All Stories

  1. Deficiency Mutations of Alpha-1 Antitrypsin. Effects on Folding, Function, and Polymerization

    Article • American Journal of Respiratory Cell and Molecular Biology, January 2016, American Thoracic Society

    Dr Bibek Gooptu

  2. Interactions between N‐linked glycosylation and polymerisation of neuroserpin within the endoplasmic reticulum

    Article • FEBS Journal, October 2015, Wiley

    Dr Bibek Gooptu, Dr Elena Miranda

  3. An integrative approach combining ion mobility mass spectrometry, X-ray crystallography, and nuclear magnetic resonance spectroscopy to study the conformational dynamics of α1 -antitrypsin upon ligand binding

    Article • Protein Science, July 2015, Wiley

    Dr Bibek Gooptu

  4. 1.92 angstrom crystal structure of A1AT:TTAI ternary complex

    Article • June 2015, Protein Data Bank, Rutgers University

    Dr Bibek Gooptu

  5. Characterising the association of latency with α1-antitrypsin polymerisation using a novel monoclonal antibody

    Article • The International Journal of Biochemistry & Cell Biology, January 2015, Elsevier

    Dr Bibek Gooptu

  6. Tacrolimus in idiopathic inflammatory myopathy-associated interstitial lung disease: defining roles and responders

    Article • Rheumatology, October 2014, Oxford University Press (OUP)

    Dr Bibek Gooptu

  7. Therapeutic targeting of misfolding and conformational change in α1-antitrypsin deficiency

    Article • Future Medicinal Chemistry, June 2014, Future Science

    Dr Bibek Gooptu

  8. The molecular and cellular pathology of α1-antitrypsin deficiency

    Article • Trends in Molecular Medicine, February 2014, Elsevier

    Dr Bibek Gooptu

  9. Reactive centre loop mutants of α-1-antitrypsin reveal position-specific effects on intermediate formation along the polymerization pathway

    Article • Bioscience Reports, June 2013, Portland Press Ltd.

    Dr Bibek Gooptu

  10. Three New Alpha1-Antitrypsin Deficiency Variants Help to Define a C-Terminal Region Regulating Conformational Change and Polymerization

    Article • PLoS ONE, June 2012, PLOS

    Dr Bibek Gooptu

  11. In Silico Assessment of Potential Druggable Pockets on the Surface of α1-Antitrypsin Conformers

    Article • PLoS ONE, May 2012, PLOS

    Dr Bibek Gooptu

  12. Structural Dynamics Associated with Intermediate Formation in an Archetypal Conformational Disease

    Article • Structure, March 2012, Elsevier

    Dr Bibek Gooptu, Dr Christopher A Waudby

  13. Therapeutic target-site variability in α1-antitrypsin characterized at high resolution

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, November 2011, International Union of Crystallography

    Dr Bibek Gooptu

  14. 1H, 15N and 13C backbone resonance assignments of the archetypal serpin α1-antitrypsin

    Article • Biomolecular NMR Assignments, November 2011, Springer Science + Business Media

    Dr Bibek Gooptu

  15. NMR Spectroscopy Reveals Structural Dynamics Of Alpha1-Antitrypsin In Health And Disease

    Article • May 2011, American Thoracic Society

    Dr Bibek Gooptu

  16. 18 The structural biology of α1-antitrypsin deficiency and the serpinopathies

    Article • January 2011, De Gruyter

    Dr Bibek Gooptu

  17. Targeting Serpins in High-Throughput and Structure-Based Drug Design

    Article • January 2011, Elsevier

    Dr Bibek Gooptu

  18. The Serpinopathies

    Article • January 2011, Elsevier

    Dr Bibek Gooptu

  19. Defining the mechanism of polymerization in the serpinopathies

    Article • Proceedings of the National Academy of Sciences, September 2010, Proceedings of the National Academy of Sciences

    Dr Bibek Gooptu

  20. A novel monoclonal antibody to characterize pathogenic polymers in liver disease associated with α1-antitrypsin deficiency

    Article • Hepatology, May 2010, Wiley

    Dr Bibek Gooptu

  21. Mechanisms of emphysema in  1-antitrypsin deficiency: molecular and cellular insights

    Article • European Respiratory Journal, July 2009, European Respiratory Society (ERS)

    Dr Bibek Gooptu

  22. Conformational Pathology of the Serpins: Themes, Variations, and Therapeutic Strategies

    Article • Annual Review of Biochemistry, June 2009, Annual Reviews

    Dr Bibek Gooptu

  23. α 1 -Antitrypsin deficiency, chronic obstructive pulmonary disease and the serpinopathies

    Article • Clinical Science, June 2009, Portland Press Ltd.

    Dr Bibek Gooptu

  24. Crystallographic and Cellular Characterisation of Two Mechanisms Stabilising the Native Fold of α1-Antitrypsin: Implications for Disease and Drug Design

    Article • Journal of Molecular Biology, April 2009, Elsevier

    Dr Bibek Gooptu

  25. Polymers and inflammation: disease mechanisms of the serpinopathies

    Article • The Journal of Experimental Medicine, June 2008, Rockefeller University Press

    Dr Bibek Gooptu

  26. Small Molecules Block the Polymerization of Z α 1 -Antitrypsin and Increase the Clearance of Intracellular Aggregates

    Article • Journal of Medicinal Chemistry, November 2007, American Chemical Society (ACS)

    Dr Bibek Gooptu

  27. Oxygen alert cards and controlled oxygen: preventing emergency admissions at risk of hypercapnic acidosis receiving high inspired oxygen concentrations in ambulances and A&E departments

    Article • Emergency Medicine Journal, July 2006, BMJ

    Dr Bibek Gooptu

  28. Nucleation of α 1 -Antichymotrypsin Polymerization †

    Article • Biochemistry, March 2003, American Chemical Society (ACS)

    Dr Bibek Gooptu

  29. Inactive conformation of the serpin α1-antichymotrypsin indicates two-stage insertion of the reactive loop: Implications for inhibitory function and conformational disease

    Article • Proceedings of the National Academy of Sciences, January 2000, Proceedings of the National Academy of Sciences

    Dr Bibek Gooptu

  30. Familial dementia caused by polymerization of mutant neuroserpin

    Article • Nature, September 1999, Nature

    Dr Bibek Gooptu

  31. Conformational changes and disease — serpins, prions and Alzheimer's

    Article • Current Opinion in Structural Biology, December 1998, Elsevier

    Dr Bibek Gooptu