All Stories

  1. A bacterial dual positive and negative selection system for dCas9 activity

    Article • PLoS ONE, June 2022, PLOS

    Professor Marc Ostermeier

  2. On the role of alginate structure in complexing with lysozyme and application for enzyme delivery

    Article • Food Hydrocolloids, February 2016, Elsevier

    Professor Marc Ostermeier

  3. Environmental changes bridge evolutionary valleys

    Article • Science Advances, January 2016, American Association for the Advancement of Science

    Professor Marc Ostermeier

  4. Enzymatic protein switches built from paralogous input domains

    Article • Biotechnology and Bioengineering, October 2015, Wiley

    Professor Marc Ostermeier

  5. Electrochemical activation of engineered protein switches

    Article • Biotechnology and Bioengineering, September 2015, Wiley

    Professor Marc Ostermeier

  6. Design of protein switches based on an ensemble model of allostery

    Article • Nature Communications, April 2015, Nature

    Professor Marc Ostermeier

  7. Rational Design of a Fusion Protein to Exhibit Disulfide-Mediated Logic Gate Behavior

    Article • ACS Synthetic Biology, April 2015, American Chemical Society (ACS)

    Professor Marc Ostermeier

  8. Characterization of Monobody Scaffold Interactions with Ligand via Force Spectroscopy and Steered Molecular Dynamics

    Article • Scientific Reports, February 2015, Nature

    Professor Marc Ostermeier

  9. Advancements in the Development of HIF-1α-Activated Protein Switches for Use in Enzyme Prodrug Therapy

    Article • PLoS ONE, November 2014, PLOS

    Professor Marc Ostermeier

  10. The thymidylate kinase genes from Mycobacterium tuberculosis and methicillin-resistant Staphylococcus aureus confer 3′-azido-3′-deoxythymidine resistance to Escherichia coli

    Article • FEMS Microbiology Letters, November 2014, Oxford University Press (OUP)

    Professor Marc Ostermeier

  11. Directed Evolution of Improved Zinc Finger Methyltransferases

    Article • PLoS ONE, May 2014, PLOS

    Professor Marc Ostermeier

  12. Correction: Targeted DNA Methylation Using an Artificially Bisected M.HhaI Fused to Zinc Fingers

    Article • PLoS ONE, January 2014, PLOS

    Professor Marc Ostermeier

  13. The High-Affinity Maltose Switch MBP317-347 has Low Affinity for Glucose: Implications for Targeting Tumors with Metabolically Directed Enzyme Prodrug Therapy

    Article • Chemical Biology & Drug Design, December 2013, Wiley

    Professor Marc Ostermeier

  14. Non-allosteric enzyme switches possess larger effector-induced changes in thermodynamic stability than their non-switch analogs

    Article • Protein Science, March 2013, Wiley

    Professor Marc Ostermeier

  15. Protein Switch Engineering by Domain Insertion

    Article • January 2013, Elsevier

    Professor Marc Ostermeier

  16. PFunkel: Efficient, Expansive, User-Defined Mutagenesis

    Article • PLoS ONE, December 2012, PLOS

    Professor Marc Ostermeier

  17. Targeted DNA Methylation Using an Artificially Bisected M.HhaI Fused to Zinc Fingers

    Article • PLoS ONE, September 2012, PLOS

    Professor Marc Ostermeier

  18. Structure of an Engineered β-Lactamase Maltose Binding Protein Fusion Protein: Insights into Heterotropic Allosteric Regulation

    Article • PLoS ONE, June 2012, PLOS

    Professor Marc Ostermeier

  19. A Hot-Spot Motif Characterizes the Interface between a Designed Ankyrin-Repeat Protein and Its Target Ligand

    Article • Biophysical Journal, February 2012, Elsevier

    Professor Marc Ostermeier

  20. In Vitro Recombination of Non-Homologous Genes Can Result in Gene Fusions that Confer a Switching Phenotype to Cells

    Article • PLoS ONE, November 2011, PLOS

    Professor Marc Ostermeier

  21. Molecular Imprinting of Maltose Binding Protein: Tuning Protein Recognition at the Molecular Level

    Article • Macromolecules, May 2011, American Chemical Society (ACS)

    Professor Marc Ostermeier

  22. Abstract 536: A hypoxia-activated protein switch as a potential anticancer therapeutic

    Article • Cancer Research, April 2011, American Association for Cancer Research (AACR)

    Professor Marc Ostermeier

  23. Circular Permutation of Proteins

    Article • March 2011, Wiley

    Professor Marc Ostermeier

  24. Surface-tethered protein switches

    Article • Chemical Communications, January 2011, Royal Society of Chemistry

    Professor Marc Ostermeier

  25. Sites in the AAV5 capsid tolerant to deletions and tandem duplications

    Article • Archives of Biochemistry and Biophysics, April 2010, Elsevier

    Professor Marc Ostermeier

  26. Designing switchable enzymes

    Article • Current Opinion in Structural Biology, August 2009, Elsevier

    Professor Marc Ostermeier

  27. Design and synthesis of a β-lactamase activated 5-fluorouracil prodrug

    Article • Bioorganic & Medicinal Chemistry Letters, February 2009, Elsevier

    Professor Marc Ostermeier

  28. Morphogen-defined patterning of Escherichia coli enabled by an externally tunable band-pass filter

    Article • Journal of Biological Engineering, January 2009, Springer Science + Business Media

    Professor Marc Ostermeier

  29. An engineered split M.HhaI-zinc finger fusion lacks the intended methyltransferase specificity

    Article • Biochemical and Biophysical Research Communications, December 2008, Elsevier

    Professor Marc Ostermeier

  30. Structure Prediction of Domain Insertion Proteins from Structures of Individual Domains

    Article • Structure, April 2008, Elsevier

    Professor Marc Ostermeier

  31. Directed evolution for drug and nucleic acid delivery

    Article • Advanced Drug Delivery Reviews, December 2007, Elsevier

    Professor Marc Ostermeier

  32. As easy as flipping a switch?

    Article • Current Opinion in Chemical Biology, June 2007, Elsevier

    Professor Marc Ostermeier

  33. Ligand binding and allostery can emerge simultaneously

    Article • Protein Science, May 2007, Wiley

    Professor Marc Ostermeier

  34. Beyond Cataloging the Library of Babel

    Article • Chemistry & Biology, March 2007, Elsevier

    Professor Marc Ostermeier

  35. Modulation of effector affinity by hinge region mutations also modulates switching activity in an engineered allosteric TEM1 β-lactamase switch

    Article • Archives of Biochemistry and Biophysics, February 2006, Elsevier

    Professor Marc Ostermeier

  36. Enhanced Catalytic Efficiency of Aminoglycoside Phosphotransferase (3′)-IIa Achieved Through Protein Fragmentation and Reassembly

    Article • Journal of Molecular Biology, October 2005, Elsevier

    Professor Marc Ostermeier

  37. Protein fragment complementation in M.HhaI DNA methyltransferase

    Article • Biochemical and Biophysical Research Communications, September 2005, Elsevier

    Professor Marc Ostermeier

  38. Mathematical expressions useful in the construction, description and evaluation of protein libraries

    Article • Biomolecular Engineering, June 2005, Elsevier

    Professor Marc Ostermeier

  39. A Molecular Switch Created by In Vitro Recombination of Nonhomologous Genes

    Article • Chemistry & Biology, November 2004, Elsevier

    Professor Marc Ostermeier

  40. Creation of an Allosteric Enzyme by Domain Insertion

    Article • Journal of Molecular Biology, February 2004, Elsevier

    Professor Marc Ostermeier

  41. Construction of Protein Fragment Complementation Libraries Using Incremental Truncation

    Article • January 2004, Elsevier

    Professor Marc Ostermeier

  42. Synthetic gene libraries: in search of the optimal diversity

    Article • Trends in Biotechnology, June 2003, Elsevier

    Professor Marc Ostermeier

  43. Theoretical distribution of truncation lengths in incremental truncation libraries

    Article • Biotechnology and Bioengineering, March 2003, Wiley

    Professor Marc Ostermeier

  44. Evolution of protein function by Domain swapping

    Article • January 2001, Elsevier

    Professor Marc Ostermeier

  45. A two-phagemid system for the creation of non-phage displayed antibody libraries approaching one trillion members

    Article • Journal of Immunological Methods, April 2000, Elsevier

    Professor Marc Ostermeier

  46. Incremental truncation as a strategy in the engineering of novel biocatalysts

    Article • Bioorganic & Medicinal Chemistry, October 1999, Elsevier

    Professor Marc Ostermeier

  47. Hybrid enzymes: manipulating enzyme design

    Article • Trends in Biotechnology, June 1998, Elsevier

    Professor Marc Ostermeier

  48. Folding and aggregation of TEM β-lactamase: Analogies with the formation of inclusion bodies inEscherichia coli

    Article • Protein Science, November 1994, Wiley

    Professor Marc Ostermeier

  49. The Creation of ITCHY Hybrid Protein Libraries

    Article • Springer Science + Business Media

    Professor Marc Ostermeier

  50. Preparation of SCRATCHY Hybrid Protein Libraries Size- and In-Frame Selection of Nucleic Acid Sequences

    Article • Springer Science + Business Media

    Professor Marc Ostermeier