All Stories

  1. Higher-order structure and conformational change in biopharmaceuticals

    Article • Journal of Chemical Technology & Biotechnology, June 2018, Wiley

    Dr David Gervais

  2. Robust quantitation of basic-protein higher-order aggregates using size-exclusion chromatography

    Article • Journal of Pharmaceutical and Biomedical Analysis, May 2017, Elsevier

    Dr David Gervais

  3. Understanding the process-induced formation of minor conformational variants of Erwinia chrysanthemi l-asparaginase

    Article • Enzyme and Microbial Technology, March 2017, Elsevier

    Dr David Gervais

  4. Protein deamidation in biopharmaceutical manufacture: understanding, control and impact

    Article • Journal of Chemical Technology & Biotechnology, December 2015, Wiley

    Dr David Gervais

  5. Structural Characterisation of Non-Deamidated Acidic Variants of Erwinia chrysanthemi L-asparaginase Using Small-Angle X-ray Scattering and Ion-Mobility Mass Spectrometry

    Article • Pharmaceutical Research, June 2015, Springer Science + Business Media

    Dr David Gervais

  6. Capillary isoelectric focusing of a difficult-to-denature tetrameric enzyme using alkylurea–urea mixtures

    Article • Analytical Biochemistry, November 2014, Elsevier

    Dr David Gervais

  7. Recombinant Deamidated Mutants of Erwinia chrysanthemi l-Asparaginase Have Similar or Increased Activity Compared to Wild-Type Enzyme

    Article • Molecular Biotechnology, May 2014, Springer Science + Business Media

    Dr David Gervais

  8. Measurement of Subvisible Particulates in Lyophilised Erwinia chrysanthemi l-asparaginase and Relationship with Clinical Experience

    Article • The AAPS Journal, May 2014, American Association of Pharmaceutical Scientists (AAPS)

    Dr David Gervais

  9. Control of process-induced asparaginyl deamidation during manufacture of Erwinia chrysanthemi l-asparaginase

    Article • Process Biochemistry, September 2013, Elsevier

    Dr David Gervais

  10. Validation of a 30-year-old process for the manufacture of l-asparaginase from Erwinia chrysanthemi

    Article • Bioprocess and Biosystems Engineering, August 2012, Springer Science + Business Media

    Dr David Gervais

  11. Study of radial compression high-performance liquid chromatographic columns for preparative chromatography

    Article • Journal of Chromatography A, July 1995, Elsevier

    Dr David Gervais