All Stories

  1. Host susceptibility and structural and immunological insight of S proteins of two SARS-CoV-2 closely related bat coronaviruses

    Article • Cell Discovery, July 2023, Springer Science + Business Media

    Dr Zhaohui Qian

  2. Optimization and Deoptimization of Codons in SARS‐CoV‐2 and Related Implications for Vaccine Development

    Article • Advanced Science, June 2023, Wiley

    Dr Zhaohui Qian

  3. Adaptive Evolution of the Spike Protein in Coronaviruses

    Article • Molecular Biology and Evolution, April 2023, Oxford University Press (OUP)

    Dr Zhaohui Qian

  4. A Competitive Panning Method Reveals an Anti-SARS-CoV-2 Nanobody Specific for an RBD-ACE2 Binding Site

    Article • Vaccines, February 2023, MDPI AG

    Dr Zhaohui Qian

  5. Effect of polymorphism in Rhinolophus affinis ACE2 on entry of SARS-CoV-2 related bat coronaviruses

    Article • PLoS Pathogens, January 2023, PLOS

    Dr Zhaohui Qian

  6. Mouse models susceptible to HCoV-229E and HCoV-NL63 and cross protection from challenge with SARS-CoV-2

    Article • Proceedings of the National Academy of Sciences, January 2023, Proceedings of the National Academy of Sciences

    Malik Peiris, Dr Zhaohui Qian

  7. A Lentiviral Pseudotype System to Characterize SARS-CoV-2 Glycoprotein

    Article • December 2022, Springer Science + Business Media

    Dr Zhaohui Qian

  8. Characterization of SARS-CoV-2 Glycoprotein Using a Quantitative Cell–Cell Fusion System

    Article • December 2022, Springer Science + Business Media

    Dr Zhaohui Qian

  9. A Host-Harbored Metabolic Susceptibility of Coronavirus Enables Broad-Spectrum Targeting

    Article • December 2022, Cold Spring Harbor Laboratory Press

    Dr Zhaohui Qian

  10. Relative vaccine effectiveness against Delta and Omicron COVID-19 after homologous inactivated vaccine boosting: a retrospective cohort study

    Article • BMJ Open, November 2022, BMJ

    Dr Zhaohui Qian

  11. A comprehensive survey of bat sarbecoviruses across China in relation to the origins of SARS-CoV and SARS-CoV-2

    Article • National Science Review, October 2022, Oxford University Press (OUP)

    Dr Zhaohui Qian

  12. Optimization and deoptimization of codons in SARS-CoV-2 and the implications for vaccine development

    Article • September 2022, Cold Spring Harbor Laboratory Press

    Dr Zhaohui Qian

  13. A Bispecific Antibody Targeting RBD and S2 Potently Neutralizes SARS-CoV-2 Omicron and Other Variants of Concern

    Article • Journal of Virology, August 2022, ASM Journals

    Dr Zhaohui Qian

  14. Simultaneous measurement of the antibody responses against SARS-CoV-2 and its multiple variants by a phage display mediated immuno-multiplex quantitative PCR-based assay

    Article • Frontiers in Microbiology, August 2022, Frontiers

    Dr Zhaohui Qian

  15. A case–case study on the effect of primary and booster immunization with China-produced COVID-19 vaccines on prevention of pneumonia and viral load among vaccinated persons infected by Delta and Omicron variants

    Article • Emerging Microbes & Infections, August 2022, Taylor & Francis

    Dr Zhaohui Qian

  16. Kathryn V. Holmes: A Career of Contributions to the Coronavirus Field

    Article • Viruses, July 2022, MDPI AG

    Dr Zhaohui Qian

  17. A Bispecific Antibody Targeting RBD and S2 Potently Neutralizes SARS-CoV-2 Omicron and Other Variants of Concern

    Article • May 2022, Cold Spring Harbor Laboratory Press

    Dr Zhaohui Qian

  18. The stalk domain of SARS-CoV-2 NSP13 is essential for its helicase activity

    Article • Biochemical and Biophysical Research Communications, April 2022, Elsevier

    Dr Zhaohui Qian

  19. Evolutionary dynamics of the severe acute respiratory syndrome coronavirus 2 genomes

    Article • Medical Review, February 2022, De Gruyter

    Dr Zhaohui Qian

  20. Negatively charged phospholipids accelerate the membrane fusion activity of the plant-specific insert domain of an aspartic protease

    Article • Journal of Biological Chemistry, January 2022, Elsevier

    Dr Zhaohui Qian

  21. SARS-CoV-2's origin should be investigated worldwide for pandemic prevention

    Article • The Lancet, October 2021, Elsevier

    Dr Zhaohui Qian

  22. A comprehensive survey of bat sarbecoviruses across China for the origin tracing of SARS-CoV and SARS-CoV-2

    Article • September 2021, Research Square

    Dr Zhaohui Qian

  23. On the origin of SARS-CoV-2—The blind watchmaker argument

    Article • Science China Life Sciences, July 2021, Springer Science + Business Media

    alice hughes, Dr Zhaohui Qian

  24. The Rhinolophus affinis bat ACE2 and multiple animal orthologs are functional receptors for bat coronavirus RaTG13 and SARS-CoV-2

    Article • Science Bulletin, June 2021, Elsevier

    Dr Zhaohui Qian

  25. Author Correction: Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV

    Article • Nature Communications, April 2021, Springer Science + Business Media

    Dr Zhaohui Qian

  26. The Rhinolophus affinis bat ACE2 and multiple animal orthologs are functional receptors for bat coronavirus RaTG13 and SARS-CoV-2

    Article • November 2020, Cold Spring Harbor Laboratory Press

    Dr Zhaohui Qian

  27. Insights into the mechanism of membrane fusion induced by the plant defense element, plant-specific insert

    Article • Journal of Biological Chemistry, October 2020, Elsevier

    Dr Zhaohui Qian

  28. Human monoclonal antibodies block the binding of SARS-CoV-2 spike protein to angiotensin converting enzyme 2 receptor

    Article • Cellular and Molecular Immunology, April 2020, Springer Science + Business Media

    Dr Zhaohui Qian

  29. Human monoclonal antibodies block the binding of SARS-CoV-2 spike protein to angiotensin converting enzyme 2 receptor

    Article • April 2020, Cold Spring Harbor Laboratory Press

    Dr Zhaohui Qian

  30. Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV

    Article • Nature Communications, March 2020, Springer Science + Business Media

    Dr Zhaohui Qian

  31. On the origin and continuing evolution of SARS-CoV-2

    Article • National Science Review, March 2020, Oxford University Press (OUP)

    Dr Zhaohui Qian

  32. Identification of a novel coronavirus causing severe pneumonia in human: a descriptive study

    Article • Chinese Medical Journal, February 2020, Wolters Kluwer Health

    Dr Zhaohui Qian

  33. Glycine 29 Is Critical for Conformational Changes of the Spike Glycoprotein of Mouse Hepatitis Virus A59 Triggered by either Receptor Binding or High pH

    Article • Journal of Virology, October 2019, ASM Journals

    Dr Zhaohui Qian

  34. A highly efficient in vivo plasmid editing tool based on CRISPR-Cas12a and phage λ Red recombineering

    Article • Journal of Genetics and Genomics, September 2019, Elsevier

    Dr Zhaohui Qian

  35. Identification of H209 as Essential for pH 8-Triggered Receptor-Independent Syncytium Formation by S Protein of Mouse Hepatitis Virus A59

    Article • Journal of Virology, March 2018, ASM Journals

    Dr Zhaohui Qian

  36. Crystal structure of the receptor binding domain of the spike glycoprotein of human betacoronavirus HKU1

    Article • Nature Communications, May 2017, Springer Science + Business Media

    Dr Zhaohui Qian

  37. Structural and Molecular Evidence Suggesting Coronavirus-driven Evolution of Mouse Receptor

    Article • Journal of Biological Chemistry, February 2017, Elsevier

    Dr Zhaohui Qian

  38. Identification of the Fusion Peptide-Containing Region in Betacoronavirus Spike Glycoproteins

    Article • Journal of Virology, March 2016, ASM Journals

    Dr Zhaohui Qian

  39. Platform technology to generate broadly cross-reactive antibodies to α-helical epitopes in hemagglutinin proteins from influenza A viruses

    Article • Biopolymers, March 2016, Wiley

    Dr Zhaohui Qian

  40. Deciphering the bat virome catalog to better understand the ecological diversity of bat viruses and the bat origin of emerging infectious diseases

    Article • The ISME Journal, August 2015, Springer Science + Business Media

    Dr Zhaohui Qian

  41. Identification of the Receptor-Binding Domain of the Spike Glycoprotein of Human Betacoronavirus HKU1

    Article • Journal of Virology, June 2015, ASM Journals

    Dr Zhaohui Qian

  42. Isolation, propagation, genome analysis and epidemiology of HKU1 betacoronaviruses

    Article • Journal of General Virology, April 2014, Society for General Microbiology

    Dr Zhaohui Qian

  43. Role of the Spike Glycoprotein of Human Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in Virus Entry and Syncytia Formation

    Article • PLoS ONE, October 2013, PLOS

    Dr Zhaohui Qian

  44. Human Coronavirus HKU1 Infection of Primary Human Type II Alveolar Epithelial Cells: Cytopathic Effects and Innate Immune Response

    Article • PLoS ONE, July 2013, PLOS

    Dr Zhaohui Qian

  45. Engineered Regulatory T Cells Coexpressing MHC Class II:Peptide Complexes Are Efficient Inhibitors of Autoimmune T Cell Function and Prevent the Development of Autoimmune Arthritis

    Article • The Journal of Immunology, June 2013, The American Association of Immunologists

    Dr Zhaohui Qian

  46. Innate Immune Response of Human Alveolar Type II Cells Infected with Severe Acute Respiratory Syndrome–Coronavirus

    Article • American Journal of Respiratory Cell and Molecular Biology, June 2013, American Thoracic Society

    Dr Zhaohui Qian

  47. Strategies for Designing Peptide Immunogens To Elicit α-Helical Conformation-Specific Antibodies Reactive with Native Proteins

    Article • January 2012, American Chemical Society (ACS)

    Dr Zhaohui Qian

  48. Crystal structure of mouse coronavirus receptor-binding domain complexed with its murine receptor

    Article • Proceedings of the National Academy of Sciences, June 2011, Proceedings of the National Academy of Sciences

    Dr Zhaohui Qian

  49. An Autoantigen-Specific, Highly Restricted T Cell Repertoire Infiltrates the Arthritic Joints of Mice in an HLA-DR1 Humanized Mouse Model of Autoimmune Arthritis

    Article • The Journal of Immunology, July 2010, The American Association of Immunologists

    Dr Zhaohui Qian

  50. Complementation of a Binding-Defective Retrovirus by a Host Cell Receptor Mutant

    Article • Journal of Virology, June 2004, ASM Journals

    Dr Zhaohui Qian

  51. An Aromatic Side Chain Is Required at Residue 8 of SU for Fusion of Ecotropic Murine Leukemia Virus

    Article • Journal of Virology, January 2004, ASM Journals

    Dr Zhaohui Qian

  52. A Point Mutation in the Binding Subunit of a Retroviral Envelope Protein Arrests Virus Entry at Hemifusion

    Article • Journal of Virology, January 2004, ASM Journals

    Dr Zhaohui Qian

  53. Identification of a Critical Basic Residue on the Ecotropic Murine Leukemia Virus Receptor

    Article • Journal of Virology, August 2003, ASM Journals

    Dr Zhaohui Qian