All Stories

  1. Understanding responder neurobiology in schizophrenia using a quantitative systems pharmacology model: Application to iloperidone

    Article • Journal of Psychopharmacology, February 2015, SAGE Publications

    Hugo Geerts

  2. Quantitative systems pharmacology as an extension of PK/PD modeling in CNS research and development

    Article • Journal of Pharmacokinetics and Pharmacodynamics, January 2013, Springer Science + Business Media

    Hugo Geerts

  3. A strategy for developing new treatment paradigms for neuropsychiatric and neurocognitive symptoms in Alzheimer’s disease

    Article • Frontiers in Pharmacology, January 2013, Frontiers

    Hugo Geerts

  4. Systems pharmacology modeling in neuroscience: Prediction and outcome of PF-04995274, a 5-HT4 partial agonist, in a clinical scopolamine impairment trial

    Article • Advances in Alzheimer s Disease, January 2013, Scientific Research Publishing, Inc,

    Hugo Geerts

  5. Blinded Prospective Evaluation of Computer-Based Mechanistic Schizophrenia Disease Model for Predicting Drug Response

    Article • PLoS ONE, December 2012, PLOS

    Hugo Geerts

  6. A Quantitative Systems Pharmacology Computer Model for Schizophrenia Efficacy and Extrapyramidal Side Effects

    Article • Drug Development Research, April 2012, Wiley

    Hugo Geerts

  7. Simulations of symptomatic treatments for Alzheimer's disease: computational analysis of pathology and mechanisms of drug action

    Article • Alzheimer s Research & Therapy, January 2012, Springer Science + Business Media

    Hugo Geerts

  8. α7 Nicotinic receptor modulators for cognitive deficits in schizophrenia and Alzheimer's disease

    Article • Expert Opinion on Investigational Drugs, November 2011, Informa Healthcare

    Hugo Geerts

  9. Mechanistic disease modeling as a useful tool for improving CNS drug research and development

    Article • Drug Development Research, December 2010, Wiley

    Hugo Geerts

  10. Pharmacological Validation in Animal Models of Dementia

    Article • October 2010, Springer Science + Business Media

    Hugo Geerts

  11. Not all partial dopamine D2 receptor agonists are the same in treating schizophrenia. Exploring the effects of bifeprunox and aripiprazole using a computer model of a primate striatal dopaminergic synapse

    Article • Neuropsychiatric Disease and Treatment, September 2010, Taylor & Francis

    Hugo Geerts

  12. Of Mice and Men

    Article • CNS Drugs, November 2009, Springer Science + Business Media

    Hugo Geerts

  13. P4–364: Contribution of nicotinic receptor pharmacology to galantamine's clinical effect on working memory. A computer simulation study

    Article • Alzheimer s & Dementia, July 2006, Wiley

    Hugo Geerts

  14. Brain levels and acetylcholinesterase inhibition with galantamine and donepezil in rats, mice, and rabbits

    Article • Brain Research, February 2005, Elsevier

    Hugo Geerts

  15. Indicators of neuroprotection with galantamine

    Article • Brain Research Bulletin, January 2005, Elsevier

    Hugo Geerts

  16. La synapse virtuelle : quel apport pour la compréhension de la neurotransmission ?

    Article • Therapies, January 2004, Elsevier

    Hugo Geerts

  17. Nicotinic Cholinergic Modulation: Galantamine as a Prototype

    Article • CNS Drug Reviews, December 2002, Wiley

    Hugo Geerts

  18. In Vitro Studies of Flemish, Dutch, and Wild-Type β-Amyloid Provide Evidence for Two-Staged Neurotoxicity

    Article • Neurobiology of Disease, November 2002, Elsevier

    Hugo Geerts

  19. ApoE genotype: No influence on galantamine treatment efficacy nor on rate of decline in Alzheimer's disease

    Article • Neurobiology of Aging, May 2000, Elsevier

    Hugo Geerts

  20. Rescue of protein tau-induced axonopathy by GSK-3β in [GSK-3β X HTAU-4R] double transgenic mice

    Article • Neurobiology of Aging, May 2000, Elsevier

    Hugo Geerts

  21. Enovin, a member of the glial cell‐line‐derived neurotrophic factor (GDNF) family with growth promoting activity on neuronal cells

    Article • European Journal of Biochemistry, December 1999, Wiley

    Hugo Geerts

  22. Neuropathobiology in Transgenic Mice: The Case of Alzheimer's Disease

    Article • Springer Science + Business Media

    Hugo Geerts