All Stories

  1. Chapter 7 – Pathogenesis of otitis media – A review of the literature between 2015 and 2019

    Article • International Journal of Pediatric Otorhinolaryngology, December 2019, Elsevier

    Dr Anders P Hakansson

  2. The human milk protein-lipid complex HAMLET disrupts glycolysis and induces death in Streptococcus pneumoniae

    Article • Journal of Biological Chemistry, November 2019, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Anders P Hakansson

  3. HAMLET, a Protein Complex from Human Milk, Has Bactericidal Activity and Enhances the Activity of Antibiotics against Pathogenic Streptococci

    Article • Antimicrobial Agents and Chemotherapy, October 2019, ASM Journals

    Dr Anders P Hakansson

  4. Growing and Characterizing Biofilms Formed by Streptococcus pneumoniae

    Article • January 2019, Springer Science + Business Media

    Dr Anders P Hakansson

  5. A Protein Complex from Human Milk Enhances the Activity of Antibiotics and Drugs againstMycobacterium tuberculosis

    Article • Antimicrobial Agents and Chemotherapy, November 2018, ASM Journals

    Dr Anders P Hakansson

  6. BAMLET kills chemotherapy-resistant mesothelioma cells, holding oleic acid in an activated cytotoxic state

    Article • PLoS ONE, August 2018, PLOS

    Dr Anders P Hakansson

  7. Bacterial-Host Interactions: Physiology and Pathophysiology of Respiratory Infection

    Article • Physiological Reviews, April 2018, American Physiological Society

    Dr Anders P Hakansson

  8. Streptococcus pneumoniae Modulates Staphylococcus aureus Biofilm Dispersion and the Transition from Colonization to Invasive Disease

    Article • mBio, January 2018, ASM Journals

    Dr Anders P Hakansson, Anthony A Campagnari

  9. Streptococcus pneumoniae Otitis Media Pathogenesis and How It Informs Our Understanding of Vaccine Strategies

    Article • Current Otorhinolaryngology Reports, May 2017, Springer Science + Business Media

    Dr Anders P Hakansson

  10. Panel 6: Vaccines

    Article • Otolaryngology, April 2017, SAGE Publications

    Professor Melinda M Pettigrew, Dr Stephen J Barenkamp, Dr Anders P Hakansson

  11. Panel 4: Report of the Microbiology Panel

    Article • Otolaryngology, April 2017, SAGE Publications

    Dr Stephen J Barenkamp, Dr Anders P Hakansson

  12. Low NF-κB Activation and Necroptosis in Alveolar Macrophages: A New Virulence Property of Streptococcus pneumoniae

    Article • The Journal of Infectious Diseases, March 2017, Oxford University Press (OUP)

    Dr Anders P Hakansson

  13. In Vitro and In Vivo Biofilm Formation by Pathogenic Streptococci

    Article • December 2016, Springer Science + Business Media

    Dr Anders P Hakansson

  14. Host Physiologic Changes Induced by Influenza A Virus Lead toStaphylococcus aureusBiofilm Dispersion and Transition from Asymptomatic Colonization to Invasive Disease

    Article • mBio, August 2016, ASM Journals

    Dr Anders P Hakansson, Anthony A Campagnari

  15. In situ pneumococcal vaccine production and delivery through a hybrid biological-biomaterial vector

    Article • Science Advances, July 2016, American Association for the Advancement of Science

    Mingfu Chen, Dr Anders P Hakansson

  16. Directed vaccination against pneumococcal disease

    Article • Proceedings of the National Academy of Sciences, June 2016, Proceedings of the National Academy of Sciences

    Dr Anders P Hakansson

  17. Novel Strategy To Protect against Influenza Virus-Induced Pneumococcal Disease without Interfering with Commensal Colonization

    Article • Infection and Immunity, March 2016, ASM Journals

    Dr Anders P Hakansson

  18. Structure and Potential Cellular Targets of HAMLET-like Anti-Cancer Compounds made from Milk Components

    Article • Journal of Pharmacy & Pharmaceutical Sciences, November 2015, University of Alberta Libraries

    Dr Anders P Hakansson

  19. Halothane Modulates the Type I Interferon Response to Influenza and Minimizes the Risk of Secondary Bacterial Pneumonia through Maintenance of Neutrophil Recruitment in an Animal Model

    Article • Anesthesiology, September 2015, Wolters Kluwer Health

    Dr Anders P Hakansson

  20. Absence of capsule reveals glycan-mediated binding and recognition of salivary mucin MUC7 byStreptococcus pneumoniae

    Article • Molecular Oral Microbiology, August 2015, Wiley

    Dr Anders P Hakansson

  21. Streptococcus pneumoniae biofilm formation and dispersion during colonization and disease

    Article • Frontiers in Cellular and Infection Microbiology, January 2015, Frontiers

    Dr Anders P Hakansson

  22. Protective effects of human milk antimicrobial peptides against bacterial infection

    Article • Jornal de Pediatria, January 2015, Elsevier

    Dr Anders P Hakansson

  23. Mannosylated poly(beta-amino esters) for targeted antigen presenting cell immune modulation

    Article • Biomaterials, January 2015, Elsevier

    Dr Anders P Hakansson, Mingfu Chen

  24. Pneumococcal Genetic Transformation During Colonization and Biofilm Formation

    Article • January 2015, Elsevier

    Dr Anders P Hakansson

  25. Biomaterials at the interface of nano- and micro-scale vector–cellular interactions in genetic vaccine design

    Article • Journal of Materials Chemistry B, September 2014, Royal Society of Chemistry

    Dr Anders P Hakansson

  26. Dynamic Changes in the Streptococcus pneumoniae Transcriptome during Transition from Biofilm Formation to Invasive Disease upon Influenza A Virus Infection

    Article • Infection and Immunity, August 2014, ASM Journals

    Dr Anders P Hakansson, Professor Melinda M Pettigrew

  27. Hybrid bio-synthetic gene delivery

    Article • Proceedings of the National Academy of Sciences, August 2014, Proceedings of the National Academy of Sciences

    Dr Anders P Hakansson, Mingfu Chen

  28. Monitoring Changes in Membrane Polarity, Membrane Integrity, and Intracellular Ion Concentrations in Streptococcus pneumoniae Using Fluorescent Dyes

    Article • Journal of Visualized Experiments, February 2014, MyJove Corporation

    Dr Anders P Hakansson

  29. Pneumococcal Adaptive Responses to Changing Host Environments

    Article • The Journal of Infectious Diseases, February 2014, Oxford University Press (OUP)

    Dr Anders P Hakansson

  30. Small‐angle X‐ray scattering of BAMLET at pH 12: A complex of α‐lactalbumin and oleic acid

    Article • Proteins Structure Function and Bioinformatics, January 2014, Wiley

    Dr Anders P Hakansson

  31. Streptococcus pyogenes Biofilm Growth In Vitro and In Vivo and Its Role in Colonization, Virulence, and Genetic Exchange

    Article • The Journal of Infectious Diseases, January 2014, Oxford University Press (OUP)

    Dr Anders P Hakansson

  32. Biofilm Formation Enhances Fomite Survival of Streptococcus pneumoniae and Streptococcus pyogenes

    Article • Infection and Immunity, December 2013, ASM Journals

    Dr Anders P Hakansson

  33. A Complex of Equine Lysozyme and Oleic Acid with Bactericidal Activity against Streptococcus pneumoniae

    Article • PLoS ONE, November 2013, PLOS

    Dr Anders P Hakansson

  34. Internalization and Trafficking of Nontypeable Haemophilus influenzae in Human Respiratory Epithelial Cells and Roles of IgA1 Proteases for Optimal Invasion and Persistence

    Article • Infection and Immunity, November 2013, ASM Journals

    Dr Anders P Hakansson

  35. Interkingdom Signaling Induces Streptococcus pneumoniae Biofilm Dispersion and Transition from Asymptomatic Colonization to Disease

    Article • mBio, July 2013, ASM Journals

    Dr Anders P Hakansson

  36. Sensitization of Staphylococcus aureus to Methicillin and Other Antibiotics In Vitro and In Vivo in the Presence of HAMLET

    Article • PLoS ONE, May 2013, PLOS

    Dr Anders P Hakansson

  37. High Levels of Genetic Recombination during Nasopharyngeal Carriage and Biofilm Formation in Streptococcus pneumoniae

    Article • mBio, September 2012, ASM Journals

    Dr Anders P Hakansson

  38. The Human Milk Protein-Lipid Complex HAMLET Sensitizes Bacterial Pathogens to Traditional Antimicrobial Agents

    Article • PLoS ONE, August 2012, PLOS

    Dr Anders P Hakansson

  39. A Novel Initiation Mechanism of Death in Streptococcus pneumoniae Induced by the Human Milk Protein-Lipid Complex HAMLET and Activated during Physiological Death

    Article • Journal of Biological Chemistry, June 2012, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Anders P Hakansson

  40. Pneumococcal Interactions with Epithelial Cells Are Crucial for Optimal Biofilm Formation and ColonizationIn VitroandIn Vivo

    Article • Infection and Immunity, May 2012, ASM Journals

    Dr Anders P Hakansson

  41. Oleic acid is a key cytotoxic component of HAMLET-like complexes

    Article • Biological Chemistry, January 2012, De Gruyter

    Dr Anders P Hakansson

  42. A novel method for preparation of HAMLET-like protein complexes

    Article • Biochimie, September 2011, Elsevier

    Dr Anders P Hakansson

  43. Role of Dihydrolipoamide Dehydrogenase in Regulation of Raffinose Transport in Streptococcus pneumoniae

    Article • Journal of Bacteriology, May 2011, ASM Journals

    Dr Anders P Hakansson

  44. Apoptosis-Like Death in Bacteria Induced by HAMLET, a Human Milk Lipid-Protein Complex

    Article • PLoS ONE, March 2011, PLOS

    Dr Anders P Hakansson

  45. Streptolysin O Inhibits Clathrin-Dependent Internalization of Group A Streptococcus

    Article • mBio, February 2011, ASM Journals

    Dr Anders P Hakansson

  46. PerR Confers Phagocytic Killing Resistance and Allows Pharyngeal Colonization by Group A Streptococcus

    Article • PLoS Pathogens, September 2008, PLOS

    Dr Anders P Hakansson

  47. Enzymatic Characterization of Dihydrolipoamide Dehydrogenase from Streptococcus pneumoniae Harboring Its Own Substrate

    Article • Journal of Biological Chemistry, August 2007, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Anders P Hakansson

  48. Mg2+ signalling defines the group A streptococcal CsrRS (CovRS) regulon

    Article • Molecular Microbiology, July 2007, Wiley

    Dr Anders P Hakansson

  49. Capsule does not block antibody binding to PspA, a surface virulence protein of Streptococcus pneumoniae

    Article • Microbial Pathogenesis, May 2006, Elsevier

    Dr Anders P Hakansson

  50. Enhancement of Streptolysin O Activity and Intrinsic Cytotoxic Effects of the Group A Streptococcal Toxin, NAD-Glycohydrolase

    Article • Journal of Biological Chemistry, January 2006, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Anders P Hakansson

  51. Extracellular group A Streptococcus induces keratinocyte apoptosis by dysregulating calcium signalling

    Article • Cellular Microbiology, April 2005, Wiley

    Dr Anders P Hakansson

  52. Cytolysin-dependent evasion of lysosomal killing

    Article • Proceedings of the National Academy of Sciences, March 2005, Proceedings of the National Academy of Sciences

    Dr Anders P Hakansson

  53. Relative Roles of Genetic Background and Variation in PspA in the Ability of Antibodies to PspA To Protect against Capsular Type 3 and 4 Strains of Streptococcus pneumoniae

    Article • Infection and Immunity, August 2003, ASM Journals

    Dr Anders P Hakansson, Dr Larry S. McDaniel

  54. Regions of PspA/EF3296 Best Able To Elicit Protection against Streptococcus pneumoniae in a Murine Infection Model

    Article • Infection and Immunity, March 2003, ASM Journals

    Dr Anders P Hakansson

  55. Characterization of the dihydrolipoamide dehydrogenase from Streptococcus pneumoniae and its role in pneumococcal infection

    Article • Molecular Microbiology, April 2002, Wiley

    Dr Anders P Hakansson

  56. Hamlet — A Complex from Human Milk that Induces Apoptosis in Tumor Cells but Spares Healthy Cells

    Article • January 2002, Springer Science + Business Media

    Dr Anders P Hakansson

  57. In Vivo Activation of Dendritic Cells and T Cells during Salmonella enterica Serovar Typhimurium Infection

    Article • Infection and Immunity, September 2001, ASM Journals

    Dr Anders P Hakansson

  58. Characterization of Binding of Human Lactoferrin to Pneumococcal Surface Protein A

    Article • Infection and Immunity, May 2001, ASM Journals

    Dr Anders P Hakansson

  59. Morphological and functionalin vitroandin vivocharacterization of the mouse corpus cavernosum

    Article • British Journal of Pharmacology, March 2001, Wiley

    Dr Anders P Hakansson

  60. A folding variant of human α‐lactalbumin induces mitochondrial permeability transition in isolated mitochondria

    Article • European Journal of Biochemistry, January 2001, Wiley

    Dr Anders P Hakansson

  61. Conversion of α-lactalbumin to a protein inducing apoptosis

    Article • Proceedings of the National Academy of Sciences, April 2000, Proceedings of the National Academy of Sciences

    Dr Anders P Hakansson

  62. A folding variant of α‐lactalbumin with bactericidal activity against Streptococcus pneumoniae

    Article • Molecular Microbiology, April 2000, Wiley

    Dr Anders P Hakansson

  63. A folding variant of α‐lactalbumin with bactericidal activity against Streptococcus pneumoniae

    Article • Molecular Microbiology, February 2000, Wiley

    Dr Anders P Hakansson

  64. Protease Activation in Apoptosis Induced by MAL

    Article • Experimental Cell Research, June 1999, Elsevier

    Dr Anders P Hakansson

  65. Molecular Characterization of  -Lactalbumin Folding Variants That Induce Apoptosis in Tumor Cells

    Article • Journal of Biological Chemistry, March 1999, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Anders P Hakansson

  66. Multimeric α-Lactalbumin from Human Milk Induces Apoptosis through a Direct Effect on Cell Nuclei

    Article • Experimental Cell Research, February 1999, Elsevier

    Dr Anders P Hakansson

  67. Aspects on the Interaction ofStreptococcus pneumoniaeandHaemophilus influenzaewith Human Respiratory Tract Mucosa

    Article • American Journal of Respiratory and Critical Care Medicine, October 1996, American Thoracic Society

    Dr Anders P Hakansson

  68. Antibodies to pneumococcal polysaccharides in human milk: lack of relationship to colonization and acute otitis media

    Article • The Pediatric Infectious Disease Journal, June 1996, Wolters Kluwer Health

    Dr Anders P Hakansson

  69. Apoptosis induced by a human milk protein.

    Article • Proceedings of the National Academy of Sciences, August 1995, Proceedings of the National Academy of Sciences

    Dr Anders P Hakansson

  70. Article • PLOS

    Dr Anders P Hakansson

  71. Article • PLOS

    Dr Anders P Hakansson

  72. Article • PLOS

    Dr Anders P Hakansson

  73. Article • PLOS

    Dr Anders P Hakansson

  74. Article • PLOS

    Dr Anders P Hakansson

  75. Article • PLOS

    Dr Anders P Hakansson

  76. Article • PLOS

    Dr Anders P Hakansson

  77. Article • PLOS

    Dr Anders P Hakansson

  78. Article • PLOS

    Dr Anders P Hakansson

  79. Article • PLOS

    Dr Anders P Hakansson