytes

    Article • Journal of Cellular Physiology, February 2009, Wiley

    Professor Jan Nedergaard

  26. 脂身でもなければ肉でもない

    Article • Nature Digest, December 2008, Nature

    Professor Jan Nedergaard

  27. Developmental biology: Neither fat nor flesh

    Article • Nature, August 2008, Nature

    Professor Jan Nedergaard

  28. Studies of Thermogenesis and Mitochondrial Function in Adipose Tissues

    Article • January 2008, Springer Science + Business Media

    Professor Jan Nedergaard

  29. Ca2+-independent effects of BAPTA and EGTA on single-channel Cl− currents in brown adipocytes

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, November 2007, Elsevier

    Professor Jan Nedergaard

  30. Norepinephrine but not hypoxia stimulates HIF-1α gene expression in brown adipocytes

    Article • Biochemical and Biophysical Research Communications, November 2005, Elsevier

    Professor Jan Nedergaard

  31. Cold-induced expression of the VEGF gene in brown adipose tissue is independent of thermogenic oxygen consumption

    Article • FEBS Letters, October 2005, Wiley

    Professor Jan Nedergaard

  32. Uncoupling proteins: current status and therapeutic prospects

    Article • EMBO Reports, October 2005, EMBO

    Professor Jan Nedergaard

  33. α1- and β1-Adrenoceptor Signaling Fully Compensates for β3-Adrenoceptor Deficiency in Brown Adipocyte Norepinephrine-Stimulated Glucose Uptake

    Article • Endocrinology, May 2005, Endocrine Society

    Professor Jan Nedergaard

  34. Effects of Cations on Brown Adipose Tissue in Relation to Possible Metabolic Consequences of Membrane Depolarisation

    Article • European Journal of Biochemistry, March 2005, Wiley

    Professor Jan Nedergaard

  35. Brown Adipose Tissue: Development and Function

    Article • January 2004, Elsevier

    Professor Jan Nedergaard

  36. Thermogenesis Inhibition in Brown Adipocytes Is a Specific Property of Volatile Anesthetics

    Article • Anesthesiology, February 2003, Wolters Kluwer Health

    Professor Jan Nedergaard

  37. The ‘Novel’‘Uncoupling’ Proteins UCP2 and UCP3: What Do They Really do? Pros and Cons for Suggested Functions

    Article • Experimental Physiology, January 2003, Wiley

    Professor Jan Nedergaard

  38. A novel pathway for adrenergic stimulation of cAMP-response-element-binding protein (CREB) phosphorylation: mediation via α1-adrenoceptors and protein kinase C activation

    Article • Biochemical Journal, May 2002, Portland Press Ltd.

    Professor Jan Nedergaard

  39. Life without UCP1

    Article • Biochemical Society Transactions, October 2001, Portland Press Ltd.

    Professor Jan Nedergaard

  40. As the proliferation promoter noradrenaline induces expression of ICER (induced cAMP early repressor) in proliferative brown adipocytes, ICER may not be a universal tumour suppressor

    Article • Biochemical Journal, February 2001, Portland Press Ltd.

    Professor Jan Nedergaard

  41. Differential adrenergic regulation of the gene expression of the β-adrenoceptor subtypes β1, β2 and β3 in brown adipocytes

    Article • Biochemical Journal, May 2000, Portland Press Ltd.

    Professor Jan Nedergaard

  42. Differential adrenergic regulation of the gene expression of the β-adrenoceptor subtypes β1, β2 and β3 in brown adipocytes

    Article • Biochemical Journal, May 2000, Portland Press Ltd.

    Professor Jan Nedergaard

  43. Is there a Life in the Cold without UCP1? Uncoupling Proteins and Thermoregulatory Thermogenesis

    Article • January 2000, Springer Science + Business Media

    Professor Jan Nedergaard

  44. β1to β3Switch in Control of Cyclic Adenosine Monophosphate during Brown Adipocyte Development Explains Distinct β-Adrenoceptor Subtype Mediation of Proliferation and Differentiation1

    Article • Endocrinology, September 1999, Endocrine Society

    Professor Jan Nedergaard

  45. Regulation of the Activity of 27 pS Nonselective Cation Channels in Excised Membrane Patches from Rat Brown-Fat Cells

    Article • Cellular Physiology and Biochemistry, November 1998, Karger Publishers

    Professor Jan Nedergaard

  46. NONSHIVERING THERMOGENESIS AND BROWN ADIPOSE TISSUE

    Article • June 1998, World Scientific Pub Co Pte Lt

    Professor Jan Nedergaard

  47. Carteolol is a weak partial agonist on β 3 -adrenergic receptors in brown adipocytes

    Article • Canadian Journal of Physiology and Pharmacology, April 1998, Canadian Science Publishing

    Professor Jan Nedergaard

  48. Kinetics of the inhibition of mitochondrial respiration by NO

    Article • FEBS Letters, November 1997, Wiley

    Professor Jan Nedergaard

  49. Differential regulation of the expression of α 1 -adrenergic receptor subtype genes in brown adipose tissue

    Article • Biochemical Journal, March 1997, Portland Press Ltd.

    Professor Jan Nedergaard

  50. Adrenergic stimulation of lipoprotein lipase gene expression in rat brown adipocytes differentiated in culture: mediation via β3- and α1-adrenergic receptors

    Article • Biochemical Journal, February 1997, Portland Press Ltd.

    Professor Jan Nedergaard

  51. RIBONUCLEOTIDE REDUCTASE GENE EXPRESSION IN MOUSE BROWN ADIPOSE TISSUE

    Article • Biochemical Society Transactions, November 1996, Portland Press Ltd.

    Professor Jan Nedergaard

  52. SWITCH IN CROSS-TALK OF β & α 1 ADRENOCEPTORS IN CULTURED BROWN FAT CELLS

    Article • Biochemical Society Transactions, November 1996, Portland Press Ltd.

    Professor Jan Nedergaard

  53. Induction of uncoupling protein in brown adipose tissue

    Article • Biochemical Pharmacology, September 1996, Elsevier

    Professor Jan Nedergaard

  54. Cold-induced reduction in G i α proteins in brown adipose tissue. Effects on the cellular hypersensitization to noradrenaline caused by pertussis-toxin treatment

    Article • Biochemical Journal, March 1996, Portland Press Ltd.

    Professor Jan Nedergaard

  55. Postnatal selective suppression of lipoprotein lipase gene expression in brown adipose tissue (relative to the expression of the gene for the uncoupling protein) is not due to adrenergic insensitivity: a possible specific inhibitory effect of colostrum

    Article • Biochemical Journal, February 1996, Portland Press Ltd.

    Professor Jan Nedergaard

  56. Halothane Selectively Inhibits Nonshivering Thermogenesis

    Article • Survey of Anesthesiology, December 1995, Wolters Kluwer Health

    Professor Jan Nedergaard

  57. Halothane Selectively Inhibits Nonshivering Thermogenesis

    Article • Anesthesiology, February 1995, Wolters Kluwer Health

    Professor Jan Nedergaard

  58. Choline+ is a low-affinity ligand for α1-adrenoceptors

    Article • Biochemical Pharmacology, October 1994, Elsevier

    Professor Jan Nedergaard

  59. Thermogenesis in Brown Adipocytes Is Inhibited by Volatile Anesthetic Agents A Factor Contributing to Hypothermia in Infants?

    Article • Anesthesiology, July 1994, Wolters Kluwer Health

    Professor Jan Nedergaard

  60. Sulfonates are low-affinity ligands for the GDP-binding site of brown-fat mitochondria

    Article • Biochimica et Biophysica Acta (BBA) - Bioenergetics, May 1994, Elsevier

    Professor Jan Nedergaard

  61. Brown Adipose Tissue: Receptors and Recruitment

    Article • January 1994, Springer Science + Business Media

    Professor Jan Nedergaard

  62. Nonselective Cation Channels in Brown and White Fat Cells

    Article • January 1993, Springer Science + Business Media

    Professor Jan Nedergaard

  63. Chapter 17 The uncoupling protein thermogenin and mitochondrial thermogenesis

    Article • January 1992, Elsevier

    Professor Jan Nedergaard

  64. Norepinephrine-induced synthesis of the uncoupling protein thermogenin (UCP) and its mitochondrial targeting in brown adipocytes differentiated in culture

    Article • FEBS Letters, July 1990, Wiley

    Professor Jan Nedergaard

  65. α1 -Adrenergic stimulation of Cl− efflux in isolated brown adipocytes

    Article • FEBS Letters, March 1990, Wiley

    Professor Jan Nedergaard

  66. NADH-sensitive propionyl-CoA hydrolase in brown-adipose-tissue mitochondria of the rat

    Article • Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, September 1989, Elsevier

    Professor Jan Nedergaard

  67. α1- and β-Adrenergic regulation of intracellular Ca2+ levels in brown adipocytes

    Article • Biochemical and Biophysical Research Communications, August 1989, Elsevier

    Professor Jan Nedergaard

  68. Brown adipocytes differentiated in vitro can express the gene for the uncoupling protein thermogenin: Effects of hypothyroidism and norepinephrine

    Article • Experimental Cell Research, May 1989, Elsevier

    Professor Jan Nedergaard

  69. DNA synthesis in mouse brown adipose tissue is under β-adrenergic control

    Article • Experimental Cell Research, February 1989, Elsevier

    Professor Jan Nedergaard

  70. Shivering and Nonshivering Thermogenesis in Birds: A Mammalian View

    Article • January 1989, Springer Science + Business Media

    Professor Jan Nedergaard

  71. Regulation of the Amount and Activity of the Uncoupling Protein Thermogenin in Brown Adipose Tissue

    Article • January 1989, Springer Science + Business Media

    Professor Jan Nedergaard

  72. Physiological activation of brown adipose tissue destabilizes thermogenin mRNA

    Article • FEBS Letters, November 1987, Wiley

    Professor Jan Nedergaard

  73. α1-Adrenergic inositol trisphosphate production in brown adipocytes is Na+ dependent

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, October 1987, Elsevier

    Professor Jan Nedergaard

  74. Apparent unmasking of [3H]GDP binding in rat brown-fat mitochondria is due to mitochondrial swelling

    Article • European Journal of Biochemistry, May 1987, Wiley

    Professor Jan Nedergaard

  75. ?- and?-adrenergic control of thermogenin mRNA expression in brown adipose tissue

    Article • Bioscience Reports, July 1986, Portland Press Ltd.

    Professor Jan Nedergaard

  76. ‘Neuropeptide tyrosine’ (NPY) is co-stored with noradrenaline in vascular but not in parenchymal sympathetic nerves of brown adipose tissue

    Article • Experimental Cell Research, June 1986, Elsevier

    Professor Jan Nedergaard

  77. Brown adipose tissue thermogenesis in neonatal and cold-adapted animals

    Article • Biochemical Society Transactions, April 1986, Portland Press Ltd.

    Professor Jan Nedergaard

  78. β-adrenergic stimulation of fatty acid release from brown fat cells differentiated in monolayer culture

    Article • Life Sciences, February 1986, Elsevier

    Professor Jan Nedergaard

  79. Effects of guanine nucleotides and cations on agonist affinity of α1-adrenoceptors in brown adipose tissue

    Article • European Journal of Pharmacology, September 1985, Elsevier

    Professor Jan Nedergaard

  80. Brown adipose tissue: molecular mechanisms controlling activity and thermogenesis

    Article • January 1985, Elsevier

    Professor Jan Nedergaard

  81. Presence of a Ca2+-dependent K+ channel in brown adipocytes. Possible role in maintenance ofα1-adrenergic stimulation

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, January 1985, Elsevier

    Professor Jan Nedergaard

  82. Increased α1-adrenergic receptor density in brown adipose tissue of cold-acclimated rats and hamsters

    Article • European Journal of Pharmacology, November 1984, Elsevier

    Professor Jan Nedergaard

  83. Increased ?1 receptor density in brown adipose tissue of cafeteria-fed rats

    Article • Bioscience Reports, October 1984, Portland Press Ltd.

    Professor Jan Nedergaard

  84. Na+-dependent regulation of extramitochondrial Ca2+ by rat-liver mitochondria

    Article • European Journal of Biochemistry, October 1984, Wiley

    Professor Jan Nedergaard

  85. A possible physiological role of the Na + /Ca 2+ exchange mechanism of brown-fat mitochondria in the mediation of α 1 -adrenergic signals

    Article • Biochemical Society Transactions, June 1984, Portland Press Ltd.

    Professor Jan Nedergaard

  86. Na+-dependent, alpha-adrenergic mobilization of intracellular (mitochondrial) Ca2+ in brown adipocytes

    Article • European Journal of Biochemistry, May 1984, Wiley

    Professor Jan Nedergaard

  87. Chapter 10 Thermogenic mitochondria

    Article • January 1984, Elsevier

    Professor Jan Nedergaard

  88. Development of brown fat cells in monolayer culture

    Article • Experimental Cell Research, November 1983, Elsevier

    Professor Jan Nedergaard

  89. Biochemical aspects of acclimation to cold

    Article • Journal of Thermal Biology, January 1983, Elsevier

    Professor Jan Nedergaard

  90. Exclusive occurrence of thermogenin antigen in brown adipose tissue

    Article • FEBS Letters, December 1982, Wiley

    Professor Jan Nedergaard

  91. PEROXISOMAL ?-OXIDATION IN BROWN FAT

    Article • Annals of the New York Academy of Sciences, May 1982, Wiley

    Professor Jan Nedergaard

  92. The Brown Fat Cell

    Article • January 1982, Elsevier

    Professor Jan Nedergaard

  93. CONTROL BY EXTRAMITOCHONDRIAL Na + OF EXTRA-MITOCHONDRIAL Ca ++ LEVELS: A POSSIBLE MECHANISM FOR HORMONAL EFFECTS IN LIVER

    Article • Biochemical Society Transactions, April 1981, Portland Press Ltd.

    Professor Jan Nedergaard

  94. Thermogenic effect of ACYL-CoA in brown fat

    Article • Cryobiology, February 1981, Elsevier

    Professor Jan Nedergaard

  95. Cationic regulation of brown adipose tissue metabolism

    Article • Cryobiology, February 1981, Elsevier

    Professor Jan Nedergaard

  96. Cold-induced proliferation of brown fat peroxisomes

    Article • Cryobiology, February 1981, Elsevier

    Professor Jan Nedergaard

  97. PHYSIOLOGICAL UNCOUPLING IN BROWN FAT MITOCHONDRIA

    Article • January 1981, Elsevier

    Professor Jan Nedergaard

  98. PEROXISOMES IN BROWN FAT

    Article • January 1981, Elsevier

    Professor Jan Nedergaard

  99. A POSSIBLE METABOLIC EFFECT OF MEMBRANE DEPOLARISATION IN BROWN ADIPOSE TISSUE

    Article • January 1981, Elsevier

    Professor Jan Nedergaard

  100. AN ATTEMPT TO DIFFERENTIATE BETWEEN α- AND β-ADRENERGIC RESPIRATORY RESPONSES IN HAMSTER BROWN FAT CELLS

    Article • January 1981, Elsevier

    Professor Jan Nedergaard

  101. Effects of Monovalent Cations on Ca(2+) Transport in Mitochondria; A Comparison between Brown Fat and Liver Mitochondria from Rat.

    Article • Acta Chemica Scandinavica, January 1980, Danish Chemical Society

    Professor Jan Nedergaard

  102. The Physiological Role of Pyruvate Carboxylation in Hamster Brown Adipose Tissue

    Article • European Journal of Biochemistry, March 1979, Wiley

    Professor Jan Nedergaard

  103. [1] Overview—Preparation and properties of mitochondria from different sources

    Article • January 1979, Elsevier

    Professor Jan Nedergaard

  104. Brown adipose tissue and non-shivering thermogenesis

    Article • Journal of Thermal Biology, April 1978, Elsevier

    Professor Jan Nedergaard

  105. Energy Dissipation in Brown Fat

    Article • January 1978, Springer Science + Business Media

    Professor Jan Nedergaard

  106. THE BIOCHEMICAL MECHANISM OF THERMOGENESIS IN BROWN ADIPOSE TISSUE

    Article • January 1978, Elsevier

    Professor Jan Nedergaard

  107. Microcalorimetry of isolated mammalian cells

    Article • Nature, June 1977, Nature

    Professor Jan Nedergaard

  108. Metabolite and Ion Fluxes and Ion Channels

    Article • Springer Science + Business Media

    Professor Jan Nedergaard

  109. Cultures of Adipose Precursor Cells from Brown Adipose Tissue and of Clonal Brown-Adipocyte- Like Cell Lines

    Article • Springer Science + Business Media

    Professor Jan Nedergaard

  110. Respiratory and Thermogenic Capacities of Cells and Mitochondria from Brown and White Adipose Tissue

    Article • Springer Science + Business Media

    Professor Jan Nedergaard