All Stories

  1. Safety levels of systemic IL-12 induced by cDNA expression as a cancer therapeutic

    Article • Immunotherapy, November 2021, Future Medicine

    Dr Howard A Young

  2. Promise and complexity of lupus mouse models

    Article • Nature Immunology, May 2021, Springer Science + Business Media

    Dr Howard A Young

  3. Lessons learned: new insights on the role of cytokines in COVID-19

    Article • Nature Immunology, March 2021, Springer Science + Business Media

    Dr Howard A Young

  4. The dynamic changes in cytokine responses in COVID-19: a snapshot of the current state of knowledge

    Article • Nature Immunology, August 2020, Springer Science + Business Media

    Dr Howard A Young

  5. Meeting Overview: Interferon Lambda—Disease Impact and Therapeutic Potential

    Article • Journal of Interferon & Cytokine Research, October 2019, Mary Ann Liebert Inc

    Dr Howard A Young

  6. Ion Gresser 1928–2019

    Article • Nature Immunology, June 2019, Springer Science + Business Media

    Dr Howard A Young

  7. Report on the 2018 Cancer, Autoimmunity, and Immunology Conference

    Article • The Journal of Immunology, April 2019, The American Association of Immunologists

    Dr Howard A Young, Colleen Curran

  8. Thymic expression of IL-4 and IL-15 after systemic inflammatory or infectious Th1 disease processes induce the acquisition of "innate" characteristics during CD8+ T cell development

    Article • PLoS Pathogens, January 2019, PLOS

    Dr Howard A Young

  9. Critical role of post-transcriptional regulation for IFN-γ in tumor-infiltrating T cells

    Article • OncoImmunology, October 2018, Taylor & Francis

    Dr Howard A Young

  10. Interferon-Gamma

    Article • January 2018, Springer Science + Business Media

    Dr Howard A Young

  11. Rapid and Rigorous IL-17A Production by a Distinct Subpopulation of Effector Memory T Lymphocytes Constitutes a Novel Mechanism of Toxic Shock Syndrome Immunopathology

    Article • The Journal of Immunology, February 2017, The American Association of Immunologists

    Dr Howard A Young

  12. Therapeutic and immunological interventions in primary biliary cholangitis: from mouse models to humans

    Article • Archives of Medical Science, January 2017, Termedia Sp. z.o.o.

    Dr Howard A Young

  13. Aging Converts Innate B1a Cells into Potent CD8+T Cell Inducers

    Article • The Journal of Immunology, March 2016, The American Association of Immunologists

    Dr Howard A Young

  14. Interferon γ: An Overview of Its Functions in Health and Disease

    Article • January 2016, Elsevier

    Dr Howard A Young

  15. Impact of dietary components on NK and Treg cell function for cancer prevention

    Article • Molecular Carcinogenesis, April 2015, Wiley

    Dr Howard A Young

  16. IFN-gamma AU-rich element removal promotes chronic IFN-gamma expression and autoimmunity in mice

    Article • Journal of Autoimmunity, September 2014, Elsevier

    Dr Howard A Young, Dr Philipp Kaldis

  17. IFN-gamma causes aplastic anemia by altering HSC composition and interrupting lineage differentiation

    Article • Experimental Hematology, August 2014, Elsevier

    Dr Howard A Young

  18. Abrogation of TNFα Production during Cancer Immunotherapy Is Crucial for Suppressing Side Effects Due to the Systemic Expression of IL-12

    Article • PLoS ONE, February 2014, PLOS

    Dr Howard A Young

  19. Impaired HCV Clearance in HIV/HCV Coinfected Subjects Treated with PegIFN and RBV Due to Interference of IFN Signaling by IFNαR2a

    Article • Journal of Interferon & Cytokine Research, January 2014, Mary Ann Liebert Inc

    Dr Howard A Young

  20. Faculty of 1000 evaluation for IL-4 blocks TH1-polarizing/inflammatory cytokine gene expression during monocyte-derived dendritic cell differentiation through histone hypoacetylation.

    Article • October 2013, Faculty of 1000, Ltd.

    Dr Howard A Young

  21. The talented interferon-gamma

    Article • Advances in Bioscience and Biotechnology, January 2013, Scientific Research Publishing, Inc,

    Dr Howard A Young

  22. Interleukin-18 in Pulmonary Inflammatory Diseases

    Article • Journal of Interferon & Cytokine Research, October 2012, Mary Ann Liebert Inc

    Dr Howard A Young

  23. IFN-Gamma

    Article • January 2012, Springer Science + Business Media

    Dr Howard A Young

  24. IFN-γ

    Article • January 2012, Springer Science + Business Media

    Dr Howard A Young

  25. CS13-7. Loss of Ifn-g 3’Untranslated Region Au-rich Element Affects b220+ b Cell and Plasmacytoid Dendritic cell Populations in a Novel Murine Lupus Model

    Article • Cytokine, October 2011, Elsevier

    Dr Howard A Young

  26. Differential microRNA regulation of HLA-C expression and its association with HIV control

    Article • Nature, April 2011, Nature

    Dr Howard A Young

  27. Localized Delivery of Interferon-β by Lactobacillus Exacerbates Experimental Colitis

    Article • PLoS ONE, February 2011, PLOS

    Dr Howard A Young

  28. Interferon-γ links ultraviolet radiation to melanomagenesis in mice

    Article • Nature, January 2011, Nature

    Dr Howard A Young, Sean Davis

  29. PS3-50 Differential transcriptosome profiles and antiviral effect of interferon-λ and interferon-α on HCV-infected and uninfected hepatoma cells

    Article • Cytokine, October 2010, Elsevier

    Dr Howard A Young

  30. CS3-5 miRNA interacts with AU-rich elements stabilizing interferon gamma gene

    Article • Cytokine, October 2010, Elsevier

    Dr Howard A Young

  31. SS4-4 Ku70 is a novel cytosolic DNA sensor and induces type-III IFN rather than Type-I IFN

    Article • Cytokine, October 2010, Elsevier

    Dr Howard A Young

  32. CS1-2 Targeted removal of IFN-gamma 3′untranslated region AU-rich element alters B cell function resulting in lupus-like disease in C57BL6 mice

    Article • Cytokine, October 2010, Elsevier

    Dr Howard A Young

  33. Interleukin-26: An IL-10-related cytokine produced by Th17 cells

    Article • Cytokine & Growth Factor Reviews, October 2010, Elsevier

    Dr Howard A Young

  34. PL3-5 A novel role of IL-22R1 as a possible driver of inflammation in ALK+ anaplastic large cell lymphoma

    Article • Cytokine, October 2010, Elsevier

    Dr Howard A Young

  35. Interferon Therapy for Malignant Solid Tumors

    Article • Current Drug Therapy, May 2010, Bentham Science Publishers

    Dr Howard A Young

  36. Clinical Use of Interferon-γ

    Article • Annals of the New York Academy of Sciences, December 2009, Wiley

    Dr Howard A Young

  37. Role of Proinflammatory Cytokines IL-18 and IL-1β in Bleomycin-Induced Lung Injury in Humans and Mice

    Article • American Journal of Respiratory Cell and Molecular Biology, December 2009, American Thoracic Society

    Dr Howard A Young

  38. Lentiviral Gene Transduction in Human and Mouse NK Cell Lines

    Article • November 2009, Springer Science + Business Media

    Dr Howard A Young

  39. Novel gene expression patterns in IFN-gamma 3′untranslated region AU-rich element-deleted mice

    Article • Cytokine, October 2009, Elsevier

    Dr Howard A Young

  40. Structural conservation of interferon gamma among vertebrates

    Article • Cytokine & Growth Factor Reviews, April 2009, Elsevier

    Dr Howard A Young

  41. SY-12 The Role of miRNAs in the regulation of interferon-gamma gene expression

    Article • Cytokine, September 2008, Elsevier

    Dr Howard A Young

  42. 293 IFN-γ 3′untranslated region AU-RICH element-deleted mice have altered immune structure and function

    Article • Cytokine, September 2008, Elsevier

    Dr Howard A Young

  43. Modulation of lymphocyte function with inhibitory CD2: Loss of NK and NKT cells

    Article • Cellular Immunology, September 2007, Elsevier

    Dr Howard A Young

  44. 54 Challenging Evolution: Eliminating the IFN-gamma 3 ARE Effects T Cell Homeostasis

    Article • Cytokine, July 2007, Elsevier

    Dr Howard A Young

  45. Pulmonary Inflammation and Emphysema

    Article • American Review of Respiratory Disease, July 2007, American Thoracic Society

    Dr Howard A Young

  46. Post-transcriptional control of the interferon system

    Article • Biochimie, June 2007, Elsevier

    Dr Howard A Young

  47. The Proinflammatory Cytokine Interleukin-18 Alters Multiple Signaling Pathways to Inhibit Natural Killer Cell Death

    Article • Journal of Interferon & Cytokine Research, October 2006, Mary Ann Liebert Inc

    Dr Howard A Young

  48. Interferon-γ: Gene and Protein Structure, Transcription Regulation, and Actions

    Article • June 2006, Wiley

    Dr Howard A Young

  49. IL-18 as critical co-stimulatory molecules in modulating the immune response of ITAM bearing lymphocytes

    Article • Seminars in Immunology, June 2006, Elsevier

    Dr Howard A Young

  50. Unraveling the Pros and Cons of Interferon-γ Gene Regulation

    Article • Immunity, May 2006, Elsevier

    Dr Howard A Young

  51. Synergistic Effect of IL-2, IL-12, and IL-18 on Thymocyte Apoptosis and Th1/Th2 Cytokine Expression

    Article • The Journal of Immunology, February 2005, The American Association of Immunologists

    Dr Howard A Young

  52. Mouse Ly49 NK receptors: balancing activation and inhibition

    Article • Molecular Immunology, February 2005, Elsevier

    Dr Howard A Young

  53. A Distal Region in the Interferon-γ Gene Is a Site of Epigenetic Remodeling and Transcriptional Regulation by Interleukin-2

    Article • Journal of Biological Chemistry, July 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Howard A Young

  54. Aging of innate immunity: functional comparisons of NK/LAK cells obtained from bulk cultures of young and aged mouse spleen cells in high concentrations of interleukin-2

    Article • Experimental Gerontology, January 2004, Elsevier

    Dr Howard A Young

  55. IFN-  Polymorphisms (IFN-  +2109 and IFN-  +3810) Are Associated with Severe Hepatic Fibrosis in Human Hepatic Schistosomiasis (Schistosoma mansoni)

    Article • The Journal of Immunology, November 2003, The American Association of Immunologists

    Dr Howard A Young

  56. CD2 mediates activation of the IFN-γ intronic STAT binding region in mucosal T cells

    Article • European Journal of Immunology, May 2003, Wiley

    Dr Howard A Young

  57. The distinct patterns of T cell IFN-γ promoter responses in LPMC are generated in PBL following IL-2 treatment

    Article • Gastroenterology, April 2003, Elsevier

    Dr Howard A Young

  58. Interferon-γ

    Article • January 2003, Elsevier

    Dr Howard A Young

  59. IL-7 withdrawal induces a stress pathway activating p38 and Jun N-terminal kinases

    Article • Cellular Signalling, September 2002, Elsevier

    Dr Howard A Young

  60. Growth Factor Independent-1 Induced by IL-4 Regulates Th2 Cell Proliferation

    Article • Immunity, May 2002, Elsevier

    Dr Howard A Young

  61. Differential inducibility of the transcriptional repressor ICER and its role in modulation of Fas ligand expression in T and NK lymphocytes

    Article • European Journal of Immunology, January 2002, Wiley

    Dr Howard A Young

  62. Dampened SOCS: An altered balance between STAT activating and SOCS inhibitory signals regulate interferon-γ expression in LPMC

    Article • Gastroenterology, April 2001, Elsevier

    Dr Howard A Young

  63. In vivo administration of IL-18 can induce IgE production through Th2 cytokine induction and up-regulation of CD40 ligand (CD154) expression on CD4+ T cells

    Article • European Journal of Immunology, July 2000, Wiley

    Dr Howard A Young

  64. A dual role for the -204 to -172 bp region of the IFN-Γ promoter: An activator of expression in LPL while a silencer of expression in PBL

    Article • Gastroenterology, April 2000, Elsevier

    Dr Howard A Young

  65. CD2-mediated activation of stat: transactivation of the lFN-Г intronic stat cis-element is unique for LPMC and independent of IL-12

    Article • Gastroenterology, April 2000, Elsevier

    Dr Howard A Young

  66. CNS Interleukin-3 (IL-3) Expression and Neurological Syndrome in Antisense-IL-3 Transgenic Mice

    Article • Journal of Neuropathology & Experimental Neurology, May 1999, Oxford University Press (OUP)

    Dr Howard A Young

  67. Infection with Human Immunodeficiency Virus Type 1 Upregulates DNA Methyltransferase, Resulting in De Novo Methylation of the Gamma Interferon (IFN-γ) Promoter and Subsequent Downregulation of IFN-γ Production

    Article • Molecular and Cellular Biology, September 1998, ASM Journals

    Dr Howard A Young

  68. Identification of both Cd2 enhancer and repressor elements within the interferon-λ promoter which regulate cytokine secretion in lamina propria T-cells

    Article • Gastroenterology, April 1998, Elsevier

    Dr Howard A Young

  69. Interferon Expression by B Cells

    Article • Methods, January 1997, Elsevier

    Dr Howard A Young

  70. Regulation of Interferon-γ Gene Expression

    Article • Journal of Interferon & Cytokine Research, August 1996, Mary Ann Liebert Inc

    Dr Howard A Young

  71. Regulation of interferon-γ gene transcription

    Article • Seminars in Virology, June 1995, Elsevier

    Dr Howard A Young

  72. Inhibition of tumor growth and enhancement of metastasis after transfection of the γ-interferon gene

    Article • International Journal of Cancer, September 1993, Wiley

    Dr Howard A Young

  73. IL-7 regulation of cytotoxic lymphocytes: Pore-forming protein gene expression, interferon-γ production, and cytotoxicity of human peripheral blood lymphocyte subsets

    Article • Cellular Immunology, December 1991, Elsevier

    Dr Howard A Young

  74. Interferon-γ: Producer cells, activation stimuli, and molecular genetic regulation

    Article • Pharmacology & Therapeutics, January 1990, Elsevier

    Dr Howard A Young

  75. Coordinate-Enhanced Expression of Three Adhesion Molecules (LFA-3, CD2, and LFA-1) and Three Other Molecules (4B4, UCHL1, and Pgp-1) Defines a Human T Cell Subset Containing Memory Cells and Characterized by Enhanced γ Interferon Production

    Article • January 1989, Springer Science + Business Media

    Dr Howard A Young

  76. Characterization of Interleukin 2 and Phorbol Myristate Acetate Augmentation of Expression of Transfected Human Interferon-γ Genomic DNA

    Article • Journal of Interferon Research, August 1988, Mary Ann Liebert Inc

    Dr Howard A Young

  77. Faculty of 1000 evaluation for Temporal response of the human virome to immunosuppression and antiviral therapy.

    Article • Faculty of 1000, Ltd.

    Dr Howard A Young