All Stories

  1. A CRIS in the Desert: The Implementation of Pure at KAUST A Case Study in Information Exchange

    Article • Procedia Computer Science, January 2017, Elsevier

    Dr Manus W Ward

  2. ‘Mild mitochondrial uncoupling’ induced protection against neuronal excitotoxicity requires AMPK activity

    Article • Biochimica et Biophysica Acta (BBA) - Bioenergetics, May 2012, Elsevier

    Dr Manus W Ward

  3. Calpains Are Downstream Effectors of bax-Dependent Excitotoxic Apoptosis

    Article • Journal of Neuroscience, February 2012, Society for Neuroscience

    Dr Manus W Ward

  4. Role of 5′-Adenosine Monophosphate-Activated Protein Kinase in Cell Survival and Death Responses in Neurons

    Article • Antioxidants & Redox Signaling, May 2011, Mary Ann Liebert Inc

    Dr Manus W Ward

  5. Bcl-2 homology domain 3-only proteins Puma and Bim mediate the vulnerability of CA1 hippocampal neurons to proteasome inhibition in vivo

    Article • European Journal of Neuroscience, December 2010, Wiley

    Dr Manus W Ward

  6. Characterization of Puma-Dependent and Puma-Independent Neuronal Cell Death Pathways following Prolonged Proteasomal Inhibition

    Article • Molecular and Cellular Biology, October 2010, ASM Journals

    Dr Manus W Ward

  7. AMP-activated Protein Kinase Mediates Apoptosis in Response to Bioenergetic Stress through Activation of the Pro-apoptotic Bcl-2 Homology Domain-3-only Protein BMF

    Article • Journal of Biological Chemistry, September 2010, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Manus W Ward

  8. Extracellular calcium depletion transiently elevates oxygen consumption in neurosecretory PC12 cells through activation of mitochondrial Na+/Ca2+ exchange

    Article • Biochimica et Biophysica Acta (BBA) - Bioenergetics, September 2010, Elsevier

    Dr Manus W Ward

  9. INS-1 Cells Undergoing Caspase-Dependent Apoptosis Enhance the Regenerative Capacity of Neighboring Cells

    Article • Diabetes, August 2010, American Diabetes Association

    Dr Manus W Ward

  10. Differential expression patterns of Puma and Hsp70 following proteasomal stress in the hippocampus are key determinants of neuronal vulnerability

    Article • Journal of Neurochemistry, April 2010, Wiley

    Dr Manus W Ward

  11. The amyloid precursor protein intracellular domain (AICD) disrupts actin dynamics and mitochondrial bioenergetics

    Article • Journal of Neurochemistry, April 2010, Wiley

    Dr Manus W Ward

  12. AMP kinase–mediated activation of the BH3-only protein Bim couples energy depletion to stress-induced apoptosis

    Article • The Journal of Cell Biology, March 2010, Rockefeller University Press

    Dr Manus W Ward

  13. Quantitative Analysis of Membrane Potentials

    Article • October 2009, Springer Science + Business Media

    Dr Manus W Ward

  14. Regulation of Glucose Transporter 3 Surface Expression by the AMP-Activated Protein Kinase Mediates Tolerance to Glutamate Excitation in Neurons

    Article • Journal of Neuroscience, March 2009, Society for Neuroscience

    Dr Manus W Ward

  15. TOXI-SIM—A simulation tool for the analysis of mitochondrial and plasma membrane potentials

    Article • Journal of Neuroscience Methods, January 2009, Elsevier

    Dr Manus W Ward

  16. Depletion of 14-3-3 zeta elicits endoplasmic reticulum stress and cell death, and increases vulnerability to kainate-induced injury in mouse hippocampal cultures

    Article • Journal of Neurochemistry, July 2008, Wiley

    Dr Manus W Ward

  17. NMDA receptor-mediated excitotoxic neuronal apoptosis in vitro and in vivo occurs in an ER stress and PUMA independent manner

    Article • Journal of Neurochemistry, May 2008, Wiley

    Dr Manus W Ward

  18. Dynamics of Intracellular Oxygen in PC12 Cells upon Stimulation of Neurotransmission

    Article • Journal of Biological Chemistry, December 2007, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Manus W Ward

  19. Mitochondrial and Plasma Membrane Potential of Cultured Cerebellar Neurons during Glutamate-Induced Necrosis, Apoptosis, and Tolerance

    Article • Journal of Neuroscience, August 2007, Society for Neuroscience

    Dr Manus W Ward

  20. Article • BMC Cell Biology, January 2007, Springer Science + Business Media

    Dr Manus W Ward

  21. Modulation of Gene Expression and Cytoskeletal Dynamics by the Amyloid Precursor Protein Intracellular Domain (AICD)

    Article • Molecular Biology of the Cell, October 2006, American Society for Cell Biology (ASCB)

    Dr Manus W Ward

  22. Apoptosis induced by proteasome inhibition in cancer cells: predominant role of the p53/PUMA pathway

    Article • Oncogene, September 2006, Nature

    Dr Manus W Ward

  23. P2-032

    Article • Alzheimer s & Dementia, July 2006, Elsevier

    Dr Manus W Ward

  24. Real Time Single Cell Analysis of Bid Cleavage and Bid Translocation during Caspase-dependent and Neuronal Caspase-independent Apoptosis

    Article • Journal of Biological Chemistry, December 2005, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Manus W Ward

  25. Excitotoxic Injury to Mitochondria Isolated from Cultured Neurons

    Article • Journal of Biological Chemistry, June 2005, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Manus W Ward

  26. Cellular and subcellular calcium accumulation during glutamate-induced injury in cerebellar granule neurons

    Article • Journal of Neurochemistry, February 2005, Wiley

    Dr Manus W Ward

  27. Hypertonic shock inhibits growth factor receptor signaling, induces caspase-3 activation, and causes reversible fragmentation of the mitochondrial network

    Article • AJP Cell Physiology, February 2005, American Physiological Society

    Dr Manus W Ward

  28. Constitutive and functional expression of cyclooxygenase 2 in the murine proximal colon

    Article • Neurogastroenterology & Motility, December 2004, Wiley

    Dr Manus W Ward

  29. Neuronal Apoptosis: BH3-Only Proteins the Real Killers?

    Article • Journal of Bioenergetics and Biomembranes, August 2004, Springer Science + Business Media

    Dr Manus W Ward

  30. Inducible Expression of a Dominant Negative DNA Polymerase-gamma Depletes Mitochondrial DNA and Produces a rho 0 Phenotype

    Article • Journal of Biological Chemistry, January 2003, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Manus W Ward

  31. High-throughput assessment of mitochondrial membrane potential in situ using fluorescence resonance energy transfer

    Article • Mitochondrion, May 2002, Elsevier

    Dr Manus W Ward

  32. Oxidative Stress, Mitochondrial Function, and Acute Glutamate Excitotoxicity in Cultured Cerebellar Granule Cells

    Article • Journal of Neurochemistry, December 2001, Wiley

    Dr Manus W Ward

  33. Mitochondrial membrane potential and neuronal glutamate excitotoxicity: mortality and millivolts

    Article • Trends in Neurosciences, April 2000, Elsevier

    Dr Manus W Ward

  34. Glutamate Excitotoxicity and Neuronal Energy Metabolism

    Article • Annals of the New York Academy of Sciences, November 1999, Wiley

    Dr Manus W Ward