All Stories

  1. Molecular Insights into the Specific Targeting of c-MYC G-quadruplex by Cell-Penetrating Peptides: An in silico Study

    Article • December 2023, MDPI AG

    Dr Zhiguo Wang

  2. High-efficiency depolymerization/degradation of polyethylene terephthalate plastic by a whole-cell biocatalyst

    Article • 3 Biotech, April 2023, Springer Science + Business Media

    Dr Zhiguo Wang

  3. Dysregulation of PD-L1 by UFMylation imparts tumor immune evasion and identified as a potential therapeutic target

    Article • Proceedings of the National Academy of Sciences, March 2023, Proceedings of the National Academy of Sciences

    Dr Zhiguo Wang

  4. In Silico Investigation of the Molecular Mechanism of PARP1 Inhibition for the Treatment of BRCA-Deficient Cancers

    Article • Molecules, February 2023, MDPI AG

    Dr Zhiguo Wang

  5. Thyroid hormone activities of neutral and anionic hydroxylated polybrominated diphenyl ethers to thyroid receptor β: A molecular dynamics study

    Article • Chemosphere, January 2023, Elsevier

    Dr Zhiguo Wang

  6. Computational Insight into Biotransformation Profiles of Organophosphorus Flame Retardants to Their Diester Metabolites by Cytochrome P450

    Article • Molecules, April 2022, MDPI AG

    Dr Zhiguo Wang

  7. Molecular insights into the selective binding mechanism targeting parallel human telomeric G-quadruplex

    Article • Journal of Molecular Graphics and Modelling, January 2022, Elsevier

    Dr Zhiguo Wang

  8. Rational Design of Biocatalytic Deuteration Platform of Aldehydes

    Article • ACS Catalysis, October 2021, American Chemical Society (ACS)

    Dr Zhiguo Wang

  9. Light-driven decarboxylative deuteration enabled by a divergently engineered photodecarboxylase

    Article • Nature Communications, June 2021, Springer Science + Business Media

    Dr Zhiguo Wang

  10. Inactivation Mechanism of Neuronal Nitric Oxide Synthase by (S)-2-Amino-5-(2-(methylthio)acetimidamido)pentanoic Acid: Chemical Conversion of the Inactivator in the Active Site

    Article • Inorganic Chemistry, June 2021, American Chemical Society (ACS)

    Dr Zhiguo Wang

  11. Efficient preparation of the chiral intermediate of luliconazole with Lactobacillus kefir alcohol dehydrogenase through rational rearrangement of the substrate binding pocket

    Article • Molecular Catalysis, June 2021, Elsevier

    Dr Zhiguo Wang

  12. Intramolecular Stereoselective Stetter Reaction Catalyzed by Benzaldehyde Lyase

    Article • Angewandte Chemie, March 2021, Wiley

    Dr Zhiguo Wang

  13. Intramolecular Stereoselective Stetter Reaction Catalyzed by Benzaldehyde Lyase

    Article • Angewandte Chemie International Edition, March 2021, Wiley

    Dr Zhiguo Wang

  14. Insight Derived from Molecular Dynamics Simulation into the Selectivity Mechanism Targeting c-MYC G-Quadruplex

    Article • The Journal of Physical Chemistry B, October 2020, American Chemical Society (ACS)

    Dr Zhiguo Wang

  15. In vivo evolutionary engineering of riboswitch with high-threshold for N-acetylneuraminic acid production

    Article • Metabolic Engineering, May 2020, Elsevier

    Dr Zhiguo Wang

  16. Molecular insight into the selective binding between human telomere G‐quadruplex and a negatively charged stabilizer

    Article • Clinical and Experimental Pharmacology and Physiology, January 2020, Wiley

    Dr Zhiguo Wang

  17. Antimicrobial activity and mechanism of peptide CM4 againstPseudomonas aeruginosa

    Article • Food & Function, January 2020, Royal Society of Chemistry

    Dr Zhiguo Wang

  18. Tolrestat acts atypically as a competitive inhibitor of the thermostable aldo‐keto reductase Tm1743 from Thermotoga maritima

    Article • FEBS Letters, October 2019, Wiley

    Dr Zhiguo Wang

  19. The C-terminal domain conformational switch revealed by the crystal structure of malyl-CoA lyase from Roseiflexus castenholzii

    Article • Biochemical and Biophysical Research Communications, October 2019, Elsevier

    Dr Zhiguo Wang

  20. Exploiting Cofactor Versatility to Convert a FAD‐Dependent Baeyer–Villiger Monooxygenase into a Ketoreductase

    Article • Angewandte Chemie, September 2019, Wiley

    Dr Zhiguo Wang

  21. Molecular structure, expression, and bioactivity of B-cell–activating factor of the TNF family (BAFF) and its receptor BAFF-R in cats (Felis catus)

    Article • Molecular Immunology, August 2019, Elsevier

    Dr Zhiguo Wang

  22. Cloning and high-level SUMO-mediated fusion expression of a serine protease inhibitor from Hyphantria cunea Drury that exhibits activity against papain

    Article • Protein Expression and Purification, June 2019, Elsevier

    Dr Zhiguo Wang

  23. Combined 3D-QSAR, molecular docking and molecular dynamics study on the benzimidazole inhibitors targeting HCV NS5B polymerase

    Article • Journal of Biomolecular Structure and Dynamics, March 2019, Taylor & Francis

    Dr Zhiguo Wang

  24. Roles of Telomere Biology in Cell Senescence, Replicative and Chronological Ageing

    Article • Cells, January 2019, MDPI AG

    Dr Zhiguo Wang

  25. Activation and recyclization of a benzocyclobutenone derivative catalyzed by a chiral Rh(I) complex based on DFT investigations

    Article • Chemical Papers, November 2018, Springer Science + Business Media

    Dr Zhiguo Wang

  26. Effects of cation charges on the binding of stabilizers with human telomere and TERRA G-quadruplexes

    Article • Journal of Biomolecular Structure and Dynamics, May 2018, Taylor & Francis

    Dr Zhiguo Wang

  27. QM/MM Study of the Dephosphorylation Mechanism of Adenosine 5′-(β,γ-Imido)triphosphate Catalyzed by Sulfolobus Tokodaii Hexokinase

    Article • ChemistrySelect, February 2018, Wiley

    Dr Zhiguo Wang

  28. An alternative conformation of human TrpRS suggests a role of zinc in activating non-enzymatic function

    Article • RNA Biology, September 2017, Taylor & Francis

    Dr Zhiguo Wang

  29. Semi-rational engineering of a thermostable aldo–keto reductase from Thermotoga maritima for synthesis of enantiopure ethyl-2-hydroxy-4-phenylbutyrate (EHPB)

    Article • Scientific Reports, June 2017, Springer Science + Business Media

    Dr Zhiguo Wang

  30. Identification of a potential proton donor to the linking oxygen atom in a three-metal ion assisted catalysis pathway catalyzed by Fructose-1, 6-bisphosphatase

    Article • Journal of Molecular Graphics and Modelling, May 2017, Elsevier

    Dr Zhiguo Wang

  31. Identification of a cyclodextrin inclusion complex of antimicrobial peptide CM4 and its antimicrobial activity

    Article • Food Chemistry, April 2017, Elsevier

    Dr Zhiguo Wang

  32. Effects of the central potassium ions on the G-quadruplex and stabilizer binding

    Article • Journal of Molecular Graphics and Modelling, March 2017, Elsevier

    Dr Zhiguo Wang

  33. Efficient Preparation of (S)-N-Boc-3-Hydroxylpiperidine Through Bioreduction by a Thermostable Aldo-KetoReductase

    Article • Applied Biochemistry and Biotechnology, November 2016, Springer Science + Business Media

    Dr Zhiguo Wang

  34. Identification of the active site of human mitochondrial malonyl-coenzyme a decarboxylase: A combined computational study

    Article • Proteins Structure Function and Bioinformatics, March 2016, Wiley

    Dr Zhiguo Wang

  35. Characterization of potassium binding with human telomeres

    Article • Clinical and Experimental Pharmacology and Physiology, August 2015, Wiley

    Dr Zhiguo Wang

  36. Semi-rational Directed Evolution of Monoamine Oxidase for Kinetic Resolution of rac-Mexiletine

    Article • Applied Biochemistry and Biotechnology, June 2015, Springer Science + Business Media

    Dr Zhiguo Wang

  37. Molecular dynamics and principal components of potassium binding with human telomeric intra-molecular G-quadruplex

    Article • Protein & Cell, April 2015, Springer Science + Business Media

    Dr Zhiguo Wang

  38. Identification of interferon-γ-inducible-lysosomal thiol reductase (GILT) gene in goldfish (Carassius auratus) and its immune response to LPS challenge

    Article • Fish & Shellfish Immunology, February 2015, Elsevier

    Dr Zhiguo Wang

  39. Molecular dynamics simulations of isoleucine-release pathway in GAF domain of N-CodY from Bacillus Subtilis

    Article • Journal of Molecular Graphics and Modelling, July 2013, Elsevier

    Dr Zhiguo Wang

  40. Theoretical studies on the interactions of XIAP-BIR3 domain with bicyclic and tricyclic core monovalent Smac mimetics

    Article • Journal of Molecular Graphics and Modelling, November 2010, Elsevier

    Dr Zhiguo Wang

  41. Theoretical studies on the interaction of guanine riboswitch with guanine and its closest analogues

    Article • Molecular Simulation, October 2010, Taylor & Francis

    Dr Zhiguo Wang

  42. STUDY ON THE INTERACTIONS OF Smac MIMETICS WITH XIAP-BIR3 DOMAIN BY DOCKING AND MOLECULAR DYNAMICS SIMULATIONS

    Article • Journal of Theoretical and Computational Chemistry, August 2010, World Scientific Pub Co Pte Lt

    Dr Zhiguo Wang

  43. Docking and molecular dynamics studies on the interaction of four imidazoline derivatives with potassium ion channel (Kir6.2)

    Article • Molecular Simulation, February 2010, Taylor & Francis

    Dr Zhiguo Wang

  44. Docking and molecular dynamics studies toward the binding of new natural phenolic marine inhibitors and aldose reductase

    Article • Journal of Molecular Graphics and Modelling, September 2009, Elsevier

    Dr Zhiguo Wang

  45. Theoretical studies on the interaction of modified pyrimidines and purines with purine riboswitch

    Article • Journal of Molecular Graphics and Modelling, August 2009, Elsevier

    Dr Zhiguo Wang

  46. Docking and Molecular Dynamics Study on the Inhibitory Activity of Coumarins on Aldose Reductase

    Article • The Journal of Physical Chemistry B, August 2008, American Chemical Society (ACS)

    Dr Zhiguo Wang

  47. Addition reactions of nitrones on the reconstructed C(100)-2×1 surfaces

    Article • Journal of Molecular Structure THEOCHEM, February 2008, Elsevier

    Dr Zhiguo Wang

  48. Addition Reaction of Nitrones on the Reconstructed Si(100)-2 × 1 Surface

    Article • The Journal of Physical Chemistry C, March 2007, American Chemical Society (ACS)

    Dr Zhiguo Wang

  49. Theoretical Study on Adsorption of Na+ and Na+(H2O)n (n = 1−6) on a Clean Si(111) Surface

    Article • The Journal of Physical Chemistry C, January 2007, American Chemical Society (ACS)

    Dr Zhiguo Wang

  50. Theoretical Study on the Mechanism for the Addition Reaction of SiH3with Propylene and Acetic Acid

    Article • The Journal of Physical Chemistry A, November 2006, American Chemical Society (ACS)

    Dr Zhiguo Wang