All Stories

  1. Overcoming the Challenges of Symmetry Reveals New Insights into Herpesvirus Biology

    Article • Cell, September 2019, Elsevier

    Professor David Bhella

  2. Heterologous expression of human norovirus GII.4 VP1 leads to assembly of T=4 virus-like particles

    Article • Antiviral Research, August 2019, Elsevier

    Professor David Bhella

  3. Cryo-electron microscopy: an introduction to the technique, and considerations when working to establish a national facility

    Article • Biophysical Reviews, July 2019, Springer Science + Business Media

    Professor David Bhella

  4. Asymmetric analysis reveals novel virus capsid features

    Article • Biophysical Reviews, July 2019, Springer Science + Business Media

    Professor David Bhella

  5. Heterologous Expression of Human Norovirus GII.4 VP1 Leads to Assembly of T=4 Virus-Like Particles

    Article • March 2019, Cold Spring Harbor Laboratory Press

    Professor David Bhella

  6. Calicivirus VP2 forms a portal-like assembly following receptor engagement

    Article • Nature, January 2019, Springer Science + Business Media

    Professor David Bhella

  7. Structure of the Macrobrachium rosenbergii nodavirus: A new genus within the Nodaviridae?

    Article • PLoS Biology, October 2018, PLOS

    Professor David Bhella

  8. Calicivirus VP2 forms a portal to mediate endosome escape

    Article • August 2018, Cold Spring Harbor Laboratory Press

    Professor David Bhella

  9. Structure of the Macrobrachium rosenbergii Nodavirus: A new genus within the Nodaviridae?

    Article • August 2018, Cold Spring Harbor Laboratory Press

    Professor David Bhella

  10. Structure of the herpes simplex virus portal-vertex

    Article • PLoS Biology, June 2018, PLOS

    Professor David Bhella

  11. Structure of the herpes-simplex virus portal-vertex

    Article • March 2018, Cold Spring Harbor Laboratory Press

    Professor David Bhella

  12. Virus Proteins and Nucleoproteins: An Overview

    Article • January 2018, Springer Science + Business Media

    Professor David Bhella

  13. Rift Valley fever phlebovirus NSs protein core domain structure suggests molecular basis for nuclear filaments

    Article • eLife, September 2017, eLife

    Professor David Bhella

  14. Cryo-Electron Microscopy Structure of the Macrobrachium rosenbergii Nodavirus Capsid at 7 Angstroms Resolution

    Article • Scientific Reports, May 2017, Nature

    Professor David Bhella

  15. Cryo-Electron Microscopy Structure of the Macrobrachium Rosenbergii Nodavirus Capsid at 7 Angstroms Resolution

    Article • January 2017, Cold Spring Harbor Laboratory Press

    Professor David Bhella

  16. Vesivirus 2117 capsids more closely resemble sapovirus and lagovirus particles than other known vesivirus structures

    Article • Journal of General Virology, January 2017, Society for General Microbiology

    Professor David Bhella

  17. Filamentous influenza viruses

    Article • Journal of General Virology, August 2016, Society for General Microbiology

    Professor David Bhella

  18. An N-terminal extension to the hepatitis B virus core protein forms a poorly ordered trimeric spike in assembled virus-like particles

    Article • Journal of Structural Biology, February 2015, Elsevier

    Professor David Bhella

  19. The role of cellular adhesion molecules in virus attachment and entry

    Article • Philosophical Transactions of the Royal Society B Biological Sciences, December 2014, Royal Society Publishing

    Professor David Bhella

  20. The Large Tegument Protein pUL36 Is Essential for Formation of the Capsid Vertex-Specific Component at the Capsid-Tegument Interface of Herpes Simplex Virus 1

    Article • Journal of Virology, November 2014, ASM Journals

    Professor David Bhella

  21. Strategies for maximizing ATP supply in the microsporidianEncephalitozoon cuniculi: direct binding of mitochondria to the parasitophorous vacuole and clustering of the mitochondrial porin VDAC

    Article • Cellular Microbiology, December 2013, Wiley

    Professor David Bhella

  22. Extreme Genetic Fragility of the HIV-1 Capsid

    Article • PLoS Pathogens, June 2013, PLOS

    Professor David Bhella

  23. Cryotomography of Budding Influenza A Virus Reveals Filaments with Diverse Morphologies that Mostly Do Not Bear a Genome at Their Distal End

    Article • PLoS Pathogens, June 2013, PLOS

    Professor David Bhella

  24. The respiratory syncytial virus nucleoprotein-RNA complex forms a left-handed helical nucleocapsid

    Article • Journal of General Virology, May 2013, Society for General Microbiology

    Professor David Bhella

  25. A Tail-like Assembly at the Portal Vertex in Intact Herpes Simplex Type-1 Virions

    Article • PLoS Pathogens, October 2012, PLOS

    Professor David Bhella

  26. The Cryo-Electron Microscopy Structure of Feline Calicivirus Bound to Junctional Adhesion Molecule A at 9-Angstrom Resolution Reveals Receptor-Induced Flexibility and Two Distinct Conformational Changes in the Capsid Protein VP1

    Article • Journal of Virology, August 2011, ASM Journals

    Professor David Bhella

  27. A structural analysis of M protein in coronavirus assembly and morphology

    Article • Journal of Structural Biology, April 2011, Elsevier

    Benjamin W Neuman, Professor David Bhella

  28. Solution Structure and Characterisation of the Human Pyruvate Dehydrogenase Complex Core Assembly

    Article • Journal of Molecular Biology, May 2010, Elsevier

    Professor David Bhella

  29. Synthesis of Empty Bacterial Microcompartments, Directed Organelle Protein Incorporation, and Evidence of Filament-Associated Organelle Movement

    Article • Molecular Cell, April 2010, Elsevier

    Professor David Bhella, Dr Daniel Mulvihill

  30. A Uniique Density at the Portal Vertex of HSV Virions Revealed by Asymmetric Averaging of Subtomograms

    Article • Biophysical Journal, January 2010, Elsevier

    Professor David Bhella

  31. Crystal Structure of a Nucleocapsid-Like Nucleoprotein-RNA Complex of Respiratory Syncytial Virus

    Article • Science, November 2009, American Association for the Advancement of Science

    Professor David Bhella

  32. Erratum to “Influence of Coagulation Factor X on In Vitro and In Vivo Gene Delivery by Adenovirus (Ad) 5, Ad35, and Chimeric Ad5/Ad35 Vectors”

    Article • Molecular Therapy, October 2009, Nature

    Dr Simon N. Waddington, Professor David Bhella

  33. Influence of Coagulation Factor X on In Vitro and In Vivo Gene Delivery by Adenovirus (Ad) 5, Ad35, and Chimeric Ad5/Ad35 Vectors

    Article • Molecular Therapy, July 2009, Nature

    Dr Simon N. Waddington, Professor David Bhella

  34. Paramyxovirus Ultrastructure and Genome Packaging: Cryo-Electron Tomography of Sendai Virus

    Article • Journal of Virology, June 2009, ASM Journals

    Professor David Bhella

  35. Identification of coagulation factor (F)X binding sites on the adenovirus serotype 5 hexon: effect of mutagenesis on FX interactions and gene transfer

    Article • Blood, May 2009, American Society of Hematology

    Dr Simon N. Waddington, Professor David Bhella

  36. Structural Insights into Calicivirus Attachment and Uncoating

    Article • Journal of Virology, June 2008, ASM Journals

    Professor David Bhella

  37. Adenovirus Serotype 5 Hexon Mediates Liver Gene Transfer

    Article • Cell, February 2008, Elsevier

    Dr Simon N. Waddington, Professor David Bhella

  38. Reconstitution of the Mitochondrial PrxIII Antioxidant Defence Pathway: General Properties and Factors Affecting PrxIII Activity and Oligomeric State

    Article • Journal of Molecular Biology, September 2007, Elsevier

    Professor David Bhella

  39. The 24-Angstrom Structure of Respiratory Syncytial Virus Nucleocapsid Protein-RNA Decameric Rings

    Article • Journal of Virology, June 2007, ASM Journals

    Professor David Bhella

  40. The nine C-terminal amino acids of the respiratory syncytial virus protein P are necessary and sufficient for binding to ribonucleoprotein complexes in which six ribonucleotides are contacted per N protein protomer

    Article • Journal of General Virology, January 2007, Society for General Microbiology

    Professor David Bhella

  41. Structural and Functional Insights into the Interaction of Echoviruses and Decay-accelerating Factor

    Article • Journal of Biological Chemistry, November 2005, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor David Bhella

  42. Conformational Flexibility in Recombinant Measles Virus Nucleocapsids Visualised by Cryo-negative Stain Electron Microscopy and Real-space Helical Reconstruction

    Article • Journal of Molecular Biology, July 2004, Elsevier

    Professor David Bhella

  43. The Structure of Echovirus Type 12 Bound to a Two-domain Fragment of Its Cellular Attachment Protein Decay-accelerating Factor (CD 55)

    Article • Journal of Biological Chemistry, November 2003, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor David Bhella

  44. Structure-Function Analysis of Recombinant Substrate Protein 22 kDa (SP-22): A MITOCHONDRIAL 2-CYS PEROXIREDOXIN ORGANIZED AS A DECAMERIC TOROID

    Article • Journal of Biological Chemistry, May 2003, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor David Bhella

  45. The C-terminal Domain of the Measles Virus Nucleoprotein Is Intrinsically Disordered and Folds upon Binding to the C-terminal Moiety of the Phosphoprotein

    Article • Journal of Biological Chemistry, March 2003, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor David Bhella

  46. Investigations into the amino-terminal domain of the respiratory syncytial virus nucleocapsid protein reveal elements important for nucleocapsid formation and interaction with the phosphoprotein

    Article • Virology, March 2003, Elsevier

    Professor David Bhella

  47. Analysis of Antigenicity and Topology of E2 Glycoprotein Present on Recombinant Hepatitis C Virus-Like Particles

    Article • Journal of Virology, September 2002, ASM Journals

    Professor David Bhella

  48. pH Reduction as a Trigger for Dissociation of Herpes Simplex Virus Type 1 Scaffolds

    Article • Journal of Virology, August 2002, ASM Journals

    Professor David Bhella

  49. Analysis of Antigenicity and Topology of E2 Glycoprotein Present on Recombinant Hepatitis C Virus-Like Particles

    Article • Journal of Virology, August 2002, ASM Journals

    Professor David Bhella

  50. Significant differences in nucleocapsid morphology within the Paramyxoviridae

    Article • Journal of General Virology, August 2002, Society for General Microbiology

    Professor David Bhella

  51. Kidney Cancer: The Cytokine Working Group Experience (1986 -2001): Part II: Management of IL-2 Toxicity and Studies with Other Cytokines

    Article • Medical Oncology, January 2001, Springer Science + Business Media

    Professor David Bhella

  52. Cryomicroscopy of human cytomegalovirus virions reveals more densely packed genomic DNA than in herpes simplex virus type 1

    Article • Journal of Molecular Biology, January 2000, Elsevier

    Professor David Bhella

  53. Yeast Ty retrotransposons assemble into virus-like particles whose T-numbers depend on the C-terminal length of the capsid protein 1 1Edited by J. Karn

    Article • Journal of Molecular Biology, September 1999, Elsevier

    Enca Martin-Rendon, Professor David Bhella

  54. Comparative betaherpes viral genome and virion structure

    Article • Cambridge University Press

    Professor David Bhella