All Stories

  1. Accounting for variability in ion current recordings using a mathematical model of artefacts in voltage-clamp experiments

    Article • December 2019, Cold Spring Harbor Laboratory Press

    Dr Gary R Mirams

  2. Selective recruitment of different Ca2+-dependent transcription factors by STIM1-Orai1 channel clusters

    Article • Nature Communications, June 2019, Springer Science + Business Media

    Dr Gary R Mirams

  3. Defining vitamin D status using multi-metabolite mathematical modelling: A pregnancy perspective

    Article • The Journal of Steroid Biochemistry and Molecular Biology, June 2019, Elsevier

    Dr Gary R Mirams

  4. Four ways to fit an ion channel model

    Article • April 2019, Cold Spring Harbor Laboratory Press

    Dr Gary R Mirams

  5. Rapid characterisation of hERG channel kinetics I: using an automated high-throughput system

    Article • April 2019, Cold Spring Harbor Laboratory Press

    Dr Gary R Mirams

  6. Rapid characterisation of hERG channel kinetics II: temperature dependence

    Article • April 2019, Cold Spring Harbor Laboratory Press

    Dr Gary R Mirams

  7. Probabilistic Inference on Noisy Time Series (PINTS)

    Article • Journal of Open Research Software, January 2019, Ubiquity Press, Ltd.

    Dr Gary R Mirams

  8. Representation of Multiple Cellular Phenotypes Within Tissue-Level Simulations of Cardiac Electrophysiology

    Article • Bulletin of Mathematical Biology, October 2018, Springer Science + Business Media

    Dr Gary R Mirams

  9. Reproducible model development in the cardiac electrophysiology Web Lab

    Article • Progress in Biophysics and Molecular Biology, May 2018, Elsevier

    Dr Gary R Mirams

  10. Sinusoidal voltage protocols for rapid characterisation of ion channel kinetics

    Article • The Journal of Physiology, April 2018, Wiley

    Dr Gary R Mirams

  11. Reproducible model development in the Cardiac Electrophysiology Web Lab

    Article • January 2018, Cold Spring Harbor Laboratory Press

    Dr Gary R Mirams

  12. Nonclinical cardiovascular safety of pitolisant: comparing International Conference on Harmonization S7B and Comprehensive in vitro Pro-arrhythmia Assay initiative studies

    Article • British Journal of Pharmacology, October 2017, Wiley

    Dr Gary R Mirams

  13. Early afterdepolarisation tendency as a simulated pro-arrhythmic risk indicator

    Article • August 2017, Cold Spring Harbor Laboratory Press

    Dr Gary R Mirams

  14. Sinusoidal Voltage Protocols For Rapid Characterisation Of Ion Channel Kinetics

    Article • March 2017, Cold Spring Harbor Laboratory Press

    Dr Gary R Mirams

  15. Hierarchical Bayesian inference for ion channel screening dose-response data

    Article • Wellcome Open Research, March 2017, Faculty of 1000, Ltd.

    Dr Gary R Mirams

  16. Early afterdepolarisation tendency as a simulated pro-arrhythmic risk indicator

    Article • Toxicology Research, January 2017, Oxford University Press (OUP)

    Dr Gary R Mirams

  17. Hierarchical Bayesian inference for ion channel screening dose-response data

    Article • Wellcome Open Research, November 2016, Faculty of 1000, Ltd.

    Dr Gary R Mirams

  18. Hierarchical Bayesian Modelling of Variability and Uncertainty in Synthetic Action Potential Traces

    Article • September 2016, Computing in Cardiology

    Dr Gary R Mirams

  19. Exploring temperature-dependence of hERG channel kinetics using sine wave voltage protocols

    Article • Journal of Pharmacological and Toxicological Methods, September 2016, Elsevier

    Dr Gary R Mirams

  20. Uncertainty and variability in models of the cardiac action potential: Can we build trustworthy models?

    Article • Journal of Molecular and Cellular Cardiology, July 2016, Elsevier

    Dr Gary R Mirams

  21. Computational cardiology and risk stratification for sudden cardiac death: one of the grand challenges for cardiology in the 21st century

    Article • The Journal of Physiology, June 2016, Wiley

    Dr Gary R Mirams

  22. Uncertainty and variability in computational and mathematical models of cardiac physiology

    Article • The Journal of Physiology, June 2016, Wiley

    Dr Gary R Mirams

  23. Recent developments in using mechanistic cardiac modelling for drug safety evaluation

    Article • Drug Discovery Today, June 2016, Elsevier

    Dr Gary R Mirams

  24. The Cardiac Electrophysiology Web Lab

    Article • Biophysical Journal, January 2016, Elsevier

    Dr Gary R Mirams

  25. Hydroxychloroquine reduces heart rate by modulating the hyperpolarization-activated current If: Novel electrophysiological insights and therapeutic potential

    Article • Heart Rhythm, October 2015, Elsevier

    Dr Gary R Mirams

  26. Voltage protocol design for determining hERG channel kinetics

    Article • Journal of Pharmacological and Toxicological Methods, September 2015, Elsevier

    Dr Gary R Mirams

  27. A web portal for in-silico action potential predictions

    Article • Journal of Pharmacological and Toxicological Methods, September 2015, Elsevier

    Dr Gary R Mirams

  28. Ca2+ Channel Re-localization to Plasma-Membrane Microdomains Strengthens Activation of Ca2+-Dependent Nuclear Gene Expression

    Article • Cell Reports, July 2015, Elsevier

    Dr Gary R Mirams

  29. Cardiac tissue slices: preparation, handling, and successful optical mapping

    Article • AJP Heart and Circulatory Physiology, January 2015, American Physiological Society

    Dr Gary R Mirams

  30. Cellular cardiac electrophysiology modeling with Chaste and CellML

    Article • Frontiers in Physiology, January 2015, Frontiers

    Dr Gary R Mirams

  31. Novel Voltage Protocols for Determining hERG Channel Kinetics

    Article • Biophysical Journal, January 2015, Elsevier

    Dr Gary R Mirams

  32. Application of stochastic phenomenological modelling to cell-to-cell and beat-to-beat electrophysiological variability in cardiac tissue

    Article • Journal of Theoretical Biology, January 2015, Elsevier

    Dr Gary R Mirams

  33. Prediction of Thorough QT study results using action potential simulations based on ion channel screens

    Article • Journal of Pharmacological and Toxicological Methods, November 2014, Elsevier

    Dr Gary R Mirams

  34. In silico pro-arrhythmia assessment: Can the results of the thorough QT study be predicted?

    Article • Journal of Pharmacological and Toxicological Methods, November 2014, Elsevier

    Dr Gary R Mirams

  35. Ten Simple Rules for Effective Computational Research

    Article • PLoS Computational Biology, March 2014, PLOS

    Derek Groen, Dr Alexander G Fletcher, Dr Gary R Mirams, Dr Derek Groen, Dr Christian Adam Yates

  36. Spatiotemporal Transitions in Cardiac Neuronal Co-Cultures

    Article • Biophysical Journal, January 2014, Elsevier

    Dr Gary R Mirams

  37. Evaluation of computational modelling as a preclinical proarrhythmic safety assay

    Article • Journal of Pharmacological and Toxicological Methods, July 2013, Elsevier

    Dr Gary R Mirams

  38. Variability in high-throughput ion-channel screening data and consequences for cardiac safety assessment

    Article • Journal of Pharmacological and Toxicological Methods, July 2013, Elsevier

    Dr Gary R Mirams

  39. Evaluation of an in silico cardiac safety assay: Using ion channel screening data to predict QT interval changes in the rabbit ventricular wedge

    Article • Journal of Pharmacological and Toxicological Methods, July 2013, Elsevier

    Dr Gary R Mirams

  40. Chaste: An Open Source C++ Library for Computational Physiology and Biology

    Article • PLoS Computational Biology, March 2013, PLOS

    Dr Alexander G Fletcher, Dr Nejib Zemzemi, Dr Gary R Mirams

  41. mRNA Expression Levels in Failing Human Hearts Predict Cellular Electrophysiological Remodeling: A Population-Based Simulation Study

    Article • PLoS ONE, February 2013, PLOS

    Dr Gary R Mirams

  42. A local sensitivity analysis method for developing biological models with identifiable parameters: Application to cardiac ionic channel modelling

    Article • Future Generation Computer Systems, February 2013, Elsevier

    Dr Gary R Mirams

  43. Computational assessment of drug‐induced effects on the electrocardiogram: from ion channel to body surface potentials

    Article • British Journal of Pharmacology, January 2013, Wiley

    Dr Nejib Zemzemi, Dr Gary R Mirams

  44. Estimation of Conductivity Tensors from Human Ventricular Optical Mapping Recordings

    Article • January 2013, Springer Science + Business Media

    Dr Gary R Mirams

  45. A theoretical investigation of the effect of proliferation and adhesion on monoclonal conversion in the colonic crypt

    Article • Journal of Theoretical Biology, November 2012, Elsevier

    Dr Alexander G Fletcher, Dr Gary R Mirams

  46. Application of cardiac electrophysiology simulations to pro‐arrhythmic safety testing

    Article • British Journal of Pharmacology, October 2012, Wiley

    Dr Gary R Mirams

  47. Application of human stem cell-derived cardiomyocytes in safety pharmacology requires caution beyond hERG

    Article • Journal of Molecular and Cellular Cardiology, May 2012, Elsevier

    Dr Gary R Mirams

  48. Stochasticity in Action Potential duration Enhances Dispersion of Repolarisation at Fast Pacing Rates

    Article • Biophysical Journal, January 2012, Elsevier

    Dr Gary R Mirams

  49. Distinguishing possible mechanisms for auxin-mediated developmental control in Arabidopsis: Models with two Aux/IAA and ARF proteins, and two target gene-sets

    Article • Mathematical Biosciences, January 2012, Elsevier

    Dr Gary R Mirams

  50. Is it time for in silico simulation of drug cardiac side effects?

    Article • Annals of the New York Academy of Sciences, December 2011, Wiley

    Dr Gary R Mirams

  51. Minimum Information about a Cardiac Electrophysiology Experiment (MICEE): Standardised reporting for model reproducibility, interoperability, and data sharing

    Article • Progress in Biophysics and Molecular Biology, October 2011, Elsevier

    Dr Gary R Mirams, Professor Jose Jalife

  52. High-throughput functional curation of cellular electrophysiology models

    Article • Progress in Biophysics and Molecular Biology, October 2011, Elsevier

    Dr Gary R Mirams

  53. Functional Curation: Potential Future Directions for SED-ML

    Article • Nature Reports Climate Change, September 2011, Nature

    Dr Gary R Mirams

  54. Functional Curation: Potential Future Directions for SED-ML

    Article • Nature Reports Climate Change, September 2011, Nature

    Dr Gary R Mirams

  55. Novel Approaches to Assessing Cardiac Safety – Proceedings of a Workshop

    Article • Drug Safety, May 2011, Springer Science + Business Media

    Dr Gary R Mirams

  56. The significant effect of the choice of ionic current integration method in cardiac electro-physiological simulations

    Article • International Journal for Numerical Methods in Biomedical Engineering, March 2011, Wiley

    Dr Gary R Mirams

  57. Simulation of multiple ion channel block provides improved early prediction of compounds’ clinical torsadogenic risk

    Article • Cardiovascular Research, February 2011, European Society of Cardiology

    Dr Gary R Mirams

  58. Multiscale Modeling of Colonic Crypts and Early Colorectal Cancer

    Article • December 2010, Taylor & Francis

    Dr Gary R Mirams

  59. A Local Sensitivity Analysis Method for Developing Biological Models with Identifiable Parameters: Application to L-type Calcium Channel Modelling

    Article • December 2010, Institute of Electrical & Electronics Engineers (IEEE)

    Dr Gary R Mirams

  60. A hybrid approach to multi-scale modelling of cancer

    Article • Philosophical Transactions of the Royal Society A Mathematical Physical and Engineering Sciences, October 2010, Royal Society Publishing

    Oliver Jensen, Dr Gary R Mirams

  61. Phenomenological modeling of cell-to-cell and beat-to-beat variability in isolated Guinea Pig ventricular myocytes

    Article • August 2010, Institute of Electrical & Electronics Engineers (IEEE)

    Dr Gary R Mirams

  62. Modelling Spatially Regulated β-Catenin Dynamics and Invasion in Intestinal Crypts

    Article • Biophysical Journal, August 2010, Elsevier

    Dr Gary R Mirams

  63. Chaste: A test-driven approach to software development for biological modelling

    Article • Computer Physics Communications, December 2009, Elsevier

    Dr Alexander G Fletcher, Dr Gary R Mirams

  64. An integrative computational model for intestinal tissue renewal

    Article • Cell Proliferation, October 2009, Wiley

    Dr Alexander G Fletcher, Oliver Jensen, Dr Gary R Mirams

  65. A computational study of discrete mechanical tissue models

    Article • Physical Biology, April 2009, Institute of Physics Publishing

    Dr Alexander G Fletcher, Dr Gary R Mirams

  66. A multiple timescale analysis of a mathematical model of the Wnt/β-catenin signalling pathway

    Article • Journal of Mathematical Biology, March 2009, Springer Science + Business Media

    Dr Gary R Mirams

  67. Towards a multiscale model of colorectal cancer

    Article • Journal of Biomechanics, January 2006, Elsevier

    Dr Gary R Mirams