All Stories

  1. Targeting Foam Cell Formation in Atherosclerosis: Therapeutic Potential of Natural Products
  2. Applications of Antioxidants in Metabolic Disorders and Degenerative Diseases: Mechanistic Approach
  3. Plant-derived Glycosides with α-Glucosidase Inhibitory Activity: Current Standing and Future Prospects
  4. Antioxidants: Scientific Literature Landscape Analysis
  5. Exosomes at a glance – common nominators for cancer hallmarks and novel diagnosis tools
  6. 6-Dihydroparadol, a Ginger Constituent, Enhances Cholesterol Efflux from THP-1-Derived Macrophages
  7. Chemistry and Biological Activities of the Marine Sponges of the Genera Mycale (Arenochalina), Biemna and Clathria
  8. Phytochemicals as potent modulators of autophagy for cancer therapy
  9. The Effect of Different Levels of Cu, Zn and Mn Nanoparticles in Hen Turkey Diet on the Activity of Aminopeptidases
  10. The Effect of PUFA-Rich Plant Oils and Bioactive Compounds Supplementation in Pig Diet on Color Parameters and Myoglobin Status in Long-Frozen Pork Meat
  11. Phytopharmacology of Acerola ( Malpighia spp. ) and its potential as functional food
  12. Current Insights into Oral Cancer Epigenetics
  13. Targeting activator protein 1 signaling pathway by bioactive natural agents: Possible therapeutic strategy for cancer prevention and intervention
  14. Bioactive Compounds in Functional Meat Products
  15. Pecan nuts: A review of reported bioactivities and health effects
  16. Mitochondria as pharmacological targets in Down syndrome
  17. A comprehensive review on biological properties of citrinin
  18. Plant-derived mPGES-1 inhibitors or suppressors: A new emerging trend in the search for small molecules to combat inflammation
  19. Assessment of anti-inflammatory properties of extracts from Honeysuckle (Lonicera sp. L., Caprifoliaceae) by ATR-FTIR spectroscopy
  20. Eurycomalactone Inhibits Expression of Endothelial Adhesion Molecules at a Post-Transcriptional Level
  21. Chokeberry Pomace as a Determinant of Antioxidant Parameters Assayed in Blood and Liver Tissue of Polish Merino and Wrzosówka Lambs
  22. Therapeutic potential of songorine, a diterpenoid alkaloid of the genus Aconitum
  23. The Forty-Sixth Euro Congress on Drug Synthesis and Analysis: Snapshot †
  24. Linked magnolol dimer as a selective PPARγ agonist – Structure-based rational design, synthesis, and bioactivity evaluation
  25. Nutrigenomics in cancer: Revisiting the effects of natural compounds
  26. The functional genomic studies of curcumin
  27. Bupleurum chinense Roots: a Bioactivity-Guided Approach toward Saponin-Type NF-κB Inhibitors
  28. Hepatoprotective naphthalene diglucoside from Neanotis wightiana aerial parts
  29. The Dietary Constituent Falcarindiol Promotes Cholesterol Efflux from THP-1 Macrophages by Increasing ABCA1 Gene Transcription and Protein Stability
  30. Ethnopharmacological Approaches for Therapy of Jaundice: Part I
  31. Ethnopharmacological Approaches for Therapy of Jaundice: Part II. Highly Used Plant Species from Acanthaceae, Euphorbiaceae, Asteraceae, Combretaceae, and Fabaceae Families
  32. Plant Resource Availability of Medicinal Fritillaria Species in Traditional Producing Regions in Qinghai-Tibet Plateau
  33. Significance of Microbiota in Obesity and Metabolic Diseases and the Modulatory Potential by Medicinal Plant and Food Ingredients
  34. Xanthohumol Blocks Proliferation and Migration of Vascular Smooth Muscle Cells in Vitro and Reduces Neointima Formation in Vivo
  35. Erythrodiol, an Olive Oil Constituent, Increases the Half-Life of ABCA1 and Enhances Cholesterol Efflux from THP-1-Derived Macrophages
  36. Amorpha fruticosa – A Noxious Invasive Alien Plant in Europe or a Medicinal Plant against Metabolic Disease?
  37. Bilirubin Decreases Macrophage Cholesterol Efflux and ATP‐Binding Cassette Transporter A1 Protein Expression
  38. Fenofibrate inhibits tumour intravasation by several independent mechanisms in a 3-dimensional co-culture model
  39. Potential Antiosteoporotic Natural Product Lead Compounds That Inhibit 17β-Hydroxysteroid Dehydrogenase Type 2
  40. Therapeutic role of sirtuins in neurodegenerative disease and their modulation by polyphenols
  41. Piperine inhibits ABCA1 degradation and promotes cholesterol efflux from THP-1-derived macrophages
  42. Cynaropicrin: A Comprehensive Research Review and Therapeutic Potential As an Anti-Hepatitis C Virus Agent
  43. Erratum: Pferschy-Wenzig, E.-M.; et al. Does a Graphical Abstract Bring More Visibility to Your Paper? Molecules 2016, 21, 1247
  44. The Eighth Central European Conference “Chemistry towards Biology”: Snapshot
  45. AHR/CYP1A1 interplay triggers lymphatic barrier breaching in breast cancer spheroids by inducing 12(S)-HETE synthesis
  46. Does a Graphical Abstract Bring More Visibility to Your Paper?
  47. 12(S)-HETE increases intracellular Ca2+ in lymph-endothelial cells disrupting their barrier function in vitro; stabilization by clinical drugs impairing calcium supply
  48. Natural Products to Counteract the Epidemic of Cardiovascular and Metabolic Disorders
  49. Leoligin, the Major Lignan from Edelweiss (Leontopodium nivale subsp. alpinum), Promotes Cholesterol Efflux from THP-1 Macrophages
  50. Drugs from nature targeting inflammation (DNTI): a successful Austrian interdisciplinary network project
  51. Plumericin inhibits proliferation of vascular smooth muscle cells by blocking STAT3 signaling via S-glutathionylation
  52. Silymarin Constituents Enhance ABCA1 Expression in THP-1 Macrophages
  53. Drug discovery with plant compounds
  54. Characterization of the Isosteroidal Alkaloid Chuanbeinone from Bulbus of Fritillaria pallidiflora as Novel Antitumor Agent In Vitro and In Vivo
  55. Nonprenylated Xanthones from Gentiana lutea, Frasera caroliniensis, and Centaurium erythraea as Novel Inhibitors of Vascular Smooth Muscle Cell Proliferation
  56. Activated AMPK boosts the Nrf2/HO-1 signaling axis—A role for the unfolded protein response
  57. The germacranolide sesquiterpene lactone neurolenin B of the medicinal plant Neurolaena lobata (L.) R.Br. ex Cass inhibits NPM/ALK-driven cell expansion and NF-κB-driven tumour intravasation
  58. Piperine Congeners as Inhibitors of Vascular Smooth Muscle Cell Proliferation
  59. A eudesmane-type sesquiterpene isolated from Pluchea odorata (L.) Cass. combats three hallmarks of cancer cells: Unrestricted proliferation, escape from apoptosis and early metastatic outgrowth in vitro
  60. Identification and characterization of [6]‐shogaol from ginger as inhibitor of vascular smooth muscle cell proliferation
  61. Capsaicin from chili (Capsicum spp.) inhibits vascular smooth muscle cell proliferation
  62. Lobatin B inhibits NPM/ALK and NF-κB attenuating anaplastic-large-cell-lymphomagenesis and lymphendothelial tumour intravasation
  63. Indirubin and Indirubin Derivatives for Counteracting Proliferative Diseases
  64. Screening of Vietnamese medicinal plants for NF-κB signaling inhibitors: Assessing the activity of flavonoids from the stem bark of Oroxylum indicum
  65. Glycolytic Switch in Response to Betulinic Acid in Non-Cancer Cells
  66. Plant extracts in cell-based anti-inflammatory assays—Pitfalls and considerations related to removal of activity masking bulk components
  67. Polyyne Hybrid Compounds from Notopterygium incisum with Peroxisome Proliferator-Activated Receptor Gamma Agonistic Effects
  68. Natural product agonists of peroxisome proliferator-activated receptor gamma (PPARγ): a review
  69. Identification of plumericin as a potent new inhibitor of the NF‐κB pathway with anti‐inflammatory activity in vitro and in vivo
  70. Identification of Isosilybin A from Milk Thistle Seeds as an Agonist of Peroxisome Proliferator-Activated Receptor Gamma
  71. Walnut leaf extract inhibits PTP1B and enhances glucose-uptake in vitro
  72. Activity-guided isolation of NF-κB inhibitors and PPARγ agonists from the root bark of Lycium chinense Miller
  73. Discovery and characterization of honokiol from Cortex Magnoliae as a novel promising anti-diabetic lead
  74. Identification of Chromomoric Acid C-I as an Nrf2 Activator in Chromolaena odorata
  75. NF-κB Inhibitors from Eurycoma longifolia
  76. Indirubin-3′-monoxime exerts a dual mode of inhibition towards leukotriene-mediated vascular smooth muscle cell migration
  77. Inhibition of tumour spheroid-induced prometastatic intravasation gates in the lymph endothelial cell barrier by carbamazepine: drug testing in a 3D model
  78. 12/15-Lipoxygenase Contributes to Platelet-derived Growth Factor-induced Activation of Signal Transducer and Activator of Transcription 3
  79. Imbricaric Acid and Perlatolic Acid: Multi-Targeting Anti-Inflammatory Depsides from Cetrelia monachorum
  80. Anti-inflammatory activities of 71 Austrian traditional herbal drugs
  81. Honokiol: A non-adipogenic PPARγ agonist from nature
  82. Polyacetylenes from Notopterygium incisum–New Selective Partial Agonists of Peroxisome Proliferator-Activated Receptor-Gamma
  83. In vitro characterisation of the anti-intravasative properties of the marine product heteronemin
  84. Xanthohumol attenuates tumour cell-mediated breaching of the lymphendothelial barrier and prevents intravasation and metastasis
  85. In vitro inhibition of breast cancer spheroid-induced lymphendothelial defects resembling intravasation into the lymphatic vasculature by acetohexamide, isoxsuprine, nifedipin and proadifen
  86. Cysteine-10 on 17β-Hydroxysteroid Dehydrogenase 1 Has Stabilizing Interactions in the Cofactor Binding Region and Renders Sensitivity to Sulfhydryl Modifying Chemicals
  87. The Herbal Drug Melampyrum pratense L. (Koch): Isolation and Identification of Its Bioactive Compounds Targeting Mediators of Inflammation
  88. 2-(2,4-dihydroxyphenyl)-5-(E)-propenylbenzofuran promotes endothelial nitric oxide synthase activity in human endothelial cells
  89. Ascorbate stimulates endothelial nitric oxide synthase enzyme activity by rapid modulation of its phosphorylation status
  90. Synergy Study of the Inhibitory Potential of Red Wine Polyphenols on Vascular Smooth Muscle Cell Proliferation
  91. Effects of Scrophularia extracts on tumor cell proliferation, death and intravasation through lymphoendothelial cell barriers
  92. Ratanhiaphenol III from Ratanhiae Radix is a PTP1B Inhibitor
  93. Selected Extracts of Chinese Herbal Medicines: Their Effect on NF-κB, PPARαand PPARγand the Respective Bioactive Compounds
  94. Bioguided Isolation of (9 Z )-Octadec-9-enoic Acid from Phellodendron amurense Rupr. and Identification of Fatty Acids as PTP1B Inhibitors
  95. Lignan Derivatives from Krameria lappacea Roots Inhibit Acute Inflammation in Vivo and Pro-inflammatory Mediators in Vitro
  96. Resveratrol inhibits migration and Rac1 activation in EGF‐ but not PDGF‐activated vascular smooth muscle cells
  97. Identification of Ostruthin from Peucedanum ostruthium Rhizomes as an Inhibitor of Vascular Smooth Muscle Cell Proliferation
  98. Discovery of a novel IKK-β inhibitor by ligand-based virtual screening techniques
  99. Resveratrol blocks Akt activation in angiotensin II- or EGF-stimulated vascular smooth muscle cells in a redox-independent manner
  100. Bioactivity-Guided Isolation of 1,2,3,4,6-Penta-O-galloyl-d-glucopyranose from Paeonia lactiflora Roots As a PTP1B Inhibitor
  101. Indirubin-3'-Monoxime Blocks Vascular Smooth Muscle Cell Proliferation by Inhibition of Signal Transducer and Activator of Transcription 3 Signaling and Reduces Neointima Formation In Vivo
  102. Bioactivity-Guided Isolation of 1,2,3,4,6-Penta-O-galloyl-d-glucopyranose from Paeonia lactiflora Roots As a PTP1B Inhibitor
  103. Computer-Aided Discovery, Validation, and Mechanistic Characterization of Novel Neolignan Activators of Peroxisome Proliferator-Activated Receptor γ
  104. Mineralocorticoid receptors: Emerging complexity and functional diversity
  105. Inhibition of growth factor mediated Akt phosphorylation in vascular smooth muscle cells by resveratrol: the contribution of SH2 domain containing phosphatase 2 and reactive oxygen species
  106. Cell cycle-dependent regulation of extra-adrenal glucocorticoid synthesis in murine intestinal epithelial cells
  107. Direct protein–protein interaction of 11β-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase in the endoplasmic reticulum lumen
  108. Hexose-6-phosphate Dehydrogenase Modulates 11β-Hydroxysteroid Dehydrogenase Type 1-Dependent Metabolism of 7-keto- and 7β-hydroxy-neurosteroids
  109. Readjusting the Glucocorticoid Balance: An Opportunity for Modulators of 11β -Hydroxysteroid Dehydrogenase Type 1 Activity?
  110. Impaired Protein Stability of 11beta-Hydroxysteroid Dehydrogenase Type 2: A Novel Mechanism of Apparent Mineralocorticoid Excess
  111. Differential Regulation of Glucocorticoid Synthesis in Murine Intestinal EpithelialVersusAdrenocortical Cell Lines
  112. Disruption of glucocorticoid action by environmental chemicals: Potential mechanisms and relevance
  113. Coffee inhibits the reactivation of glucocorticoids by 11β‐hydroxysteroid dehydrogenase type 1: A glucocorticoid connection in the anti‐diabetic action of coffee?
  114. Why is 11β-hydroxysteroid dehydrogenase type 1 facing the endoplasmic reticulum lumen?
  115. Organotins Disrupt the 11β-Hydroxysteroid Dehydrogenase Type 2–Dependent Local Inactivation of Glucocorticoids
  116. Hexose‐6‐phosphate dehydrogenase determines the reaction direction of 11β‐hydroxysteroid dehydrogenase type 1 as an oxoreductase
  117. Appropriate Function of 11 -Hydroxysteroid Dehydrogenase Type 1 in the Endoplasmic Reticulum Lumen Is Dependent on Its N-terminal Region Sharing Similar Topological Determinants with 50-kDa Esterase
  118. A rapid screening assay for inhibitors of 11β-hydroxysteroid dehydrogenases (11β-HSD): flavanone selectively inhibits 11β-HSD1 reductase activity
  119. Inhibition of 11β-hydroxysteroid dehydrogenase type 2 by dithiocarbamates