All Stories

  1. Screening of Preselected Libraries TargetingMycobacterium abscessusfor Drug Discovery

    Article • Antimicrobial Agents and Chemotherapy, July 2018, ASM Journals

    Professor Yossef Av-Gay

  2. Biophysical Characterization of the Tandem FHA Domain Regulatory Module from the Mycobacterium tuberculosis ABC Transporter Rv1747

    Article • Structure, July 2018, Elsevier

    Professor Yossef Av-Gay

  3. Synthesis, antimycobacterial activity and influence on mycobacterial InhA and PknB of 12-membered cyclodepsipeptides

    Article • Bioorganic & Medicinal Chemistry, July 2018, Elsevier

    Professor Yossef Av-Gay

  4. Protein tyrosine kinase, PtkA, is required for Mycobacterium tuberculosis growth in macrophages

    Article • Scientific Reports, January 2018, Nature

    Professor Yossef Av-Gay, Clement Tsui

  5. Nitric oxide inhalations in bronchiolitis: A pilot, randomized, double-blinded, controlled trial

    Article • Pediatric Pulmonology, November 2017, Wiley

    Professor Yossef Av-Gay

  6. Genome Sequences of the Mycobacterium tuberculosis H37Rv-ptkA Deletion Mutant and Its Parental Strain

    Article • Genome Announcements, November 2017, ASM Journals

    Professor Yossef Av-Gay, Clement Tsui

  7. Nitric oxide charged catheters as a potential strategy for prevention of hospital acquired infections

    Article • PLoS ONE, April 2017, PLOS

    Professor Yossef Av-Gay

  8. System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis

    Article • Journal of Visualized Experiments, April 2017, MyJove Corporation

    Professor Yossef Av-Gay

  9. Epigenetic Phosphorylation Control of Mycobacterium tuberculosis Infection and Persistence

    Article • Microbiology Spectrum, April 2017, ASM Journals

    Professor Yossef Av-Gay

  10. Aminorifamycins and Sporalactams Produced in Culture by a Micromonospora sp. Isolated from a Northeastern-Pacific Marine Sediment Are Potent Antibiotics

    Article • Organic Letters, February 2017, American Chemical Society (ACS)

    Professor Yossef Av-Gay

  11. Ergothioneine Maintains Redox and Bioenergetic Homeostasis Essential for Drug Susceptibility and Virulence of Mycobacterium tuberculosis

    Article • Cell Reports, January 2016, Elsevier

    Professor Yossef Av-Gay

  12. Intracellular Growth of Bacterial Pathogens: The Role of Secreted Effector Proteins in the Control of Phagocytosed Microorganisms

    Article • Microbiology Spectrum, December 2015, ASM Journals

    Professor Yossef Av-Gay

  13. Phosphorylation of Mycobacterium tuberculosis protein tyrosine kinase A PtkA by Ser/Thr protein kinases

    Article • Biochemical and Biophysical Research Communications, November 2015, Elsevier

    Professor Yossef Av-Gay

  14. Development of an Intracellular Screen for New Compounds Able To Inhibit Mycobacterium tuberculosis Growth in Human Macrophages

    Article • Antimicrobial Agents and Chemotherapy, October 2015, ASM Journals

    Professor Yossef Av-Gay

  15. Regulation of Ergothioneine Biosynthesis and Its Effect on Mycobacterium tuberculosis Growth and Infectivity

    Article • Journal of Biological Chemistry, July 2015, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Yossef Av-Gay

  16. Immunoevasion and immunosuppression of the macrophage byMycobacterium tuberculosis

    Article • Immunological Reviews, February 2015, Wiley

    Professor Yossef Av-Gay

  17. Phosphorylation control of protein tyrosine phosphatase A activity in Mycobacterium tuberculosis

    Article • FEBS Letters, December 2014, Wiley

    Professor Yossef Av-Gay

  18. Mycobacterium tuberculosis Promotes Anti-apoptotic Activity of the Macrophage by PtpA Protein-dependent Dephosphorylation of Host GSK3α

    Article • Journal of Biological Chemistry, September 2014, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Yossef Av-Gay

  19. Microbial Protein-tyrosine Kinases

    Article • Journal of Biological Chemistry, February 2014, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Yossef Av-Gay

  20. Sydowiols A–C: Mycobacterium tuberculosis protein tyrosine phosphatase inhibitors from an East China Sea marine-derived fungus, Aspergillus sydowii

    Article • Tetrahedron Letters, November 2013, Elsevier

    Professor Yossef Av-Gay

  21. Mycobacterium tuberculosis Nucleoside Diphosphate Kinase Inactivates Small GTPases Leading to Evasion of Innate Immunity

    Article • PLoS Pathogens, July 2013, PLOS

    Professor Yossef Av-Gay

  22. Chemical constituents, anti-inflammatory and antioxidant activities of bark extracts fromPrunus tucumanensisLillo

    Article • Natural Product Research, May 2013, Taylor & Francis

    Professor Yossef Av-Gay

  23. Gaseous nitric oxide reduces influenza infectivity in vitro

    Article • Nitric Oxide, May 2013, Elsevier

    Professor Yossef Av-Gay

  24. Antimicrobial activity, cytotoxicity and inflammatory response of novel plastics embedded with silver nanoparticles

    Article • Future Microbiology, March 2013, Future Medicine

    Professor Yossef Av-Gay

  25. Disruption of the serine/threonine protein kinase H affects phthiocerol dimycocerosates synthesis in Mycobacterium tuberculosis

    Article • Microbiology, February 2013, Society for General Microbiology

    Professor Yossef Av-Gay

  26. Mycobacterium tuberculosis-secreted phosphatases: from pathogenesis to targets for TB drug development

    Article • Trends in Microbiology, February 2013, Elsevier

    Professor Yossef Av-Gay

  27. Mycobacterium tuberculosis modulators of the macrophage's cellular events

    Article • Microbes and Infection, November 2012, Elsevier

    Professor Yossef Av-Gay

  28. A phase I clinical study of inhaled nitric oxide in healthy adults

    Article • Journal of Cystic Fibrosis, July 2012, Elsevier

    Professor Yossef Av-Gay

  29. Nitazoxanide Stimulates Autophagy and Inhibits mTORC1 Signaling and Intracellular Proliferation of Mycobacterium tuberculosis

    Article • PLoS Pathogens, May 2012, PLOS

    Professor Yossef Av-Gay

  30. Antibacterial activity, inflammatory response, coagulation and cytotoxicity effects of silver nanoparticles

    Article • Nanomedicine Nanotechnology Biology and Medicine, April 2012, Elsevier

    Professor Yossef Av-Gay

  31. Antimicrobial, Anti-Inflammatory, Antiparasitic, and Cytotoxic Activities of Laennecia confusa

    Article • The Scientific World JOURNAL, January 2012, Hindawi Publishing Corporation

    Professor Yossef Av-Gay

  32. Antimicrobial activities of sesquiterpene lactones and inositol derivatives from Hymenoxys robusta

    Article • Phytochemistry, December 2011, Elsevier

    Professor Yossef Av-Gay

  33. Mycobacterium tuberculosis protein tyrosine phosphatase (PtpA) excludes host vacuolar-H + –ATPase to inhibit phagosome acidification

    Article • Proceedings of the National Academy of Sciences, November 2011, Proceedings of the National Academy of Sciences

    Professor Yossef Av-Gay

  34. The Mycobacterial Transcriptional Regulator whiB7 Gene Links Redox Homeostasis and Intrinsic Antibiotic Resistance

    Article • Journal of Biological Chemistry, November 2011, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Yossef Av-Gay

  35. Antimicrobial, anti-inflammatory, antiparasitic, and cytotoxic activities of Galium mexicanum

    Article • Journal of Ethnopharmacology, September 2011, Elsevier

    Professor Yossef Av-Gay

  36. Reply

    Article • Urology, August 2011, Elsevier

    Professor Yossef Av-Gay

  37. Comparative Efficacy of Commercially Available and Emerging Antimicrobial Urinary Catheters Against Bacteriuria Caused by E. coli In Vitro

    Article • Urology, August 2011, Elsevier

    Professor Yossef Av-Gay

  38. Coresistance to Isoniazid and Ethionamide Maps to Mycothiol Biosynthetic Genes in Mycobacterium bovis

    Article • Antimicrobial Agents and Chemotherapy, June 2011, ASM Journals

    Professor Yossef Av-Gay

  39. Synergistic Drug Combinations for Tuberculosis Therapy Identified by a Novel High-Throughput Screen

    Article • Antimicrobial Agents and Chemotherapy, May 2011, ASM Journals

    Santiago Ramon Garcia, Professor Yossef Av-Gay

  40. Prospects for TB Therapeutics TargetingMycobacterium tuberculosisPhosphosignaling Networks

    Article • May 2011, Wiley

    Professor Yossef Av-Gay

  41. Precise Null Deletion Mutations of the Mycothiol Synthesis Genes Reveal Their Role in Isoniazid and Ethionamide Resistance in Mycobacterium smegmatis

    Article • Antimicrobial Agents and Chemotherapy, April 2011, ASM Journals

    Professor Yossef Av-Gay

  42. Synthesis, characterization, and evaluation of antimicrobial and cytotoxic effect of silver and titanium nanoparticles

    Article • Nanomedicine Nanotechnology Biology and Medicine, October 2010, Elsevier

    Professor Yossef Av-Gay

  43. Antimycobacterial activity of UDP-galactopyranose mutase inhibitors

    Article • International Journal of Antimicrobial Agents, October 2010, Elsevier

    Professor Yossef Av-Gay

  44. MmpS4 promotes glycopeptidolipids biosynthesis and export in Mycobacterium smegmatis

    Article • Molecular Microbiology, September 2010, Wiley

    Professor Yossef Av-Gay

  45. Convergence of Ser/Thr and Two-component Signaling to Coordinate Expression of the Dormancy Regulon in Mycobacterium tuberculosis

    Article • Journal of Biological Chemistry, July 2010, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Yossef Av-Gay

  46. Inhibition of Mycobacterium tuberculosis tyrosine phosphatase PtpA by synthetic chalcones: Kinetics, molecular modeling, toxicity and effect on growth

    Article • Bioorganic & Medicinal Chemistry, June 2010, Elsevier

    Professor Yossef Av-Gay, Prof. Dr. RAFAEL VICTORIO CARVALHO GUIDO

  47. Protein kinase and phosphatase signaling in Mycobacterium tuberculosis physiology and pathogenesis

    Article • Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, March 2010, Elsevier

    Professor Yossef Av-Gay

  48. Inositol monophosphate phosphatase genes of Mycobacterium tuberculosis

    Article • BMC Microbiology, January 2010, Springer Science + Business Media

    Professor Yossef Av-Gay

  49. Slow Release of Nitric Oxide from Charged Catheters and Its Effect on Biofilm Formation by Escherichia coli

    Article • Antimicrobial Agents and Chemotherapy, November 2009, ASM Journals

    Professor Yossef Av-Gay

  50. Glutathione disulfide and S-nitrosoglutathione detoxification byMycobacteriumtuberculosisthioredoxin system

    Article • FEBS Letters, September 2009, Wiley

    Professor Yossef Av-Gay

  51. Mycobacterium tuberculosis PtkA is a novel protein tyrosine kinase whose substrate is PtpA

    Article • Biochemical Journal, June 2009, Portland Press Ltd.

    Professor Yossef Av-Gay

  52. The serine/threonine protein kinase PknI controls the growth of Mycobacterium tuberculosis upon infection

    Article • FEMS Microbiology Letters, June 2009, Oxford University Press (OUP)

    Professor Yossef Av-Gay

  53. Gaseous nitric oxide bactericidal activity retained during intermittent high-dose short duration exposure

    Article • Nitric Oxide, February 2009, Elsevier

    Professor Yossef Av-Gay

  54. Signalling Inhibitors Against Mycobacterium tuberculosis – Early Days of a New Therapeutic Concept in Tuberculosis

    Article • Current Medicinal Chemistry, November 2008, Bentham Science Publishers

    Professor Yossef Av-Gay

  55. Mycothiol biosynthesis is essential for ethionamide susceptibility inMycobacterium tuberculosis

    Article • Molecular Microbiology, September 2008, Wiley

    Professor Yossef Av-Gay

  56. Mycobacterium tuberculosis Virulence Is Mediated by PtpA Dephosphorylation of Human Vacuolar Protein Sorting 33B

    Article • Cell Host & Microbe, May 2008, Elsevier

    Professor Yossef Av-Gay

  57. Molecular cloning and biochemical characterization of a serine threonine protein kinase, PknL, from Mycobacterium tuberculosis

    Article • Protein Expression and Purification, April 2008, Elsevier

    Professor Yossef Av-Gay

  58. Mycobacterium smegmatis biofilm formation and sliding motility are affected by the serine/threonine protein kinase PknF

    Article • FEMS Microbiology Letters, January 2008, Oxford University Press (OUP)

    Professor Yossef Av-Gay

  59. Comparative analysis of mutants in the mycothiol biosynthesis pathway in Mycobacterium smegmatis

    Article • Biochemical and Biophysical Research Communications, November 2007, Elsevier

    Professor Yossef Av-Gay

  60. Mycobacterium bovis Bacillus Calmette-Guerin Secreting Active Cathepsin S Stimulates Expression of Mature MHC Class II Molecules and Antigen Presentation in Human Macrophages

    Article • The Journal of Immunology, October 2007, The American Association of Immunologists

    Professor Yossef Av-Gay

  61. Lipoamide dehydrogenase mediates retention of coronin-1 on BCG vacuoles, leading to arrest in phagosome maturation

    Article • Journal of Cell Science, October 2007, The Company of Biologists

    Professor Yossef Av-Gay

  62. Lipoamide dehydrogenase mediates retention of coronin-1 on BCG vacuoles, leading to arrest in phagosome maturation

    Article • Journal of Cell Science, August 2007, The Company of Biologists

    Professor Yossef Av-Gay

  63. Innate Protection of Mycobacterium smegmatis against the Antimicrobial Activity of Nitric Oxide Is Provided by Mycothiol

    Article • Antimicrobial Agents and Chemotherapy, July 2007, ASM Journals

    Professor Yossef Av-Gay

  64. Mycothiol-dependent proteins in actinomycetes

    Article • FEMS Microbiology Reviews, April 2007, Oxford University Press (OUP)

    Professor Yossef Av-Gay

  65. Novel substrates of Mycobacterium tuberculosis PknH Ser/Thr kinase

    Article • Biochemical and Biophysical Research Communications, March 2007, Elsevier

    Professor Yossef Av-Gay

  66. Mycobacterium avium subsp. paratuberculosis PtpA Is an Endogenous Tyrosine Phosphatase Secreted during Infection

    Article • Infection and Immunity, September 2006, ASM Journals

    Professor Yossef Av-Gay

  67. Mycobacterium tuberculosis transporter MmpL7 is a potential substrate for kinase PknD

    Article • Biochemical and Biophysical Research Communications, September 2006, Elsevier

    Professor Yossef Av-Gay, Jacobus de Waard

  68. Purification and characterization of Mycobacterium tuberculosis 1d-myo-inosityl-2-acetamido-2-deoxy-α-d-glucopyranoside deacetylase, MshB, a mycothiol biosynthetic enzyme

    Article • Protein Expression and Purification, June 2006, Elsevier

    Professor Yossef Av-Gay

  69. Mycothiol-dependent mycobacterial response to oxidative stress

    Article • FEBS Letters, April 2006, Wiley

    Professor Yossef Av-Gay

  70. In vitro properties of antimicrobial bromotyrosine alkaloids

    Article • Journal of Medical Microbiology, April 2006, Society for General Microbiology

    Professor Yossef Av-Gay

  71. Mycobacterial manipulation of the host cell

    Article • FEMS Microbiology Reviews, November 2005, Oxford University Press (OUP)

    Professor Yossef Av-Gay

  72. Mycobacterium bovis BCG Attenuates Surface Expression of Mature Class II Molecules through IL-10-Dependent Inhibition of Cathepsin S

    Article • The Journal of Immunology, October 2005, The American Association of Immunologists

    Professor Yossef Av-Gay

  73. Deletion of the Mycobacterium tuberculosis pknH Gene Confers a Higher Bacillary Load during the Chronic Phase of Infection in BALB/c Mice

    Article • Journal of Bacteriology, August 2005, ASM Journals

    Professor Yossef Av-Gay

  74. Thiol specific oxidative stress response in Mycobacteria

    Article • FEMS Microbiology Letters, August 2005, Oxford University Press (OUP)

    Professor Yossef Av-Gay

  75. Two-Component Systems, Protein Kinases, and Signal Transduction in Mycobacterium tuberculosis

    Article • January 2005, ASM Journals

    Professor Yossef Av-Gay

  76. Targeted Mutagenesis of the Mycobacterium smegmatis mca Gene, Encoding a Mycothiol-Dependent Detoxification Protein

    Article • Journal of Bacteriology, September 2004, ASM Journals

    Professor Yossef Av-Gay

  77. The Mycobacterium tuberculosis protein serine/threonine kinase PknG is linked to cellular glutamate/glutamine levels and is important for growth in vivo

    Article • Molecular Microbiology, May 2004, Wiley

    Professor Yossef Av-Gay

  78. Development of a Liposome Formulation of Ethambutol

    Article • Antimicrobial Agents and Chemotherapy, May 2004, ASM Journals

    Professor Yossef Av-Gay

  79. Screening of compounds toxicity against human Monocytic cell line-THP-1 by flow cytometry

    Article • Biological Procedures Online, January 2004, Springer Science + Business Media

    Professor Yossef Av-Gay

  80. The Mycobacterium tuberculosis ino1 gene is essential for growth and virulence

    Article • Molecular Microbiology, December 2003, Wiley

    Professor Yossef Av-Gay

  81. Kinome Analysis of Host Response to Mycobacterial Infection: a Novel Technique in Proteomics

    Article • Infection and Immunity, October 2003, ASM Journals

    Professor Yossef Av-Gay

  82. Characterization of Mycobacterium tuberculosis Mycothiol S -Conjugate Amidase †

    Article • Biochemistry, October 2003, American Chemical Society (ACS)

    Professor Yossef Av-Gay

  83. The Crystal Structure of 1-D-myo-Inosityl 2-Acetamido-2-deoxy- -D-glucopyranoside Deacetylase (MshB) from Mycobacterium tuberculosis Reveals a Zinc Hydrolase with a Lactate Dehydrogenase Fold

    Article • Journal of Biological Chemistry, September 2003, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Yossef Av-Gay

  84. The Glycosyltransferase Gene Encoding the Enzyme Catalyzing the First Step of Mycothiol Biosynthesis (mshA)

    Article • Journal of Bacteriology, June 2003, ASM Journals

    Professor Yossef Av-Gay

  85. Inactivation of mshB, a key gene in the mycothiol biosynthesis pathway in Mycobacterium smegmatis

    Article • Microbiology, May 2003, Society for General Microbiology

    Professor Yossef Av-Gay

  86. Identification and characterization of a diamide sensitive mutant of Mycobacterium smegmatis

    Article • FEMS Microbiology Letters, March 2003, Oxford University Press (OUP)

    Professor Yossef Av-Gay

  87. Mycothiol-Deficient Mycobacterium smegmatis Mutants Are Hypersensitive to Alkylating Agents, Free Radicals, and Antibiotics

    Article • Antimicrobial Agents and Chemotherapy, November 2002, ASM Journals

    Professor Yossef Av-Gay

  88. Evidence That Plant-Like Genes in Chlamydia Species Reflect an Ancestral Relationship between Chlamydiaceae, Cyanobacteria, and the Chloroplast

    Article • Genome Research, July 2002, Cold Spring Harbor Laboratory Press

    Professor Yossef Av-Gay

  89. Expression and localization of the Mycobacterium tuberculosis protein tyrosine phosphatase PtpA

    Article • Research in Microbiology, May 2002, Elsevier

    Professor Yossef Av-Gay

  90. A protein kinase inhibitor as an antimycobacterial agent

    Article • FEMS Microbiology Letters, December 2001, Oxford University Press (OUP)

    Professor Yossef Av-Gay

  91. Monitoring promoter activity and protein localization in Mycobacterium spp. using green fluorescent protein

    Article • Gene, February 2001, Elsevier

    Professor Yossef Av-Gay

  92. N-Acetyl-1-d-myo-Inosityl-2-Amino-2-Deoxy-α-d-Glucopyranoside Deacetylase (MshB) Is a Key Enzyme in Mycothiol Biosynthesis

    Article • Journal of Bacteriology, December 2000, ASM Journals

    Professor Yossef Av-Gay

  93. A Novel Mycothiol-Dependent Detoxification Pathway in Mycobacteria Involving Mycothiol S -Conjugate Amidase †

    Article • Biochemistry, September 2000, American Chemical Society (ACS)

    Professor Yossef Av-Gay

  94. Cholesterol is accumulated by mycobacteria but its degradation is limited to non-pathogenic fast-growing mycobacteria

    Article • Canadian Journal of Microbiology, September 2000, Canadian Science Publishing

    Professor Yossef Av-Gay

  95. The eukaryotic-like Ser/Thr protein kinases of Mycobacterium tuberculosis

    Article • Trends in Microbiology, May 2000, Elsevier

    Professor Yossef Av-Gay

  96. Cholesterol is accumulated by mycobacteria but its degradation is limited to non-pathogenic fast-growing mycobacteria

    Article • Canadian Journal of Microbiology, January 2000, Canadian Science Publishing

    Professor Yossef Av-Gay

  97. Species identification and phylogenetic relationships based on partial HSP60 gene sequences within the genus Staphylococcus

    Article • International Journal of Systematic Bacteriology, July 1999, Society for General Microbiology

    Professor Yossef Av-Gay

  98. Uncontrolled Release of Harmful Microorganisms

    Article • Science, June 1999, American Association for the Advancement of Science

    Professor Yossef Av-Gay

  99. Characterization ofMycobacterium smegmatisMutants Defective in 1-d-myo-Inosityl-2-amino-2-deoxy-α-d-glucopyranoside and Mycothiol Biosynthesis

    Article • Biochemical and Biophysical Research Communications, February 1999, Elsevier

    Professor Yossef Av-Gay

  100. Gene organization in the trxA/B–oriC region of the Streptomyces coelicolor chromosome and comparison with other eubacteria

    Article • Gene, September 1998, Elsevier

    Professor Yossef Av-Gay

  101. Components of Eukaryotic-like Protein Signaling Pathways in Mycobacterium tuberculosis

    Article • Microbial & Comparative Genomics, January 1997, Mary Ann Liebert Inc

    Professor Yossef Av-Gay

  102. Streptomyces contain a 7.0 kDa cold shock like protein

    Article • Nucleic Acids Research, January 1992, Oxford University Press (OUP)

    Professor Yossef Av-Gay

  103. High level expression in Escherichia coli of isopenicillin N synthase genes from Flavobacterium and Streptomyces , and recovery of active enzyme from inclusion bodies

    Article • FEMS Microbiology Letters, December 1991, Oxford University Press (OUP)

    Professor Yossef Av-Gay

  104. High level expression in Escherichia coli of isopenicillin N synthase genes from Flavobacterium and Streptomyces, and recovery of active enzyme from inclusion bodies

    Article • FEMS Microbiology Letters, December 1991, Oxford University Press (OUP)

    Professor Yossef Av-Gay