All Stories

  1. The structure of INI1/hSNF5 RPT1 and its interactions with the c-MYC:MAX heterodimer provide insights into the interplay between MYC and the SWI/SNF chromatin remodeling complex

    Article • FEBS Journal, October 2018, Wiley

    Dr Giovanna Zinzalla

  2. A selective high affinity MYC-binding compound inhibits MYC:MAX interaction and MYC-dependent tumor cell proliferation

    Article • Scientific Reports, July 2018, Springer Science + Business Media

    Dr Giovanna Zinzalla

  3. Targeting MYC: is it getting any easier?

    Article • Future Medicinal Chemistry, October 2016, Future Science

    Dr Giovanna Zinzalla

  4. A New Way Forward in Cancer Drug Discovery: Inhibiting the SWI/SNF Chromatin Remodelling Complex

    Article • ChemBioChem, January 2016, Wiley

    Dr Giovanna Zinzalla

  5. Zinzalla

    Article • Future Medicinal Chemistry, October 2015, Future Science

    Dr Giovanna Zinzalla

  6. Targeting protein–protein interactions (PPIs) of transcription factors: Challenges of intrinsically disordered proteins (IDPs) and regions (IDRs)

    Article • Progress in Biophysics and Molecular Biology, October 2015, Elsevier

    Dr Giovanna Zinzalla

  7. Solution Structure of the Smarc Domain

    Article • August 2015, Protein Data Bank, Rutgers University

    Dr Giovanna Zinzalla

  8. The SWI/SNF Subunit INI1 Contains an N-Terminal Winged Helix DNA Binding Domain that Is a Target for Mutations in Schwannomatosis

    Article • Structure, July 2015, Elsevier

    Dr Giovanna Zinzalla

  9. Tetracycline analogues with a selective inhibitory effect on HIF-1α

    Article • MedChemComm, January 2014, Royal Society of Chemistry

    Professor David Edwin Thurston, Dr Giovanna Zinzalla

  10. Investigation of the protein alkylation sites of the STAT3:STAT3 inhibitor Stattic by mass spectrometry

    Article • Bioorganic & Medicinal Chemistry Letters, August 2013, Elsevier

    Dr Khondaker Miraz Rahman, Dr Giovanna Zinzalla

  11. Small-Molecule Inhibition of c-MYC:MAX Leucine Zipper Formation Is Revealed by Ion Mobility Mass Spectrometry

    Article • Journal of the American Chemical Society, November 2012, American Chemical Society (ACS)

    Dr Giovanna Zinzalla

  12. Molecular Dynamics Studies of the STAT3 Homodimer:DNA Complex: Relationships between STAT3 Mutations and Protein–DNA Recognition

    Article • Journal of Chemical Information and Computer Sciences, May 2012, American Chemical Society (ACS)

    Dr Giovanna Zinzalla

  13. ChemInform Abstract: One-Pot Synthesis of Fused-Tetracyclic Scaffolds Employing a Lewis Acid Promoted Domino Reaction of Naphthoquinones.

    Article • ChemInform, October 2011, Wiley

    Dr Giovanna Zinzalla

  14. One-Pot Synthesis of Fused-Tetracyclic Scaffolds Employing a Lewis Acid Promoted Domino Reaction of Naphthoquinones

    Article • Synthesis, June 2011, Thieme Publishing Group

    Dr Giovanna Zinzalla

  15. Abstract 279: Use of GFP-STAT3βtc for EMSA analysis of protein-protein and protein-DNA interactions in tumorigenic signalling pathways

    Article • Cancer Research, April 2011, American Association for Cancer Research (AACR)

    Dr Giovanna Zinzalla

  16. Abstract 1382: Use of polarized light spectroscopy (CD) to study STAT3 folding and STAT3:ligand interactions

    Article • Cancer Research, April 2011, American Association for Cancer Research (AACR)

    Dr Giovanna Zinzalla

  17. A novel small-molecule inhibitor of IL-6 signalling

    Article • Bioorganic & Medicinal Chemistry Letters, December 2010, Elsevier

    Dr Khondaker Miraz Rahman, Dr Giovanna Zinzalla

  18. 113 Novel small-molecule inhibitors of Interleukin-6 (IL-6) signalling

    Article • European Journal of Cancer Supplements, November 2010, Elsevier

    Dr Giovanna Zinzalla

  19. ChemInform Abstract: Facile Oxidation of Electron-Poor Benzo[b]thiophenes to the Corresponding Sulfones with an Aqueous Solution of H2O2 and P2O5.

    Article • ChemInform, July 2010, Wiley

    Dr Giovanna Zinzalla

  20. ChemInform Abstract: Stereoselective Hetero Diels-Alder Reactions of Chiral Tricarbonyl (η6-Benzaldehyde)chromium Complexes.

    Article • ChemInform, May 2010, Wiley

    Professor Emanuela Licandro, Dr Giovanna Zinzalla

  21. Abstract 5454: Novel STAT3:STAT3 small-molecule inhibitors as potential anticancer agents

    Article • Cancer Research, April 2010, American Association for Cancer Research (AACR)

    Dr Giovanna Zinzalla

  22. Facile nucleophilic substitution at the C3a tertiary carbon of the 3a-bromohexahydropyrrolo[2,3-b]indole scaffold

    Article • Organic & Biomolecular Chemistry, January 2010, Royal Society of Chemistry

    Dr Giovanna Zinzalla

  23. Facile oxidation of electron-poor benzo[b]thiophenes to the corresponding sulfones with an aqueous solution of H2O2 and P2O5

    Article • Chemical Communications, January 2010, Royal Society of Chemistry

    Dr Giovanna Zinzalla

  24. Targeting protein–protein interactions for therapeutic intervention: a challenge for the future

    Article • Future Medicinal Chemistry, April 2009, Future Science

    Dr Giovanna Zinzalla

  25. Natural-Product-Like Spiroketals and Fused Bicyclic Acetals as Potential Therapeutic Agents for B-Cell Chronic Lymphocytic Leukaemia

    Article • ChemMedChem, December 2008, Wiley

    Dr Giovanna Zinzalla

  26. Chemical Variation of Natural-Product-Like Scaffolds: Design, Synthesis, and Biological Activity of Fused Bicyclic Acetal Derivatives

    Article • Angewandte Chemie International Edition, March 2007, Wiley

    Dr Giovanna Zinzalla

  27. Chemical Variation of Natural-Product-Like Scaffolds: Design, Synthesis, and Biological Activity of Fused Bicyclic Acetal Derivatives

    Article • Angewandte Chemie, March 2007, Wiley

    Dr Giovanna Zinzalla

  28. Chemical variation of natural product-like scaffolds: design and synthesis of spiroketal derivatives

    Article • Organic & Biomolecular Chemistry, January 2006, Royal Society of Chemistry

    Dr Giovanna Zinzalla

  29. A Thymine-PNA Monomer as New Isocyanide Component in the Ugi Reaction: A Direct Entry to PNA Dimers

    Article • Synlett, January 2004, Thieme Publishing Group

    Dr Giovanna Zinzalla

  30. Polymer-Supported Haloarene Chromium Dicarbonyl Isonitrile Complexes:  A Study of Their Synthesis and Reactivity

    Article • Journal of Combinatorial Chemistry, November 2003, American Chemical Society (ACS)

    Dr Giovanna Zinzalla

  31. Synthesis of Chiral Chromium Tricarbonyl Labeled Thymine PNA Monomers via the Ugi Reaction

    Article • Organic Letters, November 2002, American Chemical Society (ACS)

    Professor Emanuela Licandro, Dr Giovanna Zinzalla

  32. Stereoselective hetero Diels–Alder reactions of chiral tricarbonyl (η6-benzaldehyde)chromium complexes

    Article • Tetrahedron Asymmetry, August 2001, Elsevier

    Professor Emanuela Licandro, Dr Giovanna Zinzalla