All Stories

  1. Bacterial pathogenesis: Pathogenic bacteria attack RHIM

    Article • Nature Microbiology, March 2017, Nature

    Dr Francis Ka-Ming Chan

  2. Distinct Kinase-Independent Role of RIPK3 in CD11c + Mononuclear Phagocytes in Cytokine-Induced Tissue Repair

    Article • Cell Reports, March 2017, Elsevier

    Dr Francis Ka-Ming Chan

  3. Necroptosis: Mechanisms and Relevance to Disease

    Article • Annual Review of Pathology Mechanisms of Disease, January 2017, Annual Reviews

    Dr Francis Ka-Ming Chan

  4. The Inflammatory Signal Adaptor RIPK3: Functions Beyond Necroptosis

    Article • January 2017, Elsevier

    Dr Francis Ka-Ming Chan

  5. RIPK3 Slams the Brake on Leukemogenesis

    Article • Cancer Cell, July 2016, Elsevier

    Dr Francis Ka-Ming Chan

  6. Border Security: The Role of RIPK3 in Epithelium Homeostasis

    Article • Frontiers in Cell and Developmental Biology, June 2016, Frontiers

    Dr Francis Ka-Ming Chan

  7. Necroptosis-independent signaling by the RIP kinases in inflammation

    Article • Cellular and Molecular Life Sciences, April 2016, Springer Science + Business Media

    Dr Francis Ka-Ming Chan

  8. Regulation of RIPK3- and RHIM-dependent Necroptosis by the Proteasome

    Article • Journal of Biological Chemistry, January 2016, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Francis Ka-Ming Chan

  9. This article describes the molecular circuitry that regulates necroptosis and its biological roles.

    Article • Annual Review of Immunology, March 2015, Annual Reviews

    Dr Francis Ka-Ming Chan

  10. A RIPK3–Caspase 8 Complex Mediates Atypical Pro–IL-1β Processing

    Article • The Journal of Immunology, January 2015, The American Association of Immunologists

    Dr Francis Ka-Ming Chan

  11. The Necroptosis Adaptor RIPK3 Promotes Injury-Induced Cytokine Expression and Tissue Repair

    Article • Immunity, October 2014, Elsevier

    Dr Francis Ka-Ming Chan

  12. Cell biology: A guardian angel of cell integrity

    Article • Nature, September 2014, Nature

    Dr Francis Ka-Ming Chan

  13. Staying Alive: Cell Death in Antiviral Immunity

    Article • Molecular Cell, April 2014, Elsevier

    Dr Francis Ka-Ming Chan

  14. Necrosis-dependent and independent signaling of the RIP kinases in inflammation

    Article • Cytokine & Growth Factor Reviews, April 2014, Elsevier

    Dr Francis Ka-Ming Chan

  15. RIPK3 Takes Another Deadly Turn

    Article • Science, March 2014, American Association for the Advancement of Science

    Dr Francis Ka-Ming Chan

  16. Programmed Necrosis in Immunity and Inflammatory Diseases

    Article • January 2014, Springer Science + Business Media

    Dr Francis Ka-Ming Chan

  17. Positive and negative phosphorylation regulates RIP1- and RIP3-induced programmed necrosis

    Article • Biochemical Journal, December 2013, Portland Press Ltd.

    Dr Francis Ka-Ming Chan

  18. Programmed Necrosis/Necroptosis: An Inflammatory Form of Cell Death

    Article • October 2013, Springer Science + Business Media

    Dr Francis Ka-Ming Chan

  19. CYLD Deubiquitinates RIP1 in the TNFα-Induced Necrosome to Facilitate Kinase Activation and Programmed Necrosis

    Article • PLoS ONE, October 2013, PLOS

    Dr Francis Ka-Ming Chan

  20. RIP3: a molecular switch for necrosis and inflammation

    Article • Genes & Development, August 2013, Cold Spring Harbor Laboratory Press

    Dr Francis Ka-Ming Chan

  21. Detection of Necrosis by Release of Lactate Dehydrogenase Activity

    Article • January 2013, Springer Science + Business Media

    Dr Francis Ka-Ming Chan

  22. The RIP1/RIP3 Necrosome Forms a Functional Amyloid Signaling Complex Required for Programmed Necrosis

    Article • Cell, July 2012, Elsevier

    Dr Francis Ka-Ming Chan

  23. RIP3 Finds Partners in Crime

    Article • Cell, January 2012, Elsevier

    Dr Francis Ka-Ming Chan

  24. RIP1-Dependent and Independent Effects of Necrostatin-1 in Necrosis and T Cell Activation

    Article • PLoS ONE, August 2011, PLOS

    Dr Francis Ka-Ming Chan

  25. Functional complementation between FADD and RIP1 in embryos and lymphocytes

    Article • Nature, March 2011, Nature

    Dr Francis Ka-Ming Chan

  26. A RNA Interference Screen Identifies RIP3 as an Essential Inducer of TNF-Induced Programmed Necrosis

    Article • October 2010, Springer Science + Business Media

    Dr Francis Ka-Ming Chan

  27. Viral Cell Death Inhibitor MC159 Enhances Innate Immunity against Vaccinia Virus Infection

    Article • Journal of Virology, August 2010, ASM Journals

    Dr Francis Ka-Ming Chan

  28. The molecular regulation of programmed necrotic cell injury

    Article • Trends in Biochemical Sciences, August 2010, Elsevier

    Dr Francis Ka-Ming Chan

  29. Going up in flames: necrotic cell injury and inflammatory diseases

    Article • Cellular and Molecular Life Sciences, June 2010, Springer Science + Business Media

    Dr Francis Ka-Ming Chan

  30. Lipopolysaccharide-induced expression of TRAIL promotes dendritic cell differentiation

    Article • Immunology, April 2010, Wiley

    Dr Francis Ka-Ming Chan

  31. Physiological consequences of programmed necrosis, an alternative form of cell demise

    Article • Molecules and Cells, March 2010, Springer Science + Business Media

    Dr Francis Ka-Ming Chan

  32. This paper identified RIPK3 in a RNAi screen as a key necroptosis mediator.

    Article • Cell, June 2009, Elsevier

    Dr Francis Ka-Ming Chan

  33. Three is better than one: Pre-ligand receptor assembly in the regulation of TNF receptor signaling

    Article • Cytokine, February 2007, Elsevier

    Dr Francis Ka-Ming Chan

  34. Competitive Control of Independent Programs of Tumor Necrosis Factor Receptor-Induced Cell Death by TRADD and RIP1

    Article • Molecular and Cellular Biology, May 2006, ASM Journals

    Dr Francis Ka-Ming Chan

  35. Editorial [Hot Topic: Tumor Necrosis Factor (Guest Editor: Francis Ka-Ming Chan)]

    Article • Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents, December 2005, Bentham Science Publishers

    Dr Francis Ka-Ming Chan

  36. Preligand assembly domain-mediated ligand-independent association between TRAIL receptor 4 (TR4) and TR2 regulates TRAIL-induced apoptosis

    Article • Proceedings of the National Academy of Sciences, November 2005, Proceedings of the National Academy of Sciences

    Dr Francis Ka-Ming Chan

  37. Amelioration of inflammatory arthritis by targeting the pre-ligand assembly domain of tumor necrosis factor receptors

    Article • Nature Medicine, September 2005, Nature

    Dr Francis Ka-Ming Chan

  38. A Role for Tumor Necrosis Factor Receptor-2 and Receptor-interacting Protein in Programmed Necrosis and Antiviral Responses

    Article • Journal of Biological Chemistry, October 2003, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Francis Ka-Ming Chan

  39. Tumor necrosis factor family ligands and receptors in the immune system: Targets for future pharmaceuticals

    Article • Drug News & Perspectives, January 2002, Prous Science

    Dr Francis Ka-Ming Chan

  40. Fluorescence resonance energy transfer analysis of cell surface receptor interactions and signaling using spectral variants of the green fluorescent protein

    Article • Cytometry, January 2001, Wiley

    Dr Francis Ka-Ming Chan

  41. Signaling by the TNF Receptor Superfamily and T Cell Homeostasis

    Article • Immunity, October 2000, Elsevier

    Dr Francis Ka-Ming Chan

  42. Measurement of Molecular Interactions in Living Cells by Fluorescence Resonance Energy Transfer Between Variants of the Green Fluorescent Protein

    Article • Science Signaling, June 2000, American Association for the Advancement of Science

    Dr Francis Ka-Ming Chan

  43. Measurement of Molecular Interactions in Living Cells by Fluorescence Resonance Energy Transfer Between Variants of the Green Fluorescent Protein

    Article • Science Signaling, June 2000, American Association for the Advancement of Science

    Dr Francis Ka-Ming Chan

  44. A crucial role for p80 TNF-R2 in amplifying p60 TNF-R1 apoptosis signals in T lymphocytes

    Article • European Journal of Immunology, February 2000, Wiley

    Dr Francis Ka-Ming Chan

  45. A crucial role for p80 TNF-R2 in amplifying p60 TNF-R1 apoptosis signals in T lymphocytes

    Article • European Journal of Immunology, February 2000, Wiley

    Dr Francis Ka-Ming Chan

  46. Inherited Human Caspase 10 Mutations Underlie Defective Lymphocyte and Dendritic Cell Apoptosis in Autoimmune Lymphoproliferative Syndrome Type II

    Article • Cell, July 1999, Elsevier

    Dr Francis Ka-Ming Chan

  47. MATURE T LYMPHOCYTE APOPTOSIS—Immune Regulation in a Dynamic and Unpredictable Antigenic Environment

    Article • Annual Review of Immunology, April 1999, Annual Reviews

    Dr Francis Ka-Ming Chan

  48. The role of CTLA-4 during the activation of resting CD4+ T-cells

    Article • Immunology Letters, May 1997, Elsevier

    Dr Francis Ka-Ming Chan

  49. NMR structural characterization of the CDK inhibitor p19INK4d

    Article • FEBS Letters, January 1997, Wiley

    Dr Francis Ka-Ming Chan

  50. A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selection

    Article • Immunity, September 1995, Elsevier

    Dr Francis Ka-Ming Chan

  51. Identification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4.

    Article • Molecular and Cellular Biology, May 1995, ASM Journals

    Dr Francis Ka-Ming Chan

  52. A role for the cytoplasmic tail of the β chain of CD8 in thymic selection

    Article • Immunity, July 1994, Elsevier

    Dr Francis Ka-Ming Chan

  53. Monitoring Molecular Interactions in Living Cells Using Flow Cytometric Analysis of Fluorescence Resonance Energy Transfer

    Article • Springer Science + Business Media

    Dr Francis Ka-Ming Chan

  54. Flow Cytometric Analysis of Fluorescence Resonance Energy Transfer: A Tool for High-Throughput Screening of Molecular Interactions in Living Cells

    Article • Springer Science + Business Media

    Dr Francis Ka-Ming Chan