All Stories

  1. Toxicity testing in the 21st century: progress in the past decade and future perspectives

    Article • Archives of Toxicology, December 2019, Springer Science + Business Media

    Dr John Fredrick Wambaugh

  2. Assessing Toxicokinetic Uncertainty and Variability in Risk Prioritization

    Article • Toxicological Sciences, September 2019, Oxford University Press (OUP)

    Dr John Fredrick Wambaugh

  3. New approach methodologies for exposure science

    Article • Current Opinion in Toxicology, June 2019, Elsevier

    Dr John Fredrick Wambaugh

  4. Using the concordance of in vitro and in vivo data to evaluate extrapolation assumptions

    Article • PLoS ONE, May 2019, PLOS

    Dr John Fredrick Wambaugh

  5. Empirical models for anatomical and physiological changes in a human mother and fetus during pregnancy and gestation

    Article • PLoS ONE, May 2019, PLOS

    Dr Richard S Judson, Dr John Fredrick Wambaugh

  6. Estimating Uncertainty in the Context of New Approach Methodologies for Potential Use in Chemical Safety Evaluation

    Article • Current Opinion in Toxicology, April 2019, Elsevier

    Dr Richard S Judson, Dr John Fredrick Wambaugh

  7. Challenges in working towards an internal threshold of toxicological concern (iTTC) for use in the safety assessment of cosmetics: Discussions from the Cosmetics Europe iTTC Working Group workshop

    Article • Regulatory Toxicology and Pharmacology, April 2019, Elsevier

    Dr John Fredrick Wambaugh

  8. The next generation blueprint of computational toxicology at the U.S. Environmental Protection Agency

    Article • Toxicological Sciences, March 2019, Oxford University Press (OUP)

    Dr Antony John Williams, Dr John Fredrick Wambaugh, Dr Russell S Thomas

  9. Consensus Modeling of Median Chemical Intake for the U.S. Population Based on Predictions of Exposure Pathways

    Article • Environmental Science & Technology, December 2018, American Chemical Society (ACS)

    Dr John Fredrick Wambaugh

  10. Comment on: Dong et al. (2017) “Issues raised by the reference doses for perfluorooctonate sulfonate and perfluorooctanoic acid.”

    Article • Environment International, December 2018, Elsevier

    Dr John Fredrick Wambaugh

  11. Advancements in Life Cycle Human Exposure and Toxicity Characterization

    Article • Environmental Health Perspectives, December 2018, Environmental Health Perspectives

    Dr John Fredrick Wambaugh

  12. Empirical Models for Anatomical and Physiological Changes in a Human Mother and Fetus During Pregnancy and Gestation

    Article • October 2018, Cold Spring Harbor Laboratory Press

    Dr Richard S Judson, Dr John Fredrick Wambaugh

  13. Rapid experimental measurements of physicochemical properties to inform models and testing

    Article • The Science of The Total Environment, September 2018, Elsevier

    Dr Antony John Williams, Dr kamel mansouri, Dr John Fredrick Wambaugh

  14. Advancing internal exposure and physiologically-based toxicokinetic modeling for 21st-century risk assessments

    Article • Journal of Exposure Science & Environmental Epidemiology, August 2018, Springer Science + Business Media

    Dr John Fredrick Wambaugh

  15. Utilizing Threshold of Toxicological Concern (TTC) with high throughput exposure predictions (HTE) as a risk-based prioritization approach for thousands of chemicals

    Article • Computational Toxicology, August 2018, Elsevier

    Dr John Fredrick Wambaugh

  16. In vitro to in vivo extrapolation for high throughput prioritization and decision making

    Article • Toxicology in Vitro, March 2018, Elsevier

    Dr John Fredrick Wambaugh, Dr Nicole Kleinstreuer

  17. Suspect Screening Analysis of Chemicals in Consumer Products

    Article • Environmental Science & Technology, February 2018, American Chemical Society (ACS)

    Andrew D McEachran, Dr John Fredrick Wambaugh, Dr Antony John Williams

  18. Defining toxicological tipping points in neuronal network development

    Article • Toxicology and Applied Pharmacology, February 2018, Elsevier

    Dr John Fredrick Wambaugh

  19. High-throughput in-silico prediction of ionization equilibria for pharmacokinetic modeling

    Article • The Science of The Total Environment, February 2018, Elsevier

    Dr John Fredrick Wambaugh, Dr kamel mansouri, Dr Antony John Williams

  20. Evaluating In Vitro-In Vivo Extrapolation of Toxicokinetics

    Article • Toxicological Sciences, January 2018, Oxford University Press (OUP)

    Dr John Fredrick Wambaugh

  21. Computational Tools for ADMET Profiling

    Article • January 2018, Wiley

    Dr John Fredrick Wambaugh, Dr Antony John Williams

  22. Integrating tools for non-targeted analysis research and chemical safety evaluations at the US EPA

    Article • Journal of Exposure Analysis and Environmental Epidemiology, December 2017, Nature

    Andrew D McEachran, Dr John Fredrick Wambaugh, Dr Antony John Williams

  23. The CompTox Chemistry Dashboard: a community data resource for environmental chemistry

    Article • Journal of Cheminformatics, November 2017, Springer Science + Business Media

    Dr Antony John Williams, Andrew D McEachran, Dr John Fredrick Wambaugh, Dr kamel mansouri, Dr Grace Patlewicz

  24. High-throughput dietary exposure predictions for chemical migrants from food contact substances for use in chemical prioritization

    Article • Environment International, November 2017, Elsevier

    Dr John Fredrick Wambaugh

  25. Evaluation and calibration of high-throughput predictions of chemical distribution to tissues

    Article • Journal of Pharmacokinetics and Pharmacodynamics, October 2017, Springer Science + Business Media

    Dr John Fredrick Wambaugh

  26. Identifying populations sensitive to environmental chemicals by simulating toxicokinetic variability

    Article • Environment International, September 2017, Elsevier

    Dr John Fredrick Wambaugh

  27. A Method for Identifying Prevalent Chemical Combinations in the U.S. Population

    Article • Environmental Health Perspectives, August 2017, Environmental Health Perspectives

    Dr John Fredrick Wambaugh

  28. An Intuitive Approach for Predicting Potential Human Health Risk with the Tox21 10k Library

    Article • Environmental Science & Technology, August 2017, American Chemical Society (ACS)

    Dr John Fredrick Wambaugh

  29. From the exposome to mechanistic understanding of chemical-induced adverse effects

    Article • Environment International, February 2017, Elsevier

    Dr John Fredrick Wambaugh

  30. httk: R Package for High-Throughput Toxicokinetics

    Article • Journal of Statistical Software, January 2017, Foundation for Open Access Statistic

    Dr John Fredrick Wambaugh

  31. High-throughput screening of chemicals as functional substitutes using structure-based classification models

    Article • Green Chemistry, January 2017, Royal Society of Chemistry

    Dr John Fredrick Wambaugh

  32. A Liver-Centric Multiscale Modeling Framework for Xenobiotics

    Article • PLoS ONE, September 2016, PLOS

    Dr John Fredrick Wambaugh

  33. Analysis of the Effects of Cell Stress and Cytotoxicity onIn VitroAssay Activity Across a Diverse Chemical and Assay Space

    Article • Toxicological Sciences, September 2016, Oxford University Press (OUP)

    Dr Nicole Kleinstreuer, Dr John Fredrick Wambaugh

  34. ToxCast Chemical Landscape: Paving the Road to 21st Century Toxicology

    Article • Chemical Research in Toxicology, July 2016, American Chemical Society (ACS)

    Dr Antony John Williams, Dr John Fredrick Wambaugh, Dr kamel mansouri, Jayaram Kancherla

  35. Editor's Highlight: Analysis of the Effects of Cell Stress and Cytotoxicity onIn VitroAssay Activity Across a Diverse Chemical and Assay Space

    Article • Toxicological Sciences, May 2016, Oxford University Press (OUP)

    Dr Kevin M Crofton, Dr John Fredrick Wambaugh, Dr Nicole Kleinstreuer

  36. Using mass spectrometry and reference databases to identify chemicals in house dust

    Article • Environment International, March 2016, Elsevier

    Dr Antony John Williams, Dr John Fredrick Wambaugh

  37. Development of a quantitative morphological assessment of toxicant-treated zebrafish larvae using brightfield imaging and high-content analysis

    Article • Journal of Applied Toxicology, February 2016, Wiley

    Dr John Fredrick Wambaugh

  38. Characterization and prediction of chemical functions and weight fractions in consumer products

    Article • Toxicology Reports, January 2016, Elsevier

    Dr John Fredrick Wambaugh

  39. Computational Exposure Science: An Emerging Discipline to Support 21st-Century Risk Assessment

    Article • Environmental Health Perspectives, November 2015, Environmental Health Perspectives

    Dr John Fredrick Wambaugh

  40. Incorporating High-Throughput Exposure Predictions With Dosimetry-Adjusted In Vitro Bioactivity to Inform Chemical Toxicity Testing

    Article • Toxicological Sciences, August 2015, Oxford University Press (OUP)

    Dr Keith Houck, Dr John Fredrick Wambaugh

  41. Identifiability of PBPK models with applications to dimethylarsinic acid exposure

    Article • Journal of Pharmacokinetics and Pharmacodynamics, July 2015, Springer Science + Business Media

    Dr John Fredrick Wambaugh

  42. Toxicokinetic Triage for Environmental Chemicals

    Article • Toxicological Sciences, June 2015, Oxford University Press (OUP)

    Dr John Fredrick Wambaugh

  43. Exploring consumer exposure pathways and patterns of use for chemicals in the environment

    Article • Toxicology Reports, January 2015, Elsevier

    Dr Richard S Judson, Dr John Fredrick Wambaugh

  44. Dosimetric Anchoring of Toxicological Studies

    Article • January 2015, Springer Science + Business Media

    Dr John Fredrick Wambaugh

  45. Rapid, automated approach to estimate human exposure to over 8,000 environmental chemicals

    Article • Environmental Science & Technology, November 2014, American Chemical Society (ACS)

    Dr Richard S Judson, Dr John Fredrick Wambaugh

  46. Incorporating Population Variability and Susceptible Subpopulations into Dosimetry for High-Throughput Toxicity Testing

    Article • Toxicological Sciences, August 2014, Oxford University Press (OUP)

    Dr John Fredrick Wambaugh, Dr Russell S Thomas

  47. In Vitroand Modelling Approaches to Risk Assessment from the U.S. Environmental Protection Agency ToxCast Programme

    Article • Basic & Clinical Pharmacology & Toxicology, April 2014, Wiley

    Dr Richard S Judson, Dr Keith Houck, Dr John Fredrick Wambaugh, Dr Kevin M Crofton, Dr Russell S Thomas

  48. Development of a consumer product ingredient database for chemical exposure screening and prioritization

    Article • Food and Chemical Toxicology, March 2014, Elsevier

    Dr Richard S Judson, Dr John Fredrick Wambaugh

  49. Erratum

    Article • Toxicological Sciences, January 2014, Oxford University Press (OUP)

    Dr Richard S Judson, Dr John Fredrick Wambaugh, Dr Russell S Thomas

  50. Dosimetric Anchoring of In Vivo and In Vitro Studies for Perfluorooctanoate and Perfluorooctanesulfonate

    Article • Toxicological Sciences, September 2013, Oxford University Press (OUP)

    Dr Richard S Judson, Dr John Fredrick Wambaugh, Dr Nicole Kleinstreuer

  51. Comparison of modeling approaches to prioritize chemicals based on estimates of exposure and exposure potential

    Article • The Science of The Total Environment, August 2013, Elsevier

    Dr John Fredrick Wambaugh

  52. High-Throughput Models for Exposure-Based Chemical Prioritization in the ExpoCast Project

    Article • Environmental Science & Technology, July 2013, American Chemical Society (ACS)

    Dr Richard S Judson, Dr John Fredrick Wambaugh

  53. Relative Impact of Incorporating Pharmacokinetics on Predicting In Vivo Hazard and Mode of Action from High-Throughput In Vitro Toxicity Assays

    Article • Toxicological Sciences, January 2013, Oxford University Press (OUP)

    Dr Richard S Judson, Dr John Fredrick Wambaugh, Dr Russell S Thomas

  54. Incorporating exposure information into the toxicological prioritization index decision support framework

    Article • The Science of The Total Environment, October 2012, Elsevier

    Dr Richard S Judson, Dr John Fredrick Wambaugh

  55. Systems Toxicology from Genes to Organs

    Article • August 2012, Springer Science + Business Media

    Dr John Fredrick Wambaugh

  56. P68—Parsimonious development of a physiologically based pharmacokinetic model for PFOA

    Article • Reproductive Toxicology, July 2012, Elsevier

    Dr John Fredrick Wambaugh

  57. Response to "Accurate Risk-Based Chemical Screening * Relies on Robust Exposure Estimates"

    Article • Toxicological Sciences, April 2012, Oxford University Press (OUP)

    Dr Richard S Judson, Dr John Fredrick Wambaugh, Dr Russell S Thomas

  58. Modeling In Vitro Cell-Based Assays Experiments

    Article • January 2012, Elsevier

    Dr Richard S Judson, Dr John Fredrick Wambaugh

  59. Physiologically Based Pharmacokinetic Model Use in Risk Assessment--Why Being Published Is Not Enough

    Article • Toxicological Sciences, November 2011, Oxford University Press (OUP)

    Dr John Fredrick Wambaugh

  60. Integration of Dosimetry, Exposure, and High-Throughput Screening Data in Chemical Toxicity Assessment

    Article • Toxicological Sciences, September 2011, Oxford University Press (OUP)

    Dr Richard S Judson, Dr John Fredrick Wambaugh, Dr Russell S Thomas

  61. Comparative pharmacokinetics of perfluorononanoic acid in rat and mouse☆

    Article • Toxicology, March 2011, Elsevier

    Dr John Fredrick Wambaugh

  62. Using Nuclear Receptor Activity to Stratify Hepatocarcinogens

    Article • PLoS ONE, February 2011, PLOS

    Dr Richard S Judson, Dr Keith Houck, Dr John Fredrick Wambaugh

  63. Simulating Quantitative Cellular Responses Using Asynchronous Threshold Boolean Network Ensembles

    Article • BMC Systems Biology, January 2011, Springer Science + Business Media

    Dr John Fredrick Wambaugh

  64. Simple models for granular force networks

    Article • Physica D Nonlinear Phenomena, September 2010, Elsevier

    Dr John Fredrick Wambaugh

  65. Incorporating Human Dosimetry and Exposure into High-Throughput In Vitro Toxicity Screening

    Article • Toxicological Sciences, July 2010, Oxford University Press (OUP)

    Dr Richard S Judson, Dr John Fredrick Wambaugh, Dr Russell S Thomas

  66. Virtual Tissues in Toxicology

    Article • Journal of Toxicology and Environmental Health Part B, June 2010, Taylor & Francis

    Dr John Fredrick Wambaugh

  67. Force networks and elasticity in granular silos

    Article • The European Physical Journal E, June 2010, Springer Science + Business Media

    Dr John Fredrick Wambaugh

  68. Simulating Microdosimetry in a Virtual Hepatic Lobule

    Article • PLoS Computational Biology, April 2010, PLOS

    Dr John Fredrick Wambaugh

  69. Modeling single and repeated dose pharmacokinetics of PFOA in mice

    Article • Reproductive Toxicology, June 2009, Elsevier

    Dr John Fredrick Wambaugh

  70. Modeling Single and Repeated Dose Pharmacokinetics of PFOA in Mice

    Article • Toxicological Sciences, December 2008, Oxford University Press (OUP)

    Dr John Fredrick Wambaugh

  71. Comparing models for perfluorooctanoic acid pharmacokinetics using Bayesian analysis

    Article • Journal of Pharmacokinetics and Pharmacodynamics, December 2008, Springer Science + Business Media

    Dr John Fredrick Wambaugh

  72. Response to perturbations for granular flow in a hopper

    Article • Physical Review E, November 2007, American Physical Society (APS)

    Dr John Fredrick Wambaugh

  73. Shear and loading in channels: Oscillatory shearing and edge currents of superconducting vortices

    Article • April 2003, American Physical Society (APS)

    Dr John Fredrick Wambaugh

  74. Ratchet-induced segregation and transport of nonspherical grains

    Article • March 2002, American Physical Society (APS)

    Dr John Fredrick Wambaugh

  75. Superconducting Fluxon Pumps and Lenses

    Article • Physical Review Letters, December 1999, American Physical Society (APS)

    Dr John Fredrick Wambaugh