All Stories

  1. Sirtuin-3 Promotes Adipogenesis, Osteoclastogenesis, and Bone Loss in Aging Male Mice

    Article • Endocrinology, July 2017, Endocrine Society

    Dr Eric Verdin

  2. Aging Promotes Sirtuin 3-Dependent Cartilage Superoxide Dismutase 2 Acetylation and Osteoarthritis

    Article • Arthritis & Rheumatology, July 2016, Wiley

    Dr Eric Verdin

  3. Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype

    Article • Cell Metabolism, February 2016, Elsevier

    Dr Eric Verdin

  4. SIRT3 Blocks Aging-Associated Tissue Fibrosis in Mice by Deacetylating and Activating Glycogen Synthase Kinase 3β

    Article • Molecular and Cellular Biology, December 2015, ASM Journals

    Dr Eric Verdin

  5. vitamin B3 rediscovered

    Article • Science, December 2015, American Association for the Advancement of Science

    Dr Eric Verdin

  6. Correction: Repressive LTR Nucleosome Positioning by the BAF Complex Is Required for HIV Latency

    Article • PLoS Biology, November 2015, PLOS

    Dr Eric Verdin

  7. Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits

    Article • Nature Reports Stem Cells, September 2015, Nature

    Dr Eric Verdin

  8. SIRT5 Regulates both Cytosolic and Mitochondrial Protein Malonylation with Glycolysis as a Major Target

    Article • Molecular Cell, July 2015, Elsevier

    Dr Eric Verdin

  9. HIV Latency Is Established Directly and Early in Both Resting and Activated Primary CD4 T Cells

    Article • PLoS Pathogens, June 2015, PLOS

    Dr Vincenzo Calvanese, Dr Eric Verdin

  10. MicroRNA-155 Reinforces HIV Latency

    Article • Journal of Biological Chemistry, April 2015, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Eric Verdin

  11. SIRT3 and SIRT5 Regulate the Enzyme Activity and Cardiolipin Binding of Very Long-Chain Acyl-CoA Dehydrogenase

    Article • PLoS ONE, March 2015, PLOS

    Dr Eric Verdin

  12. Reviewing the Path to an HIV Cure

    Article • Annual Review of Medicine, January 2015, Annual Reviews

    Dr Eric Verdin

  13. 50 years from obscurity to mainstream: the amazing story of protein acetylation

    Article • Nature Reviews Molecular Cell Biology, December 2014, Nature

    Dr Eric Verdin

  14. Activation of SIRT3 by the NAD+ Precursor Nicotinamide Riboside Protects from Noise-Induced Hearing Loss

    Article • Cell Metabolism, December 2014, Elsevier

    Dr William T Harkcom, Dr William Harkcom, Dr Eric Verdin

  15. A-107 Dual Fluorescence HIV Reporter to Study HIV latency

    Article • JAIDS Journal of Acquired Immune Deficiency Syndromes, November 2014, Wolters Kluwer Health

    Dr Eric Verdin

  16. β-hydroxybutyrate: Much more than a metabolite

    Article • Diabetes Research and Clinical Practice, November 2014, Elsevier

    Dr Eric Verdin

  17. The growing landscape of lysine acetylation links metabolism and cell signalling

    Article • Nature Reviews Molecular Cell Biology, July 2014, Nature

    Dr Eric Verdin

  18. The Many Faces of Sirtuins: Coupling of NAD metabolism, sirtuins and lifespan

    Article • Nature Reports Stem Cells, January 2014, Nature

    Dr Eric Verdin

  19. Ketone bodies as signaling metabolites

    Article • Trends in Endocrinology and Metabolism, January 2014, Elsevier

    Dr Eric Verdin

  20. HIV-1 Chromatin, Transcription, and the Regulatory Protein Tat

    Article • January 2014, Springer Science + Business Media

    Dr Eric Verdin

  21. An In-Depth Comparison of Latent HIV-1 Reactivation in Multiple Cell Model Systems and Resting CD4+ T Cells from Aviremic Patients

    Article • PLoS Pathogens, December 2013, PLOS

    Dr Nancie M Archin, Dr Eric Verdin

  22. SIRT5 Regulates the Mitochondrial Lysine Succinylome and Metabolic Networks

    Article • Cell Metabolism, December 2013, Elsevier

    Dr Eric Verdin

  23. Dual-color HIV reporters trace a population of latently infected cells and enable their purification

    Article • Virology, November 2013, Elsevier

    Dr Vincenzo Calvanese, Dr Eric Verdin

  24. Mitochondrial SIRT4-type proteins in Caenorhabditis elegans and mammals interact with pyruvate carboxylase and other acetylated biotin-dependent carboxylases

    Article • Mitochondrion, November 2013, Elsevier

    Dr Eric Verdin

  25. The nexus of chromatin regulation and intermediary metabolism

    Article • Nature, October 2013, Nature

    Dr Eric Verdin

  26. Acetylphosphate: A Novel Link between Lysine Acetylation and Intermediary Metabolism in Bacteria

    Article • Molecular Cell, July 2013, Elsevier

    Dr Eric Verdin

  27. MicroRNAs of the miR-17∼92 family are critical regulators of TFH differentiation

    Article • Nature Immunology, June 2013, Nature

    Dr Eric Verdin

  28. Reactivation of latent HIV by histone deacetylase inhibitors

    Article • Trends in Microbiology, June 2013, Elsevier

    Dr Vincenzo Calvanese, Dr Eric Verdin

  29. Three Rules for HIV Latency: Location, Location, and Location

    Article • Cell Host & Microbe, June 2013, Elsevier

    Dr Eric Verdin

  30. Rejuvenating SIRT1 Activators

    Article • Cell Metabolism, May 2013, Elsevier

    Dr Eric Verdin

  31. C103 Identification, purification and characterization of latently-infected cells using novel fluorescent HIV viruses

    Article • JAIDS Journal of Acquired Immune Deficiency Syndromes, April 2013, Wolters Kluwer Health

    Dr Vincenzo Calvanese, Dr Eric Verdin

  32. BET bromodomain-targeting compounds reactivate HIV from latency via a Tat-independent mechanism

    Article • Cell Cycle, February 2013, Taylor & Francis

    Dr Vincenzo Calvanese, Dr Eric Verdin

  33. Reactivation of latent HIV-1 in central memory CD4+ T cells through TLR-1/2 stimulation

    Article • Retrovirology, January 2013, Springer Science + Business Media

    Dr Nancie M Archin, Dr Eric Verdin

  34. Therapy for latent HIV-1 infection: the role of histone deacetylase inhibitors

    Article • Antiviral Chemistry and Chemotherapy, January 2013, International Medical Press

    Dr Eric Verdin

  35. Inhibitors of the NAD + -Dependent Protein Desuccinylase and Demalonylase Sirt5

    Article • ACS Medicinal Chemistry Letters, December 2012, American Chemical Society (ACS)

    Dr Eric Verdin

  36. Whole-organism screening for gluconeogenesis identifies activators of fasting metabolism

    Article • Nature Methods, December 2012, Nature

    Dr Eric Verdin

  37. The Longevity of Sirtuins

    Article • Cell Reports, December 2012, Elsevier

    Dr Eric Verdin

  38. CNS SIRT3 Expression Is Altered by Reactive Oxygen Species and in Alzheimer’s Disease

    Article • PLoS ONE, November 2012, PLOS

    Dr Eric Verdin

  39. Nuclear export of histone deacetylase 7 during thymic selection is required for immune self-tolerance

    Article • The EMBO Journal, October 2012, Wiley

    Dr Eric Verdin

  40. Mitochondrial sirtuins: regulators of protein acylation and metabolism

    Article • Trends in Endocrinology and Metabolism, September 2012, Elsevier

    Dr Eric Verdin

  41. Inhibition of SIRT2 Potentiates the Anti-motility Activity of Taxanes: Implications for Antineoplastic Combination Therapies

    Article • Neoplasia, September 2012, Elsevier

    Dr Eric Verdin

  42. Dietary restriction attenuates age-associated muscle atrophy by lowering oxidative stress in mice even in complete absence of CuZnSOD

    Article • Aging Cell, August 2012, Wiley

    Dr Eric Verdin

  43. Immunosenescence and HIV

    Article • Current Opinion in Immunology, August 2012, Elsevier

    Dr Eric Verdin

  44. Towards an HIV cure: a global scientific strategy

    Article • Nature Reviews Immunology, July 2012, Nature

    Dr Eric Verdin

  45. Receptor-interacting protein (RIP) and Sirtuin-3 (SIRT3) are on opposite sides of anoikis and tumorigenesis

    Article • Cancer, June 2012, Wiley

    Dr Eric Verdin

  46. HIV latency: experimental systems and molecular models

    Article • FEMS Microbiology Reviews, May 2012, Oxford University Press (OUP)

    Dr Eric Verdin

  47. Mitochondrial Acetylome Analysis in a Mouse Model of Alcohol-Induced Liver Injury Utilizing SIRT3 Knockout Mice

    Article • Journal of Proteome Research, March 2012, American Chemical Society (ACS)

    Dr Eric Verdin

  48. Metabolic Regulation, Mitochondria and the Life-Prolonging Effect of Rapamycin: A Mini-Review

    Article • Gerontology, January 2012, Karger Publishers

    Dr Eric Verdin

  49. New transcription regulatory mechanisms of latent HIV LTR

    Article • Retrovirology, January 2012, Springer Science + Business Media

    Dr Eric Verdin

  50. Repressive LTR Nucleosome Positioning by the BAF Complex Is Required for HIV Latency

    Article • PLoS Biology, November 2011, PLOS

    Dr Eric Verdin

  51. Two-pronged Binding with Bromodomain-containing Protein 4 Liberates Positive Transcription Elongation Factor b from Inactive Ribonucleoprotein Complexes

    Article • Journal of Biological Chemistry, November 2011, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Eric Verdin

  52. Mitochondrial Acetylomic Analysis in a Mouse Model of Alcohol-Induced Liver Injury Utilizing SIRT3 Knockout Mice

    Article • Free Radical Biology and Medicine, November 2011, Elsevier

    Dr Eric Verdin

  53. SIRT3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome

    Article • Molecular Cell, October 2011, Elsevier

    Dr Eric Verdin

  54. SIRT3 and cancer: Tumor promoter or suppressor?

    Article • Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, August 2011, Elsevier

    Dr Eric Verdin

  55. Abstract 4768: Receptor interacting protein (RIP) and Sirtuin-3 (SIRT3) on opposite sides of anoikis resistance and promotes tumorigenesis

    Article • Cancer Research, April 2011, American Association for Cancer Research (AACR)

    Dr Eric Verdin

  56. 123 Molecular Mechanisms of HIV Latency

    Article • JAIDS Journal of Acquired Immune Deficiency Syndromes, April 2011, Wolters Kluwer Health

    Dr Eric Verdin

  57. In vivo, in vitro, and in silico analysis of methylation of the HIV-1 provirus

    Article • Methods, January 2011, Elsevier

    Dr Eric Verdin

  58. Epigenetic regulation of HIV latency

    Article • Current Opinion in HIV and AIDS, January 2011, Wolters Kluwer Health

    Dr Eric Verdin

  59. Calorie Restriction Reduces Oxidative Stress by SIRT3-Mediated SOD2 Activation

    Article • Cell Metabolism, December 2010, Elsevier

    Dr Eric Verdin

  60. Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling

    Article • Trends in Biochemical Sciences, December 2010, Elsevier

    Dr Eric Verdin

  61. SIRT3 Deacetylates Mitochondrial 3-Hydroxy-3-Methylglutaryl CoA Synthase 2 and Regulates Ketone Body Production

    Article • Cell Metabolism, December 2010, Elsevier

    Dr Eric Verdin

  62. Sirtuin‐3 (SIRT3), a novel potential therapeutic target for oral cancer

    Article • Cancer, November 2010, Wiley

    Dr Eric Verdin

  63. Regulatory signal transduction pathways for class IIa histone deacetylases

    Article • Current Opinion in Pharmacology, August 2010, Elsevier

    Dr Eric Verdin

  64. Mitochondrial sirtuins

    Article • Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, August 2010, Elsevier

    Dr Eric Verdin

  65. Acetate metabolism and aging: An emerging connection

    Article • Mechanisms of Ageing and Development, July 2010, Elsevier

    Dr Eric Verdin

  66. HAT Trick: p300, Small Molecule, Inhibitor

    Article • Chemistry & Biology, May 2010, Elsevier

    Dr Eric Verdin

  67. Measuring fatty acid oxidation in tissue homogenates

    Article • Protocol Exchange, April 2010, Nature

    Dr Eric Verdin

  68. SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation

    Article • Nature, March 2010, Nature

    Dr Eric Verdin

  69. The Cellular Lysine Methyltransferase Set7/9-KMT7 Binds HIV-1 TAR RNA, Monomethylates the Viral Transactivator Tat, and Enhances HIV Transcription

    Article • Cell Host & Microbe, March 2010, Elsevier

    Dr Eric Verdin

  70. CpG methylation controls reactivation of HIV from latency

    Article • Retrovirology, January 2010, Springer Science + Business Media

    Dr Eric Verdin

  71. CpG Methylation Controls Reactivation of HIV from Latency

    Article • PLoS Pathogens, August 2009, PLOS

    Dr Eric Verdin

  72. Epigenetic Regulation of HIV-1 Latency by Cytosine Methylation

    Article • PLoS Pathogens, June 2009, PLOS

    Dr Eric Verdin

  73. A New Splice Variant of the Mouse SIRT3 Gene Encodes the Mitochondrial Precursor Protein

    Article • PLoS ONE, March 2009, PLOS

    Dr Eric Verdin

  74. CELL BIOLOGY: Stress Response and Aging

    Article • Science, February 2009, American Association for the Advancement of Science

    Dr Eric Verdin

  75. Pyridylalanine-Containing Hydroxamic Acids as Selective HDAC6 Inhibitors

    Article • ChemMedChem, February 2009, Wiley

    Dr Eric Verdin

  76. Chapter 8 Acetylation of Mitochondrial Proteins

    Article • January 2009, Elsevier

    Dr Eric Verdin

  77. Thiobarbiturates as Sirtuin Inhibitors: Virtual Screening, Free-Energy Calculations, and Biological Testing

    Article • ChemMedChem, December 2008, Wiley

    Dr Eric Verdin

  78. Chair's Introduction

    Article • October 2008, Wiley

    Dr Eric Verdin

  79. HDAC7 Regulates Apoptosis in Developing Thymocytes

    Article • October 2008, Wiley

    Dr Eric Verdin

  80. Tat Acetylation: A Regulatory Switch between Early and Late Phases in HIV Transcription Elongation

    Article • October 2008, Wiley

    Dr Eric Verdin

  81. Structure–Activity Studies on Splitomicin Derivatives as Sirtuin Inhibitors and Computational Prediction of Binding Mode

    Article • Journal of Medicinal Chemistry, March 2008, American Chemical Society (ACS)

    Dr Eric Verdin

  82. Conserved Metabolic Regulatory Functions of Sirtuins

    Article • Cell Metabolism, February 2008, Elsevier

    Dr Eric Verdin

  83. AROuSing SIRT1: Identification of a Novel Endogenous SIRT1 Activator

    Article • Molecular Cell, November 2007, Elsevier

    Dr Eric Verdin

  84. Interphase Nucleo-Cytoplasmic Shuttling and Localization of SIRT2 during Mitosis

    Article • PLoS ONE, August 2007, PLOS

    Dr Eric Verdin

  85. Design and evaluation of ‘Linkerless’ hydroxamic acids as selective HDAC8 inhibitors

    Article • Bioorganic & Medicinal Chemistry Letters, May 2007, Elsevier

    Dr Eric Verdin

  86. Breast cancer associated transcriptional repressor PLU-1/JARID1B interacts directly with histone deacetylases

    Article • International Journal of Cancer, January 2007, Wiley

    Dr Eric Verdin

  87. Adenosine Mimetics as Inhibitors of NAD + -Dependent Histone Deacetylases, from Kinase to Sirtuin Inhibition

    Article • Journal of Medicinal Chemistry, December 2006, American Chemical Society (ACS)

    Dr Eric Verdin

  88. Histone Deacetylases

    Article • January 2006, Springer Science + Business Media

    Dr Eric Verdin

  89. The Class IIa Histone Deacetylases

    Article • January 2006, Springer Science + Business Media

    Dr Eric Verdin

  90. The Class III Protein Deacetylases

    Article • January 2006, Springer Science + Business Media

    Dr Eric Verdin

  91. NF-κB p50 promotes HIV latency through HDAC recruitment and repression of transcriptional initiation

    Article • The EMBO Journal, December 2005, Wiley

    Dr Eric Verdin

  92. Molecular mechanisms of HIV-1 proviral latency

    Article • Expert Review of Anti-infective Therapy, October 2005, Taylor & Francis

    Dr Eric Verdin

  93. Preparation of enzymatically active recombinant class III protein deacetylases

    Article • Methods, August 2005, Elsevier

    Dr Eric Verdin

  94. Effect of inhibitors of histone deacetylase on the induction of cell differentiation in murine and human erythroleukemia cell lines

    Article • Anti-Cancer Drugs, July 2005, Wolters Kluwer Health

    Dr Eric Verdin

  95. SIRT1 Regulates HIV Transcription via Tat Deacetylation

    Article • PLoS Biology, February 2005, PLOS

    Dr Eric Verdin

  96. The Flavoring Agent Dihydrocoumarin Reverses Epigenetic Silencing and Inhibits Sirtuin Deacetylases

    Article • PLoS Genetics, January 2005, PLOS

    Dr Eric Verdin

  97. Subtype Selective Substrates for Histone Deacetylases

    Article • Journal of Medicinal Chemistry, October 2004, American Chemical Society (ACS)

    Dr Eric Verdin

  98. Expression of Histone Deacetylase 8, a Class I Histone Deacetylase, Is Restricted to Cells Showing Smooth Muscle Differentiation in Normal Human Tissues

    Article • American Journal Of Pathology, August 2004, Elsevier

    Dr Eric Verdin

  99. Nonisotopic substrate for assaying both human zinc and NAD+-dependent histone deacetylases

    Article • Analytical Biochemistry, August 2003, Elsevier

    Dr Eric Verdin

  100. Acetylation of Tat Defines a CyclinT1-Independent Step in HIV Transactivation

    Article • Molecular Cell, July 2003, Elsevier

    Dr Eric Verdin

  101. Class II histone deacetylases: versatile regulators

    Article • Trends in Genetics, May 2003, Elsevier

    Dr Eric Verdin

  102. HDAC7, a Thymus-Specific Class II Histone Deacetylase, Regulates Nur77 Transcription and TCR-Mediated Apoptosis

    Article • Immunity, May 2003, Elsevier

    Dr Eric Verdin

  103. The Human Sir2 Ortholog, SIRT2, Is an NAD+-Dependent Tubulin Deacetylase

    Article • Molecular Cell, February 2003, Elsevier

    Dr Eric Verdin

  104. Measurement of Mammalian Histone Deacetylase Activity

    Article • January 2003, Elsevier

    Dr Eric Verdin

  105. Structural Basis of Lysine-Acetylated HIV-1 Tat Recognition by PCAF Bromodomain

    Article • Molecular Cell, March 2002, Elsevier

    Dr Eric Verdin

  106. Histone deacetylases inhibitors as anti-angiogenic agents altering vascular endothelial growth factor signaling

    Article • Oncogene, January 2002, Nature

    Dr Eric Verdin

  107. Enzymatic Activity Associated with Class II HDACs Is Dependent on a Multiprotein Complex Containing HDAC3 and SMRT/N-CoR

    Article • Molecular Cell, January 2002, Elsevier

    Dr Eric Verdin

  108. The emerging role of class II histone deacetylases

    Article • Biochemistry and Cell Biology, June 2001, Canadian Science Publishing

    Dr Eric Verdin

  109. The emerging role of class II histone deacetylases

    Article • Biochemistry and Cell Biology, January 2001, Canadian Science Publishing

    Dr Eric Verdin

  110. Acetylation of the HIV-1 Tat protein by p300 is important for its transcriptional activity

    Article • Current Biology, December 1999, Elsevier

    Dr Eric Verdin

  111. Cloning and Characterization of the Murine Histone Deacetylase (HDAC3)

    Article • Biochemical and Biophysical Research Communications, September 1999, Elsevier

    Dr Eric Verdin

  112. Reduction of histone acetylation in mitosis through loss of histone acetyltransferases and deacetylases from chromatin

    Article • Biochemistry and Cell Biology, August 1999, Canadian Science Publishing

    Dr Eric Verdin

  113. Genomic Organization and Chromosomal Localization of the Human Histone Deacetylase 3 Gene

    Article • Genomics, March 1999, Elsevier

    Dr Eric Verdin

  114. Reduction of histone acetylation in mitosis through loss of histone acetyltransferases and deacetylases from chromatin

    Article • Biochemistry and Cell Biology, January 1999, Canadian Science Publishing

    Dr Eric Verdin

  115. Role of chromatin in the transcriptional regulation of HIV-1

    Article • Journal of Cancer Research and Clinical Oncology, January 1995, Springer Science + Business Media

    Dr Eric Verdin

  116. The restricted nature of HIV-1 tropism for cultured neural cells

    Article • Virology, December 1992, Elsevier

    Dr Eric Verdin

  117. Persistent infection with a nontransforming RNA virus leads to impaired growth factor receptors and response

    Article • Journal of Cellular Physiology, September 1986, Wiley

    Dr Eric Verdin

  118. Insulin Oscillations per se Do Not Affect Glucose Turnover Parameters in Normal Man*

    Article • The Journal of Clinical Endocrinology & Metabolism, August 1986, Endocrine Society

    Dr Eric Verdin