All Stories

  1. Agonism for the bile acid receptor GPBAR1 reverses liver and vascular damage in a mouse model of steatohepatitis
  2. Theonellasterone, a steroidal metabolite isolated from a Theonella sponge, protects peroxiredoxin-1 from oxidative stress reactions
  3. Mechanistic insights on petrosaspongiolide M inhibitory effects on immunoproteasome and autophagy
  4. Heteronemin, a marine sponge terpenoid, targets TDP-43, a key factor in several neurodegenerative disorders
  5. N-Formyl-7-amino-11-cycloamphilectene, a marine sponge metabolite, binds to tubulin and modulates microtubule depolymerization
  6. In cell scalaradial interactome profiling using a bio-orthogonal clickable probe
  7. Copper Promotes TFF1-Mediated Helicobacter pylori Colonization
  8. Perthamide C Inhibits eNOS and iNOS Expression and Has Immunomodulating Activity In Vivo
  9. Chemical proteomics-driven discovery of oleocanthal as an Hsp90 inhibitor
  10. The Inactivation Mechanism of Human Group IIA Phospholipase A2 by Scalaradial
  11. Plakilactones from the Marine Sponge Plakinastrella mamillaris. Discovery of a New Class of Marine Ligands of Peroxisome Proliferator-Activated Receptor γ
  12. Modulation of Tau Protein Fibrillization by Oleocanthal
  13. Chemical Proteomics Reveals Heat Shock Protein 60 To Be the Main Cellular Target of the Marine Bioactive Sesterterpene Suvanine
  14. Anti-inflammatory cyclopeptides from the marine sponge Theonella swinhoei
  15. Modulation of Proteasome Machinery by Natural and Synthetic Analogues of the Marine Bioactive Compound Petrosaspongiolide M
  16. Discovery That Theonellasterol a Marine Sponge Sterol Is a Highly Selective FXR Antagonist That Protects against Liver Injury in Cholestasis
  17. Heat shock proteins as key biological targets of the marine natural cyclopeptide perthamide C
  18. Inside Cover: The Binding Mode of Cladocoran A to the Human Group IIA Phospholipase A2 (ChemBioChem 17/2011)
  19. The nuclear receptor FXR regulates hepatic transport and metabolism of glutamine and glutamate
  20. The Binding Mode of Cladocoran A to the Human Group IIA Phospholipase A2
  21. Structure-based design, synthesis and preliminary anti-inflammatory activity of bolinaquinone analogues
  22. Chemical proteomics reveals bolinaquinone as a clathrin-mediated endocytosis inhibitor
  23. New insights on the interaction mechanism between tau protein and oleocanthal, an extra-virgin olive-oil bioactive component
  24. Petrosaspongiolide M inactivates proteasome in vitro and in cell assays
  25. Inside Cover: Chemical Proteomics Discloses Petrosapongiolide M, an Antiinflammatory Marine Sesterterpene, as a Proteasome Inhibitor (Angew. Chem. Int. Ed. 23/2010)
  26. Copper binds the carboxy-terminus of trefoil protein 1 (TFF1), favoring its homodimerization and motogenic activity
  27. Perthamides C and D, two new potent anti-inflammatory cyclopeptides from a Solomon Lithistid sponge Theonella swinhoei
  28. The molecular mechanism of human group IIA phospholipase A2 inactivation by bolinaquinone
  29. Effects of petrosaspongiolide R on the surface topology of bee venom PLA2: A limited proteolysis and mass spectrometry analysis
  30. The Binding Mode of Petrosaspongiolide M to the Human Group IIA Phospholipase A2: Exploring the Role of Covalent and Noncovalent Interactions in the Inhibition Process
  31. Homophymine A, an Anti-HIV Cyclodepsipeptide from the Sponge Homophymia sp.
  32. Scalaradial, a Dialdehyde‐Containing Marine Metabolite That Causes an Unexpected Noncovalent PLA2 Inactivation
  33. Copper-binding activity of Trefoil factor 1 (TFF1): A new perspective in the study of the multifunctional roles of TFFs
  34. Structure and Function of Bacterial Kid-Kis and Related Toxin-Antitoxin Systems
  35. Interactions between the toxin Kid of the bacterial parD system and the antitoxins Kis and MazE
  36. Chemistry and Biology of Anti-Inflammatory Marine Natural Products:Molecules Interfering with Cyclooxygenase, NF-kB and Other Unidentified Targets
  37. Chemistry and Biology of Antiinflammatory Marine Natural Products: Phospholipase A2 Inhibitors
  38. The Molecular Mechanism of Bee Venom Phospholipase A2 Inactivation by Bolinaquinone
  39. Callipeltins F—I: New Antifungal Peptides from the Marine Sponge Latrunculia sp.
  40. Model for RNA Binding and the Catalytic Site of the RNase Kid of the Bacterial parD Toxin–Antitoxin System
  41. Quantum Mechanical Calculation of Coupling Constants in the Configurational Analysis of Flexible Systems: Determination of the Configuration of Callipeltin A
  42. Callipeltins F–I: new antifungal peptides from the marine sponge Latrunculia sp.
  43. Concise Synthesis of All Stereoisomers of β-Methoxytyrosine and Determination of the Absolute Configuration of the Residue in Callipeltin A
  44. The inactivation of phospholipase A2 by scalaradial: a biomimetic study by electrospray mass spectrometry
  45. Further insights on the structural aspects of PLA2 inhibition by γ-hydroxybutenolide-containing natural products: a comparative study on petrosaspongiolides M–R