All Stories

  1. SIRT1 enzymatically potentiates 1,25-dihydroxyvitamin D 3 signaling via vitamin D receptor deacetylation
  2. Total and Free Circulating Vitamin D and Vitamin D–Binding Protein in Relation to Colorectal Cancer Risk in a Prospective Study of African Americans
  3. Greater Adherence to Cancer Prevention Guidelines Is Associated with Higher Circulating Concentrations of Vitamin D Metabolites in a Cross-Sectional Analysis of Pooled Participants from 2 Chemoprevention Trials
  4. Retinoid X Receptor Selective Agonists and their Synthetic Methods
  5. EDITORIAL: Rexinoids
  6. Modeling, Synthesis, and Biological Evaluation of Potential Retinoid X Receptor (RXR)-Selective Agonists: Analogues of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene) and 6-(Ethyl(5,5,8,8-tetrahydronaphthalen...
  7. Association between Circulating Vitamin D Metabolites and Fecal Bile Acid Concentrations
  8. Physical activity, sedentary behavior, and vitamin D metabolites
  9. 1,25-Dihydroxyvitamin D and Klotho
  10. Vitamin D and Colorectal, Breast, and Prostate Cancers: A Review of the Epidemiological Evidence
  11. Vitamin D Nutrient-Gene Interactions and Healthful Aging
  12. List of Contributors
  13. CYP24A1andCYP27B1Polymorphisms, Concentrations of Vitamin D Metabolites, and Odds of Colorectal Adenoma Recurrence
  14. Distinct functional modes of SUMOylation for retinoid X receptor alpha
  15. Abstract 1888: Calcium, magnesium, and vitamin D metabolites in colorectal adenoma prevention
  16. FGF23 gene regulation by 1,25-dihydroxyvitamin D: opposing effects in adipocytes and osteocytes
  17. Vitamin D, Autism, and Depression
  18. Resveratrol Potentiates Vitamin D and Nuclear Receptor Signaling
  19. Analysis of differential secondary effects of novel rexinoids: select rexinoid X receptor ligands demonstrate differentiated side effect profiles
  20. Concentrations of the Vitamin D Metabolite 1,25(OH)2D and Odds of Metabolic Syndrome and its Components
  21. Associations between circulating 1,25(OH)2D concentration and odds of metachronous colorectal adenoma
  22. Sentrin/SUMO Specific Proteases as Novel Tissue-Selective Modulators of Vitamin D Receptor-Mediated Signaling
  23. Associations between Vitamin D-Binding Protein Isotypes, Circulating 25(OH)D Levels, and Vitamin D Metabolite Uptake in Colon Cancer Cells
  24. Regulation of late cornified envelope genes relevant to psoriasis risk by plant-derived cyanidin
  25. Modeling, Synthesis, and Biological Evaluation of Potential Retinoid X Receptor (RXR) Selective Agonists: Novel Analogues of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene) and (E)-3-(3-(1,2,3,4-tetrahydro-1,...
  26. Vitamin D receptor-mediated control of Soggy, Wise, and Hairless gene expression in keratinocytes
  27. Control of late cornified envelope genes relevant to psoriasis risk: upregulation by 1,25-dihydroxyvitamin D3 and plant-derived delphinidin
  28. Association between circulating concentrations of 25(OH)D and colorectal adenoma: A pooled analysis
  29. CYP24A1 and CYP27B1 Polymorphisms Modulate Vitamin D Metabolism in Colon Cancer Cells
  30. Synthesis and biological evaluation of halogenated curcumin analogs as potential nuclear receptor selective agonists
  31. 1,25-Dihydroxyvitamin D3 Regulation of Fibroblast Growth Factor-23 Expression in Bone Cells: Evidence for Primary and Secondary Mechanisms Modulated by Leptin and Interleukin-6
  32. Vitamin D
  33. Abstract B32: Role of megalin in uptake of 1 ,25(OH)2D in colon cancer cells
  34. Abstract 29: Molecular epidemiology of Gc-globulin isotype, circulating 25(OH)D levels, and uptake of vitamin D metabolites in colon cancer cells.
  35. Discovery of novel vitamin D receptor interacting proteins that modulate 1,25-dihydroxyvitamin D3 signaling
  36. Inside Cover: Modeling, Synthesis and Biological Evaluation of Potential Retinoid X Receptor-Selective Agonists: Novel Halogenated Analogues of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene) (ChemMedChem 9/2012
  37. Modeling, Synthesis and Biological Evaluation of Potential Retinoid X Receptor-Selective Agonists: Novel Halogenated Analogues of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene)
  38. Molecular Mechanisms of Vitamin D Action
  39. Polymorphic Variation in the GC and CASR Genes and Associations with Vitamin D Metabolite Concentration and Metachronous Colorectal Neoplasia
  40. Abstract B103: Effect of over-the-counter vitamin D supplementation on circulating 25-hydroxyvitamin D concentration
  41. Vitamin D receptor controls expression of the anti-aging klotho gene in mouse and human renal cells
  42. The role of vitamin D in the FGF23, klotho, and phosphate bone-kidney endocrine axis
  43. Vitamin D receptor (VDR)-mediated actions of 1α,25(OH)2vitamin D3: Genomic and non-genomic mechanisms
  44. Vitamin D: Marker or Mechanism of Action?
  45. Circulating fibroblast growth factor-23 is associated with increased risk for metachronous colorectal adenoma
  46. Nuclear Vitamin D Receptor: Natural Ligands, Molecular Structure–Function, and Transcriptional Control of Vital Genes
  47. Contributors
  48. Abstract B36: Circulating FGF-23 is associated with metachronous colorectal adenomas
  49. Curcumin: a novel nutritionally derived ligand of the vitamin D receptor with implications for colon cancer chemoprevention
  50. Association between polymorphic variation in VDR and RXRA and circulating levels of vitamin D metabolites
  51. The nuclear vitamin D receptor controls the expression of genes encoding factors which feed the “Fountain of Youth” to mediate healthful aging
  52. 1,25-Dihydroxyvitamin D3Is a Novel Transcriptional Regulator of the Anti-Aging Gene Klotho in Human and Mouse Kidney Cells.
  53. Modeling, Synthesis and Biological Evaluation of Potential Retinoid X Receptor (RXR) Selective Agonists for the Treatment of Cutaneous T-Cell Lymphoma.
  54. Sentrin/SUMO Specific Proteases as Novel Tissue-Selective Co-Activator Proteins That Modulate Signalling by Vitamin D Receptor and Retinoid X Receptor Alpha.
  55. Vitamin D Regulation of the Epidermal Differentiation Complex To Maintain Healthy Skin and Curb Inflammatory Epidermal Diseases.
  56. Conversion of the anti-tumor agent tasidotin (ILX651) to its active metabolite by prolyl oligopeptidase
  57. Genetic Polymorphisms in Vitamin D Receptor VDR/RXRA Influence the Likelihood of Colon Adenoma Recurrence
  58. Modeling, Synthesis and Biological Evaluation of Potential Retinoid X Receptor (RXR) Selective Agonists: Novel Analogues of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene)
  59. Vitamin D, Calcium, and Colorectal Neoplasia: New Insights on Mechanisms of Action
  60. Vitamin D receptor ligands, adenomatous polyposis coli, and the vitamin D receptorFokI polymorphism collectively modulate β-catenin activity in colon cancer cells
  61. Vitamin D receptor: molecular signaling and actions of nutritional ligands in disease prevention
  62. Presence of a TA Haplotype in the APC Gene Containing the Common 1822 Polymorphism and Colorectal Adenoma
  63. Vitamin D Receptor: Key Roles in Bone Mineral Pathophysiology, Molecular Mechanism of Action, and Novel Nutritional Ligands
  64. 1,25-Dihydroxyvitamin D3/VDR-mediated induction of FGF23 as well as transcriptional control of other bone anabolic and catabolic genes that orchestrate the regulation of phosphate and calcium mineral metabolism
  65. Nuclear Vitamin D Receptor: Structure-Function, Molecular Control of Gene Transcription, and Novel Bioactions
  66. Molecular and functional comparison of 1,25-dihydroxyvitamin D3 and the novel vitamin D receptor ligand, lithocholic acid, in activating transcription of cytochrome P450 3A4
  67. List of Contributors
  68. Phosphorylation of human vitamin D receptor serine-182 by PKA suppresses 1,25(OH)2D3-dependent transactivation
  69. 1,25-Dihydroxyvitamin D3Down-regulation ofPHEXGene Expression Is Mediated by Apparent Repression of a 110 kDa Transfactor That Binds to a Polyadenine Element in the Promoter
  70. Two Basic Amino Acids C-Terminal of the Proximal Box Specify Functional Binding of the Vitamin D Receptor to Its Rat Osteocalcin Deoxyribonucleic Acid- Responsive Element
  71. Physical and Functional Interaction between the Vitamin D Receptor and Hairless Corepressor, Two Proteins Required for Hair Cycling
  72. Liganded VDR induces CYP3A4 in small intestinal and colon cancer cells via DR3 and ER6 vitamin D responsive elements
  73. Isolation of baculovirus-expressed human vitamin D receptor: DNA responsive element interactions and phosphorylation of the purified receptor
  74. Functionally relevant polymorphisms in the human nuclear vitamin D receptor gene
  75. The Polymorphic N Terminus in Human Vitamin D Receptor Isoforms Influences Transcriptional Activity by Modulating Interaction with Transcription Factor IIB
  76. The Polymorphic N Terminus in Human Vitamin D Receptor Isoforms Influences Transcriptional Activity by Modulating Interaction with Transcription Factor IIB
  77. Biochemical Evidence for a 170-Kilodalton, AF-2-Dependent Vitamin D Receptor/Retinoid X Receptor Coactivator That Is Highly Expressed in Osteoblasts
  78. Vitamin D receptor displays DNA binding and transactivation as a heterodimer with the retinoid X receptor, but not with the thyroid hormone receptor
  79. Characterization of Unique DNA-Binding and Transcriptional-Activation Functions in the Carboxyl-Terminal Extension of the Zinc Finger Region in the Human Vitamin D Receptor†
  80. Vitamin D receptor displays DNA binding and transactivation as a heterodimer with the retinoid X receptor, but not with the thyroid hormone receptor
  81. Steroid hormone receptors: Evolution, ligands, and molecular basis of biologic function
  82. Novel nuclear localization signal between the two DNA‐binding zinc fingers in the human vitamin D receptor
  83. Novel nuclear localization signal between the two DNA-binding zinc fingers in the human vitamin D receptor
  84. Suppression of ANP Gene Transcription by Liganded Vitamin D Receptor : Involvement of Specific Receptor Domains
  85. Heterodimeric DNA Binding by the Vitamin D Receptor and Retinoid X Receptors Is Enhanced by 1,25-Dihydroxyvitamin D3and Inhibited by 9-cis-Retinoic Acid
  86. The Nuclear Vitamin D Receptor: Biological and Molecular Regulatory Properties Revealed
  87. Mutations in the 1,25-Dihydroxyvitamin D3Receptor Identifying C-terminal Amino Acids Required for Transcriptional Activation That Are Functionally Dissociated from Hormone Binding, Heterodimeric DNA Binding, and Interaction with Basal Transcription Fac...
  88. Vitamin D receptors from patients with resistance to 1,25-dihydroxyvitamin D3: point mutations confer reduced transactivation in response to ligand and impaired interaction with the retinoid X receptor heterodimeric partner.
  89. Human vitamin D receptor phosphorylation by casein kinase II at Ser-208 potentiates transcriptional activation.
  90. A composite element binding the vitamin D receptor, retinoid X receptor alpha, and a member of the CTF/NF-1 family of transcription factors mediates the vitamin D responsiveness of the c-fos promoter.
  91. Inhibition of ligand induced promoter occupancyin vivoby a dominant negative RXR
  92. The T-Box near the Zinc Fingers of the Human Vitamin D Receptor Is Required for Heterodimeric DNA Binding and Transactivation
  93. A highly conserved region in the hormone-binding domain of the human vitamin D receptor contains residues vital for heterodimerization with retinoid X receptor and for transcriptional activation.
  94. New understanding of the molecular mechanism of receptor-mediated genomic actions of the vitamin D hormone
  95. Receptor mediated genomic action of the 1,25(OH)2D3 hormone: Expression of the human vitamin D receptor in E. coli
  96. Transcription factor TFIIB and the vitamin D receptor cooperatively activate ligand-dependent transcription.
  97. Purified Human Vitamin D Receptor Overexpressed in Escherichia coli and Baculovirus Systems Does Not Bind 1,25-Dihydroxyvitamin D3 Hormone Efficiently Unless Supplemented with a Rat Liver Nuclear Extract
  98. The 1,25-dihydroxyvitamin D3 receptor is phosphorylated in response to 1,25-dihydroxyvitamin D3 and 22-oxacalcitriol in rat osteoblasts, and by casein kinase II, in vitro
  99. Phosphorylation of the Human 1,25-Dihydroxyvitamin D3 Receptor by cAMP-Dependent Protein-Kinase, In Vitro, and in Transfected COS-7 Cells
  100. Human vitamin D receptor is selectively phosphorylated by protein kinase C on serine 51, a residue crucial to its trans-activation function.
  101. Vitamin D Receptor Phosphorylation in Transfected ROS 17/2.8 Cells Is Localized to the N-Terminal Region of the Hormone-Binding Domain
  102. The Vitamin D-Responsive Element in the Rat Bone Gla Protein Gene Is an Imperfect Direct Repeat That Cooperates with Other Cis-Elements in 1,25-Dihydroxyvitamin D3- Mediated Transcriptional Activation