All Stories

  1. Chikungunya Virus Overcomes Polyamine Depletion by Mutation of nsP1 and the Opal Stop Codon To Confer Enhanced Replication and Fitness

    Article • Journal of Virology, May 2017, ASM Journals

    Professor Marco Vignuzzi

  2. Inhibition of Polyamine Biosynthesis Is a Broad-Spectrum Strategy against RNA Viruses

    Article • Journal of Virology, August 2016, ASM Journals

    Professor Marco Vignuzzi

  3. Low-Fidelity Polymerases of Alphaviruses Recombine at Higher Rates To Overproduce Defective Interfering Particles

    Article • Journal of Virology, December 2015, ASM Journals

    Professor Marco Vignuzzi

  4. Inhibition of mTORC1 Enhances the Translation of Chikungunya Proteins via the Activation of the MnK/eIF4E Pathway

    Article • PLoS Pathogens, August 2015, PLOS

    Professor Marco Vignuzzi

  5. Alphavirus, Chikungunya virus nsp2 helicase fidelity variant

    Article • Journal of Virology, August 2015, ASM Journals

    Professor Marco Vignuzzi

  6. Interdisciplinarity and Infectious Diseases: An Ebola Case Study

    Article • PLoS Pathogens, August 2015, PLOS

    Professor Marco Vignuzzi

  7. Group Selection and Contribution of Minority Variants during Virus Adaptation Determines Virus Fitness and Phenotype

    Article • PLoS Pathogens, May 2015, PLOS

    Professor Marco Vignuzzi

  8. Mutations in Coronavirus Nonstructural Protein 10 Decrease Virus Replication Fidelity

    Article • Journal of Virology, April 2015, ASM Journals

    Professor Marco Vignuzzi

  9. Structure-Function Relationships Underlying the Replication Fidelity of Viral RNA-Dependent RNA Polymerases

    Article • Journal of Virology, October 2014, ASM Journals

    Professor Marco Vignuzzi

  10. Ribavirin: a drug active against many viruses with multiple effects on virus replication and propagation. Molecular basis of ribavirin resistance

    Article • Current Opinion in Virology, October 2014, Elsevier

    Professor Marco Vignuzzi

  11. RNA Virus Population Diversity, an Optimum for Maximal Fitness and Virulence

    Article • Journal of Biological Chemistry, September 2014, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Marco Vignuzzi

  12. Emergence and Transmission of Arbovirus Evolutionary Intermediates with Epidemic Potential

    Article • Cell Host & Microbe, June 2014, Elsevier

    Dr Philippe BUCHY, Professor Marco Vignuzzi

  13. Alphavirus Mutator Variants Present Host-Specific Defects and Attenuation in Mammalian and Insect Models

    Article • PLoS Pathogens, January 2014, PLOS

    Professor Marco Vignuzzi

  14. Coronaviruses Lacking Exoribonuclease Activity Are Susceptible to Lethal Mutagenesis: Evidence for Proofreading and Potential Therapeutics

    Article • PLoS Pathogens, August 2013, PLOS

    Professor Marco Vignuzzi

  15. Reverse Genetics and Quasispecies

    Article • October 2012, Wiley

    Professor Marco Vignuzzi

  16. Closing the gap: the challenges in converging theoretical, computational, experimental and real-life studies in virus evolution

    Article • Current Opinion in Virology, October 2012, Elsevier

    Professor Marco Vignuzzi

  17. Viruses: foe, freeloader or friend?

    Article • Current Opinion in Microbiology, August 2012, Elsevier

    Professor Marco Vignuzzi

  18. Biomedical implications of viral mutation and evolution

    Article • Future Virology, April 2012, Future Medicine

    Professor Marco Vignuzzi

  19. Mutational Robustness of an RNA Virus Influences Sensitivity to Lethal Mutagenesis

    Article • Journal of Virology, December 2011, ASM Journals

    Professor Marco Vignuzzi

  20. RNA virus population diversity: implications for inter-species transmission

    Article • Current Opinion in Virology, December 2011, Elsevier

    Professor Marco Vignuzzi

  21. Isolation of Fidelity Variants of RNA Viruses and Characterization of Virus Mutation Frequency

    Article • Journal of Visualized Experiments, June 2011, MyJove Corporation

    Professor Marco Vignuzzi

  22. Host Alternation of Chikungunya Virus Increases Fitness while Restricting Population Diversity and Adaptability to Novel Selective Pressures

    Article • Journal of Virology, November 2010, ASM Journals

    Professor Marco Vignuzzi

  23. Fidelity Variants of RNA Dependent RNA Polymerases Uncover an Indirect, Mutagenic Activity of Amiloride Compounds

    Article • PLoS Pathogens, October 2010, PLOS

    Professor Marco Vignuzzi

  24. RNA Polymerase Fidelity Variants of the Picornaviruses Uncover A Novel, Indirect RNA Mutagenic Activity for Amiloride Compounds

    Article • Antiviral Research, April 2010, Elsevier

    Professor Marco Vignuzzi

  25. Engineering attenuated virus vaccines by controlling replication fidelity

    Article • Nature Reports Stem Cells, February 2008, Nature

    Professor Marco Vignuzzi

  26. Evolutionary constraints on chaperone-mediated folding provide an antiviral approach refractory to development of drug resistance

    Article • Genes & Development, January 2007, Cold Spring Harbor Laboratory Press

    Professor Marco Vignuzzi

  27. Quasispecies diversity determines pathogenesis through cooperative interactions in a viral population

    Article • December 2005, Nature

    Professor Marco Vignuzzi

  28. Remote Site Control of an Active Site Fidelity Checkpoint in a Viral RNA-dependent RNA Polymerase

    Article • Journal of Biological Chemistry, May 2005, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Marco Vignuzzi

  29. Ribavirin and lethal mutagenesis of poliovirus: molecular mechanisms, resistance and biological implications

    Article • Virus Research, February 2005, Elsevier

    Professor Marco Vignuzzi

  30. Expression of a Membrane-Anchored Glycoprotein, the Influenza Virus Hemagglutinin, by Dicistronic Replicons Derived from the Poliovirus Genome

    Article • Journal of Virology, May 2002, ASM Journals

    Professor Marco Vignuzzi

  31. Naked RNA immunization with replicons derived from poliovirus and Semliki Forest virus genomes for the generation of a cytotoxic T cell response against the influenza A virus nucleoprotein

    Article • Journal of General Virology, July 2001, Society for General Microbiology

    Professor Marco Vignuzzi