All Stories

  1. Proof of concept: Pull down assay using bovine serum albumin and an immunomodulator small molecule
  2. Stereoselective Intramolecular [2+2] Trapping of 1,2‐Cyclohexadienes: a Route to Rigid, Angularly Fused Tricyclic Scaffolds
  3. 2 + 2 Trapping of Acyloxy-1,2-cyclohexadienes with Styrenes and Electron-Deficient Olefins
  4. Repurposing Antimalarial Pyronaridine as a DNA Repair Inhibitor to Exploit the Full Potential of Gold-Nanoparticle-Mediated Radiation Response
  5. PET Imaging of Fructose Metabolism in a Rodent Model of Neuroinflammation with 6-[18F]fluoro-6-deoxy-D-fructose
  6. A Fluorescence-Based Assay to Probe Inhibitory Effect of Fructose Mimics on GLUT5 Transport in Breast Cancer Cells
  7. Towards Selective Binding to the GLUT5 Transporter: Synthesis, Molecular Dynamics and In Vitro Evaluation of Novel C-3-Modified 2,5-Anhydro-D-mannitol Analogs
  8. Inhibition of triple negative breast cancer metastasis and invasiveness by novel drugs that target epithelial to mesenchymal transition
  9. Cover Feature: Lithium Hydroxide Assisted Endo ‐Selective [4+4]‐Photocycloaddition of Pyran‐2‐ones (Eur. J. Org. Chem. 16/2021)
  10. Lithium Hydroxide Assisted Endo ‐Selective [4+4]‐Photocycloaddition of Pyran‐2‐ones
  11. Pharmacological targets and emerging treatments for respiratory syncytial virus bronchiolitis
  12. Enhancing the activity of platinum-based drugs by improved inhibitors of ERCC1–XPF-mediated DNA repair
  13. Design, synthesis, and evaluation of positron emission tomography/fluorescence dual imaging probes for targeting facilitated glucose transporter 1 (GLUT1)
  14. Generation and trapping of electron-deficient 1,2-cyclohexadienes. Unexpected hetero-Diels–Alder reactivity
  15. Design, synthesis and in vitro cell-free/cell-based biological evaluations of novel ERCC1-XPF inhibitors targeting DNA repair pathway
  16. A Mild Method for the Generation and Interception of 1,2-Cycloheptadienes with 1,3-Dipoles
  17. Computer‐aided drug design of small molecule inhibitors of the ERCC1‐XPF protein–protein interaction
  18. Comprehensive in vitro characterization of PD-L1 small molecule inhibitors
  19. Targeting DNA Repair in Tumor Cells via Inhibition of ERCC1–XPF
  20. Strain-Activated Diels–Alder Trapping of 1,2-Cyclohexadienes: Intramolecular Capture by Pendent Furans
  21. Asymmetric synthesis of (+)-laurencin using a stereoselective Stevens [1,2]-shift of a sulfonium ylide
  22. The calcium sensitizer drug MCI-154 binds the structural C-terminal domain of cardiac troponin C
  23. Dual Catalytic Synthesis of Antiviral Compounds Based on Metallocarbene–Azide Cascade Chemistry
  24. One-Pot Generation of Bicyclo[3.1.0]hexanols and Cyclohexanones by Double Interrupted Nazarov Reactions
  25. Molecular Imaging of GLUT1 and GLUT5 in Breast Cancer: A Multitracer Positron Emission Tomography Imaging Study in Mice
  26. Synthesis and biological evaluation of structurally simplified noscapine analogues as microtubule binding agents
  27. Tunable GLUT-Hexose Binding and Transport via Modulation of Hexose C-3 Hydrogen-Bonding Capabilities
  28. Intercepting the Nazarov Oxyallyl Intermediate with α-Formyl­vinyl Anion Equivalents to Access Formal Morita–Baylis–Hillman Alkylation Products
  29. Oxidation‐Initiated Cyclizations of Pentadienyl Ethers: An Alternative Entry to the Nazarov Reaction
  30. Oxidation‐Initiated Cyclizations of Pentadienyl Ethers: An Alternative Entry to the Nazarov Reaction
  31. Fluorescent Hexose Conjugates Establish Stringent Stereochemical Requirement by GLUT5 for Recognition and Transport of Monosaccharides
  32. Medium-Sized Cyclic Ethers via Stevens [1,2]-Shift of Mixed Monothioacetal-Derived Sulfonium Ylides: Application to Formal Synthesis of (+)-Laurencin
  33. Evidence for heterolytic cleavage of a cyclic oxonium ylide: implications for the mechanism of the Stevens [1,2]-shift
  34. Interrupting the Nazarov Cyclization with Bromine
  35. Structures reveal details of small molecule binding to cardiac troponin
  36. Efficient Trapping of 1,2-Cyclohexadienes with 1,3-Dipoles
  37. A new antiproliferative noscapine analogue: chemical synthesis and biological evaluation
  38. Efficient and Easy Access to Optically Pure Tetrasubstituted Tetra­hydrofurans via Stereoselective Opening ofC2-Symmetric Epoxide and Aziridine Rings
  39. 1,4‐Diketones from Cross‐Conjugated Dienones: Potassium Permanganate‐Interrupted Nazarov Reaction
  40. Diastereoselective N-quaternization of piperidines
  41. Reactivity and Stereoselectivity of 6π and Nazarov Electrocyclizations of Bridged Bicyclic Trienes and Divinyl Ketones
  42. New fluorinated fructose analogs as selective probes of the hexose transporter protein GLUT5
  43. Correction: New fluorinated fructose analogs as selective probes of the hexose transporter protein GLUT5
  44. Experimental and Computational Studies on Interrupted Nazarov Reactions: Exploration of Umpolung Reactivity at the α-Carbon of Cyclopentanones
  45. Formal Homologous Aldol Reactions: Interrupting the Nazarov Cyclization via Carboalkoxylation of Alkynes
  46. Ready Access to Alkylidenecyclopentenones by Nazarov Cyclization/β-Elimination of 2-Hydroxyalkyl-1,4-dien-3-ones
  47. α-Hydroxycyclopentanones via one-pot oxidation of the trimethylaluminum-mediated Nazarov reaction with triplet oxygen
  48. Azide trapping of metallocarbenes: generation of reactive C-acylimines and domino trapping with nucleophiles
  49. Efficient synthesis of bicyclo[6.3.0]undecadienones by Nazarov cyclization/regioselective elimination
  50. ChemInform Abstract: Organoaluminum‐Mediated Interrupted Nazarov Reaction.
  51. Hydroxylic additives enhance yield and scalability of silicon-directed Nazarov reaction
  52. Organoaluminum‐Mediated Interrupted Nazarov Reaction
  53. Organoaluminum‐Mediated Interrupted Nazarov Reaction
  54. Nazarov Reactions of Vinyl Cyclopropylamines: An Approach to the Imino-Nazarov Problem
  55. Intramolecular generation and rearrangement of oxonium ylides: methodology studies and their application in synthesis
  56. Prion inhibition with multivalent PrPSc binding compounds
  57. Regioselective synthesis of 2-iminooxazinones from dioxinones and carbodiimides
  58. Superacid-catalyzed Friedel–Crafts cyclization of unactivated alkenes
  59. Lithium Hydroperoxide
  60. Construction of α-amido-indanones via formal allenamide hydroacylation–Nazarov cyclization
  61. Preparation and Synthetic Applications of Azetidines
  62. Homologous Mukaiyama Reactions via Trapping of the Nazarov Intermediate with Silyloxyalkenes
  63. Radiopharmacological evaluation of 6-deoxy-6-[18F]fluoro-d-fructose as a radiotracer for PET imaging of GLUT5 in breast cancer
  64. Expedient Route to the Tigliane-Daphnane Skeleton via Oxonium Ylide [1,2]-Shift
  65. Intermolecular [3 + 3]-Cycloadditions of Azides with the Nazarov Intermediate
  66. Olefination of α,α′-Divinyl Ketones through Catalytic Meyer−Schuster Rearrangement
  67. Handbook of Synthetic Photochemistry
  68. ChemInform Abstract: Heteroaromatic Trapping of Tricyclic 2‐Oxidocyclopentenyl Cations: A Surprisingly Efficient Example of Intermolecular Interrupted Nazarov Reaction.
  69. Silver(I)‐Mediated Electrocyclic Processes
  70. Brønsted Acid-Mediated Nazarov Cyclization of Vinylallenes
  71. Heteroaromatic Trapping of Tricyclic 2-Oxidocyclopentenyl Cations: A Surprisingly Efficient Example of Intermolecular Interrupted Nazarov Reaction
  72. ChemInform Abstract: Interrupting the Nazarov Reaction: Domino and Cascade Processes Utilizing Cyclopentenyl Cations
  73. The Photochemistry of Dienes and Polyenes: Application to the Synthesis of Complex Molecules
  74. Synthesis and characterization of 6-deoxy-6-fluoro-d-fructose as a potential compound for imaging breast cancer with PET
  75. Cyclization of Cross-Conjugated Trienes: The Vinylogous Nazarov Reaction
  76. Fused ring systems derived from reactions of half-open titanocenes with diynes: Syntheses, characterization, cage rearrangements, and structural studies
  77. One-Carbon Ring Expansion of Azetidines via Ammonium Ylide [1,2]-Shifts: A Simple Route to Substituted Pyrrolidines
  78. Diastereocontrol in [4+4]-photocycloadditions of pyran-2-ones: effect of ring substituents and chiral ketal
  79. Interrupting the Nazarov reaction: domino and cascade processes utilizing cyclopentenyl cations
  80. Ring Expansion of Lactones and Lactams via Propiolate 1-Carbon Intercalation
  81. Concise Route to Triquinanes from Pyran-2-ones
  82. ChemInform Abstract: Survey of Chemical Synthesis of the Pyrrolizidine Alkaloids Turneforcidine and Platynecine
  83. Cyclooctatrienes from pyran-2-ones via a tandem [4 + 4]-photocycloaddition/decarboxylation process
  84. Construction of aryl-substituted triquinanes through the interrupted Nazarov reaction
  85. Domino Electrocyclization/Azide-Capture/Schmidt Rearrangement of Dienones:  One-Step Synthesis of Dihydropyridones from Simple Building Blocks
  86. Interrupted Nazarov Reactions Using Dichlorocyclopropanes:  A Novel Mode of Arene Trapping
  87. Efficient intermolecular 3+2 trapping of the Nazarov intermediate with vinyl sulfides
  88. Highly Stereoselective 6π Electrocyclization of Bridged Bicyclic 1,3,5-Trienes
  89. Intramolecular Azide Trapping of the Nazarov Intermediate:  Formation of Peroxy-Bridged Indolizidinones via a Deep-Seated Rearrangement and Aerobic Oxidation
  90. Survey of Chemical Syntheses of the Pyrrolizidine Alkaloids Turneforcidine and Platynecine
  91. Polycyclic oxonium ylides — Use of cyclic acetals as convenient scaffolds in the construction of fused bicyclic compounds containing a medium ring
  92. [1,2]- or [2,3]-Rearrangement of Onium Ylides of Allyl and Benzyl Ethers and Sulfides via in Situ-Generated Iodonium Ylides
  93. Recent Advances in the Stevens Rearrangement of Ammonium Ylides. Application to the Synthesis of Alkaloid Natural Products
  94. Diastereoselective [4 + 4]-Photocycloaddition Reactions of Pyran-2-ones:  Rapid Access to Functionalized 5−8−5 Skeletons
  95. A New Approach to the Nazarov Reaction via Sequential Electrocyclic Ring Opening and Ring Closure
  96. Recent advances in the Stevens rearrangement of ammonium ylides. Application to the synthesis of alkaloid natural products
  97. Construction of fused bis(pyran) units from enones via a hydrosilylation–dihydroxylation–acetalization–reduction sequence
  98. Unexpected Participation of an Unconjugated Olefin during Nazarov Cyclization of Bridged Bicyclic Dienones
  99. Halide trapping of the Nazarov intermediate in strained polycyclic systems: a new interrupted Nazarov reaction
  100. Ring Expansion of Azetidinium Ylides:  Rapid Access to the Pyrrolizidine Alkaloids Turneforcidine and Platynecine
  101. Stereoselective Nazarov Cyclizations of Bridged Bicyclic Dienones
  102. Hydrazulene Ring Systems via Heteroatom-Assisted [1,2]-Shift of Oxonium and Sulfonium Ylides
  103. Rearrangement Processes of Oxonium and Ammonium Ylides Formed by Rhodium(II)‐Catalyzed Carbene Transfer
  104. Solvent Trapping of Photochemically Generated Pyran-4-one-Derived Oxyallyls: A Convenient Cyclopentannulation Method
  105. A Convenient Method for the Synthesis of Terminal (E)-1,3-Dienes
  106. Convenient route to centro-substituted triquinacene skeletons via the interrupted Nazarov reaction
  107. Ammonium, Oxonium and Sulfonium Ylides—Generation of Ammonium Ylides from Metal Carbenoids
  108. Photochemical Rearrangement and Trapping Reactions of 4‐Pyrones
  109. Catalyst and Ring Size Effects on Periselectivity of Oxonium Ylide Rearrangements
  110. Efficient construction of benzohydrindenones from aryltrienones via domino Nazarov electrocyclization – electrophilic aromatic substitution
  111. Improved Yields with Added Copper(I) Salts in Carbonylative Stille Couplings of Sterically Hindered Vinylstannanes
  112. Cyclooctanoid Ring Systems from Mixed Acetals via Heteroatom-Assisted [1,2]-Shift of Oxonium Ylides
  113. Photochemical Rearrangement and Trapping Reactions of 4-Pyrones
  114. Formal Intermolecular 4 + 4 Approach to Cyclooctanoids:  4 + 3 Capture of the Nazarov Oxyallyl Intermediate with Simple 1,3-Dienes
  115. Stereoselective formation and rearrangement of morpholinium ylides derived from copper carbenoids
  116. New Efficient Iterative Approaches to Polycyclic Ethers
  117. New Efficient Iterative Approaches to Polycyclic Ethers
  118. A Novel, Stereoselective Silyl-Directed Stevens [1,2]-Shift of Ammonium Ylides
  119. Equilibrium and Kinetic Analyses of the Interactions between Vitamin B12 Binding Proteins and Cobalamins by Surface Plasmon Resonance
  120. Cyclic oxonium ylides: building blocks for iterative synthesis of polycyclic ethers
  121. ChemInform Abstract: Solvent Trapping of Photochemically Generated Pyran‐4‐one‐Derived Oxyallyls: A Convenient Cyclopentannulation Method.
  122. Highly Efficient Trapping of the Nazarov Intermediate with Substituted Arenes
  123. Iterative Approach to Polycyclic Ethers Based on Stereoselective Oxonium Ylide [2,3]-Shifts
  124. Lithium Hydroperoxide
  125. Synthesis and Characterization of Fluorescent Cobalamin (CobalaFluor) Derivatives for Imaging
  126. 10-Deacetyl baccatin III dimethyl sulfoxide disolvate
  127. Ionic Hydrogenation of Oxyallyl Intermediates: The Reductive Nazarov Cyclization
  128. ChemInform Abstract: Intermolecular Trapping of the Nazarov Intermediate: Domino Electrocyclization/[3 + 2] Cycloadditions with Allylsilanes.
  129. Intermolecular Trapping of the Nazarov Intermediate: Domino Electrocyclization/[3+2] Cycloadditions with Allylsilanes
  130. Coumarin derivatives and breast-feeding
  131. Synthesis, characterization, and organic chemistry of an edge-bridged half-open titanocene
  132. Formation of Hydrindans and Tricyclo[4.3.0.03,8]nonanes via 6-Endo Trapping of the Nazarov Oxyallyl Intermediate
  133. Nazarov-Initiated Diastereoselective Cascade Polycyclization of Aryltrienones1
  134. Chirality Transfer from Carbon to Nitrogen to Carbon via Cyclic Ammonium Ylides
  135. Synthesis of Bridged Bicyclic Ethers and Fused Oxetanes from Pyran-4-ones via Tandem Solvent Trapping and Norrish Type II Cyclization1
  136. A Novel Cycloisomerization of Tetraenones:  4+3 Trapping of the Nazarov Oxyallyl Intermediate
  137. The reductive Nazarov cyclization
  138. Medium ring ethers via [1,2]-shift of acetal-derived oxonium ylides
  139. 1,3-Dioxolan-2-ylium cations from acylfurans: Conversion of furyl ketones to esters under nonoxidative conditions
  140. Highly Diastereoselective Cycloisomerization of Acyclic Trienones. The Interrupted Nazarov Reaction
  141. A short, enantioselective synthesis of (−)-epilupinine from proline via a spirocyclic ammonium ylide
  142. Sonolysis Promotes Indirect Co−C Bond Cleavage of Alkylcob(III)alamin Bioconjugates
  143. The Photochemistry of Dienes and Polyenes: Application to the Synthesis of Complex Molecules
  144. Tandem Enamine Michael Additions to 4-(Mesyloxy)cyclopentenones:  Bridged Tricyclic Skeletons via a Net [3 + 2] Construction1
  145. Photocyclization and photocycloaddition reactions of 4- and 2-pyrones
  146. Efficient Construction of Bi- and Tricyclic Cyclooctanoid Systems via Crossed [4+4]-Photocycloadditions of Pyran-2-ones1
  147. The Total Synthesis of a Natural Cardenolide:  (+)-Digitoxigenin
  148. Unexpected and efficient photochemical rearrangement of 6-hydroxyethylpyran-2-ones to 4-AIkylidene-5,6-dihydropyrans
  149. Unprecedented Diastereoselective Addition Reactions of 6,6-Dimethylcyclohexadienyl Titanium Complexes to Aldehydes and Ketones
  150. Intramolecular carboxylic acid trapping of pyran-4-one derived zwitterions: A novel synthesis of fused bicyclic lactones
  151. Profound Catalyst Effects in the Generation and Reactivity of Carbenoid-Derived Cyclic Ylides
  152. Applications of Stevens [1,2]-Shifts of Cyclic Ammonium Ylides. A Route to Morpholin-2-ones
  153. Piperidines via Ammonium Ylide [1,2]-Shifts: A Concise, Enantioselective Route to (-)-Epilupinine from Proline Ester
  154. Intramolecular [4 + 3]-cycloadditions of photochemically generated oxyallyl zwitterions: a route to functionalized cyclooctanoid skeletons
  155. Photochemical ring-contraction of fused bicyclic 4-pyrones: A novel 2-step cyclopentannulation approach
  156. Pseudocine substitution via internal delivery. Formal cyclopentadienone-ketone Michael adducts from 4-hydroxycyclopentenones
  157. Intramolecular arene trapping of pyran-4-one derived zwitterions: a two-step synthesis of tetrahydrobenz[e]inden-1-ones
  158. Intramolecular [4+4]-photocycloadditions of 2-pyrones: an efficient approach to cyclooctanoid construction
  159. Pseudocine substitution of 4-(mesyloxy)-2-cyclopentenones: an efficient route to 2,4-disubstituted 2-cyclopentenones
  160. Intramolecular alkene trapping of pyran-4-one-derived Zwitterions: a novel synthesis of diquinanes and hydrindans
  161. New route to substituted piperidines via the Stevens [1,2]-shift of ammonium ylides
  162. O-Bridged medium sized rings via bicyclic oxonium ylides
  163. Novel bicyclic oxazolines via nitrile capture of photochemically generated oxyallyl zwitterions
  164. One-Step Synthesis of Tertiary α-Amino Ketones and α-Amino Esters From Amines and Diazocarbonyl Compounds
  165. The Stevens [1,2]-shift of oxonium ylides: a route to substituted tetrahydrofuranones
  166. The photochemistry of pyran-4-ones: intramolecular trapping of the zwitterionic intermediate with pendant hydroxyl groups
  167. Ylides by the desilylation of .alpha.-silyl onium salts
  168. Nonstabilized imidate ylides by the desilylation method: a route to the pyrrolizidine alkaloids retronecine and indicine
  169. Thioimidate methylides by the desilylation method: an improved synthesis of pyrrolines and pyrroles