All Stories

  1. Shining Light on an mGlu5 Photoswitchable NAM: A Theoretical Perspective

    Article • Current Neuropharmacology, June 2016, Bentham Science Publishers

    Dr Cyril Goudet

  2. New 4-Functionalized Glutamate Analogues Are Selective Agonists at Metabotropic Glutamate Receptor Subtype 2 or Selective Agonists at Metabotropic Glutamate Receptor Group III

    Article • Journal of Medicinal Chemistry, February 2016, American Chemical Society (ACS)

    Dr Cyril Goudet

  3. Allosteric modulation of metabotropic glutamate receptors by chloride ions

    Article • The FASEB Journal, June 2015, Federation of American Societies For Experimental Biology (FASEB)

    Dr Cyril Goudet

  4. Synthesis and studies on the mGluR agonist activity of FAP4 stereoisomers

    Article • Bioorganic & Medicinal Chemistry Letters, June 2015, Elsevier

    Dr Cyril Goudet

  5. Therapeutic potential of group III metabotropic glutamate receptor ligands in pain

    Article • Current Opinion in Pharmacology, February 2015, Elsevier

    Dr Cyril Goudet

  6. Determination of the absolute configuration of phosphinic analogues of glutamate

    Article • Organic & Biomolecular Chemistry, January 2015, Royal Society of Chemistry

    Professor Françoise Colobert, Dr Cyril Goudet

  7. Overlapping binding sites drive allosteric agonism and positive cooperativity in type 4 metabotropic glutamate receptors

    Article • The FASEB Journal, October 2014, Federation of American Societies For Experimental Biology (FASEB)

    Dr Cyril Goudet

  8. Exploring the Active Conformation of Cyclohexane Carboxylate Positive Allosteric Modulators of the Type 4 Metabotropic Glutamate Receptor

    Article • ChemMedChem, September 2014, Wiley

    Dr Cyril Goudet

  9. An allosteric modulator to control endogenous G protein-coupled receptors with light

    Article • Nature Methods, August 2014, Nature

    Dr Cyril Goudet

  10. S.24.01 mGluR4 ligands and pain

    Article • European Neuropsychopharmacology, October 2012, Elsevier

    Dr Cyril Goudet

  11. α-Amino-β-fluorocyclopropanecarboxylic acids as a new tool for drug development: Synthesis of glutamic acid analogs and agonist activity towards metabotropic glutamate receptor 4

    Article • Bioorganic & Medicinal Chemistry, August 2012, Elsevier

    Dr Cyril Goudet

  12. Metabotropic Receptors for Glutamate and GABA

    Article • March 2012, IntechOpen

    Dr Cyril Goudet

  13. Dimers and beyond: The functional puzzles of class C GPCRs

    Article • Pharmacology & Therapeutics, April 2011, Elsevier

    Dr Cyril Goudet

  14. Class C receptor activation mechanisms illustrated by mGlu and GABAB receptors. A review.

    Article • Flavour and Fragrance Journal, February 2011, Wiley

    Dr Cyril Goudet

  15. Chapter 11. Metabotropic Glutamate Receptors: A Paradigm of Structural and Functional Receptor Complexity

    Article • January 2011, Royal Society of Chemistry

    Dr Cyril Goudet

  16. A critical pocket close to the glutamate binding site of mGlu receptors opens new possibilities for agonist design

    Article • Neuropharmacology, January 2011, Elsevier

    Dr Cyril Goudet

  17. The complexity of their activation mechanism opens new possibilities for the modulation of mGlu and GABAB class C G protein-coupled receptors

    Article • Neuropharmacology, January 2011, Elsevier

    Dr Cyril Goudet

  18. Integrated Synthetic, Pharmacological, and Computational Investigation of cis-2-(3,5-Dichlorophenylcarbamoyl)cyclohexanecarboxylic Acid Enantiomers As Positive Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 4

    Article • ChemMedChem, December 2010, Wiley

    Dr Cyril Goudet

  19. A Virtual Screening Hit Reveals New Possibilities for Developing Group III Metabotropic Glutamate Receptor Agonists

    Article • Journal of Medicinal Chemistry, April 2010, American Chemical Society (ACS)

    Dr Cyril Goudet

  20. Metabotropic receptors for glutamate and GABA in pain

    Article • Brain Research Reviews, April 2009, Elsevier

    Dr Cyril Goudet

  21. Group III metabotropic glutamate receptors inhibit hyperalgesia in animal models of inflammation and neuropathic pain

    Article • Pain, June 2008, Wolters Kluwer Health

    Dr Cyril Goudet

  22. l -(+)-2-Amino-4-thiophosphonobutyric Acid ( l -thioAP4), a New Potent Agonist of Group III Metabotropic Glutamate Receptors:  Increased Distal Acidity Affords Enhanced Potency

    Article • Journal of Medicinal Chemistry, September 2007, American Chemical Society (ACS)

    Dr Cyril Goudet

  23. Synthesis and Biological Evaluation of 1-Amino-2-Phosphonomethylcyclopropanecarboxylic Acids, New Group III Metabotropic Glutamate Receptor Agonists

    Article • Journal of Medicinal Chemistry, July 2007, American Chemical Society (ACS)

    Dr Cyril Goudet

  24. d-myo-Inositol 1-phosphate as a surrogate of d-myo-inositol 1,4,5-tris phosphate to monitor G protein-coupled receptor activation

    Article • Analytical Biochemistry, November 2006, Elsevier

    Dr Cyril Goudet

  25. Asymmetric Functioning of Dimeric Metabotropic Glutamate Receptors Disclosed by Positive Allosteric Modulators

    Article • Journal of Biological Chemistry, April 2005, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Cyril Goudet

  26. Evidence for a single heptahelical domain being turned on upon activation of a dimeric GPCR

    Article • The EMBO Journal, January 2005, Wiley

    Dr Cyril Goudet

  27. Allosteric modulators of class-C G-protein-coupled receptors open new possibilities for therapeutic application

    Article • Drug Discovery Today Therapeutic Strategies, September 2004, Elsevier

    Dr Cyril Goudet

  28. An overview of toxins and genes from the venom of the Asian scorpion Buthus martensi Karsch

    Article • Toxicon, September 2002, Elsevier

    Dr Cyril Goudet

  29. Characterization of two Bunodosoma granulifera toxins active on cardiac sodium channels

    Article • British Journal of Pharmacology, November 2001, Wiley

    Dr Cyril Goudet

  30. Electrophysiological characterization of Bm K M1, an α-like toxin from Buthus martensi Karsch venom

    Article • FEBS Letters, April 2001, Wiley

    Dr Cyril Goudet

  31. Cluster Organization and Pore Structure of Ion Channels Formed by Beticolin 3, a Nonpeptidic Fungal Toxin

    Article • Biophysical Journal, December 1999, Elsevier

    Dr Cyril Goudet

  32. Magnesium ions promote assembly of channel‐like structures from beticolin 0, a non‐peptide fungal toxin purified from Cercospora beticola

    Article • The Plant Journal, May 1998, Wiley

    Dr Cyril Goudet

  33. Electrophysiological properties of the hypokalaemic periodic paralysis mutation (R528H) of the skeletal muscle α 1S subunit as expressed in mouse L cells

    Article • FEBS Letters, March 1996, Wiley

    Dr Cyril Goudet